Chromatin Biology Group
The chromatin biology group focuses on epigenetic regulation in embryonic stem cells and cancer.
Back from left: Guro Cecilie Mustorp, Aruna Abraham, Martin Falck, Ragnhild Eskeland (PI), Hallvard Austin Wæhler, Ankush Sharma, Melanie Engelfriet, Mohamed Abdelhalim, Nils Anders Labba. Front from left: Marie Rogne, Tasmia Jinnurine, Beata Nadratowska-Wesolowska . Photo: Åslaug Brynildsen.
The main interest in our lab is to understand how gene activity is regulated by local composition (histone modifications and variants), chromatin structure and nuclear organisation. We uniquely combine in vitro and in vivo approaches to study these epigenetic mechanisms during in embryonic stem cell differentiation, in cancer cells and after exposure to drugs.
Figure: Our aim is to investigate how chromatin organization is disrupted in the context of genomic variation and epigenetic remodelling in cancer to unravel molecular mechanisms that can form the basis for new novel therapy strategies. (Image, Private)
Our research is funded by:
Anders Jahre Legat
Nansenfondet og de forbundne fond
Wedel Jarlsberg Fond