Andrea Halaburkova

Postdoctoral Fellow - Chromatin Biology Group

Email andrea.halaburkova@medisin.uio.no

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Visiting address Sognsvannveien 9 Domus Medica 0372 Oslo

Postal address Postboks 1112 Biokjemi 0317 Oslo

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Academic interests

I am postdoc in Ragnhild Eskeland group. I study the role of protein complexes in epigenetic regulation of chromatin structure in cancer cells. I am using imaging techniques, molecular biology and biochemical methods such as Fluorescence in situ hybridization (FISH).

Education

PhD (2017) Molecular cytology, Faculty of Science/ Department of Cell biology, Pavol Jozef Safarik University in Kosice, Slovakia

Master (2010) Applied Technologies for Biomedical Laboratory Diagnostics, Faculty of Science and Technology, Statal University in Urbino Carlo Bo, Italy

Bachelor (2008) Biomedical Laboratory Methods, Faculty of Medicine, Statal University in Milano, Italy

Positions held

2025-present Postdoc: Chromatin biology group, The Faculty of Medicine/Department of Biochemistry, University of Oslo, Norway
2022-2025 Researcher: Cell dynamics group, The Faculty of Mathematics and Natural Sciences/Department of Biosciences, University of Oslo, Norway
2021-2022 Postdoc: Cancer Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM, CNRS, Lyon, France
2017-2021 Postdoc: Epigenetic group, International Agency for Research on Cancer (IARC-WHO), Lyon, France
2011-2012 Scientific assistant: molecular cytology, Faculty of Science/ Department of Cell biology, Pavol Jozef Safarik University, in Kosice, Slovakia
2009-2010 Diagnostic laboratory technician, Department of Pathology/ Section of Immunohistochemistry, National Tumour Institute in Milan (Istituto Nazionale dei Tumori), Milan, Italy

Hovet O, Nahali N, Halaburkova A, Haugen LH, Paulsen J, Progida C; Nuclear mechano-confinement induces geometry-dependent HP1α condensate alterations. Commun Biol. 2025 Feb 25;8(1):308. doi: 10.1038/s42003-025-07732-6.PMID: 40000755

Halaburkova A, Cahais V, Novoloaca A, Khoueiry R, GhantousA, Herceg Z; Pan-cancer genome and transcriptome analysis and orthogonal experimental assessment of epigenetic driver genes. Genome Res. 2020 Oct;30(10):1517-1532. doi: 10.1101/gr.268292.120. Epub 2020 Sep 22.PMID: 32963031

Sklias A*, Halaburkova A*, Vanzan L, Fernandez Jimenez N, Cuenin C, Bouaoun L, Cahais V, Ythier V, Sallé A, Renard C, Le Calvez-Kelm F, Khoueiry R, Murr R, Herceg Z; Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation. Nucleic Acids Res. 2021 Sep 27;49(17):9738-9754. doi: 10.1093/nar/gkab697.PMID: 34403459

Fanfone D, Chong Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Hector Hernandez-Vargas H, Tait S, Hennino A, Ichim G, Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Elife. 2022 Mar 8;11:e73150. doi: 10.7554/eLife.73150.PMID: 35256052

Halaburková A, Jendželovský R, Kovaľ J, Herceg Z, Fedoročko P, Ghantous A; Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A. Clin Epigenetics. 2017 Jun 8;9:62. doi: 10.1186/s13148-017-0359-x. eCollection 2017.PMID: 28603560

Gyurászová K, Mikeš J, Halaburková A, Jendželovský R, Fedoročko P. YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy. Photochem Photobiol Sci. 2016 Jun 8;15(6):812-21. doi: 10.1039/c5pp00438a. Epub 2016 May 31.PMID: 27241169

Hovet, Oda; Nahali, Negar; Halaburkova, Andrea; Haugen, Linda Hofstad; Paulsen, Jonas & Progida, Cinzia Anita Maria (2025). Nuclear mechano-confinement induces geometry-dependent HP1α condensate alterations. Communications Biology. 8. doi: 10.1038/s42003-025-07732-6. Full text in Research Archive Show summary
Cells sense external physical cues through complex processes involving signaling pathways, cytoskeletal dynamics, and transcriptional regulation to coordinate a cellular response. A key emerging principle underlying such mechanoresponses is the interplay between nuclear morphology, chromatin organization, and the dynamic behavior of nuclear bodies such as HP1α condensates. Here, applying Airyscan super-resolution live cell imaging, we report a hitherto undescribed level of mechanoresponse triggered by cell confinement below their resting nuclear diameter, which elicits changes in the number, size and dynamics of HP1α nuclear condensates. Utilizing biophysical polymer models, we observe radial redistribution of HP1α condensates within the nucleus, influenced by changes in nuclear geometry. These insights shed new light on the complex relationship between external forces and changes in nuclear shape and chromatin organization in cell mechanoreception.

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Published May 10, 2026 8:28 PM - Last modified May 10, 2026 8:28 PM