Anne Spurkland

Professor - Molecular Immunology
Image of Anne Spurkland
Norwegian version of this page
Phone +47 22851125
Mobile phone +47-41574078
Room 2501
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo

Academic interests

  • Autoimmune disease
  • T cell activation
  • Molecular immunology
  • Genetics
  • Neuroinflammation

Courses taught

  • Anatomy
  • Immunity. Evolutionary and patient oriented perspectives.

Background

Education

  • MD. University of Oslo, 1986
  • PhD Universvity of Oslo, 1993
  • Specialised in Immunology and Transfusion Medicine, 2000

Positions held

  • 1988-1992: Research fellow, Norwegian Research Council
  • 1993-1994: Resident physician, Red Cross Blood bank, Oslo
  • 1995: Resident physician, Department of immunology and blood transfusion, Ullevål Hospital, Oslo
  • 1995-1999: Researcher, Institute of transplantation Immunology, Rikshospitalet
  • 2000-2001: Resident physician, Institute of Immunology, Rikshospitalet
  • 2001: Assistant professor, UiO
  • 2001-to present: Professor, UiO

Memberships

  • Member of the Royal Norwegian Society of Sciences and Letters
  • Member of the Norwegian Academy of Science and Letters
  • Member of the Norwegian Society for Immunology

Collaboration

  • Partner in Genetic Analysis of Multiple Sclerosis in Europeans (GAMES) 2000-dd
  • Partner in International Multiple Sclerosis Consortium (IMSGC) 2008-dd
  • Member of Management Committee COST Neurinfnet 2009-2011
Tags: Blood and immunology, Genetic and epidemiology, Brain and nervous system, Life science

Publications

Borowicz P, Sundvold V, Chan H, Abrahamsen G, Kjelstrup K, Nyman TA, Spurkland A: Tyr192 regulates lymphocyte-specific tyrosine kinase activity in T cells. J. Immunol. 207:1128-1137, doi: 10.4049/jimmunol.2001105, 2021.

Borowicz P, Chan H, Hauge A, Spurkland A. Adaptor proteins: Flexible and dynamic modulators of immune cell signalling. Scand J Immunol.  Nov;92(5):e12951. doi: 10.1111/sji.12951, 2020.

Andersen TCB, Kristiansen PE, Huszenicza Z, Johansson MU, Gopalakrishnan RP, Boyken S, Sundvold-Gjerstad V, Granum S, Sørli M, Backe PH, Fulton DB, Karlsson BG, Andreotti AH, Spurkland A: The SH3 domains of Itk and Lck compete for adjacent sites on T cell-specific adapter protein. J Biol Chem. 294 (42), 15480-15494, doi: 10.1074/jbc.RA119.008318, 2019.

Gordon EJ, Fukuhara D, Weström S, Padhan N, Sjöström EO, van Meeteren L, He L, Orsenigo F, Dejana E4, Bentley K, Spurkland A, Claesson-Welsh L:The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci. Signal. Jul 19;9(437):ra72, doi: 10.1126/scisignal.aad9256, 2016.

Granum S, Sundvold-Gjerstad V, Abrahamsen G, Berge T, Koll L, Sørlie M, Spurkland A. Itk and the adapter TSAd co-operate to promote phosphorylation dependent altered specificity of Lck. Science Signaling, 7:p. ra118, doi: 10.1126/scisignal.2005384, 2014.

