Alexandre Corthay

• Corthay, Alexandre; Bakacs, Tibor; Thangavelu, Govindarajan & Anderson, Colin C. (2021). Tackling cancer cell dormancy: Insights from immune models, and transplantation. Seminars in Cancer Biology. ISSN 1044-579X. p. 1–12. doi: 10.1016/j.semcancer.2021.02.002.
• Stankovic, Branislava; Aamodt, Henrik; Bjørhovde, Heidi Anine Korsmo; Müller, Elisabeth; Hammarström, Clara Louise & Brustugun, Odd Terje [Show all 9 contributors for this article] (2020). The immune microenvironment in typical carcinoid lung tumour, a brief report of four cases. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12893(2), p. 1–12. doi: 10.1111/sji.12893. Full text in Research Archive
• Frafjord, Astri; Skarshaug, Renate; Hammarström, Clara Louise; Stankovic, Branislava; Dorg, Linda Trobe & Aamodt, Henrik [Show all 11 contributors for this article] (2020). Antibody combinations for optimized staining of macrophages in human lung tumours. Scandinavian Journal of Immunology. ISSN 0300-9475. 92:e12889(1), p. 1–24. doi: 10.1111/sji.12889. Full text in Research Archive
• Waaler, Jo; Mygland, Line; Tveita, Anders Aune; Strand, Martin Frank; Solberg, Nina & Olsen, Petter Angell [Show all 19 contributors for this article] (2020). Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models. Communications Biology. ISSN 2399-3642. 3. doi: 10.1038/s42003-020-0916-2. Full text in Research Archive
• Müller, Elisabeth; Speth, Martin; Christopoulos, Panagiotis; Lunde, Anna; Avdagic, Ajna & Øynebråten, Inger [Show all 7 contributors for this article] (2018). Both type I and type II interferons can activate antitumor M1 macrophages when combined with TLR stimulation. Frontiers in Immunology. ISSN 1664-3224. 9, p. 1–16. doi: 10.3389/fimmu.2018.02520. Full text in Research Archive
• Stankovic, Branislava; Bjørhovde, Heidi Anine Korsmo; Skarshaug, Renate; Aamodt, Henrik; Frafjord, Astri & Müller, Elisabeth [Show all 14 contributors for this article] (2018). Immune Cell Composition in Human Non-small Cell Lung Cancer. Frontiers in Immunology. ISSN 1664-3224. Feb(1), p. 1–21. doi: 10.3389/fimmu.2018.03101. Full text in Research Archive
• Haabeth, Ole Audun; Fauskanger, Marte; Manzke, Melanie; Lundin, Katrin; Corthay, Alexandre & Bogen, Bjarne [Show all 7 contributors for this article] (2018). CD4+ T-cell–Mediated Rejection of MHC Class II–Positive Tumor Cells Is Dependent on Antigen Secretion and Indirect Presentation on Host APCs. Cancer Research. ISSN 0008-5472. 78(16), p. 4573–4585. doi: 10.1158/0008-5472.CAN-17-2426.
• Kurena, Baiba; Müller, Elisabeth; Christopoulos, Panagiotis; Johnsen, Ingvild Bjellmo; Stankovic, Branislava & Øynebråten, Inger [Show all 8 contributors for this article] (2017). Generation and Functional In Vitro Analysis of Semliki Forest Virus Vectors Encoding TNF-α and IFN-γ. Frontiers in Immunology. ISSN 1664-3224. 8. doi: 10.3389/fimmu.2017.01667. Full text in Research Archive
• Obando, Daniel F. González; Frafjord, Astri; Øynebråten, Inger; Corthay, Alexandre; Olivo-Marin, Jean-Christophe & Meas-Yedid, Vannary (2017). Multi-staining registration of large histology images. IEEE International Symposium on Biomedical Imaging. ISSN 1945-7928. p. 345–348. doi: 10.1109/ISBI.2017.7950534.
