Erik Dissen

Image of Erik Dissen
Norwegian version of this page
Phone +47 22851152
Mobile phone +47 91823478
Room 2502
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1105 Blindern 0317 Oslo

Academic interests

  • Immunology
  • Natural killer cell biology
  • NK cell receptors and recognition of cancer cells and intracellular infection

Courses taught

  • Cell biology
  • Immunology
  • Anatomy
  • Histology

Background

Positions

  • 2003-: Professor, Department of Anatomy, IMB, University of Oslo 
  • 1999-2003: Associate professor, Department of Anatomy, IMB, University of Oslo 
  • 1997-99: Postdoc
  • 1996-97: Military service as physician
  • 1994-95: Clinical internship, Molde county hospital/Fræna district
  • 1991-97: PhD fellowship (interrupted as above)

Education

  • 1997: PhD (Dr. med.)
  • 1995: Clinical authorization
  • 1991: MD (Cand. Med.)

Awards

  • H. M. the King´s gold medal for best thesis in medicine 1998
  • Lecturer of the year award 2004, Medical Students Association, University of Oslo

Positions held

  • Chairman, Department of anatomy, Institute of basic medical sciences 2008 – present
  • Vice Chairman 2004 -2008
  • President, Norwegian society for immunology, 2001-2003
  • Head of 2. Semester board, Faculty of medicine, 2004 – present
  • Delegate to the representative assembly of the Norwegian Cancer Society
Tags: Immunology, Life science, NK cells

