Helene Knævelsrud

Associate Professor - Division of Biochemistry

Norwegian version of this page

Email helene.knavelsrud@medisin.uio.no

Username

Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo

Postal address Postboks 1112 Blindern 0317 Oslo

Other affiliations Centres directly under the University Board (Student)

Download business card

Academic interests

My research group “Cell stress and cancer” is focused on two main goals:

to understand how autophagy is switched off in vivo and
to unravel mechanisms of autophagy involvement in cancer biology

Courses taught

Background

I have a PhD with a specialization in Biochemistry, obtained in 2013 from the University of Oslo (supervisor Anne Simonsen), on the topic of Class III PI3K and PI3P-binding proteins in autophagy. Thereafter I did my postdoctoral training in Montréal, Canada, in the laboratory of Dr. Marc Therrien, a leading expert in cancer cell signaling. Thereafter I established a project group within the laboratory of Jorrit Enserink at Oslo University Hospital on autophagy and other cancer-relevant cellular pathways using mammalian cells, Drosophila and patient samples.

Positions held

NCMM associate investigator

Partners

Tags: Cancer, Autophagy, drosophila

al Outa, Amani; Hicks, Steven; Thambawita, Vajira L B; Andresen, Siri; Enserink, Jorrit Martijn & Halvorsen, Pål [Show all 8 contributors for this article] (2023). CELLULAR, A Cell Autophagy Imaging Dataset. Scientific Data. ISSN 2052-4463. doi: 10.1038/s41597-023-02687-x. Full text in Research Archive
Johannessen, Julie Aarmo; Formica, Miriam; Haukeland, Aina Louise C.; Bråthen, Nora Rojahn; al Outa, Amani & Larsen, Miriam Aarsund [Show all 9 contributors for this article] (2023). The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. iScience. ISSN 2589-0042. 26(10), p. 1–18. doi: 10.1016/j.isci.2023.107726. Full text in Research Archive
Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud Khaled; Abdoli, Asghar & Abudu, Yakubu Princely [Show all 50 contributors for this article] (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) . Autophagy. ISSN 1554-8627. 17(1), p. 1–382. doi: 10.1080/15548627.2020.1797280.
Formica, Miriam; Storaci, Alessandra Maria; Bertolini, Irene; Carminati, Francesca; Knævelsrud, Helene & Vaira, Valentina [Show all 7 contributors for this article] (2021). V-ATPase controls tumor growth and autophagy in a Drosophila model of gliomagenesis. Autophagy. ISSN 1554-8627. 17(12), p. 4442–4452. doi: 10.1080/15548627.2021.1918915. Full text in Research Archive
Søreng, Kristiane; Knævelsrud, Helene; Holland, Petter & Simonsen, Anne (2017). HS1BP3 inhibits autophagy by regulation of PLD1. Autophagy. ISSN 1554-8627. 13(5), p. 985–986. doi: 10.1080/15548627.2017.1291483. Full text in Research Archive
Holland, Petter; Knævelsrud, Helene; Søreng, Kristiane; Mathai, Benan John; Lystad, Alf Håkon & Pankiv, Serhiy [Show all 16 contributors for this article] (2016). HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nature Communications. ISSN 2041-1723. 7. doi: 10.1038/ncomms13889. Full text in Research Archive
Knævelsrud, Helene; Carlsson, Sven R & Simonsen, Anne (2013). SNX18 tubulates recycling endosomes for autophagosome biogenesis. Autophagy. ISSN 1554-8627. 9(10), p. 1639–1641. doi: 10.4161/auto.26124.
Knævelsrud, Helene; Søreng, Kristiane; Raiborg, Camilla; Håberg, Karin; Rasmuson, Fredrik & Brech, Andreas [Show all 12 contributors for this article] (2013). Membrane remodeling by the PX-BAR protein SNX18 promotes autophagosome formation. Journal of Cell Biology. ISSN 0021-9525. 202(2), p. 331–349. doi: 10.1083/jcb.201205129.
Knævelsrud, Helene & Simonsen, Anne (2012). Lipids in autophagy: Constituents, signaling molecules and cargo with relevance to disease. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. ISSN 1388-1981. 1821(8), p. 1133–1145. doi: 10.1016/j.bbalip.2012.01.001.
Knævelsrud, Helene; Ahlquist, Terje Cruickshank; Merok, Marianne Aarstad; Nesbakken, Arild; Stenmark, Harald Alfred & Lothe, Ragnhild A [Show all 7 contributors for this article] (2010). UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy. ISSN 1554-8627. 6(7), p. 863–870. doi: 10.4161/auto.6.7.13033.
Knævelsrud, Helene & Simonsen, Anne (2010). Fighting disease by selective autophagy of aggregate-prone proteins. FEBS Letters. ISSN 0014-5793. 584(12), p. 2635–2645. doi: 10.1016/j.febslet.2010.04.041.

