Alexandre Corthay

• Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina; Olsen, Petter Angell; Aizenshtadt, Aleksandra; Fauskanger, Marte; Lund, Kaja; Brinch, Shoshy Alam; Lycke, Max; Dybing, Elisabeth; Nygaard, Vegard; Bøe, Sigurd Læines; Heintz, Karen Marie; Hovig, Eivind; Hammarström, Clara Louise; Corthay, Alexandre & Krauss, Stefan (2020). Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Communications Biology.  ISSN 2399-3642.  3(196) . doi: https://doi.org/10.1038/s42003-020-0916-2
• Haabeth, Ole Audun; Fauskanger, Marte; Manzke, Melanie; Lundin, Katrin; Corthay, Alexandre; Bogen, Bjarne & Tveita, Anders (2018). CD4+ T-cell–Mediated Rejection of MHC Class II–Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Research.  ISSN 0008-5472.  78(16), s 4573- 4585 . doi: 10.1158/0008-5472.CAN-17-2426
• Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna; Øynebråten, Inger & Corthay, Alexandre (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology.  ISSN 1664-3224.  9, s 1- 16 . doi: 10.3389/fimmu.2018.02520 Full text in Research Archive.
• Stankovic, Branislava; Bjørhovde, Heidi Anine Korsmo; Skarshaug, Renate; Aamodt, Henrik; Frafjord, Astri; Müller, Elisabeth; Hammarström, Clara Louise; Beraki, Kahsai; Bækkevold, Espen Sønderaal; Woldbæk, Per R; Helland, Åslaug; Brustugun, Odd Terje; Øynebråten, Inger & Corthay, Alexandre (2018). Immune Cell Composition in Human Non-small Cell Lung Cancer. Frontiers in Immunology.  ISSN 1664-3224.  Feb(1), s 1- 21 . doi: 10.3389/fimmu.2018.03101 Full text in Research Archive. Show summary

  Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in the world. Immunological analysis of the tumor microenvironment (immunoscore) shows great promise for improved prognosis and prediction of response to immunotherapy. However, the exact immune cell composition in NSCLC remains unclear. Here, we used flow cytometry to characterize the immune infiltrate in NSCLC tumors, non-cancerous lung tissue, regional lymph node, and blood. The cellular identity of >95% of all CD45+ immune cells was determined. Thirteen distinct immune cell types were identified in NSCLC tumors. T cells dominated the lung cancer landscape (on average 47% of all CD45+ immune cells). CD4+ T cells were the most abundant T cell population (26%), closely followed by CD8+ T cells (22%). Double negative CD4−CD8− T cells represented a small fraction (1.4%). CD19+ B cells were the second most common immune cell type in NSCLC tumors (16%), and four different B cell sub-populations were identified. Macrophages and natural killer (NK) cells composed 4.7 and 4.5% of the immune cell infiltrate, respectively. Three types of dendritic cells (DCs) were identified (plasmacytoid DCs, CD1c+ DCs, and CD141+ DCs) which together represented 2.1% of all immune cells. Among granulocytes, neutrophils were frequent (8.6%) with a high patient-to- patient variability, while mast cells (1.4%), basophils (0.4%), and eosinophils (0.3%) were less common. Across the cohort of patients, only B cells showed a significantly higher representation in NSCLC tumors compared to the distal lung. In contrast, the percentages of macrophages and NK cells were lower in tumors than in non-cancerous lung tissue. Furthermore, the fraction of macrophages with high HLA-DR expression levels was higher in NSCLC tumors relative to distal lung tissue. To make the method readily accessible, antibody panels and flow cytometry gating strategy used to identify the various immune cells are described in detail. This work should represent a useful resource for the immunomonitoring of patients with NSCLC.

• Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(2), s 84- 94 . doi: 10.1111/sji.12500
• Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi; Nagy, Zoltan A. & Øynebråten, Inger (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(4), s 242- 250 . doi: 10.1111/sji.12525 Show summary

  We discussed different proposals for how the nature of the Th1/Th2 phenotype of an immune response is determined, and favoured one, the Threshold Hypothesis, as plausible and so useful as the basis for further discussions. The activation of a target CD4 T cell can be facilitated by helper CD4 T cells when the CD4 T cells interact via an antigen-presenting cell. The Threshold Hypothesis states that tentative and robust antigen-mediated CD4 T cell cooperation results in the target CD4 T cell, respectively giving rise, upon activation, to Th1 and Th2 cells. We primarily discussed four topics. We briefly discussed in the background section certain limitations of the Th1/Th2 paradigm in understanding immune class regulation, and the remarkable anti-inflammatory properties of human IgG4 antibody. Secondly, we assessed the role of class II MHC molecules in determining the number of mature CD4 T cells and so affecting the Th1/Th2 phenotype of immune responses. We also discussed the controversial role of CD8 T cells in affecting the Th1/Th2 phenotype of responses to MHC and other antigens, and the potential role of their relative scarcity in neonates in biasing responses towards an antibody, Th2 mode. Lastly, we examined the regulation of the Th1/Th2 phenotype of both primary and ongoing immune responses in the context of the intriguing proposal that antigen initially generates different classes/subclasses of immunity and then selects, by a feedback mechanism, the most effective class. We found this interesting idea difficult to reconcile with various observations.

