Synaptic communication in healthy and diseased brains
My group studies how neurons in the mammalian brain communicate with each other at synapses. We use advanced electrophysiological, imaging and computer modeling techniques to analyze synaptic signaling mechanisms in presynaptic axons and postsynaptic dendrites.
Functional analysis of cortical interneuron axons. Inhibitory interneurons play a key role in several higher microcircuit functions, such as feedforward and feedback inhibition, high-frequency network oscillations, and temporal encoding of information in the brain. Many of these functions are critically dependent on the rapid and temporally precise release of GABA from inhibitory axon terminals. We study synaptic computation mechanisms in these interneuron axon terminals that are highly specialized in fast signaling.
Dendritic computation in the medial entorhinal cortex. Combining electrophysiological recording, 2-photon glutamate uncaging, and molecular manipulation of dendritic ion channels, we aim to understand how grid cells in the medial entorhinal cortex process synaptic input during spatial navigation.