Helga Refsum

Professor Emeritus - Division of Molecular Nutrition
Image of Helga Refsum
Norwegian version of this page
Phone +47 22851357
Room 2195
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 Oslo

Publications

  • Elshorbagy, Amany; Graham, Ian & Refsum, Helga (2020). Body mass index determines the response of plasma sulfur amino acids to methionine loading. Biochimie.  ISSN 0300-9084.  173, s 107- 113 . doi: 10.1016/j.biochi.2020.03.001
  • Henjum, Sigrun; Manger, Mari Skar; Hampel, Daniela; Brantsæter, Anne Lise; Shahab-Ferdows, Setareh; Bastani, Nasser Ezzatkhah; Strand, Tor A; Refsum, Helga & Allen, Lindsay H. (2020). Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation. European Journal of Clinical Nutrition.  ISSN 0954-3007.  74(5), s 749- 756 . doi: 10.1038/s41430-020-0567-x Show summary
  • Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas; Refsum, Helga; Jensen, Jørgen; Birkeland, Kåre I. & Drevon, Christian A (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia.  ISSN 0012-186X.  64, s 410- 423 . doi: 10.1007/s00125-020-05296-0 Full text in Research Archive.
  • Olsen, Thomas; Sollie, Ove; Nurk, Eha; Turner, Cheryl; Jernerén, Fredrik; Ivy, John L.; Vinknes, Kathrine; Clauss, Matthieu; Refsum, Helga Margaretha & Jensen, Jørgen (2020). Exhaustive Exercise and Post-exercise Protein Plus Carbohydrate Supplementation Affect Plasma and Urine Concentrations of Sulfur Amino Acids, the Ratio of Methionine to Homocysteine and Glutathione in Elite Male Cyclists. Frontiers in Physiology.  ISSN 1664-042X. . doi: 10.3389/fphys.2020.609335 Full text in Research Archive. Show summary
  • Olsen, Thomas; Turner, Cheryl; Øvrebø, Bente; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2020). Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study. BMC Research Notes.  ISSN 1756-0500.  13 . doi: 10.1186/s13104-020-05222-y Full text in Research Archive.
  • Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne; Hjorth, Marit; Bastani, Nasser Ezzatkhah; Norheim, Frode; Drevon, Christian A; Refsum, Helga Margaretha & Vinknes, Kathrine (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine.  ISSN 1479-5876.  18(122) . doi: 10.1186/s12967-020-02288-x Full text in Research Archive.
  • Pérez, Laura M.; Hooshmand, Babak; Mangialasche, Francesca; Mecocci, Patrizia; Smith, A David; Refsum, Helga; Inzitari, Marco; Fratiglioni, Laura; Rizzuto, Debora & Calderón-Larrañaga, Amaia (2020). Glutathione Serum Levels and Rate of Multimorbidity Development in Older Adults. The journals of gerontology. Series A, Biological sciences and medical sciences.  ISSN 1079-5006.  75(6), s 1089- 1094 . doi: 10.1093/gerona/glz101 Full text in Research Archive.
  • Hanvold, Susanna; Vinknes, Kathrine; Løken, Elin Bjørge; Hjartåker, Anette; Klungsøyr, Ole; Birkeland, Eline; Risstad, Hilde; Gulseth, Hanne Løvdal; Refsum, Helga & Aas, Anne-Marie (2019). Does Lifestyle Intervention After Gastric Bypass Surgery Prevent Weight Regain? A Randomized Clinical Trial. Obesity Surgery.  ISSN 0960-8923.  29(11), s 3419- 3431 . doi: 10.1007/s11695-019-04109-7
  • Hooshmand, Babak; Refsum, Helga; Smith, A David; Kalpouzos, Gregoria; Mangialasche, Francesca; Von Arnim, Christine A.F.; Kåreholt, Ingemar; Kivipelto, Miia & Fratiglioni, Laura (2019). Association of Methionine to Homocysteine Status With Brain Magnetic Resonance Imaging Measures and Risk of Dementia. JAMA psychiatry.  ISSN 2168-6238.  76(11), s 1198- 1205 . doi: 10.1001/jamapsychiatry.2019.1694 Show summary
  • Jernerén, Fredrik; Cederholm, Tommy; Refsum, Helga; Smith, A David; Turner, Cheryl; Palmblad, Jan; Eriksdotter, Maria; Hjorth, Erik; Faxen-Irving, Gerd; Wahlund, Lars-Olof; Schultzberg, Marianne; Basun, Hans & Freund-Levi, Yvonne (2019). Homocysteine status modifies the treatment effect of omega-3 fatty acids on cognition in a randomized clinical trial in mild to moderate Alzheimer's disease: The OmegAD Study. Journal of Alzheimer's Disease.  ISSN 1387-2877.  69(1), s 189- 197 . doi: 10.3233/JAD-181148
  • Lee-Ødegård, Sindre; Olsen, Thomas; Vinknes, Kathrine; Refsum, Helga; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients.  ISSN 2072-6643.  11(1) . doi: 10.3390/nu11010010 Full text in Research Archive.
  • Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga & Nygård, Ottar (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European Journal of Nutrition.  ISSN 1436-6207. . doi: 10.1007/s00394-019-02086-2 Full text in Research Archive.
