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Organoids

This platform develops standardized iPS derived organotypic structures with key attributes of the organ being modeled.

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Liver organoid with HNF4a in yellow, E-cadherin in cyan, and albumin in magenta. Scale bar: 50 uM (credit: Aleksandra Aizenshtadt).

We are developing standardized functionally validated organotypic structures, with in vivo attributes of the organs being modeled. Organoids are derived from human induced pluripotent stem cells by directed differentiation to core functional unit(s) of the organ and benchmarked to human organ tissue. Organoids are grown in modular fluidic “containers”, providing easy handling and allowing versatile modular combinations on the “organ on a chip” platform. Our main focus is on hepatic, islet and adipocyte organoids.

 

Contributing research groups:

 

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Structural analysis of a living bile duct (cholangiocyte) organoid. Gray represents label-free holotomographic imaging, while Blue depicts AI-generated segmentation of biological material. Organoid diameter: ca 100 um (credit: Thomas Combriat, Henry Hoyle).

 

Published Sep. 18, 2017 1:38 PM - Last modified Jan. 26, 2024 10:49 AM