Hesso Farhan

Professor - Cell signalling
Image of Hesso Farhan
Norwegian version of this page
Phone +47-22851217
Room 1238
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1112 Blindern 0372 OSLO

Academic interests

  • Proteostasis and its role in cancer and neurodegeneration
  • Intracellular membrane trafficking
  • Regulation of signal transduction pathways in time and space
  • Rho GTPases on endomembranes
  • Migration and invasion of cancer cells

Courses taught

  • 10 Lectures and hormones and cellular signalling in Modul 1 (MED1100)
  • 11 Lectures on the endocrine system, liver detoxification and muscle metabolism in Modul 2 (MED2200)
  • Small group teaching (LSB) in Modul 2 (MED2200) 


  • Since 2019: Professor at the University of Oslo
  • 2016-2018: Associate Professor at the University of Oslo
  • 2014: Habilitation in Cell Biology and Biochemistry at the University of Konstanz, Germany 
  • 2011-2016: Junior group leader at the Biotechnology Institute Thurgau, Switzerland and University of Konstanz, Germany
  • 2007-2011: Postdoc at the Biozentrum, University of Basel, Switzerland
  • 2004: Doctor of Medical Sciences, Medical University of Vienna, Austria
  • 2002: finished medical school at the University of Vienna, Austria

Awards and Grants

  • 2019: H2020-MSCA-ITN grant
  • 2016: Grant from the Norwegian Research Council
  • 2016: Grant from the Norwegian Cancer Society
  • 2011-2016: 3 Grants from the German Science Foundation (DFG), 3 Grants from the Swiss Science Foundation (SNF)
  • 2007: EMBO long term fellowship
  • 2004: ZAK Pharma award


  • Christian Behrends, Ludwig Maximilians University, Munich, Germany
  • Christoph Driessen, Kantonsspital St. Gallen, Switzerland
  • Santiago Schnell, University of Michigan, USA
  • Ruth Palmer, University of Gothenburg, Sweden
  • Susan Ferro-Novick, University of California at San Diego, USA
  • Eelco vanAnken, San Raffaele Scientific Institute, Milan, Italy
  • Roded Sharan, University of Tel-aviv, Israel
  • Eduardo Alvarez-Miranda, University of Talca, Chile
  • Walter Kolch, University College Dublin, Ireland
  • Boris Kholodenko, University College Dublin, Ireland
  • Franck Perez, Institut Curie, Pais, France
  • Matthias Weiss, University of Bayreuth, Germany 


Tags: Cell signalling, Cancer biology, Membrane trafficking, Metastasis, Cell biology, Proteostasis


Selected Publications:

1) Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho HC, Reggiori F, Farhan H*, Brodsky JL*, Ferro-Novick S. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science. 365, 53-60. (2019)

* Equal contribution


2) Centonze FG, Reiterer V, Nalbach K, Saito K, Pawlowski K, Behrends C, Farhan H. LTK is an ER-resident receptor tyrosine kinase that regulates secretion. J Cell Biol.  218, 2470-2480. (2019)


3) Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H. The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7function. EMBO Journal 36(3):260-273. (2017)


4) Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel B, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C. (2015) TECPR2 cooperates with LC3C to regulate COPII dependent ER export. Mol Cell, 60(1):89-104 (2015).


5) Millarte V, Boncompain G, Tillmann K, Perez F, Sztul E, Farhan H. Phospholipase C gamma 1 regulates early secretory trafficking and cell migration via interaction with p115. Mol Biol Cell. 26(12):2263-78. (2015)


6) Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Sharan R, Legler DF, Weiss M, Farhan H. Regulation of Sec16 levels and dynamics links proliferation and secretion. J Cell Sci. 128(4):670-682. (2015)


7) Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nature Commun. 5:4839. (2014)


8) Reiterer V, Fey D, Kolch W, Kholodenko B, Farhan H.Pseudophosphatase STYX modulates cell fate decisions and cell migration by spatio-temporal regulation of ERK1/2. Proc Natl Acad Sci. 110(31):E2934-2943. (2013)


9) Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady N, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D and Ivan Dikic I. Phosphorylation of the Autophagy Receptor Optineurin restricts Salmonella Growth. Science 333:228-233. (2011)


10) Farhan H, Wendeler MW, Mitrovic S, Fava E, Silberberg Y, Sharan R, Zerial M, Hauri HP. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. J Cell Biol 189:997-1011. (2010)


11) Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J  27:2043-2054. (2008)

  • Centonze, Federica Grazia & Farhan, Hesso (2019). Crosstalk of endoplasmic reticulum exit sites and cellular signaling. FEBS Letters.  ISSN 0014-5793.  s 1- 9 . doi: 10.1002/1873-3468.13569
  • Farhan, Hesso; Legler, D; Uetz-von Allmen, Edith & Rippl, Alexandra V (2018). A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking. Journal of Leukocyte Biology.  ISSN 0741-5400. . doi: 10.1002/JLB.2VMA1217-429R
  • Farhan, Hesso & Zahoor, Muhammad (2018). Crosstalk of Autophagy and the Secretory Pathway and Its Role in Diseases. International Review of Cell and Molecular Biology.  ISSN 1937-6448.  337, s 153- 184 . doi: 10.1016/bs.ircmb.2017.12.004
  • Saponara, Enrica; Visentin, Michele; Baschieri, Francesco; Seleznik, Gitta; Martinelli, Paola; Esposito, Irene; Buschmann, Johanna; Chen, Rong; Parrotta, Rossella; Borgeaud, Nathalie; Bombardo, Marta; Malagola, Ermanno; Caflisch, Amedeo; Farhan, Hesso; Graf, Rolf & Sonda, Sabrina (2018). Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. Journal of Pathology.  ISSN 0022-3417.  246(3), s 352- 365 . doi: 10.1002/path.5147
  • Farhan, Hesso; Kundu, Mondira & Ferro-Novick, Susan (2017). The link between autophagy and secretion: A story of multitasking proteins. Molecular Biology of the Cell.  ISSN 1059-1524.  28(9), s 1161- 1164 . doi: 10.1091/mbc.E16-11-0762 Full text in Research Archive.
  • Murphy, James M.; Farhan, Hesso & Eyers, Patrick A. (2017). Bio-Zombie: The rise of pseudoenzymes in biology. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 537- 544 . doi: 10.1042/BST20160400
  • Reiterer, Veronika; Pawłowski, Krzysztof & Farhan, Hesso (2017). STYX: A versatile pseudophosphatase. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 449- 456 . doi: 10.1042/BST20160279
  • Reiterer-Farhan, Veronika; Figueras‐Puig, Cristina; Le Guerroue,, Francois; Confalonieri, Stefano; Vecchi, Manuela; Jalapothu, Dasaradha; Kanse, Sandip; Deshaies, Raymond J; Di Fiore, Pier Paolo; Behrends, Christian & Farhan, Hesso (2017). The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function. EMBO Journal.  ISSN 0261-4189.  36(3), s 260- 273 . doi: 10.15252/embj.201694795
  • Farhan, Hesso (2016). Regulation of EGFR surface levels by COP II-dependent trafficking. Journal of Cell Biology.  ISSN 0021-9525.  215(4), s 441- 443 . doi: 10.1083/jcb.201611014

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Published Aug. 23, 2016 2:59 PM - Last modified Sep. 14, 2019 7:46 PM