Erik Dissen

• Mushtaq, Muhammad; Pangigadde, Pradeepa N; Darekar, Suhas; Dissen, Erik & Kashuba, Elena (2017). Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells. OncoTarget.  ISSN 1949-2553.  8(39), s 64907- 64917 . doi: 10.18632/oncotarget.17610
• Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela; Fossum, Sigbjørn; Daws, Michael Rory & Dissen, Erik (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology.  ISSN 0022-1767.  198(7), s 2556- 2567 . doi: 10.4049/jimmunol.1600930
• Golic, Michaela; Haase, Nadine; Herse, Florian; Wehner, Anika; Vercruysse, Lisbeth; Pijnenborg, Robert; Balogh, Andras; Sæther, Per Christian; Dissen, Erik; Luft, Friedrich C.; Przybyl, Lukasz; Park, Joon-Keun; Alnæs-Katjavivi, Patji; Staff, Anne Cathrine; Verlohren, Stefan; Henrich, Wolfgang; Müller, Dominik N. & Dechend, Ralf (2016). Natural killer cell reduction and uteroplacental vasculopathy. Hypertension.  ISSN 0194-911X.  68(4), s 964- 973 . doi: 10.1161/HYPERTENSIONAHA.116.07800
• Moussa, P; Abrahamsen, Greger; Fodil, N; Gopalakrishnan, Ramakrishna Prabhu; Mancini, M; Dissen, Erik; Sæther, Per Christian; Wiltshire, SA; Boivin, GA; Caignard, G; Spurkland, Anne & Vidal, SM (2015). Reduced MCMV Δm157 viral clearance in the absence of TSAd. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep09219 Full text in Research Archive.
• Pandya, Abhilash D.; Leergaard, Trygve Brauns; Dissen, Erik; Haraldsen, Guttorm & Spurkland, Anne (2014). Expression of the T cell-specific adapter protein in human tissues. Scandinavian Journal of Immunology.  ISSN 0300-9475.  80(3), s 169- 179 . doi: 10.1111/sji.12199
• Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik; Fossum, Sigbjørn & Daws, Michael Rory (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLoS ONE.  ISSN 1932-6203.  8(2) . doi: 10.1371/journal.pone.0057406
• Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology.  ISSN 0014-2980.  43(12), s 3167- 3174 . doi: 10.1002/eji.201343752
• Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics.  ISSN 0093-7711.  63(12), s 809- 820 . doi: 10.1007/s00251-011-0553-5
• Sæther, Per Christian; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2011). Rat and Mouse CD94 Associate Directly with the Activating Transmembrane Adaptor Proteins DAP12 and DAP10 and Activate NK Cell Cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  187(12), s 6365- 6373 . doi: 10.4049/jimmunol.1102345
• Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics.  ISSN 0093-7711.  62(8), s 521- 530 . doi: 10.1007/s00251-010-0455-y
• Orr, Mark T; Wu, Jun; Fang, Min; Sigal, Luis J.; Spee, Pieter; Egebjerg, Thomas; Dissen, Erik; Fossum, Sigbjørn; Phillips, Joseph H & Lanier, Lewis L. (2010). Development and Function of CD94-Deficient Natural Killer Cells. PLoS ONE.  ISSN 1932-6203.  5(11) . doi: 10.1371/journal.pone.0015184
• Dissen, Erik; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian & Fossum, Sigbjørn (2008). NK cell receptors in rodents and cattle. Seminars in Immunology.  ISSN 1044-5323.  20(6), s 369- 375
• Sæther, Per Christian; Westgaard, Ingunn Hagen; Hoelsbrekken, Sigurd Erik; Benjamin, J; Lanier, LL; Fossum, Sigbjørn & Dissen, Erik (2008). KLRE/I1 and KLRE/I2: A novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Journal of Immunology.  ISSN 0022-1767.  181, s 3177- 3182
• Lorentzen, JC; Flornes, Line Marie; Eklow, C; Backdahl, L; Ribbhammar, U; Guo, JP; Smolnikova, M; Dissen, Erik; Seddighzadeh, M; Brookes, AJ; Alfredsson, L; Klareskog, L; Padyukov, L & Fossum, Sigbjørn (2007). Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis and Rheumatism.  ISSN 0004-3591.  56, s 2620- 2632 . doi: 10.1002/art.22813
• Kveberg, Lise; Dai, Kezheng; Dissen, Erik; Ryan, James C.; Rolstad, Bent; Vaage, John Torgils & Naper, Christian (2006). Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics.  ISSN 0093-7711.  58(11), s 905- 916
• Bryceson, Yenan T.; Torgersen, Knut Martin; Inngjerdingen, Marit; Berg, Siri Fuglem; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. European Journal of Immunology.  ISSN 0014-2980.  35(4)
• Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Immunogenetics.  ISSN 0093-7711.  57(7), s 479- 486
• Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D; Dissen, Erik; Ryan, JC & Fossum, Sigbjørn (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology.  ISSN 0014-2980.  35
• Sæther, Per Christian; Westgaard, Ingunn Hagen; Flornes, Line Marie; Hoelsbrekken, Sigurd Erik; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics.  ISSN 0093-7711.  56
• Helgeland, Lars; Dissen, Erik; Dai, Kezheng; Midtvedt, Tore; Brandtzæg, Per & Vaage, John Torgils (2004). Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut. European Journal of Immunology.  ISSN 0014-2980.  34, s 3389- 3400 . doi: 10.1002/eji.200425122 Show summary