  • Solvang, Stein-Erik Hafstad; Nordrehaug, Jan Erik; Tell, Grethe S.; Nygård, Ottar; Mccann, Adrian; Ueland, Per Magne; Midttun, Øivind; Meyer, Klaus; Vedeler, Christian A.; Aarsland, Dag; Refsum, Helga; Smith, A. David & Melvær, Giil Lasse (2019). The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study. Brain, behavior, and immunity.  ISSN 0889-1591.  75, s 155- 162 . doi: 10.1016/j.bbi.2018.10.003
  • Su, Yi; Elshorbagy, Amany; Turner, Cheryl; Refsum, Helga; Chan, Ruth & Kwok, Timothy (2019). Circulating amino acids are associated with bone mineral density decline and ten-year major osteoporotic fracture risk in older community-dwelling adults. Bone.  ISSN 8756-3282.  129, s 1- 8 . doi: 10.1016/j.bone.2019.115082
  • Allen, Lindsay H.; Miller, Joshua W.; de Groot, Lisette; Rosenberg, Irwin H.; Smith, A. David; Refsum, Helga & Raiten, Daniel J. (2018). Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review. Journal of Nutrition.  ISSN 0022-3166.  148(4), s 1995S- 2027S . doi: 10.1093/jn/nxy201
  • Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga & Nygård, Ottar (2018). The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  25(15), s 1612- 1620 . doi: 10.1177/2047487318788587 Full text in Research Archive.
  • Olsen, Thomas; Øvrebø, Bente; Turner, Cheryl; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2018). Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial. Nutrients.  ISSN 2072-6643.  10(12), s 1- 15 . doi: 10.3390/nu10121822 Full text in Research Archive.
  • Smith, A. David; Refsum, Helga; Bottiglieri, Teodoro; Fenech, Michael; Hooshmand, Babak; McCaddon, Andrew; Miller, Joshua W.; Rosenberg, Irwin H. & Obeid, Rima (2018). Homocysteine and Dementia: An International Consensus Statement. Journal of Alzheimer's Disease.  ISSN 1387-2877.  62(2), s 561- 570 . doi: 10.3233/JAD-171042 Full text in Research Archive.
  • Sollie, Ove; Jeppesen, Per Bendix; Tangen, Daniel S.; Jernerén, Fredrik; Nellemann, Birgitte; Valsdottir, Thorhildur; Madsen, Klavs; Turner, Cheryl; Refsum, Helga; Skålhegg, Bjørn Steen; Ivy, John L. & Jensen, Jørgen (2018). Protein intake in the early recovery period after exhaustive exercise improves performance the following day. Journal of applied physiology.  ISSN 8750-7587.  125(6), s 1731- 1742 . doi: 10.1152/japplphysiol.01132.2017 Full text in Research Archive. Show summary
  • Wanders, Anne J.; Alssema, Marjan; De Hoon, Sabine E.M.; Feskens, Edith J.M.; van Woudenbergh, Geertruida J.; Van Der Kallen, Carla J.; Zock, Peter L.; Refsum, Helga; Drevon, Christian A; Elshorbagy, Amany; Schalkwijk, Casper G.; Stehouwer, Coen D. A.; Dekker, Jacqueline M. & Van Greevenbroek, Marleen M.J. (2018). Circulating Polyunsaturated Fatty Acids as Biomarkers for Dietary Intake across Subgroups: The CODAM and Hoorn Studies. Annals of Nutrition and Metabolism.  ISSN 0250-6807.  72(2), s 117- 125 . doi: 10.1159/000486244
  • Elshorbagy, Amany; Jernerén, Fredrik; Basta, Marianne; Basta, Caroline; Turner, Cheryl; Khaled, Maram & Refsum, Helga (2017). Amino acid changes during transition to a vegan diet supplemented with fish in healthy humans. European Journal of Nutrition.  ISSN 1436-6207.  56(5), s 1953- 1962 . doi: 10.1007/s00394-016-1237-6
  • Haj Yasein, Nadia; Berg, Ole; Jerneren, Fredrik; Refsum, Helga; Nebb, Hilde Irene & Dalen, Knut Tomas (2017). Cysteine deprivation prevents induction of peroxisome proliferator-activated receptor gamma-2 and adipose differentiation of 3T3-L1 cells. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids.  ISSN 1388-1981.  1862(6), s 623- 635 . doi: 10.1016/j.bbalip.2017.02.009
  • Hanvold, Susanna; Vinknes, Kathrine; Bastani, Nasser Ezzatkhah; Turner, Cheryl; Løken, Elin Bjørge; Mala, Tom; Refsum, Helga & Aas, Anne-Marie (2017). Plasma amino acids, adiposity, and weight change after gastric bypass surgery: are amino acids associated with weight regain?. European Journal of Nutrition.  ISSN 1436-6207.  s 1- 9 . doi: 10.1007/s00394-017-1533-9
  • Holm, Maia Blomhoff; Bastani, Nasser Ezzatkhah; Holme, Ane Moe; Zucknick, Manuela; Jansson, Thomas; Refsum, Helga; Mørkrid, Lars; Blomhoff, Rune; Henriksen, Tore & Michelsen, Trond Melbye (2017). Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLOS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185760 Full text in Research Archive.
