Jason Matthews

Professor - Molecular Toxicology
Image of Jason Matthews
Norwegian version of this page
Phone +47-22851102
Room 2201
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1046 Blindern 0317 OSLO

Academic Interests

We are interested in determining the mechanisms of aryl hydrocarbon receptor (AHR) signalling by endogenous compounds, dietary components and environmental contaminants. We study how AHR regulates gene expression, how its activation affects other receptor pathways, and how AHR functions in normal physiology, metabolic disease, cancer and inflammation/immunity. We are particularly interested in how these processes are influenced by the AHR regulated target gene, TIPARP (TCDD inducible poly-ADP-ribose polymerase). 


  • ERN3003 - Epigenetisk analyse av stam- og kreftceller
  • ERN3120 - Molecular, cellular and clinical nutrition
  • ERN2300 - Mikronæringsstoffer - fra molekylære mekanismer til klinikk
  • MED1100 - Medisinstudiet, modul 1
  • ERN4120 - Humanforsøk
  • ERN4210 - Masteremne i ernæringsbiologi

Higher education and employment history


  • 2001: Ph.D. - Department of biochemistry and Molecular Biology, Michigan State University, USA
  • 1997: B.Sc. Toxicology and Environmental Science, Faculty of Medicine, University of Western, Canada


  • 2015 – Professor, Dept of Nutrition, Faculty of Medicine, University of Oslo
  • 2011-2015 Associate Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2012-2013 – Guest Professor, Dept of Nutrition, Faculty of Medicine, University of Oslo
  • 2006-2011 Assistant Professor, Dept of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Canada
  • 2001-2006 Postdoctoral Fellow, Dept of Biosciences and Nutrition Karolinska Institute, Sweden. Supervisor: Prof. Jan-Åke Gustafsson


  • 2011 - V. E. Henderson Award – Society of Toxicology Canada
  • 2011 - Early Researcher Award – Ministry of Research and Innovation Ontario Canada
  • 2009 - R. Gaurth Hansen Award Lectureship, Michigan State University
  • 2008 - Canadian Institutes of Health New Investigator Award 


  • Prof. Hilde Irene Nebb, Assoc. Prof. Knut Tomas Dalen and Prof. Bjørn Skålegg Department of Nutrition, Faculty of Medicine, Institute for Basic Medical Sciences, University of Oslo, Oslo Norway
  • Dr. Jan Haug Anonsen and Anders Moen, Department of Biosciences, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo Norway 
  • Prof. Akinori Takaoka, M.D., Ph.D. Director of the Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
  • Dr. Carolyn Baglole, Meakins-Christie Laboratories, McGill University, Montreal, QC Canada
  • Prof. Tim Zacharewski, Department of Biochemistry, Michigan State University, East Lansing Michigan USA


Research Articles and Book Chapters

•    Nault, R., Fader, K.A., Kirby, M.P., Ahmed, S., Matthews, J., Jones, D.A., Lunt, S.Y., Zacharewski, T.R. Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicol Sci In press. 

•    Sarill, M., Zago, M., Shreidan, J.A., Nair, P., Matthews, J., Gomez, A., Hamid, Q., Eidelman, D.H., and Baglole, C.J. (2015) The aryl hydrocarbon receptor suppresses cigarette smoke-induced oxidative stress via dioxin response element (DRE)-independent regulation of sulfiredoxin 1. Free Radical Biology and Medicine 89:342-357.

•    Ahmed, S., Bott, D., Gomez, A., Tamblyn, L., Raheed, A., MacPherson, L., Sugamuri, K.S., Cho, T. Yang, S., Grant, D.M. Cummins, C. and Matthews, J. (2015) Loss of the Mono-ADP-Ribosyltransferase, TIPARP, increases sensitivity to dioxin-induced steatohepatitis and lethality. J. Biol. Chem 290(27):16824-40.

•    Bindesboll, C., Fan, Q., Ruan, H-B., MacPherson, L., Wu, J., Norgaard, R.C., Steffensen, K.R., Yang, X., Matthews, J., Mandrup, S., Nebb, H.I., Gronning-Wang, L. (2015) Liver X Receptor Regulates Hepatic Nuclear O-GlcNAc Cycling and Carbohydrate Responsive Element-Binding Protein Activity. J of Lipid Res 56(4):771-85. 

