Monshaugen, Ida; Luna, Luisa; Rhodes, Jayden; Kristiansen, Felicia Iselin Svensson; Lång, Anna Ulrika & Bøe, Stig Ove
[Show all 10 contributors for this article](2023).
Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer.
Frontiers in Oncology.
ISSN 2234-943X.
13,
p. 1–14.
doi: 10.3389/fonc.2023.1334112.
Wang, Yunhao; Li, Yanjiao; Skuland, Trine; Zhou, Chengjie; Li, Aifu & Hashim, Adnan
[Show all 13 contributors for this article](2023).
The RNA m<sup>6</sup>A landscape of mouse oocytes and preimplantation embryos.
Nature Structural & Molecular Biology.
ISSN 1545-9993.
30(5),
p. 703–709.
doi: 10.1038/s41594-023-00969-x.
Sui, Xuesong; Klungland, Arne & Gao, Lu
(2022).
RNA m6A modifications in mammalian gametogenesis and pregnancy.
Reproduction.
ISSN 1470-1626.
165(1),
p. R1–R8.
doi: 10.1530/REP-22-0112.
Lång, Emma Helena; Pedersen, Christian; Lång, Anna Ulrika; Blicher, Pernille; Klungland, Arne & Carlson, Andreas
[Show all 7 contributors for this article](2022).
Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424.
119(32).
doi: 10.1073/pnas.2201328119.
Full text in Research Archive
Khodeer, Sherif; Klungland, Arne & Dahl, John Arne
(2022).
ALKBH5 regulates somatic cell reprogramming in a phase-specific manner.
Journal of Cell Science.
ISSN 0021-9533.
135(11).
doi: 10.1242/jcs.259824.
Full text in Research Archive
Zhang, Li-Sheng; Xiong, Qing-Ping; Pérez, Sonia Peña; Liu, Chang; Wei, Jiangbo & Le, Cassy
[Show all 19 contributors for this article](2021).
ALKBH7-mediated demethylation regulates mitochondrial polycistronic RNA processing.
Nature Cell Biology.
ISSN 1465-7392.
23(7),
p. 684–691.
doi: 10.1038/s41556-021-00709-7.
Jin, Kang-Xuan; Zuo, Rujuan; Anastassiadis, Konstantinos; Klungland, Arne; Marr, Carsten & Filipczyk, Adam
(2021).
N6-methyladenosine (m6A) depletion regulates pluripotency exit by activating signaling pathways in embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424.
118(51).
doi: 10.1073/pnas.2105192118.
Full text in Research Archive
Sankar, Aditya; Lerdrup, Mads; Manaf, Adeel; Johansen, Jens Vilstrup; Gonzalez, Javier Martin & Borup, Rehannah
[Show all 13 contributors for this article](2020).
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes.
Nature Cell Biology.
ISSN 1465-7392.
22(4),
p. 380–388.
doi: 10.1038/s41556-020-0494-z.
Abakir, Abdulkadir; Giles, Tom C.; Cristini, Agnese; Foster, Jeremy M.; Dai, Nan & Starczak, Marta
[Show all 22 contributors for this article](2019).
N6-methyladenosine regulates the stability of RNA:DNA hybrids in human cells.
Nature Genetics.
ISSN 1061-4036.
52(1),
p. 48–55.
doi: 10.1038/s41588-019-0549-x.
STIM1 and ORAI1 regulate store-operated Ca2+ entry (SOCE) in most cell types, and mutations in these proteins have deleterious and diverse effects. We established a mouse line expressing the STIM1 R304 W gain-of-function mutation causing Stormorken syndrome to explore effects on organ and cell physiology. While STIM1 R304 W was lethal in the homozygous state, surviving mice presented with reduced growth, skeletal muscle degeneration, and reduced exercise endurance. Variable STIM1 expression levels between tissues directly impacted cellular SOCE capacity. In contrast to patients with Stormorken syndrome, STIM1 was downregulated in fibroblasts from Stim1R304W/R304W mice, which maintained SOCE despite constitutive protein activity. In studies using foetal liver chimeras, STIM1 protein was undetectable in homozygous megakaryocytes and platelets, resulting in impaired platelet activation and absent SOCE. These data indicate that downregulation of STIM1 R304 W effectively opposes the gain-of-function phenotype associated with this mutation, and highlight the importance of STIM1 in skeletal muscle development and integrity.
