Alexandre Corthay

Academic interests and areas of expertise
Immunology, cancer, immunotherapy
Academic background
Alexandre Corthay is a specialist in cancer immunology. He studied biology at the University of Geneva, Switzerland, and obtained a PhD at Lund University, Sweden. He is currently heading the Tumor Immunology Lab at the Department of Pathology, Oslo University Hospital, Rikshospitalet. He is in charge of the tumor-on-a-chip technology at the Hybrid Technology Hub.
Websites
Centre of Excellence – Hybrid Technology Hub
Appointments
Associate Editor for the Scandinavian Journal of Immunology and Frontiers in Immunology
Publications
- Frafjord, Astri; Skarshaug, Renate; Hammarström, Clara Louise; Stankovic, Branislava; Dorg, Linda Trobe; Aamodt, Henrik; Woldbæk, Per R; Helland, Åslaug; Brustugun, Odd Terje; Øynebråten, Inger & Corthay, Alexandre (2020). Antibody combinations for optimized staining of macrophages in human lung tumours. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12889(1), s 1- 24 . doi: 10.1111/sji.12889 Full text in Research Archive.
- Stankovic, Branislava; Aamodt, Henrik; Bjørhovde, Heidi Anine Korsmo; Müller, Elisabeth; Hammarström, Clara Louise; Brustugun, Odd Terje; Helland, Åslaug; Øynebråten, Inger & Corthay, Alexandre (2020). The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12893(2), s 1- 12 . doi: 10.1111/sji.12893 Full text in Research Archive.
- Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Fauskanger, Marte; Lund, Kaja; Mahmuda, Shoshy (Brinch, Shoshy Alam); Lycke, Eric Maximilian; Dybing, Elisabeth; Nygaard, Vegard; Bøe, Sigurd; Heintz, Karen Marie; Hovig, Eivind; Hammarström, Clara Louise; Corthay, Alexandre & Krauss, Stefan (2020). Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Communications Biology. ISSN 2399-3642. 3 . doi: 10.1038/s42003-020-0916-2 Full text in Research Archive.
- Haabeth, Ole Audun; Fauskanger, Marte; Manzke, Melanie; Lundin, Katrin; Corthay, Alexandre; Bogen, Bjarne & Tveita, Anders (2018). CD4+ T-cell–Mediated Rejection of MHC Class II–Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Research. ISSN 0008-5472. 78(16), s 4573- 4585 . doi: 10.1158/0008-5472.CAN-17-2426
- Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna; Øynebråten, Inger & Corthay, Alexandre (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology. ISSN 1664-3224. 9, s 1- 16 . doi: 10.3389/fimmu.2018.02520 Full text in Research Archive.
- Stankovic, Branislava; Bjørhovde, Heidi Anine Korsmo; Skarshaug, Renate; Aamodt, Henrik; Frafjord, Astri; Müller, Elisabeth; Hammarström, Clara Louise; Beraki, Kahsai; Bækkevold, Espen Sønderaal; Woldbæk, Per R; Helland, Åslaug; Brustugun, Odd Terje; Øynebråten, Inger & Corthay, Alexandre (2018). Immune Cell Composition in Human Non-small Cell Lung Cancer. Frontiers in Immunology. ISSN 1664-3224. Feb(1), s 1- 21 . doi: 10.3389/fimmu.2018.03101 Full text in Research Archive. Show summary
- Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), s 84- 94 . doi: 10.1111/sji.12500
- Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(4), s 242- 250 . doi: 10.1111/sji.12525 Show summary
- Christopoulos, Panagiotis; Corthay, Alexandre & Koutsilieris, Michael (2017). Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics. Cancer Treatment Reviews. ISSN 0305-7372. 63, s 79- 95 . doi: 10.1016/j.ctrv.2017.11.010
- Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava; Øynebråten, Inger; Corthay, Alexandre & Zajakina, Anna (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology. ISSN 1664-3224. 8 . doi: 10.3389/fimmu.2017.01667 Full text in Research Archive.
- Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai; Speth, Martin; Øynebråten, Inger & Corthay, Alexandre (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology. ISSN 1664-3224. 8 . doi: 10.3389/fimmu.2017.01383 Full text in Research Archive.