  • Kumar, Tivendra; Taneja, Sunita; Sachdev, Harshpal S; Refsum, Helga; Yajnik, Chittaranjan S.; Bhandari, Nita & Strand, Tor A (2017). Supplementation of vitamin B12 or folic acid on hemoglobin concentration in children 6-36 months of age: A randomized placebo controlled trial.. Clinical Nutrition.  ISSN 0261-5614.  36(4), s 986- 991 . doi: 10.1016/j.clnu.2016.07.002
  • Melvær, Giil Lasse; Midttun, Øivind; Refsum, Helga; Ulvik, Arve; Advani, Rajiv; Smith, A. David & Ueland, Per Magne (2017). Kynurenine pathway metabolites in Alzheimer's disease. Journal of Alzheimer's Disease.  ISSN 1387-2877.  60(2), s 495- 504 . doi: 10.3233/JAD-170485
  • Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Tell, Grethe S.; Blomhoff, Rune; Drevon, Christian A; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga & Nygård, Ottar (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis.  ISSN 0021-9150.  (265), s 325- 330 . doi: 10.1016/j.atherosclerosis.2017.07.020
  • Parr, Christine Louise; Magnus, Maria Christine; Karlstad, Øystein; Haugen, Alice Margaretha; Refsum, Helga; Ueland, Per Magne; Mccann, Adrian; Nafstad, Per; Håberg, Siri Eldevik; Nystad, Wenche & London, Stephanie J (2017). Maternal folate intake during pregnancy and childhood asthma in a population-based cohort. American Journal of Respiratory and Critical Care Medicine.  ISSN 1073-449X.  195(2), s 221- 228 . doi: 10.1164/rccm.201604-0788OC
  • Vinknes, Kathrine; Nurk, Eha; Tell, Grethe S.; Sulo, Gerhard; Refsum, Helga & Elshorbagy, Amany K. (2017). The relation of CUN-BAE index and BMI with body fat, cardiovascular events and diabetes during a 6-year follow-up: The hordaland health study. Clinical Epidemiology.  ISSN 1179-1349.  9, s 555- 566 . doi: 10.2147/CLEP.S145130
  • Cabout, Mieke; Alssema, Marjan; Nijpels, Giel; Stehouwer, Coen D.A.; Zock, Peter L.; Brouwer, Ingeborg A.; Elshorbagy, Amany; Refsum, Helga & Dekker, Jacqueline M. (2016). Circulating linoleic acid and alpha-linolenic acid and glucose metabolism: the Hoorn Study. European Journal of Nutrition.  ISSN 1436-6207.  Published ahead of print . doi: 10.1007/s00394-016-1261-6
  • Elshorbagy, Amany K.; Jernerén, Fredrik; Samocha-Bonet, D.; Refsum, Helga & Heilbronn, L.K. (2016). Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans. Nutrition and Diabetes.  ISSN 2044-4052.  6 . doi: 10.1038/nutd.2015.44
  • Elshorbagy, Amany K; Jernerén, Fredrik; Scudamore, Cheryl L.; McMurray, Fiona; Cater, Heather; Hough, Tertius; Cox, Roger & Refsum, Helga (2016). Exploring the lean phenotype of glutathione-depleted mice: Thiol, amino acid and fatty acid profiles. PLOS ONE.  ISSN 1932-6203.  11(10) . doi: 10.1371/journal.pone.0163214
  • Hooshmand, Babak; Mangialasche, Francesca; Kalpouzos, Grégoria; Solomon, Alina; Kåreholt, Ingemar; Smith, A. David; Refsum, Helga; Wang, Rui; Mühlmann, Marc; Ertl-Wagner, Birgit; Laukka, Erika Jonsson; Bäckman, Lars; Fratiglioni, Laura & Kivipelto, Miia (2016). Association of Vitamin B<sub>12</sub>, folate, and sulfur amino acids with brain magnetic resonance imaging measures in older adults a longitudinal population-based study. JAMA psychiatry.  ISSN 2168-6238.  73(6), s 606- 613 . doi: 10.1001/jamapsychiatry.2016.0274
  • Smith, A. David & Refsum, Helga (2016). Homocysteine, B Vitamins, and Cognitive Impairment. Annual review of nutrition.  ISSN 0199-9885.  36, s 211- 239 . doi: 10.1146/annurev-nutr-071715-050947
  • Zhang, Weihua; Jernerén, Fredrik; Lehne, Benjamin C.; Chen, Ming-Huei; Luben, Robert N.; Johnston, Carole; Elshorbagy, Amany; Eppinga, Ruben N.; Scott, William R.; Adeyeye, Elizabeth; Scott, James; Böger, Rainer H.; Khaw, Kay-Tee; Van Der Harst, Pim; Wareham, Nicholas J.; Vasan, Ramachandran S.; Chambers, John C.; Refsum, Helga & Kooner, Jaspal S. (2016). Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels. Thrombosis and Haemostasis.  ISSN 0340-6245.  116(6), s 1041- 1049 . doi: 10.1160/TH16-02-0151
  • Hanvold, Susanna; Løken, Elin Bjørge; Paus, Sofie Flottorp; de Brisis, Eva Rustad; Bjerkan, Kirsti; Refsum, Helga & Aas, Anne-Marie (2015). Great Health Benefits But No Change in Employment or Psychopharmaceutical Drug Use 2 Years After Roux-en-Y Gastric Bypass. Obesity Surgery.  ISSN 0960-8923.  25(9), s 1672- 1679 . doi: 10.1007/s11695-015-1583-0 Show summary
