Alexandre Corthay

Researcher - Centre of Excellence - Hybrid Technology Hub
Image of Alexandre Corthay
Norwegian version of this page
Phone 23074109
Room A3.M018
Username
Visiting address OUS-Rikshospitalet Dept of Pathology

Academic interests and areas of expertise

Immunology, cancer, immunotherapy

Academic background

Alexandre Corthay is a specialist in cancer immunology. He studied biology at the University of Geneva, Switzerland, and obtained a PhD at Lund University, Sweden. He is currently heading the Tumor Immunology Lab at the Department of Pathology, Oslo University Hospital, Rikshospitalet. He is in charge of the tumor-on-a-chip technology at the Hybrid Technology Hub.

Websites

Centre of Excellence – Hybrid Technology Hub

Tumor Immunology Lab  

Appointments

Associate Editor for the Scandinavian Journal of Immunology and Frontiers in Immunology

 

Tags: Immunology, Cancer research, cancer immunotherapy

Publications

  • Corthay, Alexandre; Bakacs, Tibor; Thangavelu, Govindarajan & Anderson, Colin C. (2021). Tackling cancer cell dormancy: Insights from immune models, and transplantation. Seminars in Cancer Biology. ISSN 1044-579X. p. 1–12. doi: 10.1016/j.semcancer.2021.02.002.
  • Stankovic, Branislava; Aamodt, Henrik; Bjørhovde, Heidi Anine Korsmo; Müller, Elisabeth; Hammarström, Clara Louise & Brustugun, Odd Terje [Show all 9 contributors for this article] (2020). The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12893(2), p. 1–12. doi: 10.1111/sji.12893. Full text in Research Archive
  • Frafjord, Astri; Skarshaug, Renate; Hammarström, Clara Louise; Stankovic, Branislava; Dorg, Linda Trobe & Aamodt, Henrik [Show all 11 contributors for this article] (2020). Antibody combinations for optimized staining of macrophages in human lung tumours. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12889(1), p. 1–24. doi: 10.1111/sji.12889. Full text in Research Archive
  • Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina & Olsen, Petter Angell [Show all 19 contributors for this article] (2020). Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Communications Biology. ISSN 2399-3642. 3. doi: 10.1038/s42003-020-0916-2. Full text in Research Archive
  • Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna & Øynebråten, Inger [Show all 7 contributors for this article] (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology. ISSN 1664-3224. 9, p. 1–16. doi: 10.3389/fimmu.2018.02520. Full text in Research Archive
  • Stankovic, Branislava; Bjørhovde, Heidi Anine Korsmo; Skarshaug, Renate; Aamodt, Henrik; Frafjord, Astri & Müller, Elisabeth [Show all 14 contributors for this article] (2018). Immune Cell Composition in Human Non-small Cell Lung Cancer. Frontiers in Immunology. ISSN 1664-3224. Feb(1), p. 1–21. doi: 10.3389/fimmu.2018.03101. Full text in Research Archive
  • Haabeth, Ole Audun; Fauskanger, Marte; Manzke, Melanie; Lundin, Katrin; Corthay, Alexandre & Bogen, Bjarne [Show all 7 contributors for this article] (2018). CD4+ T-cell–Mediated Rejection of MHC Class II–Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Research. ISSN 0008-5472. 78(16), p. 4573–4585. doi: 10.1158/0008-5472.CAN-17-2426.
  • Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava & Øynebråten, Inger [Show all 8 contributors for this article] (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology. ISSN 1664-3224. 8. doi: 10.3389/fimmu.2017.01667. Full text in Research Archive
  • Obando, Daniel F. González; Frafjord, Astri; Øynebråten, Inger; Corthay, Alexandre; Olivo-Marin, Jean-Christophe & Meas-Yedid, Vannary (2017). Multi-staining registration of large histology images. IEEE International Symposium on Biomedical Imaging. ISSN 1945-7928. p. 345–348. doi: 10.1109/ISBI.2017.7950534.
  • Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai & Speth, Martin [Show all 8 contributors for this article] (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology. ISSN 1664-3224. 8. doi: 10.3389/fimmu.2017.01383. Full text in Research Archive
  • Christopoulos, Panagiotis; Corthay, Alexandre & Koutsilieris, Michael (2017). Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics. Cancer Treatment Reviews. ISSN 0305-7372. 63, p. 79–95. doi: 10.1016/j.ctrv.2017.11.010.
  • Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), p. 84–94. doi: 10.1111/sji.12500.
  • Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich & Corthay, Alexandre [Show all 7 contributors for this article] (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics. ISSN 1543-8384. 14(11), p. 4098–4112. doi: 10.1021/acs.molpharmaceut.7b00795.
  • Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(4), p. 242–250. doi: 10.1111/sji.12525.
  • Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E. & Duus, Jens Øllgaard [Show all 7 contributors for this article] (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga). Carbohydrate Polymers. ISSN 0144-8617. 185, p. 27–40. doi: 10.1016/j.carbpol.2017.12.041. Full text in Research Archive
  • Joly-Battaglini, Albane; Hammarström, Clara Louise; Stankovic, Branislava; Aamodt, Henrik; Stjärne, Johan Folke Håkan & Brustugun, Odd Terje [Show all 9 contributors for this article] (2016). Rituximab efficiently depletes B cells in lung tumors and normal lung tissue. F1000. ISSN 1759-796X. 5. doi: 10.12688/f1000research.7599.1.
  • Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology. ISSN 1664-3224. 7. doi: 10.3389/fimmu.2016.00167. Full text in Research Archive
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. ISSN 2162-4011. 5(1). doi: 10.1080/2162402X.2015.1039763.
  • Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M & Haraldsen, Guttorm [Show all 8 contributors for this article] (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research. ISSN 0008-5472. 76(23), p. 6864–6876. doi: 10.1158/0008-5472.CAN-16-1219.
  • Corthay, Alexandre (2014). Does the immune system naturally protect against cancer? Frontiers in Immunology. ISSN 1664-3224. 5(MAY). doi: 10.3389/fimmu.2014.00197.
  • Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg & Hofgaard, Peter Olaf [Show all 11 contributors for this article] (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules? Frontiers in Immunology. ISSN 1664-3224. 5:174. doi: 10.3389/fimmu.2014.00174. Full text in Research Archive
  • Lorvik, Kristina Berg; Haabeth, Ole Audun; Clancy, Trevor; Bogen, Bjarne & Corthay, Alexandre (2013). Molecular profiling of tumor-specific T(H)1 cells activated in vivo. Oncoimmunology. ISSN 2162-4011. 2(5:e24383). doi: 10.4161/onci.24383.
  • Haabeth, Ole Audun; Bogen, Bjarne & Corthay, Alexandre (2012). A model for cancer-suppressive inflammation. Oncoimmunology. ISSN 2162-4011. 1(7), p. 1146–1155. doi: 10.4161/onci.21542.
  • Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine & Gjerstad, Vibeke Sundvold [Show all 9 contributors for this article] (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLOS ONE. ISSN 1932-6203. 7(10). doi: 10.1371/journal.pone.0048239.
  • Corthay, Alexandre; Lorvik, Kristina Berg & Bogen, Bjarne (2011). Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4+T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), p. 527–530. doi: 10.1111/j.1365-3083.2011.02558.x.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications. ISSN 2041-1723. 2. doi: 10.1038/ncomms1239.
  • Corthay, Alexandre; Lundin, Katrin; Lorvik, Kristina Berg; Hofgaard, Peter Olaf & Bogen, Bjarne (2009). Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells. Cancer Research. ISSN 0008-5472. 69(14), p. 5901–5907. doi: 10.1158/0008-5472.CAN-08-4816.
  • Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre & Munthe, Ludvig Andre [Show all 8 contributors for this article] (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling. ISSN 0898-6568. 21(2), p. 274–281. doi: 10.1016/j.cellsig.2008.10.013.
  • Corthay, Alexandre (2007). CD4+T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Advances in Experimental Medicine and Biology. ISSN 0065-2598. 590, p. 195–208.
  • Bogen, Bjarne; Ruffini, Pier Adelchi; Corthay, Alexandre; Brunsvik, Agnete; Frøyland, Marianne & Lundin, Katrin [Show all 9 contributors for this article] (2006). Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research. Studies in Surface Science and Catalysis. ISSN 0167-2991. 91, p. 941–948.
  • Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde & Hofgaard, Peter Olaf [Show all 8 contributors for this article] (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity. ISSN 1074-7613. 22, p. 371–383.
  • Munthe, Ludvig Andre; Corthay, Alexandre; Os, Audun; Zangani, Michael M & Bogen, Bjarne (2005). Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from immunoglobulin V region-specific T cells. Journal of Immunology. ISSN 0022-1767. 175, p. 2391–2400.
  • Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias & Dembic, Zlatko [Show all 7 contributors for this article] (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, p. 759–769.
  • Tjelle, TE; Corthay, Alexandre; Lunde, Elin; Sandlie, Inger; Michaelsen, Terje Einar & Mathiesen, I [Show all 7 contributors for this article] (2004). Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Molecular Therapy. ISSN 1525-0016. 9(3), p. 328–336.