• Christopoulos, Panagiotis; Corthay, Alexandre & Koutsilieris, Michael (2017). Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics. Cancer Treatment Reviews.  ISSN 0305-7372.  63, s 79- 95 . doi: 10.1016/j.ctrv.2017.11.010
• Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava; Øynebråten, Inger; Corthay, Alexandre & Zajakina, Anna (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01667 Full text in Research Archive.
• Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai; Speth, Martin; Øynebråten, Inger & Corthay, Alexandre (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology.  ISSN 1664-3224.  8 . doi: 10.3389/fimmu.2017.01383 Full text in Research Archive.
• Obando, Daniel F. González; Frafjord, Astri; Øynebråten, Inger; Corthay, Alexandre; Olivo-Marin, Jean-Christophe & Meas-Yedid, Vannary (2017). Multi-staining registration of large histology images. IEEE International Symposium on Biomedical Imaging.  ISSN 1945-7928.  s 345- 348 . doi: 10.1109/ISBI.2017.7950534
• Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich; Corthay, Alexandre & Griffiths, Gareth Wyn (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics.  ISSN 1543-8384.  14(11), s 4098- 4112 . doi: 10.1021/acs.molpharmaceut.7b00795
• Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E.; Duus, Jens Øllgaard & Inngjerdingen, Kari Tvete (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga).. Carbohydrate Polymers.  ISSN 0144-8617.  185, s 27- 40 . doi: 10.1016/j.carbpol.2017.12.041 Full text in Research Archive.
• Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology.  ISSN 1664-3224.  7 . doi: 10.3389/fimmu.2016.00167 Full text in Research Archive.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology.  ISSN 2162-4011.  5(1) . doi: 10.1080/2162402X.2015.1039763
• Joly-Battaglini, Albane; Hammarström, Clara Louise; Stankovic, Branislava; Aamodt, Henrik; Stjärne, Johan Folke Håkan; Brustugun, Odd Terje; Helland, Åslaug; Øynebråten, Inger & Corthay, Alexandre (2016). Rituximab efficiently depletes B cells in lung tumors and normal lung tissue. F1000.  ISSN 1759-796X.  5 . doi: 10.12688/f1000research.7599.1
• Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research.  ISSN 0008-5472.  76(23), s 6864- 6876 . doi: 10.1158/0008-5472.CAN-16-1219
• Corthay, Alexandre (2014). Does the immune system naturally protect against cancer?. Frontiers in Immunology.  ISSN 1664-3224.  5(MAY) . doi: 10.3389/fimmu.2014.00197
• Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde; Munthe, Ludvig Andre; Dembic, Zlatko; Corthay, Alexandre & Bogen, Bjarne (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules?. Frontiers in Immunology.  ISSN 1664-3224.  5:174 . doi: 10.3389/fimmu.2014.00174 Full text in Research Archive.
• Lorvik, Kristina Berg; Haabeth, Ole Audun; Clancy, Trevor; Bogen, Bjarne & Corthay, Alexandre (2013). Molecular profiling of tumor-specific T(H)1 cells activated in vivo. Oncoimmunology.  ISSN 2162-4011.  2(5:e24383) . doi: 10.4161/onci.24383
• Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine; Gjerstad, Vibeke Sundvold; Corthay, Alexandre; Bogen, Bjarne & Spurkland, Anne (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLOS ONE.  ISSN 1932-6203.  7(10)
• Haabeth, Ole Audun; Bogen, Bjarne & Corthay, Alexandre (2012). A model for cancer-suppressive inflammation. Oncoimmunology.  ISSN 2162-4011.  1(7), s 1146- 1155 . doi: 10.4161/onci.21542
• Corthay, Alexandre; Lorvik, Kristina Berg & Bogen, Bjarne (2011). Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4+T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(6), s 527- 530 . doi: 10.1111/j.1365-3083.2011.02558.x
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications.  ISSN 2041-1723.  2 . doi: 10.1038/ncomms1239
• Corthay, Alexandre; Lundin, Katrin; Lorvik, Kristina Berg; Hofgaard, Peter Olaf & Bogen, Bjarne (2009). Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells. Cancer Research.  ISSN 0008-5472.  69(14), s 5901- 5907 . doi: 10.1158/0008-5472.CAN-08-4816
• Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre; Munthe, Ludvig Andre; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling.  ISSN 0898-6568.  21(2), s 274- 281 . doi: 10.1016/j.cellsig.2008.10.013
• Corthay, Alexandre (2007). CD4+T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Advances in Experimental Medicine and Biology.  ISSN 0065-2598.  590, s 195- 208
• Bogen, Bjarne; Ruffini, Pier Adelchi; Corthay, Alexandre; Brunsvik, Agnete; Frøyland, Marianne; Lundin, Katrin; Røsjø, Egil; Thompson, Keith & Massaia, M (2006). Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research. Studies in Surface Science and Catalysis.  ISSN 0167-2991.  91, s 941- 948
• Munthe, Ludvig Andre; Corthay, Alexandre; Os, Audun; Zangani, Michael M & Bogen, Bjarne (2005). Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from immunoglobulin V region-specific T cells. Journal of Immunology.  ISSN 0022-1767.  175, s 2391- 2400 . doi: 16081810
• Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde; Hofgaard, Peter Olaf; Haraldsen, Guttorm & Bogen, Bjarne (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity.  ISSN 1074-7613.  22, s 371- 383
• Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias; Dembic, Zlatko & Bogen, Bjarne (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy.  ISSN 0340-7004.  53, s 759- 769
• Tjelle, TE; Corthay, Alexandre; Lunde, Elin; Sandlie, Inger; Michaelsen, Terje Einar; Mathiesen, I & Bogen, Bjarne (2004). Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Molecular Therapy.  ISSN 1525-0016.  9(3), s 328- 336