  • Jernerén, Fredrik; Elshorbagy, Amany K.; Oulhaj, Abderrahim; Smith, Stephen M.; Refsum, Helga & Smith, A. David (2015). Brain atrophy in cognitively impaired elderly: The importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. American Journal of Clinical Nutrition.  ISSN 0002-9165.  102(1), s 215- 221 . doi: 10.3945/ajcn.114.103283
  • Kvestad, Ingrid; Taneja, Sunita; Kumar, Tivendra; Hysing, Mari; Refsum, Helga; Yajnik, Chittaranjan S.; Bhandari, Nita & Strand, Tor (2015). Vitamin B12 and folic acid improve gross motor and problem-solving skills in young North Indian children: A randomized placebo-controlled trial. PLOS ONE.  ISSN 1932-6203.  10(6) . doi: 10.1371/journal.pone.0129915 Full text in Research Archive. Show summary
  • Oulhaj, Abderrahim; Jernerén, Fredrik; Refsum, Helga; Smith, A. David & de Jager, Celeste A. (2015). Omega-3 fatty acid status enhances the prevention of cognitive decline by B Vitamins in mild cognitive impairment. Journal of Alzheimer's Disease.  ISSN 1387-2877.  50(2), s 547- 557 . doi: 10.3233/JAD-150777
  • Strand, Tor; Taneja, Sunita; Kumar, Tivendra; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S. & Bhandari, Nita (2015). Vitamin B-12, folic acid, and growth in 6- to 30-month-old children: A randomized controlled trial. Pediatrics.  ISSN 0031-4005.  135(4), s e918- e926 . doi: 10.1542/peds.2014-1848
  • Doets, EL; Ueland, Per Magne; Tell, Grethe S; Vollset, Stein Emil; Nygård, Ottar; van't Veer, Pieter; de Groot, Lisette C.P.G.M.; Nurk, Eha; Refsum, Helga; Smith, David & Eussen, Simone (2014). Interactions between plasma concentrations of folate and markers of vitamin B12 status with cognitive performance in elderly people not exposed to folic acid fortification: the Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  111(6), s 1085- 1095 . doi: 10.1017/S000711451300336X
  • Ulak, Manjeswori; Chandyo, Ram Krishna; Adhikari, Ramesh K.; Sharma, Pushpa R.; Sommerfelt, Halvor; Refsum, Helga & Strand, Tor (2014). Cobalamin and folate status in 6 to 35 months old children presenting with acute diarrhea in Bhaktapur, Nepal. PLOS ONE.  ISSN 1932-6203.  9(3:e90097) . doi: 10.1371/journal.pone.0090079 Full text in Research Archive.
  • Yajnik, Chittaranjan S; Chandak, Giriraj R; Joglekar, Charudatta V; Katre, Prachi; Bhat, Dattatray S; Singh, Suraj N; Janipalli, Charles S; Refsum, Helga; Krishnaveni, Ghattu; Veena, Sargoor; Osmond, Clive & Fall, Caroline H (2014). Maternal homocysteine in pregnancy and offspring birthweight: Epidemiological associations and Mendelian randomization analysis. International Journal of Epidemiology.  ISSN 0300-5771.  43(5), s 1487- 1497 . doi: 10.1093/ije/dyu132
  • Douaud, Gwenaëlle; Refsum, Helga; de Jager, Celeste; Jacoby, Robin; Nichols, Thomas E; Smith, Stephen M. & Smith, A. David (2013). Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  110(23), s 9523- 9528 . doi: 10.1073/pnas.1301816110
  • Elshorbagy, AK; Nijpels, G; Valdivia-Garcia, Maria; Stehouwer, C.D.A.; Ocké, Marga C; Refsum, Helga & Dekker, J.M. (2013). S-Adenosylmethionine Is Associated with Fat Mass and Trunkal Adiposity in Older Adults. Journal of Nutrition.  ISSN 0022-3166.  143(12), s 1982- 1988 . doi: 10.3945/jn.113.179192
  • Elshorbagy, Amany K.; Valdivia-Garcia, Maria; Mattocks, Dwight A.L.; Plummer, Jason D.; Orentreich, David S.; Orentreich, Norman; Refsum, Helga & Perrone, Carmen E. (2013). Effect of taurine and N-acetylcysteine on methionine restriction-mediated adiposity resistance. Metabolism: Clinical and Experimental.  ISSN 0026-0495.  62(4), s 509- 517 . doi: 10.1016/j.metabol.2012.10.005
  • Haj-Yasein, Nadia Nabil; Dalen, Knut Tomas; Berg, Ole; Bastani, Nasser Ezzatkhah; Refsum, Helga & Nebb, Hilde Irene (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. The Journal of Inherited Metabolic Disease (JIMD).  ISSN 0141-8955.  36, s S44 . doi: 10.1007/s10545-013-9631-1
  • Nurk, Eha; Refsum, Helga; Bjelland, Ingvar; Drevon, Christian A; Tell, Grethe S; Ueland, Per Magne; Vollset, Stein Emil; Engedal, Knut Arne; Nygaard, Harald A. & Smith, David A (2013). Plasma free choline, betaine and cognitive performance: the Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  109(3), s 511- 519 . doi: 10.1017/S0007114512001249 Full text in Research Archive.