• Müller, Elisabeth; Christopoulos, Panagiotis; Halder, Sanjib; Lunde, Anna; Beraki, Kahsai & Speth, Martin [Show all 8 contributors for this article] (2017). Toll-like receptor ligands and interferon-gamma synergize for induction of antitumor M1 macrophages. Frontiers in Immunology. ISSN 1664-3224. 8. doi: 10.3389/fimmu.2017.01383. Full text in Research Archive
• Christopoulos, Panagiotis; Corthay, Alexandre & Koutsilieris, Michael (2017). Aiming for the Insulin-like Growth Factor-1 system in breast cancer therapeutics. Cancer Treatment Reviews. ISSN 0305-7372. 63, p. 79–95. doi: 10.1016/j.ctrv.2017.11.010.
• Anderson, Colin C.; Bretscher, Peter; Corthay, Alexandre; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immunological Tolerance. Part I of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), p. 84–94. doi: 10.1111/sji.12500.
• Speth, Martin; Repnik, Urska; Müller, Elisabeth; Spanier, Julia; Kalinke, Ulrich & Corthay, Alexandre [Show all 7 contributors for this article] (2017). Poly(I:C)-Encapsulating Nanoparticles Enhance Innate Immune Responses to the Tuberculosis Vaccine Bacille Calmette-Guerin (BCG) via Synergistic Activation of Innate Immune Receptors. Molecular Pharmaceutics. ISSN 1543-8384. 14(11), p. 4098–4112. doi: 10.1021/acs.molpharmaceut.7b00795.
• Bretscher, Peter; Corthay, Alexandre; Anderson, Colin C.; Dembic, Zlatko; Havele, Calliopi & Nagy, Zoltan A. [Show all 7 contributors for this article] (2017). Immune Class Regulation and Its Medical Significance Part II of a Report of a Workshop on Foundational Concepts of Immune Regulation. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(4), p. 242–250. doi: 10.1111/sji.12525. Show summary

  We discussed different proposals for how the nature of the Th1/Th2 phenotype of an immune response is determined, and favoured one, the Threshold Hypothesis, as plausible and so useful as the basis for further discussions. The activation of a target CD4 T cell can be facilitated by helper CD4 T cells when the CD4 T cells interact via an antigen-presenting cell. The Threshold Hypothesis states that tentative and robust antigen-mediated CD4 T cell cooperation results in the target CD4 T cell, respectively giving rise, upon activation, to Th1 and Th2 cells. We primarily discussed four topics. We briefly discussed in the background section certain limitations of the Th1/Th2 paradigm in understanding immune class regulation, and the remarkable anti-inflammatory properties of human IgG4 antibody. Secondly, we assessed the role of class II MHC molecules in determining the number of mature CD4 T cells and so affecting the Th1/Th2 phenotype of immune responses. We also discussed the controversial role of CD8 T cells in affecting the Th1/Th2 phenotype of responses to MHC and other antigens, and the potential role of their relative scarcity in neonates in biasing responses towards an antibody, Th2 mode. Lastly, we examined the regulation of the Th1/Th2 phenotype of both primary and ongoing immune responses in the context of the intriguing proposal that antigen initially generates different classes/subclasses of immunity and then selects, by a feedback mechanism, the most effective class. We found this interesting idea difficult to reconcile with various observations.

• Wold, Christian Winther; Kjeldsen, Christian; Corthay, Alexandre; Rise, Frode; Christensen, Bjørn E. & Duus, Jens Øllgaard [Show all 7 contributors for this article] (2017). Structural characterization of bioactive heteropolysaccharides from the medicinal fungus Inonotus obliquus (Chaga). Carbohydrate Polymers. ISSN 0144-8617. 185, p. 27–40. doi: 10.1016/j.carbpol.2017.12.041. Full text in Research Archive
• Joly-Battaglini, Albane; Hammarström, Clara Louise; Stankovic, Branislava; Aamodt, Henrik; Stjärne, Johan Folke Håkan & Brustugun, Odd Terje [Show all 9 contributors for this article] (2016). Rituximab efficiently depletes B cells in lung tumors and normal lung tissue. F1000. ISSN 1759-796X. 5. doi: 10.12688/f1000research.7599.1.
