Alexandre Corthay

Researcher - Centre of Excellence - Hybrid Technology Hub
Image of Alexandre Corthay
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Phone 23074109
Room A3.M018
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Visiting address OUS-Rikshospitalet Dept of Pathology

Academic interests and areas of expertise

Immunology, cancer, immunotherapy

Academic background

Alexandre Corthay is a specialist in cancer immunology. He studied biology at the University of Geneva, Switzerland, and obtained a PhD at Lund University, Sweden. He is currently heading the Tumor Immunology Lab at the Department of Pathology, Oslo University Hospital, Rikshospitalet. He is in charge of the tumor-on-a-chip technology at the Hybrid Technology Hub.

Websites

Centre of Excellence – Hybrid Technology Hub

Tumor Immunology Lab  

Appointments

Associate Editor for the Scandinavian Journal of Immunology and Frontiers in Immunology

 

Tags: Immunology, Cancer research, cancer immunotherapy

Publications

  • Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Fauskanger, Marte; Lund, Kaja; Brinch, Shoshy Alam; Lycke, Max; Dybing, Elisabeth; Nygaard, Vegard; Bøe, Sigurd Læines; Heintz, Karen Marie; Hovig, Eivind; Hammarström, Clara Louise; Corthay, Alexandre & Krauss, Stefan (2020). Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Communications Biology.  ISSN 2399-3642.  3(196) . doi: https://doi.org/10.1038/s42003-020-0916-2
  • Haabeth, Ole Audun; Fauskanger, Marte; Manzke, Melanie; Lundin, Katrin; Corthay, Alexandre; Bogen, Bjarne & Tveita, Anders (2018). CD4+ T-cell–Mediated Rejection of MHC Class II–Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Research.  ISSN 0008-5472.  78(16), s 4573- 4585 . doi: 10.1158/0008-5472.CAN-17-2426
  • Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna; Øynebråten, Inger & Corthay, Alexandre (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology.  ISSN 1664-3224.  9, s 1- 16 . doi: 10.3389/fimmu.2018.02520 Full text in Research Archive.
  • Stankovic, Branislava; Bjørhovde, Heidi Anine Korsmo; Skarshaug, Renate; Aamodt, Henrik; Frafjord, Astri; Müller, Elisabeth; Hammarström, Clara Louise; Beraki, Kahsai; Bækkevold, Espen Sønderaal; Woldbæk, Per R; Helland, Åslaug; Brustugun, Odd Terje; Øynebråten, Inger & Corthay, Alexandre (2018). Immune Cell Composition in Human Non-small Cell Lung Cancer. Frontiers in Immunology.  ISSN 1664-3224.  Feb(1), s 1- 21 . doi: 10.3389/fimmu.2018.03101 Full text in Research Archive. Show summary
  • Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(2), s 84- 94 . doi: 10.1111/sji.12500
  • Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(4), s 242- 250 . doi: 10.1111/sji.12525 Show summary
  • Christopoulos, Panagiotis; Corthay, Alexandre & Koutsilieris, Michael (2017). Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics. Cancer Treatment Reviews.  ISSN 0305-7372.  63, s 79- 95 . doi: 10.1016/j.ctrv.2017.11.010
  • Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava; Øynebråten, Inger; Corthay, Alexandre & Zajakina, Anna (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01667 Full text in Research Archive.
  • Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai; Speth, Martin; Øynebråten, Inger & Corthay, Alexandre (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01383 Full text in Research Archive.
  • Obando, Daniel F. González; Frafjord, Astri; Øynebråten, Inger; Corthay, Alexandre; Olivo-Marin, Jean-Christophe & Meas-Yedid, Vannary (2017). Multi-staining registration of large histology images. IEEE International Symposium on Biomedical Imaging.  ISSN 1945-7928.  s 345- 348 . doi: 10.1109/ISBI.2017.7950534
  • Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich; Corthay, Alexandre & Griffiths, Gareth Wyn (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics.  ISSN 1543-8384.  14(11), s 4098- 4112 . doi: 10.1021/acs.molpharmaceut.7b00795
  • Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E.; Duus, Jens Øllgaard & Inngjerdingen, Kari Tvete (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga).. Carbohydrate Polymers.  ISSN 0144-8617.  185, s 27- 40 . doi: 10.1016/j.carbpol.2017.12.041 Full text in Research Archive.
  • Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology.  ISSN 1664-3224.  7 . doi: 10.3389/fimmu.2016.00167 Full text in Research Archive.
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology.  ISSN 2162-4011.  5(1) . doi: 10.1080/2162402X.2015.1039763
  • Joly-Battaglini, Albane; Hammarström, Clara Louise; Stankovic, Branislava; Aamodt, Henrik; Stjärne, Johan Folke Håkan; Brustugun, Odd Terje; Helland, Åslaug; Øynebråten, Inger & Corthay, Alexandre (2016). Rituximab efficiently depletes B cells in lung tumors and normal lung tissue. F1000.  ISSN 1759-796X.  5 . doi: 10.12688/f1000research.7599.1
  • Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research.  ISSN 0008-5472.  76(23), s 6864- 6876 . doi: 10.1158/0008-5472.CAN-16-1219
  • Corthay, Alexandre (2014). Does the immune system naturally protect against cancer?. Frontiers in Immunology.  ISSN 1664-3224.  5(MAY) . doi: 10.3389/fimmu.2014.00197
  • Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde; Munthe, Ludvig Andre; Dembic, Zlatko; Corthay, Alexandre & Bogen, Bjarne (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules?. Frontiers in Immunology.  ISSN 1664-3224.  5:174 . doi: 10.3389/fimmu.2014.00174 Full text in Research Archive.
  • Lorvik, Kristina Berg; Haabeth, Ole Audun; Clancy, Trevor; Bogen, Bjarne & Corthay, Alexandre (2013). Molecular profiling of tumor-specific T(H)1 cells activated in vivo. Oncoimmunology.  ISSN 2162-4011.  2(5:e24383) . doi: 10.4161/onci.24383
  • Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine; Gjerstad, Vibeke Sundvold; Corthay, Alexandre; Bogen, Bjarne & Spurkland, Anne (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLOS ONE.  ISSN 1932-6203.  7(10)
  • Haabeth, Ole Audun; Bogen, Bjarne & Corthay, Alexandre (2012). A model for cancer-suppressive inflammation. Oncoimmunology.  ISSN 2162-4011.  1(7), s 1146- 1155 . doi: 10.4161/onci.21542
  • Corthay, Alexandre; Lorvik, Kristina Berg & Bogen, Bjarne (2011). Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4+T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(6), s 527- 530 . doi: 10.1111/j.1365-3083.2011.02558.x
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1239
  • Corthay, Alexandre; Lundin, Katrin; Lorvik, Kristina Berg; Hofgaard, Peter Olaf & Bogen, Bjarne (2009). Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells. Cancer Research.  ISSN 0008-5472.  69(14), s 5901- 5907 . doi: 10.1158/0008-5472.CAN-08-4816
  • Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre; Munthe, Ludvig Andre; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling.  ISSN 0898-6568.  21(2), s 274- 281 . doi: 10.1016/j.cellsig.2008.10.013
  • Corthay, Alexandre (2007). CD4+T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Advances in Experimental Medicine and Biology.  ISSN 0065-2598.  590, s 195- 208
  • Bogen, Bjarne; Ruffini, Pier Adelchi; Corthay, Alexandre; Brunsvik, Agnete; Frøyland, Marianne; Lundin, Katrin; Røsjø, Egil; Thompson, Keith & Massaia, M (2006). Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research. Studies in Surface Science and Catalysis.  ISSN 0167-2991.  91, s 941- 948
  • Munthe, Ludvig Andre; Corthay, Alexandre; Os, Audun; Zangani, Michael M & Bogen, Bjarne (2005). Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from immunoglobulin V region-specific T cells. Journal of Immunology.  ISSN 0022-1767.  175, s 2391- 2400 . doi: 16081810
  • Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde; Hofgaard, Peter Olaf; Haraldsen, Guttorm & Bogen, Bjarne (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity.  ISSN 1074-7613.  22, s 371- 383
  • Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias; Dembic, Zlatko & Bogen, Bjarne (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  53, s 759- 769
  • Tjelle, TE; Corthay, Alexandre; Lunde, Elin; Sandlie, Inger; Michaelsen, Terje Einar; Mathiesen, I & Bogen, Bjarne (2004). Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Molecular Therapy.  ISSN 1525-0016.  9(3), s 328- 336