  Two populations of CD8+ IEL generally express restricted, but apparently random and nonoverlapping TCR repertoires. Previous studies in mice suggested that this could be explained by a dual origin of CD8+ IEL, i.e. that CD8ab+ IEL derive from a few peripheral CD8+ T cell lymphoblasts stimulated by microbial antigens in gut-associated lymphoid tissue, whereas CD8aa+ IEL descend from an inefficient intestinal maturation pathway.We show here that the gut mucosa, instead, becomes seeded with surprisingly broad and generally nonoverlapping CD8 IEL repertoires and that oligoclonality is induced locally after microbial colonization. In germ-free (GF) rats, both CD8ab+ and CD8aa+ IEL displayed surprisingly diverse TCR Vb repertoires, although b-chain diversity tended to be somewhat restricted in the CD8aa+ subset. CDR3 length displays in individual Vb-Cb and Vb-Jb combinations generally revealed polyclonal distributions over 6–11 different lengths, similar to CD8+ lymph node T cells, and CDR3b sequencing provided further documentation of repertoire diversity. By contrast, in ex-GF rats colonized with normal commensal microflora, both CD8ab+ and CD8aa+ IEL displayed oligoclonal CDR3 length distributions for most of the Vb genes analyzed. Our data suggest that microbial colonization induces apparently random clonal expansions of CD8ab+ and CD8aa+ IEL locally in the gut.

• Morton, H. Craig; Pleass, RJ; Storset, Anne K; Dissen, Erik; Williams, JL; Brandtzæg, Per & Woof, JM (2004). Cloning and characterization of an immunoglobulin A FC receptor from cattle. Immunology.  ISSN 0019-2805.  111(2), s 204- 211
• Morton, Hugh Craig; Pleass, Richard J; Storset, Anne K.; Dissen, Erik; Williams, John L; Brandtzæg, Per & Woof, Jenny M. (2004). Cloning and characterization of an immunoglobulin A Fc receptor from cattle. Immunology.  ISSN 0019-2805.  111(2), s 204- 211
• Storset, Anne K.; Kulberg, S; Berg, I; Boysen, P; Hope, JC & Dissen, Erik (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology.  ISSN 0014-2980.  34, s 669- 676
• Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M.; Dissen, Erik & Fossum, Sigbjørn (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta}. Journal of Leukocyte Biology.  ISSN 0741-5400.  76, s 1200- 1206 . doi: 10.1189/jlb.0903428 Show summary