Publications

  • Bogdanova, Mariia; Zabirnyk, Arsenii; Malashicheva, Anna; Zihlavnikova, Katarina; Karlsen, Tommy Aleksander & Kaljusto, Mari-Liis [Show all 13 contributors for this article] (2019). Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties. Scientific Reports. ISSN 2045-2322. 9:12934, p. 1–13. doi: 10.1038/s41598-019-49016-0 Full text in Research Archive
  • Bjørnsen, Elisabeth Gyllensten; Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Henden, Camilla; Sæther, Per Christian & Boysen, Preben [Show all 8 contributors for this article] (2019). B7H6 is a functional ligand for NKp30 in rat and cattle and determines NKp30 reactivity toward human cancer cell lines. European Journal of Immunology. ISSN 0014-2980. 49(1), p. 54–65. doi: 10.1002/eji.201847746 Full text in Research Archive
  • Daws, Michael Rory; Nakken, Britt; Lobato, Pascual Ana; Josien, Regis; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With Fc?RI? and Is Expressed by Myeloid Cell Subsets in the Rat. Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060 Full text in Research Archive
  • Daws, Michael Rory; Nakken, Britt; Lobato Pascual, Ana; Regis, Josien; Dissen, Erik & Fossum, Sigbjørn (2019). Dendritic Cell Activating Receptor 1 (DCAR1) Associates With FcεRIγ and Is Expressed by Myeloid Cell Subsets in the Rat . Frontiers in Immunology. ISSN 1664-3224. 10. doi: 10.3389/fimmu.2019.01060
  • Knutsen, Linn Emilie; Dissen, Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pialek, Jaroslav & Storset, Anne [Show all 7 contributors for this article] (2018). Evidence of functional Cd94 polymorphism in a free-living house mouse population. Immunogenetics. ISSN 0093-7711. p. 1–13. doi: 10.1007/s00251-018-01100-x
  • Mushtaq, Muhammad; Pangigadde, Pradeepa N; Darekar, Suhas; Dissen, Erik & Kashuba, Elena (2017). Rat embryonic fibroblasts immortalized by MRPS18-2 protein are target for NK-cells. OncoTarget. ISSN 1949-2553. 8(39), p. 64907–64917. doi: 10.18632/oncotarget.17610
  • Thiruchelvam-Kyle, Lavanya; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian; Bjørnsen, Elisabeth Gyllensten; Pende, Daniela & Fossum, Sigbjørn [Show all 8 contributors for this article] (2017). The Activating Human NK Cell Receptor KIR2DS2 Recognizes a β2-Microglobulin–Independent Ligand on Cancer Cells. Journal of Immunology. ISSN 0022-1767. 198(7), p. 2556–2567. doi: 10.4049/jimmunol.1600930
  • Golic, Michaela; Haase, Nadine; Herse, Florian; Wehner, Anika; Vercruysse, Lisbeth & Pijnenborg, Robert [Show all 18 contributors for this article] (2016). Natural killer cell reduction and uteroplacental vasculopathy. Hypertension. ISSN 0194-911X. 68(4), p. 964–973. doi: 10.1161/HYPERTENSIONAHA.116.07800
  • Moussa, P; Abrahamsen, Greger; Fodil, N; Gopalakrishnan, Ramakrishna Prabhu; Mancini, M & Dissen, Erik [Show all 12 contributors for this article] (2015). Reduced MCMV Δm157 viral clearance in the absence of TSAd. Scientific Reports. ISSN 2045-2322. 5. doi: 10.1038/srep09219 Full text in Research Archive
  • Pandya, Abhilash D.; Leergaard, Trygve Brauns; Dissen, Erik; Haraldsen, Guttorm & Spurkland, Anne (2014). Expression of the T cell-specific adapter protein in human tissues. Scandinavian Journal of Immunology. ISSN 0300-9475. 80(3), p. 169–179. doi: 10.1111/sji.12199
  • Lobato Pascual, Ana; Sæther, Per Christian; Fossum, Sigbjørn; Dissen, Erik & Daws, Michael Rory (2013). Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcεRI-γ. European Journal of Immunology. ISSN 0014-2980. 43(12), p. 3167–3174. doi: 10.1002/eji.201343752
  • Lobato Pascual, Ana; Sæther, Per Christian; Dahle, Maria Krudtaa; Gaustad, Peter; Dissen, Erik & Fossum, Sigbjørn [Show all 7 contributors for this article] (2013). Rat Macrophage C-type Lectin is an Activating Receptor Expressed by Phagocytic Cells. PLOS ONE. ISSN 1932-6203. 8(2). doi: 10.1371/journal.pone.0057406
  • Sæther, Per Christian; Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2011). Rat and Mouse CD94 Associate Directly with the Activating Transmembrane Adaptor Proteins DAP12 and DAP10 and Activate NK Cell Cytotoxicity. Journal of Immunology. ISSN 0022-1767. 187(12), p. 6365–6373. doi: 10.4049/jimmunol.1102345
  • Fossum, Sigbjørn; Sæther, Per Christian; Vaage, John Torgils; Daws, Michael Rory & Dissen, Erik (2011). Paired opposing leukocyte receptors recognizing rapidly evolving ligands are subject to homogenization of their ligand binding domains. Immunogenetics. ISSN 0093-7711. 63(12), p. 809–820. doi: 10.1007/s00251-011-0553-5
  • Flornes, Line Mari; Nylenna, Øyvind; Sæther, Per Christian; Daws, Michael Rory; Dissen, Erik & Fossum, Sigbjørn (2010). The complete inventory of receptors encoded by the rat natural killer cell gene complex. Immunogenetics. ISSN 0093-7711. 62(8), p. 521–530. doi: 10.1007/s00251-010-0455-y
