The European Innovation Council Pathfinder Challenges program funds the international research consortium “Supervised Morphogenesis in Gastruloids” - SUMO
The project entitled “TumorChip - development of a tumor-on-a-chip platform for testing WNT signaling inhibition as an enabling factor in melanoma immune oncology” received 8 mio NOK. The funding will be used to establish a tumor-on-a-chip platform for personalized drug testing at HTH.
The Hybrid Technology Hub is a partner in the Research School for Training the Next Generation of Micro- and Nanotechnology Researchers in Norway (TNNN). The research school is coordinated by NTNU.
HTH researcher Aleksandra Aizenshtadt receives 50 000 NOK from The UiO Life Science Growth House in their first call for innovative researchers. Therese Bang received 10 000 NOK for her student project.
HTH researchers held workshops in 3D bioprinting of cell-laden scaffolds, generation of stem cell derived organoids models and engineering of organ-on-a-chip platforms. Hanne Scholz chaired a session on "Enabling technologies for beta cell transplantation" and Stefan Krauss gave an introduction to metabolism on chip.
Hanne Scholz is one of the new authors on this Editorial on Beta-Cell Fate: From Gene Circuits to Disease Mechanisms in Frontiers in Genetics
New article in Cancer Research Communications from S. Alam Brinch, A. Aizenshtadt, P. A. Olsen, Stefan Krauss and Jo Waaler. The article demonstrates the effectiveness and therapeutic window for a novel tankyrase inhibitor in mouse tumor models.
Through the initiative #scienceforukraine Espen Melum has invited Ukrainian researchers to work in his lab.
New article in biosensors from M. Busek, A.Aizenshtadt, M. Amirola-Martinez, L. Delon and S. Krauss. The article is an academic user view on the current use of Organ-on-a-Chip technology in academia and industry.
This month Hanne Scholz was a guest on the Abels Forgård radioshow and podcast talking about 3D printing of organs.
New article in Cell Cycle from Gareth Sullivan and collaborators: POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition
MSc. Frøydis Sved Skottvoll at the Department of Chemistry, Faculty of Mathematics and Natural Sciences, is defending her thesis «Liver organoids, mass spectrometry and separation science» for the degree of Philosophiae Doctor. Mar. 11, 2022 1:15 PM–4:30 PM, Zoom
Shadab Abadpour with Aleksandra Aizenshtadt, Mathias Busek, Chencheng Wang, Steven Ray Haakon Wilson, Stefan Krauss, and Hanne Scholz is one of five new teams admitted to UiO's innovation programme SPARK Norway with the project: Metabolism-on-chip
The project is entitled “Unleashing the full antitumor potential of macrophages for next-generation cancer immunotherapy”and a central part of this project will be to establish and use tumor on-a-chip technology at HTH.
New article from HTH post doc Henrik Vogt discussing epistemological and ethical issues with precision medicine.
New article in Autophagy: Autophagy modulates cell fate decisions during lineage commitment with Sean Harrison and Saphira Baumgarten as co-authors and Gareth Sullivan as senior author.
In order to stimulate excellent research and draw attention to the hospital's research activity, Oslo University Hospital rewards outstanding publications every half-year. Espen Melum and his collaborators were one of six groups awarded for articles published in the first half of 2021.
New article in Analysis and Sensing: Direct Electromembrane Extraction based Mass Spectrometry: A Tool for Studying Drug Metabolism Properties of Liver Organoids. Frøydis Sved Skottvoll is first author with Steven Wilson as senior author.
HTH Postdocotral research fellow Shadab Abadpour won Best Oral Abstract Award at the International Pancreas & Islet Transplant Association’s 2021 virtual congress (IPITA2021).
Postdocs Aleksandra Aizenshtadt and Mathias Busek have recieved a 500 000 NOK Innovation grant from HSØ for the project: Pump-less organ-on-a-chip platform – upscaling and standardization
New article in Journal of Medicinal Chemistry from Jo Waaler with Shoshy Alam Brinch and senior author Stefan Krauss titled: Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II
Chencheng Wang presented his latest research at the International Pancreas & Islet Transplant Association’s 2021 virtual congress (IPITA2021). The presentation was titled: High Glucose Concentration Increases KATP Channel Activity but Suppresses Mitochondrial Respiration Ability in Insulin-producing Cells Regenerated From Stem Cells.
Post doctoral research fellows Mathias Busek and Aleksandra Aizenshtadt recieved the 2nd price for their business plan and pitch in the Health innovation and entrepreneurship course at The School of Health Innovation.
New article in genes from Petter Angell Olsen with Stefan Krauss as senior author demonstrating that "HEK293 cells display an unexpected distribution of key components of the WNT/β-catenin signaling pathway where AXIN1, APC, DVL2 and tankyrase are all co-localized in large spherical cytoplasmic aggregates."