  • Spurkland, Anne (2021). Når blir mutant til variant? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 141(15), p. 1–4. doi: 10.4045/tidsskr.21.0492.
  • Borowicz, Pawel; Gjerstad, Vibeke Sundvold; Chan, Hanna; Abrahamsen, Greger; Kjelstrup, Hanna & Nyman, Tuula Anneli [Show all 7 contributors for this article] (2021). Tyr192 Regulates Lymphocyte-Specific Tyrosine Kinase Activity in T Cells. Journal of Immunology. ISSN 0022-1767. 207(4), p. 1128–1137. doi: 10.4049/jimmunol.2001105.
  • Eriksson, Anna Maria; Leikfoss, Ingvild Sørum; Abrahamsen, Greger; Gjerstad, Vibeke Sundvold; Mesel Isom, Martine & Keshari, Pankaj [Show all 12 contributors for this article] (2021). Exploring the role of the multiple sclerosis susceptibility gene CLEC16A in T cells. Scandinavian Journal of Immunology. ISSN 0300-9475. 94(1). doi: 10.1111/sji.13050. Full text in Research Archive
  • Habtamu, M.; Abrahamsen, Greger; Aseffa, Abraham; Andargie, E.; Ayalew, S. & Abebe, Markos [Show all 7 contributors for this article] (2020). High-throughput analysis of T cell–monocyte interaction in human tuberculosis. Clinical and Experimental Immunology. ISSN 0009-9104. 201(2), p. 187–199. doi: 10.1111/cei.13447. Full text in Research Archive
  • Borowicz, Pawel; Chan, Hanna; Hauge, Anette & Spurkland, Anne (2020). Adaptor proteins: Flexible and dynamic modulators of immune cell signalling. Scandinavian Journal of Immunology. ISSN 0300-9475. 92(6). doi: 10.1111/sji.12951. Full text in Research Archive
  • Borowicz, Pawel; Chan, Hanna; Talmo Medina, Daniel; Gumpelmair, Simon; Kjelstrup, Hanna & Spurkland, Anne (2019). A simple and efficient workflow for generation of knock-in mutations in Jurkat T cells using CRISPR/Cas9. Scandinavian Journal of Immunology. ISSN 0300-9475. doi: 10.1111/sji.12862. Full text in Research Archive
  • Andersen, Thorny Cesilie Bie; Kristiansen, Per Eugen; Huszenicza, Zsuzsa; Johansson, Maria U.; Gopalakrishnan, Ramakrishna Prabhu & Kjelstrup, Hanna [Show all 15 contributors for this article] (2019). The SH3 domains of the protein kinases ITK and LCK compete for adjacent sites on T cell-specific adapter protein. Journal of Biological Chemistry. ISSN 0021-9258. 294(42), p. 15480–15494. doi: 10.1074/jbc.RA119.008318. Full text in Research Archive
  • Patsopoulos, Nikolaos A.; Baranzini, Sergio E.; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris & Wong, Garrett [Show all 154 contributors for this article] (2019). Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. Science. ISSN 0036-8075. 365:eaav7188(6460), p. 1–12. doi: 10.1126/science.aav7188.
  • Mitrovic, Mitja; Patsopoulos, Nikolaos A.; Beecham, Ashley H.; Dankowski, Theresa; Goris, An & Dubois, Benedicte [Show all 52 contributors for this article] (2018). Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell. ISSN 0092-8674. 175(6), p. 1679–1687. doi: 10.1016/j.cell.2018.09.049. Full text in Research Archive
  • Abrahamsen, Greger; Gjerstad, Vibeke Sundvold; Mekonnen, Meseret; Bogen, Bjarne & Spurkland, Anne (2018). Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd. Scientific Reports. ISSN 2045-2322. 8:13319, p. 1–13. doi: 10.1038/s41598-018-31510-6. Full text in Research Archive
  • Mekonnen, Meseret Habtamu; Abebe, Markos; Aseffa, Abraham; Dyrhol-Riise, Anne Ma; Spurkland, Anne & Abrahamsen, Greger (2018). In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry. JIM - Journal of Immunological Methods. ISSN 0022-1759. 460, p. 93–100. doi: 10.1016/j.jim.2018.06.014. Full text in Research Archive
  • Hem, Cecilie Anne Dahl; Ekornhol, Marianne; Granum, Stine; Gjerstad, Vibeke Sundvold & Spurkland, Anne (2017). CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. Scandinavian Journal of Immunology. ISSN 0300-9475. 85(2), p. 104–112. doi: 10.1111/sji.12513.
  • Gordon, Emma; Fukuhara, D.; Weström, S.; Padhan, N.; Sjöström, Elisabeth & van Meeteren, L. [Show all 12 contributors for this article] (2016). The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling. ISSN 1945-0877. 9(437). doi: 10.1126/scisignal.aad9256.
  • Berge, Tone; Leikfoss, Ingvild Sørum; Brorson, Ina Skaara; Bos, Steffan Daniel; Page, Christian & Gustavsen, Marte Wendel [Show all 13 contributors for this article] (2016). The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by Vitamin D in CD4+ T cells. Genes and Immunity. ISSN 1466-4879. 17(2), p. 118–127. doi: 10.1038/gene.2015.61.
  • Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H.; Dilthey, Alexander T.; Xifara, Dionysia K. & Ban, Maria [Show all 55 contributors for this article] (2015). Class II HLA interactions modulate genetic risk for multiple sclerosis. Nature Genetics. ISSN 1061-4036. 47(10), p. 1107–1113. doi: 10.1038/ng.3395.

View all works in Cristin

  • Sletbakk, Marianne; Marthinsen, Kirsten; Hessen, Dag Olav; Håpnes, Arnodd; Eskeland, Ragnhild & Spurkland, Anne (2021). Bios 1 Biologi 1 (LK20) . Cappelen Damm AS. ISBN 9788202696566.
  • Spurkland, Anne (2021). Frisk nok! Håndbok i immunforsvar. Spartacus. ISBN 9788243013766. 216 p.
  • Schiøtz, Aina; Nylander, Gro; Lie, Anne Kveim; Fors, Egil Andreas; Skårderud, Finn & Godøy, Bjørn [Show all 17 contributors for this article] (2019). Blod og Bein.Lidelse, lindring og behandling i norsk medisinhistorie. Nasjonalbiblioteket. ISBN 978-82-7965-386-8. 223 p.
  • Spurkland, Anne (2017). Immun. Kroppens evige kamp for å overleve. Spartacus. ISBN 9788243008304. 416 p.