Wei, Jiangbo; Liu, Fange; Lu, Zhike; Fei, Qili; Ai, Yuxi & He, P. Cody
[Show all 13 contributors for this article](2018).
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Molecular Cell.
ISSN 1097-2765.
71(6),
p. 973–985.
doi: 10.1016/j.molcel.2018.08.011.
Askeland, Georgina; Rodinova, Marie; Štufková, Hana; Dosoudilova, Zaneta; Baxa, Monika & Smatlikova, Petra
[Show all 15 contributors for this article](2018).
A transgenic minipig model of Huntington's disease shows early signs of behavioral and molecular pathologies.
Disease Models and Mechanisms.
ISSN 1754-8403.
11(10).
doi: 10.1242/dmm.035949.
Full text in Research Archive
Alexeeva, Marina; Guragain, Prashanna; Tesfahun, Almaz Nigatu; Tomkuvienė, Miglė; Arshad, Aysha & Gerasimaitė, Rūta
[Show all 13 contributors for this article](2018).
Excision of the doubly methylated base N4,5-dimethylcytosine from DNA by Escherichia coli Nei and Fpg proteins
.
Philosophical Transactions of the Royal Society of London. Biological Sciences.
ISSN 0962-8436.
373(1748).
doi: 10.1098/rstb.2017.0337.
Full text in Research Archive
Jordan, Jennifer J.; Chhim, Sophea; Margulies, Carrie M.; Allocca, Mariacarmela; Bronson, Roderick T. & Klungland, Arne
[Show all 8 contributors for this article](2017).
ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.
Cell Death & Disease.
ISSN 2041-4889.
8.
doi: 10.1038/cddis.2017.343.
Tang, Chong; Klukovich, Rachel; Peng, Hongying; Wang, Zhuqing; Yu, Tian & Zhang, Ying
[Show all 9 contributors for this article](2017).
ALKBH5-dependent m6A demethylation controls splicing and stability of long 3'-UTR mRNAs in male germ cells.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424.
115(2),
p. E325–E333.
doi: 10.1073/pnas.1717794115.
Pawar, Tina; Bjørås, Magnar; Klungland, Arne & Eide, Lars
(2017).
Metabolism and DNA repair shape a specific modification pattern in mitochondrial DNA.
Mitochondrion (Amsterdam. Print).
ISSN 1567-7249.
40,
p. 16–28.
doi: 10.1016/j.mito.2017.09.002.
Full text in Research Archive
Aas, Aleksander; Isakson, Pauline; Bindesbøll, Christian; Alemu, Endalkachew Ashenafi; Klungland, Arne & Simonsen, Anne
(2017).
Nucleocytoplasmic shuttling of FTO does not affect starvation-induced autophagy.
PLOS ONE.
ISSN 1932-6203.
12(3).
doi: 10.1371/journal.pone.0168182.
Full text in Research Archive
Kalikstad, Betty; Kultima, Hanna Goransson; Andersstuen, Terese; Klungland, Arne & Isaksson, Anders
(2017).
Gene expression profiles in preterm infants on continuous long-term oxygen therapy suggest reduced oxidative stress-dependent signaling during hypoxia.
Molecular Medicine Reports.
ISSN 1791-2997.
15(4),
p. 1513–1526.
doi: 10.3892/mmr.2017.6185.
Full text in Research Archive
Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Robertson, Joseph; Klungland, Arne & Enserink, Jorrit
(2017).
TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424.
114(5),
p. 1039–1044.
doi: 10.1073/pnas.1615093114.
Alemu, Endalkachew Ashenafi; He, Chuan & Klungland, Arne
(2016).
ALKBHs-facilitated RNA modifications and de-modifications.
DNA Repair.
ISSN 1568-7864.
44,
p. 87–91.
doi: 10.1016/j.dnarep.2016.05.026.