•    Hecht, E., Zago, M., Rico de Souza, A., Gomez, A., Matthews, J., Hamid, Q., Eidelman, D.H., and Baglole, C.J. (2014) Aryl hydrocarbon receptor-dependent regulation of miR-196a expression controls lung fibroblast apoptosis but not proliferation. Toxicol Appl Pharmacol. Nov 280(3):511-25. 

•    MacPherson, L., Ahmed, S., Tamblyn, L., Krutmann, J., Forster, I., Weighardt, H., and Matthews, J. (2014) Aryl hydrocarbon receptor repressor and TiPARP (ARTD14) use similar, but also distinct mechanisms to repress aryl hydrocarbon receptor signaling. Int J Mol Sci. 15(5):7939-57.

•    Ahmed, S., Wang, A., Celius, T, and Matthews, J. (2014) Zinc finger nuclease-mediated knockout of AHR or ARNT in human breast cancer cells abolishes basal and ligand-dependent regulation of CYP1B1 and differentially affects estrogen receptor  transactivation Toxicol Sci. Mar;138(1):89-103

•    Lo, R., and Matthews, J. (2013) The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 (NRF2) transactivation in MCF-7 breast cancer cells. Toxicol Appl Pharmacol Jul 15;270(2):139-48.

•    MacPherson, L., Tamblyn, L., Rajendra, S., Bralha, F., McPherson, J.P., and Matthews, J. (2013) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poly(ADP-ribose) polymerase (TiPARP) is a mono-ADP-ribosyltransferase and repressor of aryl hydrocarbon receptor transactivation. Nucleic Acid Res. Feb 1;41(3):1604-21.

•    Wu, A., Dalvi, P., Lu, X., Yang, M., Riddick, D., Matthews, J., Clevenger, C.V., Ross, D.D., Harper, P., and Ito, S. (2013) Induction of multidrug resistance transporter ABCG2 by prolactin in human breast cancer cells. Mol. Pharm Feb;83(2):377-88.

•    Matthews, J. and Ahmed, S. AHR and ER mediated toxicology and chemoprevention, In Advances in Molecular Toxicology volume 7. Editor: James C Fishbein. Elsevier Amsterdam, The Netherlands 2013.

•    Lo, R and Matthews, J. (2012) High-resolution genome-wide mapping of AHR and ARNT binding sites by ChIP-Seq. Toxicol Sci August 30(2):349-61. 

•    Ahmed, S., Al-Saigh, Sarra and Matthews, J (2012) FOXA1 is essential for aryl hydrocarbon receptor-dependent regulation of cyclin G2. Mol Can Res. May 10(5):636-48.

•    Lo, R., Forgacs, A., Celius, T., MacPherson, L., Harper, P., Zacharewski, T., and Matthews, J. (2011) Identification of Aryl Hydrocarbon Receptor Binding Targets in mouse hepatic tissue treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol Nov 257(1):38-47

•    Dere, E., Lo, R., Celius, T. Matthews, J., and Zacharewski, T. (2011) Integration of Genome-Wide Computation DRE Search, AhR ChIP-chip and Gene Expression Analyses of TCDD-Elicited Responses in the Mouse Liver. BMC Genomics Jan 12(1):365.

•    Powis, M., Celius, T., and Matthews, J. (2011) Differential ligand-dependent activation and a role for Y322 in aryl hydrocarbon receptor-mediated transcription. Biochem Biophys Res Comm. Jul 410(4):859-65.

•    Celius, T and Matthews, J. (2010) Functional analysis of six aryl hydrocarbon receptor variants in human breast cancer and mouse hepatoma cell lines. Toxicology Nov 277, 59-65. 

•    MacPherson. L. and Matthews, J. (2010) Inhibition of AHR-dependent transcription by resveratrol or kaempferol is independent of estrogen receptor alpha in T-47D human breast cancer cells. Cancer Lett, Dec 299, 119-129. 

•    Pansoy, A., Ahmed, S., Valen, E., Sandelin, A., and Matthews, J. (2010) 3-methylcholanthrene-induces differential recruitment of aryl hydrocarbon receptor to human promoters. Toxicol Sci Sept 117, 90–100. 

