Arne Klungland

• Khodeer, Sherif; Klungland, Arne & Dahl, John Arne (2022). ALKBH5 regulates somatic cell reprogramming in a phase-specific manner. Journal of Cell Science. ISSN 0021-9533. 135(11). doi: 10.1242/jcs.259824.
• Su, Zhangli; Monshaugen, Ida; Wilson, Briana; Wang, Fengbin; Klungland, Arne & Ougland, Rune [Show all 7 contributors for this article] (2022). TRMT6/61A-dependent base methylation of tRNA-derived fragments regulates gene-silencing activity and the unfolded protein response in bladder cancer. Nature Communications. ISSN 2041-1723. 13(1). doi: 10.1038/s41467-022-29790-8.
• Zhao, Xu; Hendriks, Ivo A; Le Gras, Stephanie; Ye, Tao; Ramos Alonso, Lucia & Nguéa P, Aurélie [Show all 13 contributors for this article] (2022). Waves of sumoylation support transcription dynamics during adipocyte differentiation. Nucleic Acids Research (NAR). ISSN 0305-1048. 50(3), p. 1351–1369. doi: 10.1093/nar/gkac027.
• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Leiros, Ingar & Kirpekar, Finn [Show all 10 contributors for this article] (2021). Intrinsic Strand-Incision Activity of Human UNG: Implications for Nick Generation in Immunoglobulin Gene Diversification. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.762032. Full text in Research Archive
• Zhang, Li-Sheng; Xiong, Qing-Ping; Pérez, Sonia Peña; Liu, Chang; Wei, Jiangbo & Le, Cassy [Show all 19 contributors for this article] (2021). ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing. Nature Cell Biology. ISSN 1465-7392. 23(7), p. 684–691. doi: 10.1038/s41556-021-00709-7.
• Jin, Kang-Xuan; Zuo, Rujuan; Anastassiadis, Konstantinos; Klungland, Arne; Marr, Carsten & Filipczyk, Adam (2021). N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 118(51). doi: 10.1073/pnas.2105192118. Full text in Research Archive
• Hildrestrand, Gunn Annette; Rolseth, Veslemøy; Kunath, Nicolas; Suganthan, Rajikala; Jensen, Vidar & Bugaj, Anna Maria [Show all 24 contributors for this article] (2021). NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice. Communications Biology. ISSN 2399-3642. 4. doi: 10.1038/s42003-021-02864-x. Full text in Research Archive
• Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuvienė, Miglė; Arshad, Aysha; Guragain, Prashanna & Klungland, Arne [Show all 9 contributors for this article] (2021). Alleviation of C⋅C Mismatches in DNA by the Escherichia coli Fpg Protein. Frontiers in Microbiology. ISSN 1664-302X. 12. doi: 10.3389/fmicb.2021.608839. Full text in Research Archive
• Sankar, Aditya; Lerdrup, Mads; Manaf, Adeel; Johansen, Jens Vilstrup; Gonzalez, Javier Martin & Borup, Rehannah [Show all 13 contributors for this article] (2020). KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes. Nature Cell Biology. ISSN 1465-7392. 22(4), p. 380–388. doi: 10.1038/s41556-020-0494-z.
• Kong, Xiang Yi; Vik, Erik Sebastian; Nawaz, Meh Sameen; Berges, Natalia; Dahl, Tuva Børresdatter & Vågbø, Cathrine [Show all 17 contributors for this article] (2020). Deletion of Endonuclease V suppresses chemically induced hepatocellular carcinoma. Nucleic Acids Research (NAR). ISSN 0305-1048. 48(8), p. 4463–4479. doi: 10.1093/nar/gkaa115. Full text in Research Archive
• Li, Miaomiao & Klungland, Arne (2020). Modifications and interactions at the R-loop. DNA Repair. ISSN 1568-7864. 96. doi: 10.1016/j.dnarep.2020.102958.
• Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette & Rinholm, Johanne Egge [Show all 21 contributors for this article] (2020). OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. Cell reports. ISSN 2211-1247. 30(12), p. 4165–4178. doi: 10.1016/j.celrep.2020.02.063. Full text in Research Archive
• Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Muruzábal-Lecumberri, Izaskun; Haugland, Gyri Teien; Leiros, Ingar & Ruoff, Peter [Show all 15 contributors for this article] (2020). The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside. Frontiers in Microbiology. ISSN 1664-302X. 11. doi: 10.3389/fmicb.2020.00263. Full text in Research Archive
• Pilžys, Tomaš; Marcinkowski, Michał; Kukwa, Wojciech; Garbicz, Damian; Dylewska, Małgorzata & Ferenc, Karolina [Show all 15 contributors for this article] (2019). ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy. Scientific Reports. ISSN 2045-2322. 9(1). doi: 10.1038/s41598-019-49550-x.
• Abakir, Abdulkadir; Giles, Tom C.; Cristini, Agnese; Foster, Jeremy M.; Dai, Nan & Starczak, Marta [Show all 22 contributors for this article] (2019). N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells. Nature Genetics. ISSN 1061-4036. 52(1), p. 48–55. doi: 10.1038/s41588-019-0549-x.
• Zhang, Zhichao; Manaf, Adeel; Li, Yanjiao; Pérez, Sonia Peña; Suganthan, Rajikala & Dahl, John Arne [Show all 8 contributors for this article] (2019). Histone methylations define neural stem/progenitor cell subtypes in the mouse subventricular zone. Molecular Neurobiology. ISSN 0893-7648. doi: 10.1007/s12035-019-01777-5. Full text in Research Archive
• Jarøy, Emilie Grimnes; Acosta Jiménez, Lourdes Patricia; Hotta, Ryo; Goldstein, Allan M.; Emblem, Ragnhild & Klungland, Arne [Show all 7 contributors for this article] (2019). "Too much guts and not enough brains": (epi)genetic mechanisms and future therapies of Hirschsprung disease - a review. Clinical Epigenetics. ISSN 1868-7075. 11. doi: 10.1186/s13148-019-0718-x. Full text in Research Archive
• Prikrylova, Terezia; Robertson, Julia; Ferrucci, Francesca; Konorska, Dorota Joanna; Aanes, Håvard & Manaf, Adeel [Show all 16 contributors for this article] (2019). 5-hydroxymethylcytosine marks mammalian origins acting as a barrier to replication. Scientific Reports. ISSN 2045-2322. 9. doi: 10.1038/s41598-019-47528-3. Full text in Research Archive
• Alexeeva, Marina; Moen, Marivi Nabong; Grøsvik, Kristin; Tesfahun, Almaz Nigatu; Xu, Xiang Ming & Muruzábal-Lecumberri, Izaskun [Show all 12 contributors for this article] (2018). Excision of uracil from DNA by hSMUG1 includes strand incision and processing. Nucleic Acids Research (NAR). ISSN 0305-1048. 47(2), p. 779–793. doi: 10.1093/nar/gky1184. Full text in Research Archive
• Yaddehi Gamage, Thilini Hansamali Gamage; Gunnes, Gjermund; Lee, Robert Hugh; Louch, William Edward; Holmgren, Asbjørn & Bruton, Joseph D. [Show all 19 contributors for this article] (2018). STIM1 R304W causes muscle degeneration and impaired platelet activation in mice. Cell Calcium. ISSN 0143-4160. 76, p. 87–100. doi: 10.1016/j.ceca.2018.10.001. Full text in Research Archive Show summary

  STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.

• Wei, Jiangbo; Liu, Fange; Lu, Zhike; Fei, Qili; Ai, Yuxi & He, P. Cody [Show all 13 contributors for this article] (2018). Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Molecular Cell. ISSN 1097-2765. 71(6), p. 973–985. doi: 10.1016/j.molcel.2018.08.011.