View all works in Cristin

Knævelsrud, Helene; Tjønndal, Anne & Hansen, Kai Arne (2022). #sommerkroppen2022: Hva bør jeg gjøre? . Morgenbladet. ISSN 0805-3847.
Bustad, Helene J.; Flydal, Marte Innselset; Knævelsrud, Helene; Langaker, Ann Helen; Boye, Erik & Kristensen, Tom (2022). Slik utvikler vi norske fagtermer i celle-og molekylærbiologi. Tidsskrift for Den norske legeforening. ISSN 0029-2001. 142(2). doi: 10.4045/tidsskr.21.0465.
Knævelsrud, Helene; Tjønndal, Anne Beret & Hansen, Kai Arne (2022). #sommerkroppen2022: Hva bør jeg gjøre? Morgenbladet. ISSN 0805-3847.
al Outa, Amani; Knævelsrud, Helene; Laczko, Balint & Jensenius, Alexander Refsum (2022). Winner of RRI-inspired transdisciplinary side quest call. [Internet]. Centre for Digital Life Norway. Show summary
Centre for Digital Life Norway (DLN) is excited to congratulate the team behind the project “The autophagic symphony – Unveiling the final rhythm” as winner of DLN’s RRI-inspired transdisciplinary side quest call.
Bratland-Sanda, Solfrid; Knævelsrud, Helene & Eriksen, Stefka Georgieva (2021). Hvorfor er folk glade i sol og varme? Morgenbladet. ISSN 0805-3847.
Bustad, Helene J.; Flydal, Marte Innselset; Knævelsrud, Helene; Boye, Erik & Kristensen, Tom Arne (2021). Et kappløp for norsk fagspråk. Michael. ISSN 1893-9651. 18(26), p. 81–91.
Hem, Erlend; Knævelsrud, Helene & Johannessen, Helene Bustad (2020). Norsk fagspråk må styrkes. Klassekampen. ISSN 0805-3839.
Korsvoll, Nils Hallvard; Tjønndal, Anne & Knævelsrud, Helene (2020). Hvorfor er vi så besatt av alt som er julete? . Morgenbladet. ISSN 0805-3847.
Eikenes, Åsmund Husabø; Bratland-Sanda, Solfrid; Midtbøen, Arnfinn Haagensen; Bøhn, Einar Duenger; Snipstad, Sofie & Høgestøl, Sofie A.E. [Show all 7 contributors for this article] (2019). Forsker Grand Prix vil forandre forskningen din. Forskerforum.no.
Knævelsrud, Helene; Snipstad, Sofie & Eikenes, Åsmund Husabø (2018). Nullfunn gir gullfunn. Forskerforum.no.
Knævelsrud, Helene; Snipstad, Sofie & Eikenes, Åsmund Husabø (2018). Nullfunn gir gullfunn. Aftenposten (morgenutg. : trykt utg.). ISSN 0804-3116.

View all works in Cristin

Published Feb. 10, 2023 7:49 PM - Last modified Mar. 3, 2023 10:46 PM

Projects

FINALphagy

Research groups

Cell Stress and Cancer