•    Celius, T., Pansoy, A., Matthews, J. Okey, A.B. Henderson, M., Krueger, S., and Williams, D. (2010) Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver. Toxicol Appl Pharmacol Aug 247(1), 60-69. 

•    Lo, R and Matthews, J A New Class of Estrogen Receptor Beta–Selective Activators  (2010) Mol Interventions Jun;10(3):133-6 

•    Lo, R., Burgoon, L., MacPherson, L., Ahmed, S. and Matthews, J. (2010) Estrogen receptor and estrogen dependent regulation of CYP2B6 in human breast cancer cells. BBA Gen Regulatory Mechanisms. May 1799 (5-6), 469-479. 

•    Ahmed, S, Valen, E., Sandelin, A., and Matthews, J. (2009). Dioxin increases the interaction between aryl hydrocarbon receptor and estrogen receptor alpha at human promoters. Toxicol Sci 111, 254-266. 

•    Wihlen, B., Ahmed, S., Inzunza, J., and Matthews, J. (2009) Estrogen receptor subtype- and promoter-specific modulation of aryl hydrocarbon receptor transactivation. Mol Cancer Res June 7 (6), 977-986. 

•    MacPherson, L., Lo, R., Ahmed, S, Pansoy, P., and Matthews, J. (2009) Activation Function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1. Biochem Biophys Res Comm July 385, 263-268. 

•    Celius, T., Roblin, S., Harper, P.A., Boutros, P.C., Moffat, I.D., Wendelin, D., Matthews, J., Pohjanvirta, R., and Okey, A.B. (2008) Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver. Drug Metab Dispos 36, 2499-2505. 

•    Matthews, J., Wihlen, B., Heldring, N., Helguero, L., Macpherson, L., Treuter, E., Haldosen, L- A. and Gustafsson, J-A. (2007) Coplanar 3,3’,4,4’,5-pentachlorinated biphenyl and non-coplanar 2,2’,4,6,6’-pentachlorinated biphenyl differentially induce recruitment of estrogen receptor  to aryl hydrocarbon receptor target genes. Biochem J Sept 406(2), 343–353. 

•    Heldring, N., Pike, A., Andersson, S., Matthews, J., Cheng, G., Hartman, J., Tujague, M., Strom, A., Treuter, E., Warner, M., and Gustafsson, J-A. (2007) Estrogen receptors: how do they signal and what are their targets. Physiol Rev Jul 87(3), 905-931. 

•    Zhao, C., Matthews, J., Tujague, M., Wan, J., Strom, A., Toresson, G., Lam, E., Cheng, G., Gustafsson, J-A and Dahlman-Wright, K. (2007) Estrogen receptor 2 negatively regulates the transactivation of estrogen receptor  in human breast cancer cells. Cancer Res 67, 3955-3962. 

•    Matthews, J. and Gustafsson, J-A. (2006) Estrogen receptor and aryl hydrocarbon receptor signalling pathways. Nucl Recept Signal e016 Epub 2006 Jul 7 (perspective) 

•    Matthews, J. Wihlen, B., Strom, A., and Gustafsson, J-A. (2006) ERbeta modulates ERalpha-mediated transcriptional activation by altering the recruitment of c-Fos and c-Jun to estrogen responsive promoters. Mol Endocrinol Mar;20(3):534-43. 

•    Matthews, J., Almlof, T, Kietz, S. Leers, Jörg, L., and Gustafsson, J-A. (2005) Estrogen regulation of SOCS-3 in human breast cancer cells. Biochem Biophys Res Comm Sep 16;335(1), 168-174. 

•    Huang, Y-W., Matthews, J., Fertuck, K., and Zacharewski, T.R. (2005) Use of Xenopus laevis as a model for investigating in vitro and in vivo endocrine disruption in amphibians. Toxicol Appl Pharmacol Aug;24(8), 2002-2009. 

•    Matthews, J.  Whilen, B., Thomsen, J., and Gustafsson, J-A. (2005) Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor to TCDD responsive promoters. Mol Cell Biol Jul;25(13), 5317-5328. 

•    Bavner, A., Matthews, J.,  Gustafsson, J-A. and Treuter, E. (2005) A role of EID3 in tissue-specific coactivator antagonism. Nucl Acids Res Jun 24;33(11), 3561-3569. 