  • Rajagopalan, Priya; Refsum, Helga; Hua, Xue; Toga, Arthur W.; Jack, Clifford R.; Weiner, Michael W & Thompson, Paul M. (2013). Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly. Neurobiology of Aging.  ISSN 0197-4580.  34(4), s 1221- 1230 . doi: 10.1016/j.neurobiolaging.2012.10.022
  • Reinders, I; Ballegooijen, A J van; Visser, M; Elshorbagy, AK; Refsum, Helga; Henry, R.M.A.; Dekker, J.M.; Nijpels, G; Stehouwer, C.D.A. & Brouwer, I A (2013). Low Cysteine Interferes With PPARγ Activity And Reduces Adipocyte Differentiation. European Journal of Clinical Nutrition.  ISSN 0954-3007. . doi: 10.1038/ejcn.2013.167
  • Reinders, Ilse; van Ballegooijen, Adriana J.; Visser, Marjolein; Elshorbagy, Amany K.; Refsum, Helga; Henry, Ronald M.A.; Dekker, Jacqueline M.; Nijpels, Giel; Stehouwer, Coen D.A. & Brouwer, Ingeborg A. (2013). Associations of serum n-3 and n-6 polyunsaturated fatty acids with echocardiographic measures among older adults: the Hoorn Study. European Journal of Clinical Nutrition.  ISSN 0954-3007.  67(12), s 1277- 1283 . doi: 10.1038/ejcn.2013.167
  • Strand, Bjørn Heine; Langballe, Ellen Melbye; Hjellvik, Vidar; Handal, Marte; Næss, Øyvind; Knudsen, Gun Peggy; Refsum, Helga; Tambs, Kristian; Nafstad, Per; Schirmer, Henrik; Bergem, Astrid Liv Mina; Selmer, Randi; Engedal, Knut Arne; Magnus, Per & Bjertness, Espen (2013). Midlife vascular risk factors and their association with dementia deaths: Results from a Norwegian prospective study followed up for 35 years. Journal of Neurological Sciences.  ISSN 1302-1664.  324(1-2), s 124- 130 . doi: 10.1016/j.jns.2012.10.018
  • Strand, Tor A; Taneja, Sunita; Ueland, Per Magne; Refsum, Helga; Bahl, Rajiv; Schneede, Jørn; Sommerfelt, Halvor & Bhandari, Nita (2013). Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. American Journal of Clinical Nutrition.  ISSN 0002-9165.  97(2), s 310- 317 . doi: 10.3945/ajcn.111.032268
  • Taneja, Sunita; Strand, Tor A; Kumar, Tivendra; Mahesh, Madhu; Mohan, Sanjana; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S. & Bhandari, Nita (2013). Folic acid and vitamin B-12 supplementation and common infections in 6-30-mo-old children in India: a randomized placebo-controlled trial. American Journal of Clinical Nutrition.  ISSN 0002-9165.  98(3), s 731- 737 . doi: 10.3945/ajcn.113.059592
  • Vinknes, Kathrine; Dekker, Jacqueline M.; Drevon, Christian A; Refsum, Helga; Nurk, Eha; Nijpels, Giel; Stehouwer, Coen D.A.; Teerlink, Tom; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil; Ueland, Per Magne & Elshorbagy, AK (2013). Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations. Prostaglandins Leukot Essent Fatty Acids 2. Prostaglandins, Leukotrienes and Essential Fatty Acids.  ISSN 0952-3278.  89(5), s 297- 303 . doi: 10.1016/j.plefa.2013.09.007
  • Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Evaluation of the body adiposity index in a caucasian population: the Hordaland Health Study. American Journal of Epidemiology.  ISSN 0002-9262.  177(6), s 586- 592 . doi: 10.1093/aje/kws271
  • Vinknes, Kathrine; Elshorbagy, Amany K.; Drevon, Christian A; Nurk, Eha; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Associations between plasma polyunsaturated fatty acids, plasma stearoyl-CoA desaturase indices and body fat. Obesity.  ISSN 1930-7381.  21(9), s E512- E519 . doi: 10.1002/oby.20457
  • Vinknes, Kathrine; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Nygård, Ottar; Vollset, Stein Emil & Refsum, Helga (2013). Plasma stearoyl-CoA desaturase indices: Association with lifestyle, diet and body composition. Obesity.  ISSN 1930-7381.  21(3), s E294- E302 . doi: 10.1002/oby.20011
  • Vogiatzoglou, Anna; Smith, David; Nurk, Eha; Drevon, Christian A; Ueland, Per Magne; Vollset, Stein Emil; Nygaard, Harald A.; Engedal, Knut Arne; Tell, Grethe S & Refsum, Helga (2013). Cognitive function in an elderly population: Interaction between vitamin B12 status, depression and apolipoprotein E4. The Hordaland Homocysteine Study. Psychosomatic Medicine.  ISSN 0033-3174.  75(1), s 20- 29 . doi: 10.1097/PSY.0b013e3182761b6c
  • Bonilla, Carolina; Lawlor, Debbie A.; Taylor, Amy E; Gunnell, David; Ben-Shlomo, Yoav; Ness, Andrew R; Timpson, Nicholas J.; St Pourcain, Beate; Ring, Susan M.; Emmett, Pauline M; Smith, A. David; Refsum, Helga; Pennell, Craig E.; Brion, Marie-Jo A.; Smith, George Davey & Lewis, Sarah J. (2012). Vitamin B-12 Status during Pregnancy and Child's IQ at Age 8: A Mendelian Randomization Study in the Avon Longitudinal Study of Parents and Children. PLOS ONE.  ISSN 1932-6203.  7(12) . doi: 10.1371/journal.pone.0051084
  • de Jager, Celeste; Oulhaj, Abderrahim; Jacoby, Robin; Refsum, Helga & Smith, A. David (2012). Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  27(6), s 592- 600 . doi: 10.1002/gps.2758
  • Elshorbagy, AK; Valdivia-Garcia, Maria; Graham, I. M.; Reis, R Palma; Luis, A Sales; Smith, A.D. & Refsum, Helga (2012). The association of fasting plasma sulfur-containing compounds with BMI, serum lipids and apolipoproteins. NMCD. Nutrition Metabolism and Cardiovascular Diseases.  ISSN 0939-4753.  22(12), s 1031- 1038 . doi: 10.1016/j.numecd.2011.01.008
  • Elshorbagy, Amany K.; Church, Chris; Valdivia-Garcia, Maria; Smith, A. David; Refsum, Helga & Cox, Roger (2012). Dietary cystine level affects metabolic rate and glycaemic control in adult mice. Journal of Nutritional Biochemistry.  ISSN 0955-2863.  23(4), s 332- 340 . doi: 10.1016/j.jnutbio.2010.12.009
  • Elshorbagy, Amany K; Kozich, Viktor; Smith, A. David & Refsum, Helga (2012). Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies. Current opinion in clinical nutrition and metabolic care.  ISSN 1363-1950.  15(1), s 49- 57 . doi: 10.1097/MCO.0b013e32834d199f
  • Elshorbagy, Amany K; Smith, A. David; Kozich, Viktor & Refsum, Helga (2012). Cysteine and Obesity. Obesity.  ISSN 1930-7381.  20(3), s 473- 481 . doi: 10.1038/oby.2011.93
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Refsum, Helga & Butte, Nancy (2012). The Association of Cysteine with Obesity, Inflammatory Cytokines and Insulin Resistance in Hispanic Children and Adolescents. PLOS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0044166 Full text in Research Archive.