• Askeland, Georgina; Rodinova, Marie; Štufková, Hana; Dosoudilova, Zaneta; Baxa, Monika & Smatlikova, Petra [Show all 15 contributors for this article] (2018). A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies. Disease Models and Mechanisms. ISSN 1754-8403. 11(10). doi: 10.1242/dmm.035949. Full text in Research Archive
• Askeland, Georgina; Dosoudilova, Zaneta; Rodinova, Marie; Klempir, Jiri; Liskova, Irena & Kusnierczyk, Anna [Show all 11 contributors for this article] (2018). Increased nuclear DNA damage precedes mitochondrial dysfunction in peripheral blood mononuclear cells from Huntington's disease patients. Scientific Reports. ISSN 2045-2322. 8(1). doi: 10.1038/s41598-018-27985-y. Full text in Research Archive
• Ma, Chunhui; Chang, Mengqi; Lv, Hongyi; Zhang, Zhi-Wei; Zhang, Weilong & He, Xue [Show all 17 contributors for this article] (2018). RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum. Genome Biology. ISSN 1465-6906. 19(1). doi: 10.1186/s13059-018-1435-z. Full text in Research Archive
• Li, Miaomiao; Zhao, Xu; Wang, Wei; Shi, Hailing; Pan, Qingfei & Lu, Zhike [Show all 11 contributors for this article] (2018). Ythdf2-mediated m6A mRNA clearance modulates neural development in mice. Genome Biology. ISSN 1465-6906. 19(1). doi: 10.1186/s13059-018-1436-y. Full text in Research Archive
• Alexeeva, Marina; Guragain, Prashanna; Tesfahun, Almaz Nigatu; Tomkuvienė, Miglė; Arshad, Aysha & Gerasimaitė, Rūta [Show all 13 contributors for this article] (2018). Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins . Philosophical Transactions of the Royal Society of London. Biological Sciences. ISSN 0962-8436. 373(1748). doi: 10.1098/rstb.2017.0337. Full text in Research Archive
• Jordan, Jennifer J.; Chhim, Sophea; Margulies, Carrie M.; Allocca, Mariacarmela; Bronson, Roderick T. & Klungland, Arne [Show all 8 contributors for this article] (2017). ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage. Cell Death & Disease. ISSN 2041-4889. 8. doi: 10.1038/cddis.2017.343.
• Tang, Chong; Klukovich, Rachel; Peng, Hongying; Wang, Zhuqing; Yu, Tian & Zhang, Ying [Show all 9 contributors for this article] (2017). ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 115(2), p. E325–E333. doi: 10.1073/pnas.1717794115.
• Pawar, Tina; Bjørås, Magnar; Klungland, Arne & Eide, Lars (2017). Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA. Mitochondrion (Amsterdam. Print). ISSN 1567-7249. 40, p. 16–28. doi: 10.1016/j.mito.2017.09.002. Full text in Research Archive
• Landfors, Miriam; Johansen, Jostein; Aronsen, Jan Magnus; Vågbø, Cathrine Broberg; Doré, Louis C. & He, Chuan [Show all 13 contributors for this article] (2017). Genome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation. Cell Discovery. ISSN 2056-5968. 3. doi: 10.1038/celldisc.2017.13. Full text in Research Archive
• Seifermann, Marco; Ulges, Alexander; Bopp, Tobias; Melcea, Svetlana; Schäfer, Andrea & Oka, Sugako [Show all 10 contributors for this article] (2017). Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes. DNA Repair. ISSN 1568-7864. 58, p. 13–20. doi: 10.1016/j.dnarep.2017.08.005.
• Aas, Aleksander; Isakson, Pauline; Bindesbøll, Christian; Alemu, Endalkachew Ashenafi; Klungland, Arne & Simonsen, Anne (2017). Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy. PLOS ONE. ISSN 1932-6203. 12(3). doi: 10.1371/journal.pone.0168182. Full text in Research Archive
• Kalikstad, Betty; Kultima, Hanna Goransson; Andersstuen, Terese; Klungland, Arne & Isaksson, Anders (2017). Gene expression profiles in preterm infants on continuous long-term oxygen therapy suggest reduced oxidative stress-dependent signaling during hypoxia. Molecular Medicine Reports. ISSN 1791-2997. 15(4), p. 1513–1526. doi: 10.3892/mmr.2017.6185. Full text in Research Archive
• Rolseth, Veslemøy; Gomez, Luisa Fernanda Luna; Olsen, Ann-Karin; Suganthan, Rajikala; Scheffler, Katja & Neurauter, Christine Gran [Show all 15 contributors for this article] (2017). No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice. Scientific Reports. ISSN 2045-2322. 7. doi: 10.1038/s41598-017-04472-4. Full text in Research Archive
• Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Robertson, Joseph; Klungland, Arne & Enserink, Jorrit (2017). TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 114(5), p. 1039–1044. doi: 10.1073/pnas.1615093114.
