Dena Treider Alavi

• Nordengen, Anne Lene; Krutto, Annika; Kværner, Ane Sørlie; Alavi, Dena Treider; Henriksen, Hege & Smeland, Sigbjørn [Show all 11 contributors for this article] (2024). Attenuation of DNA base oxidation in post-surgery colorectal stage III patients at subsequent follow-ups. Free Radical Biology & Medicine. ISSN 0891-5849. 221, p. 75–80. doi: 10.1016/j.freeradbiomed.2024.05.029. Show summary

  DNA damage caused by oxidative reactions plays a crucial role in the pathogenesis of colorectal cancer (CRC). In a previous cross-sectional study, CRC patients diagnosed with regional disease (stage III) exhibited a higher level of DNA base oxidation in peripheral blood mononuclear cells (PBMCs) 2-9 months post-surgery compared to those with localized disease (stage I-II). To further explore this observation over time, the present study aimed to investigate DNA base oxidation in CRC patients with localized versus regional disease 6 and 12 months after the initial measurements. The present study included patients enrolled in the randomized controlled trial Norwegian Dietary Guidelines and Colorectal Cancer Survival (CRC-NORDIET). The standard comet assay, modified with the lesion-specific enzyme formamidopyrimidine DNA glycosylase (Fpg), was applied to measure DNA base oxidation in PBMCs at the 6- and 12-month follow-ups. Of the 255 patients assessed at baseline, 156 were included at the 6-month follow-up, with 89 of these patients included in the 12-month follow-up. In contrast to our observation at baseline, there were no significant differences in the levels of DNA base oxidation between patients diagnosed with localized disease and those with regional involvement at the 6- and 12-month follow-up visits (P=0.81 and P=0.09, respectively). Patients with stage III disease exhibited a significant decrease in the levels of DNA base oxidation from baseline to 6 months (P

• Nordengen, Anne Lene; Zheng, Congying; Krutto, Annika; Kværner, Ane Sørlie; Alavi, Dena Treider & Henriksen, Hege [Show all 13 contributors for this article] (2024). Effect of a personalized intensive dietary intervention on base excision repair (BER) in colorectal cancer patients: Results from a randomized controlled trial. Free Radical Biology & Medicine. ISSN 0891-5849. 218, p. 178–189. doi: 10.1016/j.freeradbiomed.2024.04.211. Show summary

  DNA repair is essential to maintain genomic integrity and may affect colorectal cancer (CRC) patients’ risk of secondary cancers, treatment efficiency, and susceptibility to various comorbidities. Bioactive compounds identified in plant food have the potential to modulate DNA repair mechanisms, but there is limited evidence of how dietary factors may affect DNA repair activity in CRC patients in remission after surgery. The aim of this study was to investigate the effect of a 6 months personalized intensive dietary intervention on DNA repair activity in post-surgery CRC patients (stage I-III). The present study included patients from the randomized controlled trial CRC-NORDIET, enrolled 2-9 months after surgery. The intervention group received an intensive dietary intervention emphasizing a prudent diet with specific plant-based foods suggested to dampen inflammation and oxidative stress, while the control group received only standard care advice. The comet-based in vitro repair assay was applied to assess DNA repair activity, specifically base excision repair (BER), in peripheral blood mononuclear cells (PBMCs). Statistical analyses were conducted using gamma generalized linear mixed models (Gamma GLMM). A total of 138 CRC patients were included, 72 from the intervention group and 66 from the control group. The BER activity in the intervention group did not change significantly compared to the control group. Our findings revealed a substantial range in both inter- and intra-individual levels of BER. In conclusion, the results do not support an effect of dietary intervention on BER activity in post-surgery CRC patients during a 6-month intervention period.

• Berg, Hedda Beate; Alavi, Dena Treider; Beichmann, Benedicte; Pesonen, Maiju; Henriksen, Christine & Paur, Ingvild [Show all 9 contributors for this article] (2024). The choice of diagnostic modality influences the proportion of low muscle strength, low muscle mass, and sarcopenia in colorectal cancer patients. Clinical Nutrition ESPEN. ISSN 2405-4577. 60, p. 17–23. doi: 10.1016/j.clnesp.2024.01.001.
• Nordengen, Anne Lene; Kværner, Ane Sørlie; Krutto, Annika; Alavi, Dena Treider; Henriksen, Hege & Henriksen, Christine [Show all 12 contributors for this article] (2023). DNA base oxidation in relation to TNM stages and chemotherapy treatment in colorectal cancer patients 2–9 months post-surgery. Free Radical Biology & Medicine. ISSN 0891-5849. 212, p. 174–185. doi: 10.1016/j.freeradbiomed.2023.12.016. Full text in Research Archive Show summary

