Jason Matthews

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Image of Jason Matthews
Norwegian version of this page
Phone +47 22851102
Room 2201
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1046 Blindern 0317 Oslo

Academic Interests

We are interested in determining the mechanisms of aryl hydrocarbon receptor (AHR) signalling by endogenous compounds, dietary components and environmental contaminants. We study how AHR regulates gene expression, how its activation affects other receptor pathways, and how AHR functions in normal physiology, metabolic disease, cancer and inflammation/immunity. We are particularly interested in how these processes are influenced by the AHR regulated target gene, TIPARP (TCDD inducible poly-ADP-ribose polymerase). 

Teaching

  • ERN1010 - Innføring i klinisk ernæring
  • ERN3200 - Molecular, cellular and clinical nutrition
  • ERN2300 - Mikronæringsstoffer - fra molekylære mekanismer til klinikk
  • MED1100 - Medisinstudiet, modul 1
  • ERN4300 - Humanforsøk

Higher education and employment history

Education

  • 2001: Ph.D. - Department of biochemistry and Molecular Biology, Michigan State University, USA
  • 1997: B.Sc. Toxicology and Environmental Science, Faculty of Medicine, University of Western, Canada

Employment

  • 2015 – Professor, Dept of Nutrition, Faculty of Medicine, University of Oslo
  • 2016 - Statu-only Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2011-2015 Associate Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2012-2013 – Guest Professor, Dept of Nutrition, Faculty of Medicine, University of Oslo
  • 2006-2011 Assistant Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2001-2006 Postdoctoral Fellow, Dept of Biosciences and Nutrition Karolinska Institute, Sweden. Supervisor: Prof. Jan-Åke Gustafsson

Honoraria

  • 2011 - V. E. Henderson Award – Society of Toxicology Canada
  • 2011 - Early Researcher Award – Ministry of Research and Innovation Ontario Canada
  • 2009 - R. Gaurth Hansen Award Lectureship, Michigan State University
  • 2008 - Canadian Institutes of Health New Investigator Award 

Cooperation

Bjørn Skålhegg, Professor, University of Oslo Department of Nutrition, Norway, we collaborate on TIPARP and its role in immune cell function and cancer.

Kristen Bjørklund Holven, Professor, University of Oslo Department of Nutrition, Norway, we collaborate on AHR’s role in atherosclerosis and cardiovascular disease.

Akinori Takaoka, Professor and Director of the Institute for Genetic Medicine, Hokkaido Univ, Sapporo, Japan we collaborate on studies involving PARP7 and innate immunity.

Tim Zacharewski, Professor Michigan State Univ, USA, collaborates with us on projects related to AHR signalling in liver and dioxin toxicity. Our work with Prof Zacharewski includes the genomic characterization of the AHR signalling pathway in rodents.

Carolyn Baglole, Assistant Professor, McGill Univ, collaborates with us on projects related to AHR signalling in lung and airway epithelial. We work together on the characterization of AHR null lung cancer.

Carolyn Cummins, Associate Professor, Univ of Toronto, collaborates with us on projects related to AHR lipid and liver homeostasis.

Jan Vondracek, Professor, Institute of Biophysics, The Czech Academy of Sciences, collaborates with my group to characterize AHR signalling in breast cancer.

Michael Cohen, Associate Professor, Oregon Health & Science University collaborates of with my group on characterizing PARP7 function and identifying new small molecule inhibitors of PARP7 activity.
 