  • Aasheim, Erlend T; Elshorbagy, Amany K; Diep, Lien My; Søvik, Torgeir Thorson; Mala, Tom; Valdivia-Garcia, Maria; Olbers, Torsten; Bøhmer, Thomas; Birkeland, Kåre I. & Refsum, Helga (2011). Effect of bariatric surgery on sulphur amino acids and glutamate. British Journal of Nutrition.  ISSN 0007-1145.  106(3), s 432- 440 . doi: 10.1017/S0007114511000201 Full text in Research Archive.
  • Bleie, Øyvind; Strand, Elin; Ueland, Per Magne; Vollset, Stein Emil; Refsum, Helga; Igland, Jannicke; Nordrehaug, Jan Erik & Nygård, Ottar (2011). Coronary blood flow in patients with stable coronary artery disease treated long term with folic acid and vitamin B12. Coronary Artery Disease.  ISSN 0954-6928.  22(4), s 270- 278 . doi: 10.1097/MCA.0b013e328344fff4
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Mattocks, Dwight A.L.; Plummer, Jason D.; Smith, A. David; Drevon, Christian A; Refsum, Helga & Perrone, Carmen E. (2011). Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. Journal of Lipid Research.  ISSN 0022-2275.  52(1), s 104- 112 . doi: 10.1194/jlr.M010215
  • Hay, Gry; Trygg, Kerstin Ulla; Whitelaw, Andrew; Johnston, Carole & Refsum, Helga (2011). Folate and cobalamin status in relation to diet in healthy 2-y-old children. American Journal of Clinical Nutrition.  ISSN 0002-9165.  93(4), s 727- 735 . doi: 10.3945/ajcn.110.003426
  • Lehmann, Donald J; Refsum, Helga; Warden, Donald R; Medway, Christopher; Wilcock, Gordon K & Smith, David (2011). The vitamin D receptor gene is associated with Alzheimer's disease. Neuroscience Letters.  ISSN 0304-3940.  504(2), s 79- 82 . doi: 10.1016/j.neulet.2011.08.057
  • Manger, Mari Skar; Strand, Tor A; Taneja, Sunita; Refsum, Helga; Ueland, Per Magne; Nygård, Ottar; Schneede, Jørn; Sommerfelt, Halvor & Bhandari, Nita (2011). Cobalamin Status Modifies the Effect of Zinc Supplementation on the Incidence of Prolonged Diarrhea in 6-to 30-Month-Old North Indian Children. Journal of Nutrition.  ISSN 0022-3166.  141(6), s 1108- 1113 . doi: 10.3945/jn.110.127415
  • Manger, Mari Skar; Taneja, Sunita; Strand, Tor A; Ueland, Per Magne; Refsum, Helga; Schneede, Jørn; Nygård, Ottar; Sommerfelt, Halvor & Bhandari, Nita (2011). Poor folate status predicts persistent diarrhea in 6- to 30-month-old north Indian children. Journal of Nutrition.  ISSN 0022-3166.  141(12), s 2226- 2232 . doi: 10.3945/jn.111.144220
  • Vinknes, Kathrine; De Vogel, Stefan; Elshorbagy, Amany K; Nurk, Eha; Drevon, Christian A; Gjesdal, Clara Gram; Tell, Grethe S; Vollset, Stein Emil & Refsum, Helga (2011). Dietary intake of protein is positively associated with percent body fat in middle-aged and older adults. Journal of Nutrition.  ISSN 0022-3166.  141(3), s 440- 446 . doi: 10.3945/jn.110.133710
  • Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah J.; Zuccolo, Luisa; Smith, George Davey; Chen, Lina; Harris, Ross; Davis, Michael I.; Marsden, Gemma; Johnston, Carole; Lane, J. Athene; Ebbing, Marta; Bønaa, Kaare Harald; Nygård, Ottar; Ueland, Per Magne; Grau, Maria V.; Baron, John A.; Donovan, Jenny L.; Neal, David E.; Hamdy, Freddie C.; Smith, A. David & Martin, Richard M. (2010). Circulating folate, vitamin B-12, homocysteine, vitamin B-12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  19(6), s 1632- 1642 . doi: 10.1158/1055-9965.EPI-10-0180
  • Collin, Simon M.; Metcalfe, Chris; Refsum, Helga; Lewis, Sarah; Smith, George Davey; Cox, Angela; Davis, M.; Marsden, Gemma; Johnston, Carole; Lane, J. Athene; Donovan, Jenny L.; Neal, David E.; Hamdy, Freddie C.; Smith, AD & Martin, Richard M (2010). Associations of Folate, Vitamin B-12, Homocysteine, and Folate-Pathway Polymorphisms with Prostate-Specific Antigen Velocity in Men with Localized Prostate Cancer. Cancer Epidemiology, Biomarkers and Prevention.  ISSN 1055-9965.  19(11), s 2833- 2838 . doi: 10.1158/1055-9965.EPI-10-0582