- Obando, Daniel F. González; Frafjord, Astri; Øynebråten, Inger; Corthay, Alexandre; Olivo-Marin, Jean-Christophe & Meas-Yedid, Vannary (2017). Multi-staining registration of large histology images. IEEE International Symposium on Biomedical Imaging. ISSN 1945-7928. s 345- 348 . doi: 10.1109/ISBI.2017.7950534
- Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich; Corthay, Alexandre & Griffiths, Gareth Wyn (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics. ISSN 1543-8384. 14(11), s 4098- 4112 . doi: 10.1021/acs.molpharmaceut.7b00795
- Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E.; Duus, Jens Øllgaard & Inngjerdingen, Kari Tvete (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga).. Carbohydrate Polymers. ISSN 0144-8617. 185, s 27- 40 . doi: 10.1016/j.carbpol.2017.12.041 Full text in Research Archive.
- Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology. ISSN 1664-3224. 7 . doi: 10.3389/fimmu.2016.00167 Full text in Research Archive.
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. ISSN 2162-4011. 5(1) . doi: 10.1080/2162402X.2015.1039763
- Joly-Battaglini, Albane; Hammarström, Clara Louise; Stankovic, Branislava; Aamodt, Henrik; Stjärne, Johan Folke Håkan; Brustugun, Odd Terje; Helland, Åslaug; Øynebråten, Inger & Corthay, Alexandre (2016). Rituximab efficiently depletes B cells in lung tumors and normal lung tissue. F1000. ISSN 1759-796X. 5 . doi: 10.12688/f1000research.7599.1
- Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research. ISSN 0008-5472. 76(23), s 6864- 6876 . doi: 10.1158/0008-5472.CAN-16-1219
- Corthay, Alexandre (2014). Does the immune system naturally protect against cancer?. Frontiers in Immunology. ISSN 1664-3224. 5(MAY) . doi: 10.3389/fimmu.2014.00197
- Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde; Munthe, Ludvig Andre; Dembic, Zlatko; Corthay, Alexandre & Bogen, Bjarne (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules?. Frontiers in Immunology. ISSN 1664-3224. 5:174 . doi: 10.3389/fimmu.2014.00174 Full text in Research Archive.
- Lorvik, Kristina Berg; Haabeth, Ole Audun; Clancy, Trevor; Bogen, Bjarne & Corthay, Alexandre (2013). Molecular profiling of tumor-specific T(H)1 cells activated in vivo. Oncoimmunology. ISSN 2162-4011. 2(5:e24383) . doi: 10.4161/onci.24383
- Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine; Gjerstad, Vibeke Sundvold; Corthay, Alexandre; Bogen, Bjarne & Spurkland, Anne (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLOS ONE. ISSN 1932-6203. 7(10) . doi: 10.1371/journal.pone.0048239
- Haabeth, Ole Audun; Bogen, Bjarne & Corthay, Alexandre (2012). A model for cancer-suppressive inflammation. Oncoimmunology. ISSN 2162-4011. 1(7), s 1146- 1155 . doi: 10.4161/onci.21542
- Corthay, Alexandre; Lorvik, Kristina Berg & Bogen, Bjarne (2011). Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4+T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), s 527- 530 . doi: 10.1111/j.1365-3083.2011.02558.x
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications. ISSN 2041-1723. 2 . doi: 10.1038/ncomms1239
- Corthay, Alexandre; Lundin, Katrin; Lorvik, Kristina Berg; Hofgaard, Peter Olaf & Bogen, Bjarne (2009). Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells. Cancer Research. ISSN 0008-5472. 69(14), s 5901- 5907 . doi: 10.1158/0008-5472.CAN-08-4816
- Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre; Munthe, Ludvig Andre; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling. ISSN 0898-6568. 21(2), s 274- 281 . doi: 10.1016/j.cellsig.2008.10.013
- Corthay, Alexandre (2007). CD4+T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Advances in Experimental Medicine and Biology. ISSN 0065-2598. 590, s 195- 208
- Bogen, Bjarne; Ruffini, Pier Adelchi; Corthay, Alexandre; Brunsvik, Agnete; Frøyland, Marianne; Lundin, Katrin; Røsjø, Egil; Thompson, Keith & Massaia, M (2006). Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research. Studies in Surface Science and Catalysis. ISSN 0167-2991. 91, s 941- 948
- Munthe, Ludvig Andre; Corthay, Alexandre; Os, Audun; Zangani, Michael M & Bogen, Bjarne (2005). Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from immunoglobulin V region-specific T cells. Journal of Immunology. ISSN 0022-1767. 175, s 2391- 2400 . doi: 16081810
- Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde; Hofgaard, Peter Olaf; Haraldsen, Guttorm & Bogen, Bjarne (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity. ISSN 1074-7613. 22, s 371- 383
- Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias; Dembic, Zlatko & Bogen, Bjarne (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, s 759- 769
- Tjelle, TE; Corthay, Alexandre; Lunde, Elin; Sandlie, Inger; Michaelsen, Terje Einar; Mathiesen, I & Bogen, Bjarne (2004). Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Molecular Therapy. ISSN 1525-0016. 9(3), s 328- 336
- Wold, Christian Winther; Corthay, Alexandre; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2020). Myteomspunnen kjuke frå folkemedisin til mogleg kreftbehandling. www.forskning.no.