• Olsen, Maria Belland; Hildrestrand, Gunn Annette; Scheffler, Katja; Vinge, Leif Erik; Alfsnes, Katrine & Palibrk, Vuk [Show all 29 contributors for this article] (2017). NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture. Cell reports. ISSN 2211-1247. 18, p. 82–92. doi: 10.1016/j.celrep.2016.12.009. Full text in Research Archive
• Klungland, Arne & Robertson, Adam Brian (2016). Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine. Free Radical Biology & Medicine. ISSN 0891-5849. 107, p. 62–68. doi: 10.1016/j.freeradbiomed.2016.11.038.
• Alemu, Endalkachew Ashenafi; He, Chuan & Klungland, Arne (2016). ALKBHs-facilitated RNA modifications and de-modifications. DNA Repair. ISSN 1568-7864. 44, p. 87–91. doi: 10.1016/j.dnarep.2016.05.026.
• Klungland, Arne; Dahl, John Arne; Greggains, Gareth; Fedorcsák, Péter & Filipczyk, Adam (2016). Reversible RNA modifications in meiosis and pluripotency. Nature Methods. ISSN 1548-7091. 14(1), p. 18–22. doi: 10.1038/nmeth.4111.
• Møllersen, Linda; Moldestad, Olve; Rowe, Alexander D.; Bjølgerud, Anja; Holm, Ingunn & Tveterås, Linda Augustin [Show all 8 contributors for this article] (2016). Effects of anthocyanins on CAG repeat instability and behaviour in Huntington's disease R6/1 mice. PLOS Currents. ISSN 2157-3999. 8(HuntingtonDisease, 2016). doi: 10.1371/currents.hd.58d04209ab6d5de0844db7ef5628ff67.
• Tekpli, Xavier; Urbanucci, Alfonso; Hashim, Adnan; Vågbø, Cathrine Broberg; Lyle, Robert & Kringen, Marianne K. [Show all 11 contributors for this article] (2016). Changes of 5-hydroxymethylcytosine distribution during myeloid and lymphoid differentiation of CD34+ cells. Epigenetics & Chromatin. ISSN 1756-8935. 9. doi: 10.1186/s13072-016-0070-8. Full text in Research Archive
• Vindedal, Gry Fluge; Thoren, Anna; Jensen, Vidar; Klungland, Arne; Zhang, Yong & Holtzman, Michael [Show all 8 contributors for this article] (2016). Removal of aquaporin-4 from glial and ependymal membranes causes brain water accumulation. Molecular and Cellular Neuroscience. ISSN 1044-7431. 77, p. 47–52. doi: 10.1016/j.mcn.2016.10.004.
• Dahl, John Arne; Jung, Inkyung; Aanes, Håvard; Greggains, Gareth; Manaf, Adeel & Lerdrup, Mads [Show all 20 contributors for this article] (2016). Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition. Nature. ISSN 0028-0836. 537(7621), p. 548–552. doi: 10.1038/nature19360.
• Liu, Fange; Clark, Wesley; Luo, Guanzheng; Wang, Xiaoyun; Fu, Ye & Wei, Jiangbo [Show all 16 contributors for this article] (2016). ALKBH1-Mediated tRNA Demethylation Regulates Translation. Cell. ISSN 0092-8674. 167(3), p. 816–828. doi: 10.1016/j.cell.2016.09.038.
