Vietri, Radulovic and Stenmark with Nature Review about ESCRT proteins in membrane dynamics
In a recent issue of Nature Reviews Molecular Cell Biology, Marina Vietri, Maja Radulovic and Harald Stenmark at CanCell review the many functions of a protein machinery specialized for membrane scission and sealing.
Many cellular processes relevant to cancer, including cytokinesis, membrane sealing and formation intraluminal vesicles in endosomes, involve abscission of narrow membrane tubes filled with cytosol. Such processes are mediated by a protein machinery known as endosomal sorting complex required for transport, ESCRT. The review by Vietri, Radulovic and Stenmark highlights the functions of ESCRT proteins in diverse membrane scission/sealing reactions and discusses their relevance to cancer and other diseases.