•    Kietz, S., Thomsen, J.S., Matthews, J.,  Pettersson, K., Strom, A., and Gustafsson, J-A. (2004) The AhR inhibits estrogen-induced estrogen receptor beta in breast cancer cells. Biochem Biophys Res Comm Jul 16;320(1), 76-82. 

•    Antonson, P., Al-Beidh, F., Matthews, J. and Gustafsson, J-A (2004) RAP250 gene: genomic structure and promoter analysis. Gene Mar 3;327(2), 233-238. 

•    Sanyal, S., Matthews, J., Bouton, D., Choi, H-S., Treuter, E., and Gustafsson, J-A. (2004) DNA-response element-dependent regulation of transcription by orphan nuclear receptor estrogen receptor- related receptor gamma (ERRgamma), Mol Endocrinol Feb;18(2), 312-325. 

•    Brunnberg, S., Pettersson, K., Rydin, E., Matthews, J., Hanberg, A., and Pongratz, I. (2003) The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc Natl Acad Sci USA May 27;100(11), 6517-6522. 

•    Matthews, J. and Gustafsson, J-A. (2003) Estrogen signalling: a subtle balance between ERalpha and ERbeta.  Mol Intervent Aug;3(5) 281-292. 

•    Matthews, J., Celius, C., Fertuk, K., Huang, Y-W., Fong, C., and Zacharewski, T.R. (2002) Ability of several natural and synthetic estrogenic chemicals to induce gene expression mediated by estrogen receptors from several vertebrate species. J Steroid Biochem Mol Bio Oct;82(2-3), 181-194. 

•    Rosen, G., O’Bryant, E., Matthews, J., Zacharewski, T.R., and Wade, J. (2002) Distribution of androgen receptor mRNA expression and immunoreactivity in the brain of the green anole lizard.  J Neuroendocrinol Jan;14(1), 19-28. 

•    Fielden, M.F., Matthews, J., Fertuck, K.F., Halgren, R.G., and Zacharewski, T.R. (2002) In silico approaches to mechanistic and predictive toxicology: an introduction to bioinformatics for toxicologists. Crit Rev Toxicol Mar;32(2), 67-112. 

•    Matthews, J., Clemons, J.H., and Zacharewski, T.R. (2001) Reciprocal mutagenesis between human alpha L349/M528 and rainbow trout M317/I496 estrogen receptor residues demonstrates their importance in ligand binding and gene expression at different temperatures. Mol Cell Endocrinol Oct 25;183(1-2), 127-139. 

•    Fertuck, K.F., Kumar, S., Sikka, H.C., Matthews, J., and Zacharewski, T.R.  (2001) Interaction of PAH-related compounds with the alpha and beta isoforms of the estrogen receptor. Toxicol Lett May 19;121(3), 167-177. 

•    Celius, T, Matthews, J., Giesy, J.P., and Zacharewski, T.R. (2001) Quantification of vitellogenin and zona radiata proteins from rainbow trout (Oncorhynchus mykiss) liver after in vivo treatment with alpha-zearalenol and estradiol-17beta using the TaqMan assay. J Steroid Biochem Mol Bio Dec 15;75(2-3), 109-119. 

•    Matthews, J., Twomey, K., and Zacharewski, T.R. (2001) Comparison of the interactions of bisphenol A and its metabolite bisphenol A glucuronide with estrogen receptors alpha and beta. Chem Res Toxicol Feb 14(2), 149-157. 

•    Fertuck, K.F., Matthews, J., and Zacharewski, T.R. (2000) Hydroxylated benzo[a]pyrene metabolites are responsible for in vitro estrogen receptor-mediated gene expression induced by benzo[a]pyrene, but do not elicit uterotrophic effects in vivo. Toxicol Sci Feb;59(2), 231-240. 

•    Matthews, J., Celius, T., Halgren, R., and Zacharewski, T.R. (2000) Differential estrogen receptor binding of estrogenic substances: a species comparison. J Steroid Biochem Mol Biol Nov 15;74(4), 223-234. 