• Lauritzen, Knut Husø; Hasan-Olive, Md Mahdi; Regnell, Christine E; Kleppa, Liv; Scheibye Knudsen, Morten & Gjedde, Albert [Show all 10 contributors for this article] (2016). A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain. Neurobiology of Aging. ISSN 0197-4580. 48, p. 34–47. doi: 10.1016/j.neurobiolaging.2016.08.005.
• Ougland, Rune; Jonson, Ida; Moen, Marivi Nabong; Nesse, Gaute; Asker, Gry & Klungland, Arne [Show all 7 contributors for this article] (2016). Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells. Cellular Physiology and Biochemistry. ISSN 1015-8987. 38(1), p. 173–184. doi: 10.1159/000438619.
• Landfors, Miriam; Nakken, Sigve; Fusser, Markus; Dahl, John Arne; Klungland, Arne & Fedorcsák, Péter (2016). Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations. Fertility and Sterility. ISSN 0015-0282. 105(5), p. 1170–1179e5. doi: 10.1016/j.fertnstert.2016.01.002.
• Weber, Alain R.; Krawczyk, Claudia; Robertson, Adam Brian; Kusnierczyk, Anna; Vågbø, Cathrine Broberg & Schürmann, David [Show all 8 contributors for this article] (2016). Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nature Communications. ISSN 2041-1723. 7. doi: 10.1038/ncomms10806. Full text in Research Archive
• Mi, Shuangli; Klungland, Arne & Yang, Yun-Gui (2016). Base-excision repair and beyond —A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015. Science China Life Sciences. ISSN 1674-7305. 59(1), p. 89–92. doi: 10.1007/s11427-015-4983-4.
• Rasmussen, Erik; Vågbø, Cathrine Broberg; Münch, Daniel; Krokan, Hans Einar; Klungland, Arne & Amdam, Gro Vang [Show all 7 contributors for this article] (2016). DNA base modifications in honey bee and fruit fly genomes suggest an active demethylation machinery with species- and tissue-specific turnover rates. Biochemistry and Biophysics Reports. ISSN 2405-5808. 6, p. 9–15. doi: 10.1016/j.bbrep.2016.02.011. Full text in Research Archive
• Ougland, Rune; Rognes, Torbjørn; Klungland, Arne & Larsen, Elisabeth (2015). Non-homologous functions of the AlkB homologs. Journal of Molecular Cell Biology. ISSN 1674-2788. 7(6), p. 494–504. doi: 10.1093/jmcb/mjv029.
• Bjørge, Monica Dahl; Hildrestrand, Gunn Annette; Scheffler, Katja; Suganthan, Rajikala; Rolseth, Veslemøy & Kusnierczyk, Anna [Show all 15 contributors for this article] (2015). Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice. Cell reports. ISSN 2211-1247. 13(12), p. 2671–2678. doi: 10.1016/j.celrep.2015.12.001. Full text in Research Archive Show summary

  Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−Mutyh−/− mice were more active and less anxious, with impaired learning ability. In contrast, Mutyh−/− mice showed moderately improved memory. We observed no apparent change in genomic 8-oxoG levels, suggesting that Ogg1 and Mutyh play minor roles in global repair in adult brain. Notably, transcriptome analysis of hippocampus revealed that differentially expressed genes in the mutants belong to pathways known to be involved in anxiety and cognition. Esr1 targets were upregulated, suggesting a role of Ogg1 and Mutyh in repression of Esr1 signaling. Thus, beyond their involvement in DNA repair, Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.

• Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne (2015). Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice. PLOS ONE. ISSN 1932-6203. 10(11). doi: 10.1371/journal.pone.0141472. Full text in Research Archive
• Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Koehler, Christian; Thiede, Bernd & Lorenz, Susanne [Show all 9 contributors for this article] (2015). Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes. Genome Research. ISSN 1088-9051. 25(6), p. 897–906. doi: 10.1101/gr.185793.114.
• Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J. & Mele, Aldo [Show all 15 contributors for this article] (2015). A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation. Genes & Development. ISSN 0890-9369. 29(19), p. 2037–2053. doi: 10.1101/gad.269415.115.
• Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald & Haugen, Øyvind Pernell [Show all 12 contributors for this article] (2015). Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure. American Journal of Physiology. Heart and Circulatory Physiology. ISSN 0363-6135. 309(3), p. H434–H449. doi: 10.1152/ajpheart.00253.2014.
• Dahl, John Arne & Klungland, Arne (2014). Micro Chromatin Immunoprecipitation (μChIP) from Early Mammalian Embryos. Methods in molecular biology. ISSN 1064-3745. 1222, p. 227–245. doi: 10.1007/978-1-4939-1594-1_17.
• Robertson, Adam Brian; Robertson, Julia; Fusser, Markus & Klungland, Arne (2014). Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination. Nucleic Acids Research (NAR). ISSN 0305-1048. 42(21), p. 13280–13293. doi: 10.1093/nar/gku1032.
• Robertson, Adam Brian; Dahl, John Arne & Klungland, Arne (2014). DNA metabolism: bases of DNA repair and regulation. Nature Chemical Biology. ISSN 1552-4450. 10(7), p. 487–488. doi: 10.1038/nchembio.1553.
• Nilsen, Anja; Fusser, Markus; Greggains, Gareth; Fedorcsak, Peter & Klungland, Arne (2014). ALKBH4 depletion in mice leads to spermatogenic defects. PLOS ONE. ISSN 1932-6203. 9(8). doi: 10.1371/journal.pone.0105113.
• Klungland, Arne & Dahl, John Arne (2014). Dynamic RNA modifications in disease. Current Opinion in Genetics and Development. ISSN 0959-437X. 26, p. 47–52. doi: 10.1016/j.gde.2014.05.006.
• Zdzalik, Daria; Vågbø, Cathrine Broberg; Kirpekar, F; Davydova, Erna; Puścian, Alicja & Maciejewska, Agnieszka M. [Show all 11 contributors for this article] (2014). Protozoan ALKBH8 Oxygenases Display both DNA Repair and tRNA Modification Activities. PLOS ONE. ISSN 1932-6203. 9(6). doi: 10.1371/journal.pone.0098729. Full text in Research Archive
• Jonson, Ida; Ougland, Rune; Klungland, Arne & Larsen, Elisabeth (2013). Oxidative stress causes DNA triplet expansion in Huntington's disease mouse embryonic stem cells. Stem Cell Research. ISSN 1873-5061. 11(3), p. 1264–1271. doi: 10.1016/j.scr.2013.08.010.
• Li, Ming-Ming; Nilsen, Anja; Shi, Yue; Fusser, Markus; Ding, Yue-He & Fu, Ye [Show all 19 contributors for this article] (2013). ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. Nature Communications. ISSN 2041-1723. 4. doi: 10.1038/ncomms2863.
• Solberg, Anja; Robertson, Adam Brian; Aronsen, Jan Magnus; Rognmo, Øivind; Sjaastad, Ivar & Wisløff, Ulrik [Show all 7 contributors for this article] (2013). Deletion of mouse Alkbh7 leads to obesity. Journal of Molecular Cell Biology. ISSN 1674-2788. 5(3), p. 194–203. doi: 10.1093/jmcb/mjt012.
• Furu, Kari & Klungland, Arne (2013). Tzfp Represses the Androgen Receptor in Mouse Testis. PLOS ONE. ISSN 1932-6203. 8(4). doi: 10.1371/journal.pone.0062314.
• Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min & Li, Charles J. [Show all 28 contributors for this article] (2013). ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Molecular Cell. ISSN 1097-2765. 49(1), p. 18–29. doi: 10.1016/j.molcel.2012.10.015.
• Ougland, Rune; Lando, David; Jonson, Ida; Dahl, John Arne; Moen, Marivi & Nordstrand, Line Mari [Show all 11 contributors for this article] (2012). ALKBH1 Is a Histone H2A Dioxygenase Involved in Neural Differentiation. Stem Cells. ISSN 1066-5099. 30(12), p. 2672–2682. doi: 10.1002/stem.1228. Full text in Research Archive
• Møllersen, Linda; Rowe, Alexander D.; Illuzzi, Jennifer L.; Hildrestrand, Gunn Annette; Gerhold, Katharina J. & Tveterås, Linda Augustin [Show all 10 contributors for this article] (2012). Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice. Human Molecular Genetics. ISSN 0964-6906. 21(22), p. 4939–4947. doi: 10.1093/hmg/dds337.