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  • Corthay, Alexandre (2017). Book Review: The foundations of immunology and their pertinence to medicine. Scandinavian Journal of Immunology.  ISSN 0300-9475.  86(2), s 119- 120 . doi: 10.1111/sji.12565
  • Corthay, Alexandre (2016). Book Review: Rediscovering the Immune System as an Integrated Organ. Scandinavian Journal of Immunology.  ISSN 0300-9475.  84(1), s 70- 71 . doi: 10.1111/sji.12440
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi.  February
  • Corthay, Alexandre & Stankovic, Branislava (2015). Characterization of immune cells in human non-small cell lung cancer (Thesis for the Master’s Degree in Molecular Biosciences).
  • Joly-Battaglini, A & Corthay, Alexandre (2015). Study of immune cells infiltrating human non-small cell lung cancer (Thesis for the Master’s Degree in Biology).
  • Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology.  ISSN 0300-9475.  77(4), s 275- 276
  • Corthay, Alexandre; Hammarström, Clara; Fauskanger, M.; Haabeth, OAW; Zangani, Miriam; Haraldsen, H.; Bogen, Bjarne & Lorvik, Kristina Berg (2012). Cancer immunotherapy by adoptive transfer of tumor-specific Th2 cells. Immunology.  ISSN 0019-2805.  137, s 706- 706
  • Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2012). Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood.  ISSN 0006-4971.  119(9), s 2176- 2177 . doi: 10.1182/blood-2011-10-388892
  • Alfsnes, Katrine; Lorvik, Kristina Berg; Audun, Ole; Haabeth, Werner; Bogen, Bjarne & Corthay, Alexandre (2011). Workshop IV - Tumor Immunology and Infectious Diseases Immunology. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 380- 380
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). A cancer-protective role of inflammation. Cytokine.  ISSN 1043-4666.  56(1), s 101- 101 . doi: 10.1016/j.cyto.2011.07.392
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(6), s 603- 603
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 384- 384
  • Lorvik, Kristina Berg; Zangani, Michael Mehrdad; Bogen, Bjarne & Corthay, Alexandre (2011). Myeloma Immunotherapy by Adoptive Transfer of Idiotype-Specific Th2 Cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 392- 392
  • Corthay, Alexandre (2009). How do Regulatory T Cells Work?. Scandinavian Journal of Immunology.  ISSN 0300-9475.  70(4), s 326- 336 . doi: 10.1111/j.1365-3083.2009.02308.x
  • Haabeth, Ole Audun; Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2009). Cytokine profile of successful cancer immunosurveillance mediated by tumor-specific CD4(+) T cells. Cytokine.  ISSN 1043-4666.  48(1-2), s 48- 48 . doi: 10.1016/j.cyto.2009.07.135
  • Corthay, Alexandre; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Transcriptomics of a successful antitumor immune response. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 209- 209
  • Haabeth, OAW; Lorvik, Kristina Berg; Aagaard, L; Bogen, Bjarne & Corthay, Alexandre (2008). Role of cytokines and chemokines for cancer immune prevention. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 218- 218
  • Lorvik, Kristina Berg; Corthay, Alexandre; Lundin, Katrin; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Role of antigen secretion for cancer immunosurveillance. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 217- 218
  • Corthay, Alexandre (2006). A three-cell model for activation of naive T helper cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  64, s 93- 96
  • Halstensen, Trond Sundby; Corthay, Alexandre & Westgaard, Arne (2005, 29. april). Immunologiens dag 29. april 2005 - populærvitenskapelig konferanse i universitetets aula. [Internett].  Norsk Selskap for Immunologi - www.norwegianimmunology.org. Show summary
  • Halstensen, Trond Sundby; Westgaard, Arne & Corthay, Alexandre (2005, 18. november). NSI's Annual General Meeting 2005. [Internett].  Abstraktbok utgitt i papirform.

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Published Dec. 2, 2019 12:44 PM - Last modified Jan. 6, 2020 4:36 PM