Publications

  • Vázquez-Gómez, Gerardo; Karasová, Martina; Tylichová, Zuzana; Kabátková, Markéta; Hampl, Aleš & Matthews, Jason [Show all 10 contributors for this article] (2022). Aryl Hydrocarbon Receptor (AhR) Limits the Inflammatory Responses in Human Lung Adenocarcinoma A549 Cells via Interference with NF-κB Signaling. Cells. ISSN 2073-4409. 11(4). doi: 10.3390/cells11040707.
  • Hutin, David; Hagen, Karoline Alvik; Shao, Peng; Sugamori, Kim; Grant, Denis M. & Matthews, Jason (2022). Reduced Colonic Mucosal Injury in 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Poly ADP-Ribose Polymerase (TIPARP/PARP7)-Deficient Mice. International Journal of Molecular Sciences. ISSN 1661-6596. 23(2). doi: 10.3390/ijms23020920.
  • Ronkainen, Justiina; Nedelec, Rozenn; Atehortua, Angelica; Balkhiyarova, Zhanna; Cascarano, Anna & Dang, Vien Ngoc [Show all 73 contributors for this article] (2022). LongITools: Dynamic longitudinal exposome trajectories in cardiovascular and metabolic noncommunicable diseases. Environmental Epidemiology. ISSN 2474-7882. 6(1). doi: 10.1097/EE9.0000000000000184.
  • Li, Bingyu B; Scott, Erica Y; Olafsen, Ninni Elise; Matthews, Jason & Wheeler, Aaron R (2021). Analysis of the effects of aryl hydrocarbon receptor expression on cancer cell invasion via three-dimensional microfluidic invasion assays. Lab on a Chip. ISSN 1473-0197. doi: 10.1039/d1lc00854d.
  • Lüscher, Bernhard; Ahel, I; Altmeyer, Matthias; Ashworth, Alan; Bai, Peter & Chang, Paul [Show all 47 contributors for this article] (2021). ADP-ribosyltransferases, an update on function and nomenclature . The FEBS Journal. ISSN 1742-464X. doi: 10.1111/febs.16142. Full text in Research Archive
  • Rodriguez, Kelly; Buch-Larsen, Sara C; Kirby, Ilsa; Rodriguez Siordia, Ivan; Hutin, David & Rasmussen, Marit [Show all 11 contributors for this article] (2021). Chemical genetics and proteome-wide site mapping reveal cysteine MARylation by PARP-7 on immune-relevant protein targets . eLIFE. ISSN 2050-084X. doi: 10.7554/eLife.60480. Full text in Research Archive
  • Hutin, David; Long, Alexandra S; Sugamori, Kim; Shao, Peng; Singh, Sachin Kumar & Rasmussen, Marit [Show all 11 contributors for this article] (2021). 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (Tiparp<sup>H532A</sup>) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality. Toxicological Sciences. ISSN 1096-6080. 183(1), p. 154–169. doi: 10.1093/toxsci/kfab075. Full text in Research Archive
  • Guerrina, Necola; Aloufi, Noof; Shi, Fangyi; Prasade, Kashmira; Mehrotra, Caitlin & Traboulsi, Hussein [Show all 10 contributors for this article] (2021). The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress. American Journal of Physiology - Lung cellular and Molecular Physiology. ISSN 1040-0605. 320(3), p. L339–L355. doi: 10.1152/AJPLUNG.00122.2020. Full text in Research Archive
  • Rasmussen, Marit; Tan, Susanna; Somisetty, Venkata Satheesh; Hutin, David; Olafsen, Ninni Elise & Moen, Anders [Show all 9 contributors for this article] (2021). PARP7 and Mono-ADP-Ribosylation Negatively Regulate Estrogen Receptor α Signaling in Human Breast Cancer Cells. Cells. ISSN 2073-4409. 10(3). doi: 10.3390/cells10030623.
  • Doskey, Claire M; Fader, Kelly A; Nault, Rance; Lydic, Todd; Matthews, Jason & Potter, Dave [Show all 9 contributors for this article] (2020). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic polyunsaturated fatty acid metabolism and eicosanoid biosynthesis in female Sprague-Dawley rats . Toxicology and Applied Pharmacology. ISSN 0041-008X. 398. doi: 10.1016/j.taap.2020.115034.
  • D'Anna, Flora; Van Dyck, Laurien; Xiong, Jieyi; Zhao, Hui; V Berrens, Rebecca & Qian, Junbin [Show all 25 contributors for this article] (2020). DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance . Genome Biology. ISSN 1465-6906. 21. doi: 10.1186/s13059-020-02087-z. Full text in Research Archive
  • Vondracek, Jan; Pěnčíková, Kateřina; Ciganek, Miroslav; Pivnička, Jakub; Karasová, Martina & Hýžďalová, Martina [Show all 14 contributors for this article] (2020). Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells . Environmental Pollution (1987). ISSN 0269-7491. 266. doi: 10.1016/j.envpol.2020.115125.
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2020). LXRα Regulates ChREBPα Transactivity in a Target Gene-Specific Manner through an Agonist-Modulated LBD-LID Interaction. Cells. ISSN 2073-4409. 9(5), p. 1–26. doi: 10.3390/cells9051214. Full text in Research Archive
  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). Open the LID: LXRα regulates ChREBPα transactivity in a target gene-specific manner through an agonist-modulated LBD-LID interaction. BioRxiv. ISSN 0362-4331. doi: 10.1101/2019.12.20.869974.
  • Grimaldi, Giulia; Vagaska, Barbora; Oleksandr, Ievglevskyi; Kondratskaya, Elena; Glover, Joel & Matthews, Jason (2019). Loss of Tiparp Results in Aberrant Layering of the Cerebral Cortex . eNeuro. ISSN 2373-2822. 6(6). doi: 10.1523/ENEURO.0239-19.2019. Full text in Research Archive
  • Volchenkov, Roman; Matthews, Jason; Zucknick, Manuela & Skålhegg, Bjørn Steen (2019). Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history. Cellular & Molecular Immunology. ISSN 1672-7681. 16(7), p. 674–675. doi: 10.1038/s41423-019-0230-4. Full text in Research Archive
  • Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Södling, Helen; Matthews, Jason & Paulsen, Steinar M [Show all 10 contributors for this article] (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 27(18), p. 4059–4068. doi: 10.1016/j.bmc.2019.07.032. Full text in Research Archive
  • Cho, Tiffany; Bott, Debbie; Ahmed, Shaimaa; Hutin, David; Gomez, Alvin & Tamblyn, Laura [Show all 10 contributors for this article] (2019). 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. International Journal of Molecular Sciences. ISSN 1661-6596. 20(9), p. 1–15. doi: 10.3390/ijms20092312. Full text in Research Archive
  • Koivisto, Anu; Olsen, Thomas; Paur, Ingvild; Paulsen, Gøran; Bastani, Nasser Ezzatkhah & Garthe, Ina [Show all 10 contributors for this article] (2019). Effects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trial. PLOS ONE. ISSN 1932-6203. 14(6). doi: 10.1371/journal.pone.0217895. Full text in Research Archive

View all works in Cristin

  • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin & Vekterud, Kristin [Show all 15 contributors for this article] (2019). LXRα interacts with the glucose-sensing transcription factor ChREBPα to regulate its transcriptional activity.

View all works in Cristin

Published Sep. 29, 2015 4:05 PM - Last modified Mar. 9, 2022 11:37 AM