  NKp46 has been identified in the human, rat, mouse, monkey, and cattle. We have generated a monoclonal antibody, WEN23, against rat NKp46. By flow cytometry, NKp46 is expressed by all natural killer (NK) cells but not by T cells, B cells, granulocytes, monocytes, dendritic cells, or macrophages. Thus, NKp46/WEN23 is the first NK cell-specific marker in the rat. In a redirected lysis assay, preincubation of the effector cells with WEN23 augmented lysis of the Fc receptor (FcR)+ murine tumor target cells, indicating that NKp46 is an activating NK cell receptor. Moreover, preincubation of the effector cells with WEN23 F(ab')2 fragments reduced killing of target cells, confirming the activating function of NKp46 and indicating that the mouse tumor target cells express a ligand for rat NKp46. Lysis of FcR- mouse and human tumor target cells was reduced after incubation of effector cells with WEN23, suggesting that rat NKp46 recognizes a ligand that is conserved between primates and rodents. By Western blot and immunoprecipitation using WEN23, NKp46 is expressed as a monomer of ~47 kDa in interleukin-2-activated NK cells. The immunoreceptor tyrosine-based activation motif bearing adaptor proteins CD3{zeta} and the {gamma} chain of FcRI for IgE (Fc{epsilon}RI{gamma}) with NKp46 from lysates of NK cells, indicating that rat NKp46 activates NK cell cytotoxicity by similar pathways as CD16.

• Flornes, Line Marie; Bryceson, Yenan T.; Spurkland, Anne; Lorentzen, JC; Dissen, Erik & Fossum, Sigbjørn (2004). Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics.  ISSN 0093-7711.  56, s 506- 517 Show summary

  In an experimental rat model, we recently mapped an arthritis susceptibility locus to the distal part of Chromosome 4 containing genes predicted to encode C-type lectin superfamily (CLSF) receptors. Here we report the cDNA cloning and positional arrangement of these receptor genes, which represent rat orthologues to human Mincle and DCIR and to mouse MCL and Dectin-2, as well as four novel receptors DCIR2, DCIR3, DCIR4 and DCAR1, not previously reported in other species. We furthermore report the cDNA cloning of human Dectin-2 and MCL, and of the mouse orthologues to the novel rat receptors. Similar to the killer-cell lectin-like receptors (KLR) some of these receptors exhibit structural features suggesting that they regulate leukocyte reactivity; e.g., human DCIR and rodent DCIR1 and DCIR2 carry an immunoreceptor tyrosine-based inhibitory motif (ITIM), predicting inhibitory function, and conversely, in all three species Mincle has a positively charged amino acid in the transmembrane region, suggesting activating function. Sequence comparisons show that the receptors form a discrete family, more closely related to group II CLSF receptors than to the group V KLR. Their distance to the KLR is underscored by their preservation of evolutionary conserved calcium/saccharide binding residues, present in group II and lacking in group V CLSF and their cellular expression patterns, with most of the genes preferentially expressed by professional antigen-presenting cells (dendritic cells, macrophages and B cells) and neutrophils. In all three species, the genes map together, forming an evolutionary conserved gene complex, which we call the antigen presenting lectin-like receptor complex (APLEC).

• Nejad, S; Bryceson, Yenan T.; Dissen, Erik; Sundvold-Gjerstad, V; Naper, Christian; Rolstad, Bent; Spurkland, Anne & Vaage, John Torgils (2004). cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells. Immunogenetics.  ISSN 0093-7711.  56(5), s 338- 342 . doi: 10.1007/s00251-004-0695-9 Show summary

  The T-cell-specific adapter protein (TSAd), encoded by the SH2D2A gene, has been implicated in modulation of proximal signaling events as well as in transcriptional regulation in human T cells. We have isolated its rat homologue (rSH2D2A) from an NK cell cDNA library and mapped the corresponding gene to chromosome 2 with a hamster-rat radiation hybrid cell panel. rSH2D2A encodes a 376 amino acid protein (rTSAd) which shows greater homology to mouse than human TSAd. In rats, rTSAd was specifically expressed by NK cells and T cells but not by other leukocytes tested. Similarly, in humans we observed abundant transcripts for TSAd in NK cells and T cells. The data suggest that TSAd may have a regulatory role in cellular activation of T and NK cells.