View all works in Cristin

  • Wold, Christian Winther; Corthay, Alexandre; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2020). Myteomspunnen kjuke frå folkemedisin til mogleg kreftbehandling. www.forskning.no.
  • Corthay, Alexandre (2017). Book Review: The foundations of immunology and their pertinence to medicine. Scandinavian Journal of Immunology. ISSN 0300-9475. 86(2), p. 119–120. doi: 10.1111/sji.12565.
  • Corthay, Alexandre (2016). Book Review: Rediscovering the Immune System as an Integrated Organ. Scandinavian Journal of Immunology. ISSN 0300-9475. 84(1), p. 70–71. doi: 10.1111/sji.12440.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi. February.
  • Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(4), p. 275–276.
  • Corthay, Alexandre; Hammarström, Clara; Fauskanger, M.; Haabeth, OAW; Zangani, Miriam & Haraldsen, H. [Show all 8 contributors for this article] (2012). Cancer immunotherapy by adoptive transfer of tumor-specific Th2 cells. Immunology. ISSN 0019-2805. 137, p. 706–706.
  • Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2012). Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood. ISSN 0006-4971. 119(9), p. 2176–2177. doi: 10.1182/blood-2011-10-388892.
  • Alfsnes, Katrine; Lorvik, Kristina Berg; Audun, Ole; Haabeth, Werner; Bogen, Bjarne & Corthay, Alexandre (2011). Workshop IV - Tumor Immunology and Infectious Diseases Immunology. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 380–380.
  • Lorvik, Kristina Berg; Zangani, Michael Mehrdad; Bogen, Bjarne & Corthay, Alexandre (2011). Myeloma Immunotherapy by Adoptive Transfer of Idiotype-Specific Th2 Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 392–392.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 384–384.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). A cancer-protective role of inflammation. Cytokine. ISSN 1043-4666. 56(1), p. 101–101. doi: 10.1016/j.cyto.2011.07.392.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), p. 603–603.
  • Corthay, Alexandre (2009). How do Regulatory T Cells Work? Scandinavian Journal of Immunology. ISSN 0300-9475. 70(4), p. 326–336. doi: 10.1111/j.1365-3083.2009.02308.x.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2009). Cytokine profile of successful cancer immunosurveillance mediated by tumor-specific CD4(+) T cells. Cytokine. ISSN 1043-4666. 48(1-2), p. 48–48. doi: 10.1016/j.cyto.2009.07.135.
  • Haabeth, OAW; Lorvik, Kristina Berg; Aagaard, L; Bogen, Bjarne & Corthay, Alexandre (2008). Role of cytokines and chemokines for cancer immune prevention. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 218–218.
  • Lorvik, Kristina Berg; Corthay, Alexandre; Lundin, Katrin; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Role of antigen secretion for cancer immunosurveillance. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 217–218.
  • Corthay, Alexandre; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Transcriptomics of a successful antitumor immune response. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 209–209.
  • Corthay, Alexandre (2006). A three-cell model for activation of naive T helper cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 64, p. 93–96.
  • Halstensen, Trond Sundby; Corthay, Alexandre & Westgaard, Arne (2005). Immunologiens dag 29. april 2005 - populærvitenskapelig konferanse i universitetets aula. [Internet]. Norsk Selskap for Immunologi - www.norwegianimmunology.org.
  • Halstensen, Trond Sundby; Westgaard, Arne & Corthay, Alexandre (2005). NSI's Annual General Meeting 2005. [Internet]. Abstraktbok utgitt i papirform.
  • Corthay, Alexandre & Stankovic, Branislava (2015). Characterization of immune cells in human non-small cell lung cancer (Thesis for the Master’s Degree in Molecular Biosciences) . Norwegian University of Life Sciences, Ås (September 21).
  • Joly-Battaglini, A & Corthay, Alexandre (2015). Study of immune cells infiltrating human non-small cell lung cancer (Thesis for the Master’s Degree in Biology). Université Paris Sud.

View all works in Cristin

Published Dec. 2, 2019 12:44 PM - Last modified Jan. 6, 2020 4:36 PM