• Kleppa, Liv; Mari, Pierre-Olivier; Larsen, Elisabeth; Lien, Guro Flor; Godon, Camille & Theil, Arjan F [Show all 11 contributors for this article] (2012). Kinetics of endogenous mouse FEN1 in base excision repair. Nucleic Acids Research (NAR). ISSN 0305-1048. 40(18), p. 9044–9059. doi: 10.1093/nar/gks673.
• Meza, Trine Johansen; Moen, Marivi; Vågbø, Cathrine Broberg; Krokan, Hans Einar; Klungland, Arne & Grini, Paul Eivind [Show all 7 contributors for this article] (2012). The DNA dioxygenase ALKBH2 protects Arabidopsis thaliana against methylation damage. Nucleic Acids Research (NAR). ISSN 0305-1048. 40(14), p. 6620–6631. doi: 10.1093/nar/gks327. Full text in Research Archive
• Calvo, Jennifer A; Meira, Lisiane B.; Lee, C.Y.; Moroski-Erkul, Catherine A; Abolhassani, Nona & Taghizadeh, Koli [Show all 11 contributors for this article] (2012). DNA repair is indispensable for survival after acute inflammation. Journal of Clinical Investigation. ISSN 0021-9738. 122(7), p. 2680–2689. doi: 10.1172/JCI63338.
• Robertson, Adam Brian; Dahl, John Arne; Ougland, Rune & Klungland, Arne (2012). Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads. Nature Protocols. ISSN 1754-2189. 7(2), p. 340–350. doi: 10.1038/nprot.2011.443.
• Nordstrand, Line Mari; Furu, Kari; Paulsen, Jonas; Rognes, Torbjørn & Klungland, Arne (2012). Alkbh1 and Tzfp repress a non-repeat piRNA cluster in pachytene spermatocytes. Nucleic Acids Research (NAR). ISSN 0305-1048. 40(21), p. 10950–10963. doi: 10.1093/nar/gks839. Full text in Research Archive
• Strømme, Petter; Dobrenis, Kostantin; Sillitoe, Roy V.; Gulinello, Maria; Ali, Nafeeza F. & Davidson, Christin [Show all 11 contributors for this article] (2011). X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction. Brain. ISSN 0006-8950. 134, p. 3369–3383. doi: 10.1093/brain/awr250.
• Lauritzen, Knut Husø; Dalhus, Bjørn; Storm, Johan Frederik; Bjørås, Magnar & Klungland, Arne (2011). Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond. Mechanisms of Ageing and Development. ISSN 0047-6374. 132(8-9), p. 424–428. doi: 10.1016/j.mad.2011.02.006.
• Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Eilert-Olsen, Martine; Gundersen, Georg Andreas; Skare, Øivind & Laake, Petter [Show all 11 contributors for this article] (2011). Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 108(43), p. 17815–17820. doi: 10.1073/pnas.1110655108.
• Haj Yasein, Nadia Nabil; Jensen, Vidar; Vindedal, Gry Fluge; Gundersen, Georg Andreas; Klungland, Arne & Ottersen, Ole Petter [Show all 8 contributors for this article] (2011). Evidence that Compromised K+ Spatial Buffering Contributes to the Epileptogenic Effect of Mutations in the Human Kir4.1 Gene (KCNJ10). Glia. ISSN 0894-1491. 59(11), p. 1635–1642. doi: 10.1002/glia.21205.
• Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne (2011). Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses. DNA Repair. ISSN 1568-7864. 10(6), p. 639–653. doi: 10.1016/j.dnarep.2011.04.011.
• Robertson, Julia; Robertson, Adam Brian & Klungland, Arne (2011). The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 411(1), p. 40–43. doi: 10.1016/j.bbrc.2011.06.077.