- Corthay, Alexandre (2017). Book Review: The foundations of immunology and their pertinence to medicine. Scandinavian Journal of Immunology. ISSN 0300-9475. 86(2), s 119- 120 . doi: 10.1111/sji.12565
- Corthay, Alexandre (2016). Book Review: Rediscovering the Immune System as an Integrated Organ. Scandinavian Journal of Immunology. ISSN 0300-9475. 84(1), s 70- 71 . doi: 10.1111/sji.12440
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi. February
- Corthay, Alexandre & Stankovic, Branislava (2015). Characterization of immune cells in human non-small cell lung cancer (Thesis for the Master’s Degree in Molecular Biosciences).
- Joly-Battaglini, A & Corthay, Alexandre (2015). Study of immune cells infiltrating human non-small cell lung cancer (Thesis for the Master’s Degree in Biology).
- Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(4), s 275- 276
- Corthay, Alexandre; Hammarström, Clara; Fauskanger, M.; Haabeth, OAW; Zangani, Miriam; Haraldsen, H.; Bogen, Bjarne & Lorvik, Kristina Berg (2012). Cancer immunotherapy by adoptive transfer of tumor-specific Th2 cells. Immunology. ISSN 0019-2805. 137, s 706- 706
- Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2012). Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood. ISSN 0006-4971. 119(9), s 2176- 2177 . doi: 10.1182/blood-2011-10-388892
- Alfsnes, Katrine; Lorvik, Kristina Berg; Audun, Ole; Haabeth, Werner; Bogen, Bjarne & Corthay, Alexandre (2011). Workshop IV - Tumor Immunology and Infectious Diseases Immunology. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s 380- 380
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). A cancer-protective role of inflammation. Cytokine. ISSN 1043-4666. 56(1), s 101- 101 . doi: 10.1016/j.cyto.2011.07.392
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), s 603- 603
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s 384- 384
- Lorvik, Kristina Berg; Zangani, Michael Mehrdad; Bogen, Bjarne & Corthay, Alexandre (2011). Myeloma Immunotherapy by Adoptive Transfer of Idiotype-Specific Th2 Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), s 392- 392
- Corthay, Alexandre (2009). How do Regulatory T Cells Work?. Scandinavian Journal of Immunology. ISSN 0300-9475. 70(4), s 326- 336 . doi: 10.1111/j.1365-3083.2009.02308.x
- Haabeth, Ole Audun; Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2009). Cytokine profile of successful cancer immunosurveillance mediated by tumor-specific CD4(+) T cells. Cytokine. ISSN 1043-4666. 48(1-2), s 48- 48 . doi: 10.1016/j.cyto.2009.07.135
- Corthay, Alexandre; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Transcriptomics of a successful antitumor immune response. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, s 209- 209
- Haabeth, OAW; Lorvik, Kristina Berg; Aagaard, L; Bogen, Bjarne & Corthay, Alexandre (2008). Role of cytokines and chemokines for cancer immune prevention. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, s 218- 218
- Lorvik, Kristina Berg; Corthay, Alexandre; Lundin, Katrin; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Role of antigen secretion for cancer immunosurveillance. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, s 217- 218
- Corthay, Alexandre (2006). A three-cell model for activation of naive T helper cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 64, s 93- 96
- Halstensen, Trond Sundby; Corthay, Alexandre & Westgaard, Arne (2005, 29. april). Immunologiens dag 29. april 2005 - populærvitenskapelig konferanse i universitetets aula. [Internett]. Norsk Selskap for Immunologi - www.norwegianimmunology.org. Show summary
- Halstensen, Trond Sundby; Westgaard, Arne & Corthay, Alexandre (2005, 18. november). NSI's Annual General Meeting 2005. [Internett]. Abstraktbok utgitt i papirform.