  • de Lau, LML; van Meurs, JBJ; Uitterlinden, André G.; Smith, AD; Refsum, Helga; Johnston, C & Breteler, MMB (2010). Genetic variation in homocysteine metabolism, cognition, and white matter lesions. Neurobiology of Aging.  ISSN 0197-4580.  31(11), s 2020- 2022 . doi: 10.1016/j.neurobiolaging.2008.10.004
  • Deshmukh, U.S.; Joglekar, Charudatta V; Lubree, Himangi G; Ramdas, LV; Bhat, Dattatray S; Naik, Sadanand S; Hardikar, P.S.; Raut, D.A.; Konde, T.B.; Wills, A.K.; Jackson, AA; Refsum, Helga; Nanivadekar, A.S.; Fall, Caroline H & Yajnik, Chittaranjan S (2010). Effect of physiological doses of oral vitamin B-12 on plasma homocysteine: a randomized, placebo-controlled, double-blind trial in India. European Journal of Clinical Nutrition.  ISSN 0954-3007.  64(5), s 495- 502 . doi: 10.1038/ejcn.2010.15
  • Ebbing, M; Bønaa, Kaare Harald; Arnesen, E; Ueland, PM; Nordrehaug, Jan Erik; Rasmussen, K; Njølstad, I; Nilsen, DW; Refsum, H; Tverdal, Aage; Vollset, Stein Emil; Schirmer, H; Bleie, Ø; Steigen, Terje; Midttun, Ø; Fredriksen, Å; Pedersen, ER & Nygård, O (2010). Combined analyses and extended follow-up of two randomized controlled homocysteine-lowering B-vitamin trials. Journal of Internal Medicine.  ISSN 0954-6820.  268(4), s 367- 382 . doi: 10.1111/j.1365-2796.2010.02259.x
  • Elshorbagy, Amany K; Valdivia-Garcia, Maria; Refsum, Helga; Smith, A.D.; Mattocks, Dwight A.L. & Perrone, Carmen E. (2010). Sulfur amino acids in methionine-restricted rats: Hyperhomocysteinemia. Nutrition - The International Journal of Applied and Basic Nutritional Sciences.  ISSN 0899-9007.  26(11-12), s 1201- 1204 . doi: 10.1016/j.nut.2009.09.017
  • Hay, Gry; Clausen, Torun; Whitelaw, Andrew; Trygg, Kerstin Ulla; Johnston, Carole; Henriksen, Tore & Refsum, Helga (2010). Maternal Folate and Cobalamin Status Predicts Vitamin Status in Newborns and 6-Month-Old Infants. Journal of Nutrition.  ISSN 0022-3166.  140(3), s 557- 564 . doi: 10.3945/jn.109.117424
  • Løland, Kjetil Halvorsen; Bleie, Øyvind; Blix, Are Jordahl; Strand, Elin; Ueland, Per Magne; Refsum, Helga; Ebbing, Marta; Nordrehaug, Jan Erik & Nygård, Ottar (2010). Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a western Norway B vitamin intervention trial (WENBIT) substudy. American Journal of Cardiology.  ISSN 0002-9149.  105(11), s 1577- 1584 . doi: 10.1016/j.amjcard.2010.01.019
  • Manger, Mari Skar; Strand, Elin; Ebbing, Marta; Seifert, Reinhard; Refsum, Helga; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Drevon, Christian A; Tell, Grethe S; Bleie, Øyvind; Vollset, Stein Emil; Pedersen, Eva Kristine Ringdal & Nygård, Ottar (2010). Dietary intake of n-3 long-chain polyunsaturated fatty acids and coronary events in Norwegian patients with coronary artery disease. American Journal of Clinical Nutrition.  ISSN 0002-9165.  92(1), s 244- 251 . doi: 10.3945/ajcn.2010.29175 Show summary
  • Nurk, Eha; Refsum, Helga; Drevon, Christian A; Tell, Grethe S; Nygaard, Harald; Engedal, Knut Arne & Smith, David A (2010). Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. British Journal of Nutrition.  ISSN 0007-1145.  104(8), s 1190- 1201 . doi: 10.1017/S0007114510001807
  • Oulhaj, Abderrahim; Refsum, Helga; Beaumont, Helen; Williams, Jonathan; King, Elizabeth; Jacoby, Robin & Smith, David (2010). Homocysteine as a predictor of cognitive decline in Alzheimer's disease. International Journal of Geriatric Psychiatry.  ISSN 0885-6230.  25(1), s 82- 90
  • Smith, AD; Smith, Stephen M.; de Jager, Celeste; Whitbread, P; Johnston, Carole; Agacinski, G; Oulhaj, Abderrahim; Bradley, Kevin M.; Jacoby, Robin & Refsum, Helga (2010). Homocysteine-Lowering by B Vitamins Slows the Rate of Accelerated Brain Atrophy in Mild Cognitive Impairment: A Randomized Controlled Trial. PLOS ONE.  ISSN 1932-6203.  5(9) . doi: 10.1371/journal.pone.0012244