•    Matthews, J., and Zacharewski, T.R. (1999) Differential binding affinities of PCBs, HO-PCBs and Aroclors with recombinant human, rainbow trout (Oncorhynchus mykiss) and reptilian (Anolis carolinensis) estrogen receptors using a semi-high throughput competitive binding assay. Toxicol Sci . Feb;53(2), 326-339. 

•    Zacharewski, T., Meek, M.D., Clemons, J.H., Wu, Z.F., Fielden, M.R. and Matthews, J. (1998) Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters. Toxicol Sci Dec;46 (2), 282-293.

Book chapters

•    Matthews, J. (2013) Alternative Negative Feedback Control in the Aryl Hydrocarbon Receptor Signaling Pathway. J of Drug Metabolism and Toxicol. Jan 4 (1) Invited Editorial 

•    Matthews, J. Aryl Hydrocarbon Receptor (AhR) Targeted by Xenobiotic Compounds and Dietary Phytochemicals, In Hormone-Disruptive Chemical Contaminants in Food. Editor: Ingemar Pongratz. RSC Issues in Toxicology Series. Cambridge, UK. 2011. 

•    Matthews, J. (2009) Estrogens as endogenous toxins. In Endogenous Toxins. Editors: P. O'Brien and R. Bruce. STMS Books Wiley-VCH Verlag GmbH & Co. Weinheim, Germany.

•    Zacharewski, T., Fertuck, K., Fielden, M., and Matthews, J. (2002) Mechanistically-based assays for the identification and characterization of endocrine disruptors. In Comprehensive Toxicology XIV: Cellular and Molecular Toxicology (Volume Editors: J.P. Vanden Heuvel, W.F. Greenlee, G.H. Perdew, W. Mattes, Editors-in-Chief: I.G. Sipes, C.A. McQueen, A.J. Gandolfi). Elsevier Science B.V., Amsterdam, The Netherlands 559-582.