• Andersen, Aram Nikolai; Landsverk, Ole J. B.; Simonsen, Anne; Bogen, Bjarne; Corthay, Alexandre & Øynebråten, Inger (2016). Coupling of HIV-1 antigen to the selective autophagy receptor SQSTM1/p62 promotes T-cell-mediated immunity. Frontiers in Immunology. ISSN 1664-3224. 7. doi: 10.3389/fimmu.2016.00167. Full text in Research Archive
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Yagita, Hideo; Bogen, Bjarne & Corthay, Alexandre (2016). Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. ISSN 2162-4011. 5(1). doi: 10.1080/2162402X.2015.1039763.
• Lorvik, Kristina Berg; Hammarström, Clara Louise; Fauskanger, Marte; Haabeth, Ole Audun; Zangani, Michael M & Haraldsen, Guttorm [Show all 8 contributors for this article] (2016). Adoptive transfer of tumor-specific Th2 cells eradicates tumors by triggering an in situ inflammatory immune response. Cancer Research. ISSN 0008-5472. 76(23), p. 6864–6876. doi: 10.1158/0008-5472.CAN-16-1219.
• Corthay, Alexandre (2014). Does the immune system naturally protect against cancer? Frontiers in Immunology. ISSN 1664-3224. 5(MAY). doi: 10.3389/fimmu.2014.00197.
• Haabeth, Ole Audun; Tveita, Anders; Fauskanger, Marte Hotvedt; Schjesvold, Fredrik Hellem; Lorvik, Kristina Berg & Hofgaard, Peter Olaf [Show all 11 contributors for this article] (2014). How do CD4+ T cells detect and eliminate tumor cells that either lack or express MHC class II molecules? Frontiers in Immunology. ISSN 1664-3224. 5:174. doi: 10.3389/fimmu.2014.00174. Full text in Research Archive
• Lorvik, Kristina Berg; Haabeth, Ole Audun; Clancy, Trevor; Bogen, Bjarne & Corthay, Alexandre (2013). Molecular profiling of tumor-specific T(H)1 cells activated in vivo. Oncoimmunology. ISSN 2162-4011. 2(5:e24383). doi: 10.4161/onci.24383.
• Haabeth, Ole Audun; Bogen, Bjarne & Corthay, Alexandre (2012). A model for cancer-suppressive inflammation. Oncoimmunology. ISSN 2162-4011. 1(7), p. 1146–1155. doi: 10.4161/onci.21542.
• Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine & Gjerstad, Vibeke Sundvold [Show all 9 contributors for this article] (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLOS ONE. ISSN 1932-6203. 7(10). doi: 10.1371/journal.pone.0048239.
• Corthay, Alexandre; Lorvik, Kristina Berg & Bogen, Bjarne (2011). Is Secretion of Tumour-specific Antigen Important for Cancer Eradication by CD4+T Cells? - Implications for Cancer Immunotherapy by Adoptive T Cell Transfer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), p. 527–530. doi: 10.1111/j.1365-3083.2011.02558.x.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrøm, Clara Louise; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer. Nature Communications. ISSN 2041-1723. 2. doi: 10.1038/ncomms1239.
• Corthay, Alexandre; Lundin, Katrin; Lorvik, Kristina Berg; Hofgaard, Peter Olaf & Bogen, Bjarne (2009). Secretion of Tumor-Specific Antigen by Myeloma Cells Is Required for Cancer Immunosurveillance by CD4(+) T Cells. Cancer Research. ISSN 0008-5472. 69(14), p. 5901–5907. doi: 10.1158/0008-5472.CAN-08-4816.