• Storset, Anne K; Kulberg, Siri; Berg, Ingvild; Boysen, Preben; Dissen, Erik & Hope, Jayne (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology.  ISSN 0014-2980.  34(3), s 669- 676
• Hoelsbrekken, Sigurd E.; Nylenna, Øyvind; Sæther, Per Christian; Slettedal, Imer Ö; Ryan, James C.; Fossum, Sigbjørn & Dissen, Erik (2003). Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Journal of Immunology.  ISSN 0022-1767.  170(5), s 2259- 2263
• Storset, Anne K.; Slettedal, Imer Ö; Williams, John L; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology.  ISSN 0014-2980.  33(4), s 980- 990
• Westgaard, Ingunn Hagen; Dissen, Erik; Torgersen, Knut Martin; Lazetic, Sascha; Lanier, Lewis L.; Phillips, JH & Fossum, Sigbjørn (2003). The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Journal of Experimental Medicine.  ISSN 0022-1007.  197(11), s 1551- 1561
• Storset, Anne K.; Slettedal, Imer Ö; Williams, John L.; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle. A bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology.  ISSN 0014-2980.  33, s 980- 990
• Naper, Christian; Hayashi, Shigenari; Løvik, Guro; Kveberg, Lise; Niemi, Eréne C.; Rolstad, Bent; Dissen, Erik; Ryan, James C. & Vaage, John Torgils (2002). Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells. Journal of Immunology.  ISSN 0022-1767.  s 5147- 5154
• Løvik, Guro; Vaage, John Torgils; Dissen, Erik; Szpirer, Claude; Ryan, James C. & Rolstad, Bent (2000). Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. European Journal of Immunology.  ISSN 0014-2980.  30, s 3355- 3362
• Berg, Siri Fuglem; Fossum, Sigbjørn & Dissen, Erik (1999). NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. European Journal of Immunology.  ISSN 0014-2980.  29, s 2000- 2006
• Berg, Siri Fuglem; Westgaard, Ingunn Hagen; Fossum, Sigbjørn & Dissen, Erik (1999). A rat gene homologous to human granule membrane protein 17 is expressed by natural killer cells, CD8+ T cells and a mast cell line. Immunogenetics.  ISSN 0093-7711.  29, s 815- 818
• Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. International Immunology.  ISSN 0953-8178.  10, s 379- 385
• Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Two genes in the rat homologous to human NKG2. European Journal of Immunology.  ISSN 0014-2980.  28, s 444- 450
• Westgaard, Ingunn Hagen; Berg, Siri Fuglem; Ørstavik, Sigurd; Fossum, Sigbjørn & Dissen, Erik (1998). Identification of a human member of the Ly-49 multigene family. European Journal of Immunology.  ISSN 0014-2980.  28, s 1839- 1846
• Dissen, Erik; Berg, Siri Fuglem; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1997). Molecular characterization of a gene in the rat homologous to human CD94. European Journal of Immunology.  ISSN 0014-2980.  27, s 2080- 2086
• Dissen, Erik & Fossum, Sigbjørn (1996). Chromosomal localization of the genes encoding rat CD4, CD8 and CD8. Immunogenetics.  ISSN 0093-7711.  44, s 312- 314
• Dissen, Erik; Ryan, James C.; Seaman, W. E. & Fossum, Sigbjørn (1996). An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Journal of Experimental Medicine.  ISSN 0022-1007.  183, s 2197- 2207
• Dissen, Erik; Vaage, John T.; Tasken, Kjetil; Jahnsen, Tore; Rolstad, Bent & Fossum, Sigbjørn (1990). Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors. International Immunology.  ISSN 0953-8178.  2(5), s 453- 461

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• Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth; Flornes, Line Mari; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2011). Oils and Health. Report to the Ministry of Health and Care Services.
• Dissen, Erik (1997). Recognition of allogeneic lymphocytes by natural killer cells. A molecular genetic study in the rat.

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