  Accumulation of DNA damage is a critical feature of genomic instability, which is a hallmark of various cancers. The enzyme-modified comet assay is a recognised method to detect specific DNA lesions at the level of individual cells. In this cross-sectional investigation, we explore possible links between clinicopathological and treatment related factors, nutritional status, physical activity and function, and DNA damage in a cohort of colorectal cancer (CRC) patients with non-metastatic disease. Levels of DNA damage in peripheral mononuclear blood cells (PBMCs) assessed 2-9 months post-surgery, were compared across tumour stage (localized (stage I-II) vs. regional (stage III) disease), localization (colon vs. rectosigmoid/rectum cancer), and adjuvant chemotherapy usage, with the last dosage administrated 2-191 days prior to sampling. Associations between DNA damage and indicators of nutritional status, physical activity and function were also explored. In PBMCs, DNA base oxidation was higher in patients diagnosed with regional compared with localized tumours (P=0.03), but no difference was seen for DNA strand breaks (P>0.05). Number of days since last chemotherapy dosage was negatively associated with DNA base oxidation (P

• Alavi, Dena Treider; Henriksen, Hege Berg; Lauritzen, Peter Mæhre; Zucknick, Manuela; Bøhn, Siv Kjølsrud & Henriksen, Christine [Show all 9 contributors for this article] (2023). Effect of a one-year personalized intensive dietary intervention on body composition in colorectal cancer patients: Results from a randomized controlled trial. Clinical Nutrition ESPEN. ISSN 2405-4577. 57, p. 414–422. doi: 10.1016/j.clnesp.2023.06.037. Full text in Research Archive
• Henriksen, Hege Berg; Henriksen, Christine; Sequeira de Sousa, Ana Rita; Alavi, Dena Helene; Augestad, Elin Maria Sandstad & Rising, Russell [Show all 12 contributors for this article] (2023). Validity and reproducibility of a whole-room indirect calorimeter for the estimation of VO<inf>2</inf>, VCO<inf>2</inf>, and resting metabolic rate. Physiological Reports. ISSN 2051-817X. 11(7). doi: 10.14814/phy2.15658. Full text in Research Archive
• Alavi, Dena Helene; Sakinis, Tomas; Henriksen, Hege; Beichmann, Benedicte; Fløtten, Ann-Monica & Blomhoff, Rune [Show all 7 contributors for this article] (2022). Body composition assessment by artificial intelligence from routine computed tomography scans in colorectal cancer: Introducing BodySegAI. JCSM Clinical Reports. ISSN 2521-3555. 7, p. 55–64. doi: 10.1002/crt2.53. Full text in Research Archive
• Henriksen, Hege; Alavi, Dena Helene & Blomhoff, Rune (2021). Precision of Lunar Dual-energy X-ray Absorptiometry (iDXA) in measuring body composition among colorectal cancer patients and healthy subjects. Clinical Nutrition ESPEN. ISSN 2405-4577. 44, p. 316–323. doi: 10.1016/j.clnesp.2021.05.025. Full text in Research Archive
• Alavi, Dena Helene; Henriksen, Hege; Lauritzen, Peter Mæhre; Kværner, Ane Sørlie; Sakinis, Tomas & Langleite, Torgrim Mikal [Show all 12 contributors for this article] (2021). Quantification of adipose tissues by Dual-Energy X-Ray Absorptiometry and Computed Tomography in colorectal cancer patients. Clinical Nutrition ESPEN. ISSN 2405-4577. 43, p. 360–368. doi: 10.1016/j.clnesp.2021.03.022. Full text in Research Archive
• Kværner, Ane Sørlie; Harnæs, Helene; Alavi, Dena Helene; Bärebring, Linnea; Henriksen, Hege & Guren, Marianne [Show all 11 contributors for this article] (2020). Bør beregning av cellegiftdose ved tarmkreft baseres på kroppssammensetning? Tidsskrift for Den norske legeforening. ISSN 0029-2001. 140(8), p. 1–10. doi: 10.4045/tidsskr.19.0769.

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