The Krauss group

The Krauss group focuses on applying developmental biology and chemical biology to organ-on-a-chip technology.

Based on a background in developmental biology and morphogenetic signals (in particular WNT and HH signaling), the Krauss group has established a program for phenocopying spatial and temporal processes in the development of organoids. In parallel, the group develops an organ-on-a-chip platform that enables vascularization and exposure to circulating immune cells. Using this strategy, we aim to develop more structured organoids than hitherto possible and at the same time achieve better functional maturation and functionality.

For organoid characterization, the group focuses predominantly on confocal microscopy, RNA sequencing (collaboration Simon Rayner), Raman spectroscopy (collaboration Molly Stevens), LC-MS (collaboration Steven Wilson), cytokine characterization (collaboration Hanne Scholz) and impedance measurements (collaboration Ørjan Martinsen).

In the chemical biology program, the group has further advanced its WNT/tankyrase inhibitor series with the lead compound OM-0815 having reached preclinical candidate status.

Selected Publications

  • Mathias Busek, Steffen Nøvik, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Thomas Combriat, Stefan Grünzner, Stefan Krauss. Thermoplastic elastomer (TPE) – Poly-(methyl methacrylate) (PMMA) hybrid devices for active pumping PDMS-free Organ-on-a-Chip systems (2021) Biosensors 2021, 11(5), 162
  • Zhang Y, Shen L, Dreissigacker K, Zhu H, Trinh-Minh T, Meng X, Tran-Manh C, Dees C, Matei AE, Chen CW, Ditschkowski M, Krauss S, Winkler J, Wolff D, Ziemer M, Beilhack A, Karrer S, Herr W, Mackensen A, Schett G, Spriewald BM, Distler JHW. Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease. (2021) Blood. Feb 2:blood.2020008720. doi: 10.1182/blood.2020008720
  • Jo Waaler, Ruben G. G. Leenders, Sven T. Sowa, Shoshy Alam Brinch, Max Lycke, Piotr Nieczypor, Sjoerd Aertssen, Sudarshan Murthy, Albert Galera-Prat, Eddy Damen, Anita Wegert, Marc Nazaré, Lari Lehtiö, and Stefan Krauss. (2020) Pre-clinical lead optimization of a 1,2,4-triazole based tankyrase inhibitor. J Med Chem. 2020 Jul 9;63(13):6834-6846
  • Jo Waaler, Line Mygland, Anders Tveita, Martin Frank Strand, Nina Therese Solberg, Petter Angell Olsen, Kaja Lund, Shoshy Alam Brinch, Max Lycke, Elisabeth Dybing, Vegard Nygaard, Sigurd Læines Bøe, Karen-Marie Heinz, Eivind Hovig, Alexandre Corthay, Stefan Krauss. (2020) Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in mouse models. Commun Biol. 2020 Apr 24;3(1):196. doi: 10.1038/s42003-020-0916-2
  • Harmonie Perdreau-Dahl, Cinzia Progida, Stefan J. Barfeld, Hanne Guldsten, Bernd Thiede, Magnus Arntzen, Oddmund Bakke, Ian G. Mills, Stefan Krauss and J. Preben Morth. (2020) Sjögren syndrome/scleroderma autoantigen 1 is a direct Tankyrase binding partner in cancer cells. Commun Biol. 2020 Mar 13;3(1):123. doi: 10.1038/s42003-020-0851-2.
Published Mar. 8, 2018 3:02 PM - Last modified June 25, 2021 9:19 AM