Klungland, Arne; Dahl, John Arne; Greggains, Gareth; Fedorcsák, Péter & Filipczyk, Adam
(2016).
Reversible RNA modifications in meiosis and pluripotency.
Nature Methods.
ISSN 1548-7091.
14(1),
p. 18–22.
doi: 10.1038/nmeth.4111.
Ougland, Rune; Jonson, Ida; Moen, Marivi Nabong; Nesse, Gaute; Asker, Gry & Klungland, Arne
[Show all 7 contributors for this article](2016).
Role of ALKBH1 in the Core Transcriptional Network of Embryonic Stem Cells.
Cellular Physiology and Biochemistry.
ISSN 1015-8987.
38(1),
p. 173–184.
doi: 10.1159/000438619.
Landfors, Miriam; Nakken, Sigve; Fusser, Markus; Dahl, John Arne; Klungland, Arne & Fedorcsák, Péter
(2016).
Sequencing of FTO and ALKBH5 in men undergoing infertility work-up identifies an infertility-associated variant and two missense mutations.
Fertility and Sterility.
ISSN 0015-0282.
105(5),
p. 1170–1179e5.
doi: 10.1016/j.fertnstert.2016.01.002.
Mi, Shuangli; Klungland, Arne & Yang, Yun-Gui
(2016).
Base-excision repair and beyond —A short summary attributed to scientific achievements of Tomas Lindahl, Nobel Prize Laureate in Chemistry 2015.
Science China Life Sciences.
ISSN 1674-7305.
59(1),
p. 89–92.
doi: 10.1007/s11427-015-4983-4.
Ougland, Rune; Rognes, Torbjørn; Klungland, Arne & Larsen, Elisabeth
(2015).
Non-homologous functions of the AlkB homologs.
Journal of Molecular Cell Biology.
ISSN 1674-2788.
7(6),
p. 494–504.
doi: 10.1093/jmcb/mjv029.
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−Mutyh−/− mice were more active and less anxious, with impaired learning ability. In contrast, Mutyh−/− mice showed moderately improved memory. We observed no apparent change in genomic 8-oxoG levels, suggesting that Ogg1 and Mutyh play minor roles in global repair in adult brain. Notably, transcriptome analysis of hippocampus revealed that differentially expressed genes in the mutants belong to pathways known to be involved in anxiety and cognition. Esr1 targets were upregulated, suggesting a role of Ogg1 and Mutyh in repression of Esr1 signaling. Thus, beyond their involvement in DNA repair, Ogg1 and Mutyh regulate hippocampal gene expression related to cognition and behavior, suggesting a role for the glycosylases in regulating adaptive behavior.
Fusser, Markus; Kernstock, Stefan; Aileni, Vinay Kumar; Jacobsen, Wolfgang Mathias; Falnes, Pål & Klungland, Arne
(2015).
Lysine methylation of the valosin-containing protein (VCP) is dispensable for development and survival of mice.
PLOS ONE.
ISSN 1932-6203.
10(11).
doi: 10.1371/journal.pone.0141472.
Full text in Research Archive
Chymkowitch, Pierre; Nguéa P, Aurélie; Aanes, Håvard; Koehler, Christian; Thiede, Bernd & Lorenz, Susanne
[Show all 9 contributors for this article](2015).
Sumoylation of Rap1 mediates the recruitment of TFIID to promote transcription of ribosomal protein genes.
Genome Research.
ISSN 1088-9051.
25(6),
p. 897–906.
doi: 10.1101/gr.185793.114.
Ke, Shengdong; Alemu, Endalkachew Ashenafi; Mertens, Claudia; Gantman, Emily Conn; Fak, John J. & Mele, Aldo
[Show all 15 contributors for this article](2015).
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Genes & Development.
ISSN 0890-9369.
29(19),
p. 2037–2053.
doi: 10.1101/gad.269415.115.
Lauritzen, Knut Husø; Kleppa, Liv; Aronsen, Jan Magnus; Eide, Lars; Carlsen, Harald & Haugen, Øyvind Pernell
[Show all 12 contributors for this article](2015).
Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure.
American Journal of Physiology. Heart and Circulatory Physiology.
ISSN 0363-6135.
309(3),
p. H434–H449.
doi: 10.1152/ajpheart.00253.2014.
Robertson, Adam Brian; Robertson, Julia; Fusser, Markus & Klungland, Arne
(2014).
Endonuclease G preferentially cleaves 5-hydroxymethylcytosine-modified DNA creating a substrate for recombination.
Nucleic Acids Research (NAR).
ISSN 0305-1048.
42(21),
p. 13280–13293.
doi: 10.1093/nar/gku1032.
Robertson, Adam Brian; Dahl, John Arne & Klungland, Arne
(2014).
DNA metabolism: bases of DNA repair and regulation.
Nature Chemical Biology.
ISSN 1552-4450.
10(7),
p. 487–488.
doi: 10.1038/nchembio.1553.
Nilsen, Anja; Fusser, Markus; Greggains, Gareth; Fedorcsak, Peter & Klungland, Arne
(2014).
ALKBH4 depletion in mice leads to spermatogenic defects.
PLOS ONE.
ISSN 1932-6203.
9(8).
doi: 10.1371/journal.pone.0105113.
Klungland, Arne & Dahl, John Arne
(2014).
Dynamic RNA modifications in disease.
Current Opinion in Genetics and Development.
ISSN 0959-437X.
26,
p. 47–52.
doi: 10.1016/j.gde.2014.05.006.
Furu, Kari & Klungland, Arne
(2013).
Tzfp Represses the Androgen Receptor in Mouse Testis.
PLOS ONE.
ISSN 1932-6203.
8(4).
doi: 10.1371/journal.pone.0062314.
Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fedorcsak, Peter; Huang, Chun-Min & Li, Charles J.
[Show all 28 contributors for this article](2013).
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility.
Molecular Cell.
ISSN 1097-2765.
49(1),
p. 18–29.
doi: 10.1016/j.molcel.2012.10.015.
Møllersen, Linda; Rowe, Alexander D.; Illuzzi, Jennifer L.; Hildrestrand, Gunn Annette; Gerhold, Katharina J. & Tveterås, Linda Augustin
[Show all 10 contributors for this article](2012).
Neil1 is a genetic modifier of somatic and germline CAG trinucleotide repeat instability in R6/1 mice.
Human Molecular Genetics.
ISSN 0964-6906.
21(22),
p. 4939–4947.
doi: 10.1093/hmg/dds337.
Robertson, Adam Brian; Dahl, John Arne; Ougland, Rune & Klungland, Arne
(2012).
Pull-down of 5-hydroxymethylcytosine DNA using JBP1-coated magnetic beads.
Nature Protocols.
ISSN 1754-2189.
7(2),
p. 340–350.
doi: 10.1038/nprot.2011.443.
Strømme, Petter; Dobrenis, Kostantin; Sillitoe, Roy V.; Gulinello, Maria; Ali, Nafeeza F. & Davidson, Christin
[Show all 11 contributors for this article](2011).
X-linked Angelman-like syndrome caused by Slc9a6 knockout in mice exhibits evidence of endosomal-lysosomal dysfunction.
Brain.
ISSN 0006-8950.
134,
p. 3369–3383.
doi: 10.1093/brain/awr250.
Lauritzen, Knut Husø; Dalhus, Bjørn; Storm, Johan Frederik; Bjørås, Magnar & Klungland, Arne
(2011).
Modeling the impact of mitochondrial DNA damage in forebrain neurons and beyond.
Mechanisms of Ageing and Development.
ISSN 0047-6374.
132(8-9),
p. 424–428.
doi: 10.1016/j.mad.2011.02.006.
Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Eilert-Olsen, Martine; Gundersen, Georg Andreas; Skare, Øivind & Laake, Petter
[Show all 11 contributors for this article](2011).
Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet.
Proceedings of the National Academy of Sciences of the United States of America.
ISSN 0027-8424.
108(43),
p. 17815–17820.
doi: 10.1073/pnas.1110655108.