• Moen, Marivi; Knævelsrud, Ingeborg; Haugland, Gyri Teien; Grøsvik, Kristin; Birkeland, Nils-Kåre & Klungland, Arne [Show all 7 contributors for this article] (2011). Uracil-DNA Glycosylase of Thermoplasma acidophilum Directs Long-Patch Base Excision Repair, Which Is Promoted by Deoxynucleoside Triphosphates and ATP/ADP, into Short-Patch Repair. Journal of Bacteriology. ISSN 0021-9193. 193(17), p. 4495–4508. doi: 10.1128/JB.00233-11.
• Van den Born, Erwin; Vågbø, Cathrine Broberg; Songe-Møller, Lene; Leihne, VIbeke; Lien, Guro Flor & Leszczynska, G [Show all 11 contributors for this article] (2011). ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. Nature Communications. ISSN 2041-1723. 2. doi: 10.1038/ncomms1173. Full text in Research Archive
• Robertson, Adam Brian; Dahl, John Arne; Vågbø, Cathrine Broberg; Tripathi, P; Krokan, Hans Einar & Klungland, Arne (2011). A novel method for the efficient and selective identification of 5-hydroxymethylcytosine in genomic DNA. Nucleic Acids Research (NAR). ISSN 0305-1048. 39(8). doi: 10.1093/nar/gkr051. Full text in Research Archive
• Fusser, Markus; Nesse, Gaute; Khobta, Andriy; Xia, Ning; Li, Huige & Klungland, Arne [Show all 7 contributors for this article] (2011). Spontaneous mutagenesis in Csb(m/m) Ogg1(−/−) mice is attenuated by dietary resveratrol. Carcinogenesis. ISSN 0143-3334. 32(1), p. 80–85. doi: 10.1093/carcin/bgq196.
• Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K & Takano, Takahiro [Show all 17 contributors for this article] (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America. ISSN 0027-8424. 108(2), p. 846–851. doi: 10.1073/pnas.1015217108.
• Nordstrand, Line Mari; Svärd, Jessica; Larsen, Elisabeth; Nilsen, Anja; Ougland, Rune & Furu, Kari [Show all 11 contributors for this article] (2010). Mice Lacking Alkbh1 Display Sex-Ratio Distortion and Unilateral Eye Defects. PLOS ONE. ISSN 1932-6203. 5(11). doi: 10.1371/journal.pone.0013827. Full text in Research Archive

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• Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuviene, Migle; Laerdahl, Jon Kristen; Klungland, Arne & Klimašauskas, Saulius [Show all 7 contributors for this article] (2018). Formamidopyrimidine-DNA glycosylase is involved in C:C mismatch repair.
• Tesfahun, Almaz Nigatu; Guragain, Prashanna; Alexeeva, Marina; Arshad, Aysha; Tomkuviene, Migle & Laerdahl, Jon K. [Show all 9 contributors for this article] (2017). Repair of dimethylated bases in DNA.
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• Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2017). Repair of double methylated bases in DNA.
• Tesfahun, Almaz Nigatu; Klungland, Arne; Klimašauskas, Saulius & Bjelland, Svein (2016). Repair of double methylated bases in DNA.
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• Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne [Show all 7 contributors for this article] (2016). hSMUG1-catalysed uracil-DNA strand incision.
• Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein (2016). Repair of double methylated bases in DNA.
• Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute & Klungland, Arne [Show all 7 contributors for this article] (2015). The Norwegian Transgenic Centre.
• Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas (2014). The Norwegian Transgenic Centre.
• Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar & Klungland, Arne [Show all 7 contributors for this article] (2014). Epigenetically modified cytosines in the honey bee genome.
• Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fu, Ye & Klungland, Arne (2013). Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases. RNA Biology. ISSN 1547-6286. 10(6), p. 915–918. doi: 10.4161/rna.24711.
• Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar & Klungland, Arne [Show all 7 contributors for this article] (2013). Presence of modified cytosines in the honey bee genome.

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