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• Corthay, Alexandre (2017). Book Review: The foundations of immunology and their pertinence to medicine. Scandinavian Journal of Immunology.  ISSN 0300-9475.  86(2), s 119- 120 . doi: 10.1111/sji.12565
• Corthay, Alexandre (2016). Book Review: Rediscovering the Immune System as an Integrated Organ. Scandinavian Journal of Immunology.  ISSN 0300-9475.  84(1), s 70- 71 . doi: 10.1111/sji.12440
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi.  February
• Corthay, Alexandre & Stankovic, Branislava (2015). Characterization of immune cells in human non-small cell lung cancer (Thesis for the Master’s Degree in Molecular Biosciences).
• Joly-Battaglini, A & Corthay, Alexandre (2015). Study of immune cells infiltrating human non-small cell lung cancer (Thesis for the Master’s Degree in Biology).
• Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology.  ISSN 0300-9475.  77(4), s 275- 276
• Corthay, Alexandre; Hammarström, Clara; Fauskanger, M.; Haabeth, OAW; Zangani, Miriam; Haraldsen, H.; Bogen, Bjarne & Lorvik, Kristina Berg (2012). Cancer immunotherapy by adoptive transfer of tumor-specific Th2 cells. Immunology.  ISSN 0019-2805.  137, s 706- 706
• Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2012). Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood.  ISSN 0006-4971.  119(9), s 2176- 2177 . doi: 10.1182/blood-2011-10-388892
• Alfsnes, Katrine; Lorvik, Kristina Berg; Audun, Ole; Haabeth, Werner; Bogen, Bjarne & Corthay, Alexandre (2011). Workshop IV - Tumor Immunology and Infectious Diseases Immunology. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 380- 380
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). A cancer-protective role of inflammation. Cytokine.  ISSN 1043-4666.  56(1), s 101- 101 . doi: 10.1016/j.cyto.2011.07.392
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(6), s 603- 603
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm; Bogen, Bjarne & Corthay, Alexandre (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 384- 384
• Lorvik, Kristina Berg; Zangani, Michael Mehrdad; Bogen, Bjarne & Corthay, Alexandre (2011). Myeloma Immunotherapy by Adoptive Transfer of Idiotype-Specific Th2 Cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 392- 392
• Corthay, Alexandre (2009). How do Regulatory T Cells Work?. Scandinavian Journal of Immunology.  ISSN 0300-9475.  70(4), s 326- 336 . doi: 10.1111/j.1365-3083.2009.02308.x
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2009). Cytokine profile of successful cancer immunosurveillance mediated by tumor-specific CD4(+) T cells. Cytokine.  ISSN 1043-4666.  48(1-2), s 48- 48 . doi: 10.1016/j.cyto.2009.07.135
• Corthay, Alexandre; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Transcriptomics of a successful antitumor immune response. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 209- 209
• Haabeth, OAW; Lorvik, Kristina Berg; Aagaard, L; Bogen, Bjarne & Corthay, Alexandre (2008). Role of cytokines and chemokines for cancer immune prevention. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 218- 218
• Lorvik, Kristina Berg; Corthay, Alexandre; Lundin, Katrin; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Role of antigen secretion for cancer immunosurveillance. Scandinavian Journal of Immunology.  ISSN 0300-9475.  68, s 217- 218
• Corthay, Alexandre (2006). A three-cell model for activation of naive T helper cells. Scandinavian Journal of Immunology.  ISSN 0300-9475.  64, s 93- 96
• Halstensen, Trond Sundby; Corthay, Alexandre & Westgaard, Arne (2005, 29. april). Immunologiens dag 29. april 2005 - populærvitenskapelig konferanse i universitetets aula. [Internett].  Norsk Selskap for Immunologi - www.norwegianimmunology.org. Show summary

  Den europeiske immunologiforeningen EFIS innstiftet "Day of Immunology", som ble markert for første gang den 29. april 2005. Norsk Selskap for Immunologi (NSI) var ansvarlig for arrangementene i Norge.

• Halstensen, Trond Sundby; Westgaard, Arne & Corthay, Alexandre (2005, 18. november). NSI's Annual General Meeting 2005. [Internett].  Abstraktbok utgitt i papirform.

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