Haj Yasein, Nadia Nabil; Jensen, Vidar; Vindedal, Gry Fluge; Gundersen, Georg Andreas; Klungland, Arne & Ottersen, Ole Petter
[Show all 8 contributors for this article](2011).
Evidence that Compromised K+ Spatial Buffering Contributes to the Epileptogenic Effect of Mutations in the Human Kir4.1 Gene (KCNJ10).
Glia.
ISSN 0894-1491.
59(11),
p. 1635–1642.
doi: 10.1002/glia.21205.
Lauritzen, Knut Husø; Chang, Cheng; Wiksén, Hege; Bergersen, Linda Hildegard & Klungland, Arne
(2011).
Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses.
DNA Repair.
ISSN 1568-7864.
10(6),
p. 639–653.
doi: 10.1016/j.dnarep.2011.04.011.
Li, Miaomiao; Klungland, Arne & Dalhus, Bjørn
(2022).
Studies on Protein-RNA:DNA Hybrid Interactions by Microscale Thermophoresis (MST).
Methods in molecular biology.
ISSN 1064-3745.
2528,
p. 239–251.
doi: 10.1007/978-1-0716-2477-7_15.
Tesfahun, Almaz Nigatu; Alexeeva, Marina; Tomkuviene, Migle; Laerdahl, Jon Kristen; Klungland, Arne & Klimašauskas, Saulius
[Show all 7 contributors for this article](2018).
Formamidopyrimidine-DNA glycosylase is involved in C:C mismatch repair.
Tesfahun, Almaz Nigatu; Guragain, Prashanna; Alexeeva, Marina; Arshad, Aysha; Tomkuviene, Migle & Laerdahl, Jon K.
[Show all 9 contributors for this article](2017).
Repair of dimethylated bases in DNA.
Tesfahun, Almaz Nigatu; Alexeeva, Marina; Guragain, Prashanna; Tomkuviene, Migle; Arshad, Aysha & Klungland, Arne
[Show all 8 contributors for this article](2017).
Repair of double methylated bases in DNA.
Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne
[Show all 7 contributors for this article](2017).
hSMUG1 is a bi-functional DNA glycosylase.
Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein
(2017).
Repair of double methylated bases in DNA.
Tesfahun, Almaz Nigatu; Klungland, Arne; Klimašauskas, Saulius & Bjelland, Svein
(2016).
Repair of double methylated bases in DNA.
Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne
[Show all 7 contributors for this article](2016).
hSMUG1-catalysed uracil-DNA strand incision.
Alexeeva, Marina; Moen, Marivi Nabong; Xu, Xiang Ming; Rasmussen, Anette; Kirpekar, Finn & Klungland, Arne
[Show all 7 contributors for this article](2016).
hSMUG1-catalysed uracil-DNA strand incision.
Tesfahun, Almaz Nigatu; Klungland, Arne; Klimasauskas, Saulius & Bjelland, Svein
(2016).
Repair of double methylated bases in DNA.
Catterall, Tara Cherie; Johnson, Inna; Khan, Shaista; Jermstad, Ingunn; Nesse, Gaute & Klungland, Arne
[Show all 7 contributors for this article](2015).
The Norwegian Transgenic Centre.
Khan, Shaista; Jermstad, Ingunn; Catterall, Tara Cherie; Nesse, Gaute; Klungland, Arne & Dalen, Knut Tomas
(2014).
The Norwegian Transgenic Centre.
Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar & Klungland, Arne
[Show all 7 contributors for this article](2014).
Epigenetically modified cytosines in the honey bee genome.
Zheng, Guanqun; Dahl, John Arne; Niu, Yamei; Fu, Ye & Klungland, Arne
(2013).
Sprouts of RNA epigenetics The discovery of mammalian RNA demethylases.
RNA Biology.
ISSN 1547-6286.
10(6),
p. 915–918.
doi: 10.4161/rna.24711.
Rasmussen, Erik; Vågbø, Cathrine Broberg; Dahl, John Arne; Münch, Daniel; Krokan, Hans Einar & Klungland, Arne
[Show all 7 contributors for this article](2013).
Presence of modified cytosines in the honey bee genome.