Due to copyright issues, an electronic copy of the thesis must be ordered from the faculty. For the faculty to have time to process the order, the order must be received by the faculty at the latest 2 days before the public defence. Orders received later than 2 days before the defence will not be processed. After the public defence, please address any inquiries regarding the thesis to the candidate.
Trial Lecture – time and place
See Trial Lecture.
Adjudication committee
- First opponent: Professor Alexander Meining, University Hospital of Wurzburg
- Second opponent: Honorary Consultant Noriko Suzuki, St. Mark's Hospital
- Third member and chair of the evaluation committee: Professor Olav Dalgard, University of Oslo
Chair of the Defence
Professor II Erlend Hem, Faculty of Medicine, University of Oslo
Principal Supervisor
Professor Michael Bretthauer, Faculty of Medicine, University of Oslo
Summary
Colorectal cancer is considered a growing health burden and a preventable disease. It is the third most common cancer and the second leading cause of cancer death worldwide. Many countries have implemented colorectal cancer screening to reduce the risk of colorectal cancer incidence and mortality. Colonoscopy is considered the gold standard of colorectal cancer screening, but it is dependent on endoscopist performance and technology used. Novel technologies such as artificial intelligence (AI) targeting improved performance and standardization is expected to play a bigger role in colonoscopy screening in the future. Clinical validation of the efficacy of AI is important in the early adoption of AI-based tools. This thesis aims to investigate the clinical performance of AI to optimize colonoscopy for colorectal cancer screening.
The thesis includes a systematic review and meta-analysis of prospective trials to determine the value of AI-based polyp and colorectal cancer detection systems, an international multicenter clinical trial comparing an AI-based device for optical diagnosis of polyps to visual inspection, and lastly a clinical implementation trial to evaluate the performance of an AI-based speedometer that monitors withdrawal speed during colonoscopy.
The studies included in this thesis show no clear proof of benefit from AI-based tools in colonoscopy screening. However, the AI-based tools may cause harm and thus increase the burden of colorectal cancer screening. This thesis does not add to the hype, but rather adds to the current understanding of where AI falls short and what is needed in order to implement AI in colorectal cancer screening with colonoscopy in the future.
Additional information
Contact the research support staff.