  • Orr, Mark T; Wu, Jun; Fang, Min; Sigal, Luis J.; Spee, Pieter & Egebjerg, Thomas [Show all 10 contributors for this article] (2010). Development and Function of CD94-Deficient Natural Killer Cells. PLOS ONE. ISSN 1932-6203. 5(11). doi: 10.1371/journal.pone.0015184
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Hoelsbrekken, Sigurd Erik; Benjamin, J; Lanier, LL & Fossum, Sigbjørn [Show all 7 contributors for this article] (2008). KLRE/I1 and KLRE/I2: A novel pair of heterodimeric receptors that inversely regulate NK cell cytotoxicity. Journal of Immunology. ISSN 0022-1767. 181, p. 3177–3182.
  • Dissen, Erik; Hoelsbrekken, Sigurd Erik; Sæther, Per Christian & Fossum, Sigbjørn (2008). NK cell receptors in rodents and cattle. Seminars in Immunology. ISSN 1044-5323. 20(6), p. 369–375.
  • Lorentzen, JC; Flornes, Line Marie; Eklow, C; Backdahl, L; Ribbhammar, U & Guo, JP [Show all 14 contributors for this article] (2007). Association of arthritis with a gene complex encoding C-type lectin-like receptors. Arthritis and Rheumatism. ISSN 0004-3591. 56, p. 2620–2632. doi: 10.1002/art.22813
  • Kveberg, Lise; Dai, Kezheng; Dissen, Erik; Ryan, James C.; Rolstad, Bent & Vaage, John Torgils [Show all 7 contributors for this article] (2006). Strain-dependent expression of four structurally related rat Ly49 receptors; correlation with NK gene complex haplotype and NK alloreactivity. Immunogenetics. ISSN 0093-7711. 58(11), p. 905–916.
  • Sæther, Per Christian; Westgaard, Ingunn Hagen; Flornes, Line Marie; Hoelsbrekken, Sigurd Erik; Ryan, James C. & Fossum, Sigbjørn [Show all 7 contributors for this article] (2005). Molecular cloning of KLRI1 and KLRI2, a novel pair of lectin-like natural killer-cell receptors with opposing signalling motifs. Immunogenetics. ISSN 0093-7711. 56.
  • Bryceson, Yenan T.; Torgersen, Knut Martin; Inngjerdingen, Marit; Berg, Siri Fuglem; Hoelsbrekken, Sigurd Erik & Fossum, Sigbjørn [Show all 7 contributors for this article] (2005). The rat orthologue to the inhibitory receptor gp49B is expressed by neutrophils and monocytes, but not by NK cells or mast cells. European Journal of Immunology. ISSN 0014-2980. 35(4).
  • Hoelsbrekken, Sigurd Erik; Fossum, Sigbjørn & Dissen, Erik (2005). Molecular cloning of LILRC1 and LILRC2 in the mouse and the rat, two novel immunoglobulin-like receptors encoded by the leukocyte receptor gene complex. Immunogenetics. ISSN 0093-7711. 57(7), p. 479–486.
  • Nylenna, Øyvind; Naper, Christian; Vaage, John Torgils; Woon, P.Y.; Gauguier, D & Dissen, Erik [Show all 7 contributors for this article] (2005). The genes and gene organization of the Ly49 region of the rat natural killer cell gene complex. European Journal of Immunology. ISSN 0014-2980. 35.
  • Morton, H. Craig; Pleass, RJ; Storset, Anne K; Dissen, Erik; Williams, JL & Brandtzæg, Per [Show all 7 contributors for this article] (2004). Cloning and characterization of an immunoglobulin A FC receptor from cattle. Immunology. ISSN 0019-2805. 111(2), p. 204–211.
  • Storset, Anne K; Kulberg, Siri; Berg, Ingvild; Boysen, Preben; Dissen, Erik & Hope, Jayne (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology. ISSN 0014-2980. 34(3), p. 669–676.
  • Morton, Hugh Craig; Pleass, Richard J; Storset, Anne K.; Dissen, Erik; Williams, John L & Brandtzæg, Per [Show all 7 contributors for this article] (2004). Cloning and characterization of an immunoglobulin A Fc receptor from cattle. Immunology. ISSN 0019-2805. 111(2), p. 204–211.
  • Storset, Anne K.; Kulberg, S; Berg, I; Boysen, P; Hope, JC & Dissen, Erik (2004). NKp46 defines a subset of bovine leukocytes with natural killer cell characteristics. European Journal of Immunology. ISSN 0014-2980. 34, p. 669–676.
  • Flornes, Line Marie; Bryceson, Yenan T.; Spurkland, Anne; Lorentzen, JC; Dissen, Erik & Fossum, Sigbjørn (2004). Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Immunogenetics. ISSN 0093-7711. 56, p. 506–517.
  • Nejad, S; Bryceson, Yenan T.; Dissen, Erik; Sundvold-Gjerstad, V; Naper, Christian & Rolstad, Bent [Show all 8 contributors for this article] (2004). cDNA cloning of a rat orthologue of SH2D2A encoding T-cell-specific adaptor protein (TSAd): expression in T and NK cells. Immunogenetics. ISSN 0093-7711. 56(5), p. 338–342. doi: 10.1007/s00251-004-0695-9
  • Helgeland, Lars; Dissen, Erik; Dai, Kezheng; Midtvedt, Tore; Brandtzæg, Per & Vaage, John Torgils (2004). Microbial colonization induces oligoclonal expansions of intraepithelial CD8 T cells in the gut. European Journal of Immunology. ISSN 0014-2980. 34, p. 3389–3400. doi: 10.1002/eji.200425122
