About the project
Diabetes and depression are both commonly occurring conditions and are associated with the modern lifestyles of today’s society. The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030. Adults with depression have a 37% increased risk of developing type 2 diabetes (8) and evidence from cross-sectional and prospective studies suggests that depressive symptoms negatively influence glucose metabolism.
Studies have shown that diabetes was twice as likely to develop in depressed individuals compared with non-depressed individuals after 13 and 8 years of follow-up, respectively. Depression may contribute to metabolic abnormalities preceding the development of diabetes, although the evidence is still conflicting.
We have employed an intervention study design with a particularly sensitive method hyperinsulinemic euglycemic clamp to quantify changes in insulin sensitivity with remission of depression. We hypothesized that a reduction in depressive symptoms would lead to a better insulin sensitivity, and possibly changes in other parameters of the metabolic syndrome.
- University of Oslo
- Oslo Health region-East
- Norwegian Medical Association
Start - Finish
2008 - 2011