Clinical Effectiveness Research
The Research Group is conducting large randomized trials and observation studies to test and compare diagnostic and therapeutic clinical interventions in different areas of clinical medicine. The overarching goal is to find out what works and what does not. More than 300,000 patients are currently enrolled in studies run by the group.
The research group September 2018. Photo: Íris Ann Sigurðardóttir.
About the group
The clinical effectiveness group at the University of Oslo and Oslo University Hospital was established in 2012 by Michael Bretthauer and Mette Kalager. The young and dynamic group performs top research in diagnostic and therapeutic interventions in several clinical areas. The current portfolio of the group includes more than 300,000 patients in clinical trials. In addition, the group runs large observational studies and tests new new statistical methods in medicine.
Signature studies of the group include the Norwegian Colorectal Cancer Prevention trial NORCCAP, the Nordic-European Initiative on Colorectal Cancer NordICC, and the European Polyp Surveillance trials EPoS.
The group wants to move barriers in clinical research and aims at improving clinical practices. The work is team-based and inclusive. Click here for news and publications.
Common medications affect screening test
Jan. 29, 2019 10:13 AM
New paper in Gastroenterology: Authors found that both aspirin, and in particular oral anticoagulants, lowers the positive predictive value of fecal testing for occult blood.
Interval cancers are not more lethal
Dec. 6, 2018 1:15 PM
One of the major concerns of cancer screening is interval cancers, which are cancers arising after a negative screening test. These cancers have been believed to be especially aggressive and have a poor prognosis. A new study shows that they are not.
The group receives research grants from many entitiescome out their amongst the Norwegian research Council, the European Union, the Norwegian cancer society, the southeast NORWAY health region, and others.
Collaboration: the group is running the regional network for clinical effectiveness in gastroenterology in South-East Norway which is a collaboration between researchers at Oslo University Hospital and the University of Oslo, Sørlandet Hospital in Arendal and Kristiansand, Telemark Hospital, Vestfold Hospital, Bærum Hospital Vestre Viken, Østfold Hospital and Innlandet Hospital.
The research group has a formal collaboration with these and other academic institutions abroad:
- Harvard T.H Chan School of Public Health, Boston, USA
- Karolinska Instituttet, Stockholm, Sweden
- Erasmus Medical Centre, Rotterdam, Netherlands
- Marie Curie Sklodowska Cancer Center, Warsawa, Poland
- Sloan Kettering Memorial Cancer Center, New York City, USA
- Uppsala University Hospital, Uppsala, Sweden
- Landspitali University Hospital, Reykjavik, Iceland