  • Antoniades, C; Shirodaria, C; Leeson, P; Bårholm, Otto Andreas; Van-Assche, T; Cunnington, C; Pillai, R; Ratnatunga, C; Tousoulis, D; Stefanadis, C; Refsum, Helga & Channon, KM (2009). MTHFR 677 C > T Polymorphism Reveals Functional Importance for 5-Methyltetrahydrofolate, Not Homocysteine, in Regulation of Vascular Redox State and Endothelial Function in Human Atherosclerosis. Circulation.  ISSN 0009-7322.  119(18), s 2507- U147 . doi: 10.1161/CIRCULATIONAHA.108.808675
  • Bhat, Dattatray S; Thuse, Nileema V; Lubree, Himangi G; Joglekar, Charudatta V; Naik, Sadanand S; Randas, Lalita V; Johnston, Carole; Refsum, Helga; Fall, Caroline H & Yajnik, Chittaranjan S (2009). Increases in plasma holotranscobalamin can be used to assess vitamin B-12 absorption in individuals with low plasma vitamin B-12. Journal of Nutrition.  ISSN 0022-3166.  139(11), s 2119- 2123 . doi: 10.3945/jn.109.107359
  • de Lau, LML; Smith, AD; Refsum, Helga; Johnston, C & Breteler, MMB (2009). Plasma vitamin B-12 status and cerebral white-matter lesions. Journal of Neurology, Neurosurgery and Psychiatry.  ISSN 0022-3050.  80(2), s 149- 157 . doi: 10.1136/jnnp.2008.149286

View all works in Cristin

  • Skålhegg, Bjørn Steen & Refsum, Helga (2012). Mat og Medisin. Kapittel 11, B-vitaminer. Cappelen Damm Akademisk.  ISBN 978-82-7634-967-2.  18 s.

View all works in Cristin

  • Refsum, Helga & Smith, A. David (2017). To the editor. JAMA pediatrics.  ISSN 2168-6203.  171(7), s 710- 711 . doi: 10.1001/jamapediatrics.2017.0866
  • Smith, A. David; Refsum, Helga & Jacoby, Robin (2016). Evidence-based prevention and treatment of dementia. Lancet Neurology.  ISSN 1474-4422.  15(10), s 1005- 1006 . doi: 10.1016/S1474-4422(16)30074-6
  • Smith, A. David; Refsum, Helga; Selhub, Jacob & Rosenberg, Irwin H. (2016). Decision on folic acid fortification in Europe must consider both risks and benefits. BMJ. British Medical Journal.  ISSN 1756-1833.  352:i734, s 1- 2 . doi: 10.1136/bmj.i734
  • Smith, David A; de Jager, Celeste A.; Refsum, Helga & Rosenberg, Irwin H. (2015). Homocysteine lowering, B vitamins, and cognitive aging. American Journal of Clinical Nutrition.  ISSN 0002-9165.  101(2), s 415- 416 . doi: 10.3945/ajcn.114.098467
  • Dalen, Knut Tomas; Haj-Yasein, Nadia Nabil; Berg, Ole; Refsum, Helga & Nebb, Hilde Irene (2014). Cysteine and adipocyte differentiation.
  • Strand, Tor; Taneja, Sunita; Kumar, Tivendra; Manger, Mari Skar; Refsum, Helga; Yajnik, Chittaranjan S & Bhandari, Nita (2014). The Effect of Daily Vitamin B12 and Folic Acid Supplementation on Growth in 6-30 Month Old Children in India: A Randomized Controlled Trial.
  • Smith, A. David & Refsum, Helga (2012). Do we need to reconsider the desirable blood level of vitamin B12?. Journal of Internal Medicine.  ISSN 0954-6820.  271(2), s 179- 182 . doi: 10.1111/j.1365-2796.2011.02485.x
  • Clarke, Robert; Halsey, J; Lewington, S; Lonn, E; Armitage, J.; Manson, JE; Bønaa, KH; Spence, JD; Nygård, Ottar; Jamison, R; Gaziano, JM; Guarino, Peter; Bennett, D; Mir, F; Peto, R.; Collins, Rory; Collaborators:, WENBIT; Ebbing, Marta; Nordrehaug, Jan Erik; Nilsen, Dennis W.T.; Refsum, Helga; Vollset, Stein Emil; Nygård, Ottar & Ueland, Per Magne (2010). Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: Meta-analysis of 8 randomized trials involving 37 485 individuals.
  • Strand, Tor A; Sharma, PR; Chandyo, RK; Refsum, Helga; Ulak, M; Adhikari, RK & Sommerfelt, Halvor (2009). FOLATE AND VITAMIN B12 STATUS IN YOUNG NEPALESE CHILDREN. Annals of Nutrition and Metabolism.  ISSN 0250-6807.  55, s 488- 489
  • Ebbing, Marta; Bønaa, Kaare Harald; Nordrehaug, Jan Erik; Ueland, Per Magne; Arnesen, Egil; Refsum, Helga; Njølstad, Inger; Nilsen, Dennis W.T.; Rasmussen, Knut & Nygård, Ottar (2009). Combined results and long-term follow-up in NORVIT and WENBIT with 6837 coronary artery disease patients: Homocysteine-lowering B-vitamin treatment does not prevent major cardiovascular events. European Heart Journal 2009: 30 (Abstract Supplement), 184. P 1274. Show summary

View all works in Cristin

Published Apr. 13, 2011 2:40 PM - Last modified Jan. 29, 2014 12:34 PM