    • Arnesen, Liv Henriette; Haj Yasein, Nadia; Tungen, Jørn Eivind; Södling, Helen; Matthews, Jason; Paulsen, Steinar M; Nebb, Hilde Irene; Sylte, Ingebrigt; Hansen, Trond Vidar & Sæther, Thomas (2019). Molecular modelling, synthesis, and biological evaluations of a 3,5-disubstituted isoxazole fatty acid analogue as a PPARα-selective agonist. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  27(18), s 4059- 4068 . doi: 10.1016/j.bmc.2019.07.032 Full text in Research Archive. Show summary
    • Cho, Tiffany; Bott, Debbie; Ahmed, Shaimaa; Hutin, David; Gomez, Alvin; Tamblyn, Laura; Zhou, Angela C.; Watts, Tania H.; Grant, Denis M & Matthews, Jason (2019). 3-Methylcholanthrene Induces Chylous Ascites in TCDD-Inducible Poly-ADP-Ribose Polymerase (Tiparp) Knockout Mice. International Journal of Molecular Sciences.  ISSN 1422-0067.  20(9), s 1- 15 . doi: 10.3390/ijms20092312
    • Koivisto, Anu; Olsen, Thomas; Paur, Ingvild; Paulsen, Gøran; Bastani, Nasser Ezzatkhah; Garthe, Ina; Raastad, Truls; Matthews, Jason; Blomhoff, Rune & Bøhn, Siv Kjølsrud (2019). Effects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trial. PLOS ONE.  ISSN 1932-6203.  14(6) . doi: 10.1371/journal.pone.0217895 Full text in Research Archive. Show summary
    • Volchenkov, Roman; Matthews, Jason; Zucknick, Karola Manuela & Skålhegg, Bjørn Steen (2019). Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history.. Cellular & Molecular Immunology.  ISSN 1672-7681. . doi: 10.1038/s41423-019-0230-4 Full text in Research Archive.
    • Volchenkov, Roman; Matthews, Jason; Zucknick, Manuela & Skålhegg, Bjørn Steen (2019). Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history. Cellular & Molecular Immunology.  ISSN 1672-7681.  16(7), s 674- 675 . doi: 10.1038/s41423-019-0230-4
    • Gomez, Alvin; Bindesbøll, Christian; Somisetty, Venkata Satheesh; Grimaldi, Giulia; Hutin, David; MacPherson, Laura; Ahmed, Shaimaa; Tamblyn, Laura; Cho, Tiffany; Nebb, Hilde Irene; Moen, Anders; Anonsen, Jan Haug; Grant, Denis M & Matthews, Jason (2018). Characterization of TCDD-inducible poly-ADP-ribose polymerase (TIPARP/ARTD14) catalytic activity. Biochemical Journal.  ISSN 0264-6021.  475(23), s 3827- 3846 . doi: 10.1042/BCJ20180347 Show summary
    • Grimaldi, Giulia; Rajemdra, Sharanya & Matthews, Jason (2018). The aryl hydrocarbon receptor regulates the expression of TIPARP and its cis long non-coding RNA, TIPARP-AS1. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  495(3), s 2356- 2362 . doi: 10.1016/j.bbrc.2017.12.113
    • Hutin, David; Grimaldi, Giulia & Matthews, Jason (2018). Methods to Study TCDD-Inducible Poly-ADP-Ribose Polymerase (TIPARP) Mono-ADP-Ribosyltransferase Activity. Methods in molecular biology.  ISSN 1064-3745.  1813, s 109- 124 . doi: 10.1007/978-1-4939-8588-3_8 Show summary
    • Hutin, David; Tamblyn, Laura; Gomez, Alvin; Grimaldi, Giulia; Soedling, Helen; Cho, Tiffany; Ahmed, Shaimaa; Lucas, Christin; Kanduri, Srinivasa Kalyana Chakravarthi; Grant, Denis M & Matthews, Jason (2018). Hepatocyte-Specific Deletion of TIPARP, a Negative Regulator of the Aryl Hydrocarbon Receptor, Is Sufficient to Increase Sensitivity to Dioxin-Induced Wasting Syndrome. Toxicological Sciences.  ISSN 1096-6080.  165(2), s 347- 360 . doi: 10.1093/toxsci/kfy136
    • Hyzdalova, Martina; Pivnicka, Jakub; Zapletal, Ondrej; Vazquez-Gomez, Gerardo; Matthews, Jason; Neca, Jiri; Pencikova, Katerina; Machala, Miroslav & Vondracek, Jan (2018). Aryl Hydrocarbon Receptor-Dependent Metabolism Plays a Significant Role in Estrogen-Like Effects of Polycyclic Aromatic Hydrocarbons on Cell Proliferation. Toxicological Sciences.  ISSN 1096-6080.  165(2), s 447- 461 . doi: 10.1093/toxsci/kfy153
    • Fader, Kelly A.; Nault, Rance; Kirby, Mathew P.; Markous, Gena; Matthews, Jason & Zacharewski, Tim R. (2017). Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicology and Applied Pharmacology.  ISSN 0041-008X.  321, s 1- 17 . doi: 10.1016/j.taap.2017.02.006
    • Fan, Qiong; Nørgaard, Rikke Christine; Bindesbøll, Christian; Lucas, Christin; Dalen, Knut Tomas; Babaie, Eshrat; Itkonen, Harri; Matthews, Jason; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2017). LXR? regulates hepatic ChREBP? activity and lipogenesis upon glucose, but not fructose feeding in mice. Nutrients.  ISSN 2072-6643.  9(7) . doi: 10.3390/nu9070678
    • Matthews, Jason (2017). AHR Toxicity and Signalling: Role of TIPARP and ADP-ribosylation. Current Opinion in Toxicology.  ISSN 2468-2020.  2, s 50- 57 . doi: 10.1016/j.cotox.2017.01.013
    • Rogers, Sarah; De Souza, Angela Rico; Zago, Michela; Iu, Matthew; Guerrina, Necola; Gomez, Alvin; Matthews, Jason & Baglole, Carolyn J. (2017). Aryl hydrocarbon receptor (AhR)-dependent regulation of pulmonary miRNA by chronic cigarette smoke exposure. Scientific Reports.  ISSN 2045-2322.  7 . doi: 10.1038/srep40539
    • Yang, Sunny Y; Ahmed, Shaimaa; Somisetty, Venkata Satheesh & Matthews, Jason (2017). Genome-wide mapping and analysis of aryl hydrocarbon receptor (AHR)- and aryl hydrocarbon receptor repressor (AHRR)-binding sites in human breast cancer cells. Archives of Toxicology.  ISSN 0340-5761.  92(1), s 225- 240 . doi: 10.1007/s00204-017-2022-x
    • Zago, Michela; Sheridan, Jared A; Traboulsi, Hussein; Hecht, Emelia; Zhang, Yelu; Guerrina, Necola; Matthews, Jason; Nair, Parameswaran; Eidelman, David H; Hamid, Qutayba & Baglole, Carolyn J. (2017). Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability. PLOS ONE.  ISSN 1932-6203.  12(7) . doi: 10.1371/journal.pone.0180881 Full text in Research Archive.
    • Bindesbøll, Christian; Tan, Susanna; Bott, Debbie; Cho, Tiffany; Tamblyn, Laura; MacPherson, Laura; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Matthews, Jason (2016). TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. Biochemical Journal.  ISSN 0264-6021.  473(7), s 899- 910 . doi: 10.1042/BJ20151077
    • Nault, Rance; Fader, Kelly A. Fader; Kirby, Mathew P.; Ahmed, Shaimaa; Matthews, Jason; Jones, Daniel; Lunt, Sophia Y. & Zacharewski, Tim R. (2016). Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicological Sciences.  ISSN 1096-6080.  149(2), s 358- 371 . doi: 10.1093/toxsci/kfv245
    • Yamada, Taisho; Horimoto, Hiromasa; Kameyama, Takeshi; Hayakawa, Sumio; Yamato, Hiroaki; Dazai, Masayoshi; Takada, Ayato; Kida, Hiroshi; Bott, Debbie; Zhou, Angela C.; Hutin, David; Watts, Tania H.; Asaka, Masahiro; Matthews, Jason & Takaoka, Akinori (2016). Constitutive aryl hydrocarbon receptor signaling constrains type I interferon-mediated antiviral innate defense. Nature Immunology.  ISSN 1529-2908.  17(6), s 687- 694 . doi: 10.1038/ni.3422
    • Bindesbøll, Christian; Fan, Qiong; Nørgaard, Rikke Christine; MacPherson, Laura; Ruan, Hai-Bin; Wu, Jing; Pedersen, Thomas Å; Steffensen, Knut R.; Yang, Xiaoyong; Matthews, Jason; Mandrup, Susanne; Nebb, Hilde Irene & Grønning-Wang, Line Mariann (2015). Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity[S. Journal of Lipid Research.  ISSN 0022-2275.  56, s 771- 785 . doi: 10.1194/jlr.M049130

