Anna Ruth Chambers

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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1103 Blindern 0317 Oslo

Academic Interests

I am broadly interested in (1) how the cerebral cortex processes sensory information in order to drive behavior, and (2) how experience (through learning, injury or disease, for example) affects the structure and function of the cortex. In order to investigate these topics, I have employed a variety of techniques, including extracellular electrophysiology, multiphoton imaging, and animal behavior. As a researcher in Koen Vervaeke's group, I am currently working towards an understanding of the microcircuit structure and function of the retrosplenial cortex, a brain region that is critical for spatial navigation and memory.

 

Education and Training

2019-present     Researcher, University of Oslo

2016-2019         Postdoc, University of Oslo

2015-2016         Postdoc, Johannes Gutenberg University 

2009-2015         Ph.D., Neurobiology, Harvard University

2005-2009         B.A., Neuroscience, Johns Hopkins University

 

Awards

  • Young Research Talents Grant (Research Council of Norway, 2019-2022)
  • Marie Skłodowska Curie Individual Fellowship (2017-2019)
  • EMBO Long-term Fellowship (2015-2016)
  • Focus Translational Neuroscience Postdoc Fellowship (JGU Mainz, 2015)
  • Graduate Student Travel Award, Advances and Perspectives in Auditory Neurophysiology (2013)
  • Becker Family Fund Scholar (Johns Hopkins Univ., 2009)
  • Charles Carroll Fulton Memorial Scholar (Johns Hopkins Univ., 2007-2009)

Selected publications

Chambers, A.R.*, Aschauer, D.F.*, Eppler, J-B., Kashube, M., Rumpel, S. (in press) A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties. Cerebral Cortex.

Chambers, A.R., Berge, C.N., Vervaeke, K. (2022). Cell-type-specific silence in thalamocortical circuits precedes hippocampal sharp-wave ripples. Cell Reports, 40 (4), 111132.

Aschauer, D.F., Eppler, J-B., Ewig, L., Chambers, A.R., Pokorny, C., Kaschube, M., Rumpel, S. (2022). Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization. Cell Reports, 38 (6), 110340.

Hennestad, E.*, Witoelar, A.*, Chambers, A.R., Vervaeke, K. (2021). Mapping vestibular and visual contributions to angular head velocity tuning in the cortex. Cell Reports, 37(12), 110134.

Hagen, E., Chambers, A.R., Einevoll, G., Pettersen, K.P., Enger, R., Stasik, A.J. (2021). RippleNet: A Recurrent Neural Network for Sharp-Wave Ripple (spw-r) Detection. Neuroinformatics 1-22.

Bojarskaite, L.*, Bjørnstad, D.M.*, Pettersen, K.H., Cunen, C., Hermansen, G.H., Åbjørsbråten, K.S., Chambers, A.R., Sprengel, R., Vervaeke, K., Tang, W., Enger, R., Nagelhus, E.A. (2020). Ca2+ signaling in astrocytes is reduced during sleep and is involved in the regulation of slow-wave sleep. Nat. Communications11(1), 1-16.

Chambers, A.R., Pilati, N., Balaram, P., Large, C.H., Kaczmarek, L., Polley, D.B. (2017) Pharmacological modulation of Kv3.1 mitigates auditory midbrain temporal processing deficits following auditory nerve damage. Scientific Reports7(1), 17496.

Chambers, A.R., Rumpel, S. (2017) A stable brain from unstable components: Emerging concepts and implications for neural computation. Neuroscience Forefront Review. Neuroscience 15;357:172-18.

Chambers, A.R.*, Salazar, J.J.*, Polley, D.B. (2016). Persistent thalamic sound processing despite profound cochlear denervation. Front. Neural Circuits. 10:72. doi:10.3389/fncir.2016.00072.

Sloas, D.C., Zhuo, R., Xue, H., Chambers, A.R., Kolaczyk, E., Polley, D.B., Sen, K. (2016) Interactions across multiple stimulus dimensions in primary auditory cortex. eNeuro, Aug 2016, ENEURO.0124-16.2016. 

Chambers, A.R., Resnik, J., Whitton, J.P., Yuan, Y., Edge, A.S., Liberman, M.C., Polley, D.B. (2016).  Central gain restores auditory processing following near-complete cochlear denervation. Neuron, 89(4); 867-79. 

Chambers, A.R., Hancock, K.E., Sen, K., Polley, D.B. (2014). Online stimulus optimization rapidly reveals multidimensional selectivity in auditory cortical neurons. J. Neurosci.34, 896375.

Guo, W., Chambers, A.R., Darrow, K.N., Hancock, K.E., Shinn-Cunningham, B.G., Polley, D.B. (2012). Robustness of cortical topography across fields, laminae, anesthetic states, and neurophysiological signal types. J. Neurosci., 32, 9159-72.

Chambers, A.R., Hancock, K.E., Maison, S.F., Liberman, M.C., Polley, D.B. (2012). Sound-evoked olivocochlear activation in unanesthetized mice. J. Assoc. Res. Otolaryngol., 13, 209-17.

Published Mar. 16, 2017 10:59 PM - Last modified Oct. 19, 2022 1:05 PM