View all works in Cristin

  • Jarmund, Anders Hagen; Spurkland, Anne; Egge, Julie Haugen & Pettersen, Jørgen (2021). Nytt funn ved NTNU: Slik kan mors immunsystem avsløre sykdom i svangerskapet. [Internet]. NRK.no.
  • Jahre, Marianne & Spurkland, Anne (2021). To fag som kan bety krise når de ikke fungerer. [Radio]. UiO Podkast.
  • Westin, Steinar & Spurkland, Anne (2021). Et kjempeviktig tiltak mot smitte. Professorer advarer mot å kaste munnbindet. VG : Verdens gang. ISSN 0805-5203. p. 14–14.
  • Spurkland, Anne (2020). Covid-19-sykdommen i pandemien.
  • Spurkland, Anne (2020). Immunforsvar i koronaens tid.
  • Spurkland, Anne (2020). Covid-19 pandemien, status og perspektiver fremover.
  • Todal, Per Anders & Spurkland, Anne (2020). Har tru på langvarig vern etter koronainfeksjon. [Newspaper]. Dag og Tid.
  • Einevoll, Gaute & Spurkland, Anne (2020). Om koronaviruset – Med Anne Spurkland #14. [Internet]. Vett og Viten.
  • Einevoll, Gaute & Spurkland, Anne (2020). Om coronaviruset. En oppdatering – med Anne Spurkland #21. [Internet]. Vett og Viten.
  • Time, Jon Kåre & Spurkland, Anne (2020). Cellekameraten. Portrett av T-cellen. [Newspaper]. Morgenbladet.
  • Solvang, Fredrik & Spurkland, Anne (2020). Debatten 07.04.2020: Delvis gjenåpning av samfunnet. [TV]. NRK.
  • Solvang, Fredrik & Spurkland, Anne (2020). Debatten 10.09.2020: Hvem får vaksinen først? [TV]. Nrk.
  • Borowicz, Pawel; Gopalakrishnan, Ramakrishna Prabhu; Chan, Hanna; Kjelstrup, Hanna; Foss, Stian & De Souza, Gustavo Antonio [Show all 8 contributors for this article] (2019). A conserved pTyr motif in the unstructured C-terminus regulates the function of the T cell specific adaptor TSAd.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Chan, Hanna; Abrahamsen, Greger; Kjelstrup, Hanna & Medina, Daniel [Show all 8 contributors for this article] (2019). Tyr192 in the Lck SH2 domain affects the regulation of Lck activity.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna; Nyman, Tuula Anneli & Spurkland, Anne (2018). Lck’s interactome is influenced by phosphorylation of Tyr192 in the Lck SH2 domain.
  • Spurkland, Anne (2018). The dead body. Syn og Segn. ISSN 0039-7717.
  • Sundbye, Bodil; Hauge, Siri Helene; Spurkland, Anne; Blomberg, Bjørn & Ørmen, Torfinn (2018). Epidemiene som truer verden. [Newspaper]. Verdens Gang.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna & Spurkland, Anne (2017). The regulatory role of Lck Tyr192 in T cell receptor signalling.
  • Borowicz, Pawel; Gopalakrishnan, Ramakrishna Prabhu; De Souza, Gustavo Antonio; Abrahamsen, Greger; Sundvold-Gjerstad, Vibeke & Spurkland, Anne (2017). The interactome of TSAd phosphopeptides in T cells.
  • Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger & Spurkland, Anne (2016). Generation of CRISPR/Cas9 mutants in order to study TCR signalling pathway.
  • Borowicz, Pawel & Spurkland, Anne (2016). Intracellular signaling in CRISPR mutated Jurkat T cells.
  • Spurkland, Anne (2016). Gjenkjent.
  • Spurkland, Anne (2016). Skamløs?
  • Spurkland, Anne (2016). Skam.
  • Spurkland, Anne (2016). Slik virker immunforsvarets hukommelse. [Internet]. Forskning.no.
  • Spurkland, Anne (2016). Immunforsvaret. Kroppens evige kamp for å overleve.
  • Spurkland, Anne (2016). Regulation of Lck specificity in TCR signal initiation.
  • Spurkland, Anne (2016). Multiple sclerosis genetics.
  • Borowicz, Pawel & Spurkland, Anne (2020). Regulation of T cell activation by two conserved phosphotyrosines in Lck and its adapter protein TSAd. Universitetet i Oslo. ISSN 978-82-8377-575-4. Full text in Research Archive

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Published Apr. 13, 2011 2:40 PM - Last modified Jan. 15, 2022 2:19 PM
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