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    • Fan, Qiong; Nørgaard, Rikke Christine; Grytten, Ivar; Ness, Cecilie Maria; Lucas, Christin; Vekterud, Kristin; Södling, Helen; Matthews, Jason; Lemma, Roza Berhanu; Gabrielsen, Odd Stokke; Bindesbøll, Christian; Ulven, Stine Marie; Nebb, Hilde Irene; Grønning-Wang, Line Mariann & Sæther, Thomas (2019). LXRα interacts with the glucose-sensing transcription factor ChREBPα to regulate its transcriptional activity.. Show summary
    • Fader, Kelly A. Fader; Nault, Rance; Kirby, Mathew P.; Markous, Gena; Matthews, Jason & Zacharewski, Tim R. (2018). Corrigendum to ?Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERB?/? activation in aryl hydrocarbon receptor-elicited hepatotoxicity? [Toxicol. Appl. Pharmacol. 321 (2017) 1?17] (S0041008X17300649) (10.1016/j.taap.2017.02.006)). Toxicology and Applied Pharmacology.  ISSN 0041-008X.  344, s 74 . doi: 10.1016/j.taap.2018.03.001
    • Bindesbøll, Christian; Tan, Susanna; MacPherson, Laura; Moen, Anders; Anonsen, Jan Haug; Grønning-Wang, Line Mariann; Nebb, Hilde Irene & Matthews, Jason (2015). TIPARP MONO-ADP-RIBOSYLATES & INCREASES LIVER X RECEPTOR TRANSACTIVATION.
    • Matthews, Jason (2015). The Intriguing world of AHR and ER crosstalk.

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    Published Sep. 29, 2015 4:05 PM - Last modified Dec. 13, 2016 6:09 PM