New article from HTH post doc Henrik Vogt discussing epistemological and ethical issues with precision medicine.
New article in Autophagy: Autophagy modulates cell fate decisions during lineage commitment with Sean Harrison and Saphira Baumgarten as co-authors and Gareth Sullivan as senior author.
In order to stimulate excellent research and draw attention to the hospital's research activity, Oslo University Hospital rewards outstanding publications every half-year. Espen Melum and his collaborators were one of six groups awarded for articles published in the first half of 2021.
New article in Analysis and Sensing: Direct Electromembrane Extraction based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids. Frøydis Sved Skottvoll is first author with Steven Wilson as senior author.
HTH Postdocotral research fellow Shadab Abadpour won Best Oral Abstract Award at the International Pancreas & Islet Transplant Association’s 2021 virtual congress (IPITA2021).
Postdocs Aleksandra Aizenshtadt and Mathias Busek have recieved a 500 000 NOK Innovation grant from HSØ for the project: Pump-less organ-on-a-chip platform – upscaling and standardization
New article in Journal of Medicinal Chemistry from Jo Waaler with Shoshy Alam Brinch and senior author Stefan Krauss titled: Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Chencheng Wang presented his latest research at the International Pancreas & Islet Transplant Association’s 2021 virtual congress (IPITA2021). The presentation was titled: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells.
Post doctoral research fellows Mathias Busek and Aleksandra Aizenshtadt recieved the 2nd price for their business plan and pitch in the Health innovation and entrepreneurship course at The School of Health Innovation.
New article in genes from Petter Angell Olsen with Stefan Krauss as senior author demonstrating that "HEK293 cells display an unexpected distribution of key components of the WNT/β-catenin signaling pathway where AXIN1, APC, DVL2 and tankyrase are all co-localized in large spherical cytoplasmic aggregates."
The Novo Nordic Foundation have awarded Hanne Scholz 1.3 million NOK for the project titled: Generation of insulin-producing cells from bile duct cells(cholangiocyte organoids)
The convergence environment MORGI (Modeling Human Multi-Organ Interaction in Disease - Cancer Cachexia) will create a platform with organ representation technology to explain communication between organs in case of disease.
Stefan Krauss will lead the new convergence enviroment ITOM - Integrated technologies for tracking organoid morphogenesis. The convergence environment will use advanced imaging technology and data analysis to improve stem cell derived organ representations.
HTH group leader Steven Wilson was a guest on last weeks Abels Tårn radio show and podcast discussing how he became interested in chemistry and the need for organoids in future drug discovery.
New article Frontiers in Cell and Developmental Biology from Gareth Sullivan and collaborators on mitochondrial adaptation when differentiating human pluripotent stem cells to cardiac progenitors and functional cardiomyocytes.
New article from Nikolaj Gadegaard and Gareth Sullivan with Sean Harrison in the journal: Macromolecular Materials and Engineering.
New publication from Gareth Sullivan and collaborators in Frontiers in Cell and Developmental Biology. The article examines how POLG mutations affect mitophagy in astrocytes and how this can be ameliorated pharmacologically.
In September Alexey Golovin joined the Hybrid Technology Hub as an engineer.
New article in Journal of Hepatology from Gareth Sullivan and collaborators. The review highlights the necessity for more realistic human-based systems to assess hepatotoxicity to guide future drug safety testing.
Shoshy Alam Brinch with Jo Waaler and Stefan Krauss is one of six new teams admitted to UiO's innovation programme SPARK Norway with the project: Tankyrase inhibition for therapy of fibrotic diseases
This month, Ludivine Delon joined the Hybrid Technology Hub – Centre for Organ on a Chip Technology – as a Postdoctoral Fellow
New article in Transplant International from Hanne Scholz and collaborators. The opinion paper summarizes the early organoid achievements and comments on the future of organoid transplantation.
Ingrid Wilhelmsen joins the Hybrid Technology Hub as a new Doctoral fellow.
Project title: Scalable directional pump-less perfusion (dPP) organ-on-a-chip platform.
Project title: Multiomic 4-dimensional identification of novel treatment targets for bile duct inflammation