• Funderud, Ane; Aas-Hanssen, Kristin; Aksaas, Anne Kristin; Hafte, Tolesa Tilahun; Corthay, Alexandre & Munthe, Ludvig Andre [Show all 8 contributors for this article] (2009). Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA). Cellular Signalling. ISSN 0898-6568. 21(2), p. 274–281. doi: 10.1016/j.cellsig.2008.10.013.
• Corthay, Alexandre (2007). CD4+T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Advances in Experimental Medicine and Biology. ISSN 0065-2598. 590, p. 195–208.
• Bogen, Bjarne; Ruffini, Pier Adelchi; Corthay, Alexandre; Brunsvik, Agnete; Frøyland, Marianne & Lundin, Katrin [Show all 9 contributors for this article] (2006). Idiotype-specific immunotherapy in multiple myeloma: suggestions for future directions of research. Studies in Surface Science and Catalysis. ISSN 0167-2991. 91, p. 941–948.
• Corthay, Alexandre; Skovseth, Dag Kristian; Lundin, Katrin; Røsjø, Egil; Omholt, Hilde & Hofgaard, Peter Olaf [Show all 8 contributors for this article] (2005). Primary antitumor immune response mediated by CD4+ T cells. Immunity. ISSN 1074-7613. 22, p. 371–383.
• Munthe, Ludvig Andre; Corthay, Alexandre; Os, Audun; Zangani, Michael M & Bogen, Bjarne (2005). Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from immunoglobulin V region-specific T cells. Journal of Immunology. ISSN 0022-1767. 175, p. 2391–2400.
• Corthay, Alexandre; Lundin, Katrin; Munthe, Ludvig Andre; Frøyland, Marianne; Gedde-Dahl, Thobias & Dembic, Zlatko [Show all 7 contributors for this article] (2004). Immunotherapy in multiple myeloma: Id-specific strategies suggested by studies in animal models. Cancer Immunology and Immunotherapy. ISSN 0340-7004. 53, p. 759–769.
• Tjelle, TE; Corthay, Alexandre; Lunde, Elin; Sandlie, Inger; Michaelsen, Terje Einar & Mathiesen, I [Show all 7 contributors for this article] (2004). Monoclonal antibodies produced by muscle after plasmid injection and electroporation. Molecular Therapy. ISSN 1525-0016. 9(3), p. 328–336.

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• Wold, Christian Winther; Corthay, Alexandre; Wangensteen, Helle & Inngjerdingen, Kari Tvete (2020). Myteomspunnen kjuke frå folkemedisin til mogleg kreftbehandling. www.forskning.no.
• Corthay, Alexandre (2017). Book Review: The foundations of immunology and their pertinence to medicine. Scandinavian Journal of Immunology. ISSN 0300-9475. 86(2), p. 119–120. doi: 10.1111/sji.12565.
• Corthay, Alexandre (2016). Book Review: Rediscovering the Immune System as an Integrated Organ. Scandinavian Journal of Immunology. ISSN 0300-9475. 84(1), p. 70–71. doi: 10.1111/sji.12440.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara Louise; Donaldson, Ian M; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2016). Kreft-spesifikke betennelsesreaksjoner kan beskytte mot kreft. BestPractice. Onkologi Hematologi. February.
• Müller, Elisabeth; Stavna, A.; Jahnsen, Frode Lars; Bakke, Oddmund & Corthay, Alexandre (2013). Using Live Imaging to Investigate the Mechanisms Underlying Tumor Cell Killing by Macrophages. Scandinavian Journal of Immunology. ISSN 0300-9475. 77(4), p. 275–276.
• Corthay, Alexandre; Hammarström, Clara; Fauskanger, M.; Haabeth, OAW; Zangani, Miriam & Haraldsen, H. [Show all 8 contributors for this article] (2012). Cancer immunotherapy by adoptive transfer of tumor-specific Th2 cells. Immunology. ISSN 0019-2805. 137, p. 706–706.
• Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2012). Fingolimod blocks immunosurveillance of myeloma and B-cell lymphoma resulting in cancer development in mice. Blood. ISSN 0006-4971. 119(9), p. 2176–2177. doi: 10.1182/blood-2011-10-388892.
• Alfsnes, Katrine; Lorvik, Kristina Berg; Audun, Ole; Haabeth, Werner; Bogen, Bjarne & Corthay, Alexandre (2011). Workshop IV - Tumor Immunology and Infectious Diseases Immunology. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 380–380.
• Lorvik, Kristina Berg; Zangani, Michael Mehrdad; Bogen, Bjarne & Corthay, Alexandre (2011). Myeloma Immunotherapy by Adoptive Transfer of Idiotype-Specific Th2 Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 392–392.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Inflammation Driven by Tumor-Specific Th1 Cells Protects against B-Cell Cancer. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(4), p. 384–384.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarstrom, C; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). A cancer-protective role of inflammation. Cytokine. ISSN 1043-4666. 56(1), p. 101–101. doi: 10.1016/j.cyto.2011.07.392.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Hammarström, Clara; Donaldson, Ian Matthew; Haraldsen, Guttorm & Bogen, Bjarne [Show all 7 contributors for this article] (2011). Cancer Immunosurveillance by CD4(+) T Cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 73(6), p. 603–603.
• Corthay, Alexandre (2009). How do Regulatory T Cells Work? Scandinavian Journal of Immunology. ISSN 0300-9475. 70(4), p. 326–336. doi: 10.1111/j.1365-3083.2009.02308.x.
• Haabeth, Ole Audun; Lorvik, Kristina Berg; Bogen, Bjarne & Corthay, Alexandre (2009). Cytokine profile of successful cancer immunosurveillance mediated by tumor-specific CD4(+) T cells. Cytokine. ISSN 1043-4666. 48(1-2), p. 48–48. doi: 10.1016/j.cyto.2009.07.135.
• Haabeth, OAW; Lorvik, Kristina Berg; Aagaard, L; Bogen, Bjarne & Corthay, Alexandre (2008). Role of cytokines and chemokines for cancer immune prevention. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 218–218.
• Lorvik, Kristina Berg; Corthay, Alexandre; Lundin, Katrin; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Role of antigen secretion for cancer immunosurveillance. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 217–218.
• Corthay, Alexandre; Lorvik, Kristina Berg; Hofgaard, Peter Olaf; Omholt, Hilde & Bogen, Bjarne (2008). Transcriptomics of a successful antitumor immune response. Scandinavian Journal of Immunology. ISSN 0300-9475. 68, p. 209–209.
• Corthay, Alexandre (2006). A three-cell model for activation of naive T helper cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 64, p. 93–96.
• Halstensen, Trond Sundby; Corthay, Alexandre & Westgaard, Arne (2005). Immunologiens dag 29. april 2005 - populærvitenskapelig konferanse i universitetets aula. [Internet]. Norsk Selskap for Immunologi - www.norwegianimmunology.org. Show summary

  Den europeiske immunologiforeningen EFIS innstiftet "Day of Immunology", som ble markert for første gang den 29. april 2005. Norsk Selskap for Immunologi (NSI) var ansvarlig for arrangementene i Norge.

• Halstensen, Trond Sundby; Westgaard, Arne & Corthay, Alexandre (2005). NSI's Annual General Meeting 2005. [Internet]. Abstraktbok utgitt i papirform.
• Corthay, Alexandre & Stankovic, Branislava (2015). Characterization of immune cells in human non-small cell lung cancer (Thesis for the Master’s Degree in Molecular Biosciences) . Norwegian University of Life Sciences, Ås (September 21).
• Joly-Battaglini, A & Corthay, Alexandre (2015). Study of immune cells infiltrating human non-small cell lung cancer (Thesis for the Master’s Degree in Biology). Université Paris Sud.

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