  • Westgaard, Ingunn Hagen; Berg, Siri F.; Vaage, John Torgils; Wang, Lawrence L; Yokoyama, Wayne M. & Dissen, Erik [Show all 7 contributors for this article] (2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{epsilon}RI{gamma} and CD3{zeta}. Journal of Leukocyte Biology. ISSN 0741-5400. 76, p. 1200–1206. doi: 10.1189/jlb.0903428
  • Storset, Anne K.; Slettedal, Imer Ö; Williams, John L.; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle. A bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology. ISSN 0014-2980. 33, p. 980–990.
  • Storset, Anne K.; Slettedal, Imer Ö; Williams, John L; Law, Andy & Dissen, Erik (2003). Natural killer cell receptors in cattle: a bovine killer cell immunoglobulin-like receptor multigene family contains members with divergent signaling motifs. European Journal of Immunology. ISSN 0014-2980. 33(4), p. 980–990.
  • Hoelsbrekken, Sigurd E.; Nylenna, Øyvind; Sæther, Per Christian; Slettedal, Imer Ö; Ryan, James C. & Fossum, Sigbjørn [Show all 7 contributors for this article] (2003). Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Journal of Immunology. ISSN 0022-1767. 170(5), p. 2259–2263.
  • Westgaard, Ingunn Hagen; Dissen, Erik; Torgersen, Knut Martin; Lazetic, Sascha; Lanier, Lewis L. & Phillips, JH [Show all 7 contributors for this article] (2003). The lectin-like receptor KLRE1 inhibits natural killer cell cytotoxicity. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 197(11), p. 1551–1561.
  • Naper, Christian; Hayashi, Shigenari; Løvik, Guro; Kveberg, Lise; Niemi, Eréne C. & Rolstad, Bent [Show all 9 contributors for this article] (2002). Characterization of a novel killer cell lectin-like receptor (KLRH1) expressed by alloreactive rat NK cells. Journal of Immunology. ISSN 0022-1767. p. 5147–5154.
  • Løvik, Guro; Vaage, John Torgils; Dissen, Erik; Szpirer, Claude; Ryan, James C. & Rolstad, Bent (2000). Characterization and molecular cloning of rat C1qRp, a receptor on NK cells. European Journal of Immunology. ISSN 0014-2980. 30, p. 3355–3362.
  • Berg, Siri Fuglem; Fossum, Sigbjørn & Dissen, Erik (1999). NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. European Journal of Immunology. ISSN 0014-2980. 29, p. 2000–2006.
  • Berg, Siri Fuglem; Westgaard, Ingunn Hagen; Fossum, Sigbjørn & Dissen, Erik (1999). A rat gene homologous to human granule membrane protein 17 is expressed by natural killer cells, CD8+ T cells and a mast cell line. Immunogenetics. ISSN 0093-7711. 29, p. 815–818.
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Molecular characterization of rat NKR-P2, a lectin-like receptor expressed by NK cells and resting T cells. International Immunology. ISSN 0953-8178. 10, p. 379–385.
  • Westgaard, Ingunn Hagen; Berg, Siri Fuglem; Ørstavik, Sigurd; Fossum, Sigbjørn & Dissen, Erik (1998). Identification of a human member of the Ly-49 multigene family. European Journal of Immunology. ISSN 0014-2980. 28, p. 1839–1846.
  • Berg, Siri Fuglem; Dissen, Erik; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1998). Two genes in the rat homologous to human NKG2. European Journal of Immunology. ISSN 0014-2980. 28, p. 444–450.
  • Dissen, Erik; Berg, Siri Fuglem; Westgaard, Ingunn Hagen & Fossum, Sigbjørn (1997). Molecular characterization of a gene in the rat homologous to human CD94. European Journal of Immunology. ISSN 0014-2980. 27, p. 2080–2086.
  • Dissen, Erik; Ryan, James C.; Seaman, W. E. & Fossum, Sigbjørn (1996). An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. Journal of Experimental Medicine (JEM). ISSN 0022-1007. 183, p. 2197–2207.
  • Dissen, Erik & Fossum, Sigbjørn (1996). Chromosomal localization of the genes encoding rat CD4, CD8 and CD8. Immunogenetics. ISSN 0093-7711. 44, p. 312–314.
  • Dissen, Erik; Vaage, John T.; Tasken, Kjetil; Jahnsen, Tore; Rolstad, Bent & Fossum, Sigbjørn (1990). Alloreactive lymphokine-activated killer cells from athymic nude rats do not express CD3-associated alpha/beta or gamma/delta T cell receptors. International Immunology. ISSN 0953-8178. 2(5), p. 453–461.

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  • Kristensen, Petter; Levy, Finn; Grahnstedt, Svein G; Martinsen, Aud; Schiel, Anja Elisabeth & Flornes, Line Mari [Show all 9 contributors for this article] (2011). Oljer og helse - et pilotprosjekt. Kartlegging av oljeeksponering, genetiske faktorer og sykdom hos pasienter som ble utredet for mulig arbeidsrelatertsykdom. Statens Arbeidsmiljøinstitutt. ISSN 1502-0932. Årgang 12(Nr. 1).
  • Dissen, Erik (1997). Recognition of allogeneic lymphocytes by natural killer cells. A molecular genetic study in the rat. Universitetet i Oslo. ISSN 82-91061-77-7.

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Published Apr. 13, 2011 2:40 PM - Last modified Jan. 8, 2020 10:16 AM