Jo Waaler

Project Group Leader
Image of Jo Waaler
Mobile phone 95148669
Room Domus Medica IV

Academic interests

WNT/tankyrase inhibitor treatment in cancer treatment Background Researcher, project group leader and PhD at the University of Oslo working on WNT/tankyrase inhbitors.

Positions held

Researcher at OUH

Publications

  1. Jo Waaler et al. Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Preprint BioRxiv doi:https://doi.org/10.1101/526343 (under revision 2018)
  2. Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov SV, von Kries JP, Lehtiö L, Krauss S*, Nazaré M*. (*Shared last authorship) (2017) Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. Journal of Medicinal Chemistry. 2017 Nov 20.
  3. Solberg, NT, Waaler J, Lund K, Mygland L, Olsen PA, Krauss S. Tankyrase Inhibition Enhances the Antiproliferative Effect of PI3K and EGFR Inhibition, Mutually Affecting b-Catenin and Akt Signaling in Colorectal Cancer. Molecular Cancer Research 16, no. 3 (2018): 543-553.
  4. Voronkov A*, Holsworth DD*, Waaler J*, Wilson SR, Ekblad B, Perdreau-Dahl H, Dinh H, Drewes G, Hopf C, Morth JP, Krauss S (2013) Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific Tankyrase 1/2 inhibitor. Journal of Medicinal Chemistry, (2013) 56 (7), 3012-23. *Shared first authorship.
  5. Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M . A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth Cancer Research, (2013), 73 (10), 3132-44.
  6. Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S (2012) A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice. Cancer Res, 72 (11), 2822-32
Published Mar. 22, 2019 2:54 PM - Last modified June 25, 2019 1:37 PM

Research groups