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Clinical Effectiveness Research

The Research Group is conducting large randomized trials and epidemiology to test and compare diagnostic and therapeutic clinical interventions in different areas of clinical medicine.The overarching goal is to find out what works and what does not.  More than 300,000 patients are currently enrolled in studies run by the Group.

The research group September 2018. Photo: Íris Ann Sigurðardóttir.

About the group

The Group collaborates with most hospitals in Norway, and with many leading research institutions worldwide. The group was established in 2012 at the University of Oslo/Oslo University Hospital and is headed by Mette Kalager.

The group originates from an active research environment within the field of gastroenterology at Telemark Hospital in Norway. They have since the 1980's conducted research on screening for colorectal cancer. The group has been responsible for several randomized trials within endoscopic screening; theTelemark Polyp Study (TPS), the Norwegian Colorectal Cancer Prevention study (NORCCAP), and the Nordic-European Initiative on Colorectal Cancer (NordICC).

The group has the main responsibility for the multinational NordICC-trial and is strongly involved in the NORCCAP and TPS studies. In 2014 they initiated a large multinational study on surveillance after polypectomy; the European Polyp Surveillance (EPoS). In addition, they conduct research on clinical issues within gastroenterology, epidemiologic studies on mammography and quality improvement of clinical practice.


  • michael_colo Overdiagnosis in Colorectal Cancer Screening? Aug. 15, 2018 10:49 AM

    Overdiagnosis is recognized as a major harm of mammography and prostate cancer screening – what about colorectal cancer screening?

  • holme_portrett Making colonoscopy smarter Aug. 15, 2018 11:24 AM

    Standardized computer-aided diagnosis (CAD) can help reduce unnecessary removal of colonic polyps with no malignant potential.


The group has received external funding from The Norwegian Research Council (NFR) and the South-Eastern Norway Regional Health Authority.


Together with collaborating research groups at Oslo University Hospital, they received grants from Stiftelsen K. G Jebsen in 2014, and formed the K. G Jebsen Colorectal Cancer Research Centre at Oslo University Hospital.

They have also formed the Regional Research Network for Clinical Effectiveness in Gastroenterology. This network has received funding from the South-Eastern Norway Regional Health Authority, and is a collaboration between researhers at Oslo University Hospital and the University of Oslo, Sørlandet Hospital in Arendal and Kristiansand, Telemark Hospital, Vestfold Hospital, Bærum Hospital Vestre Viken, Østfold Hospital and Innlandet Hospital.

The research group has a formal collaboration with several academic institutions abroad:

  • Harvard T.H Chan School of Public Health, Boston, USA
  • Karolinska Instituttet, Stockholm, Sweden
  • Erasmus Medical Centre, Rotterdam, Netherlands
  • Marie Curie Sklodowska Cancer Center, Warsawa, Poland
  • Sloan Kettering Memorial Cancer Center, New York City, USA
  • Uppsala University Hospital, Uppsala, Sweden
  • Landspitali University Hospital, Reykjavik, Iceland
Tags: Nordic, USA
Published Nov. 8, 2012 4:31 PM - Last modified Sep. 20, 2018 8:56 AM