Johanne Egge Rinholm

Associate Professor - Division of Physiology
Image of Johanne Egge Rinholm
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Mobile phone 90768382
Room 2366
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1103 Blindern 0317 Oslo

Academic interests

  • The brain and nervous system
  • Oligodendrocytes and myelin
  • Brain metabolism
  • Ischemic brain injury
  • Lactate
  • Mitochondria
  • Endoplasmic reticulum
  • Oxidative stress

Courses taught

  • Molecular medicine, physiology (MED1100 and MED2200)
  • Reproduction (MED2200)
  • Membranes and membrane transport (MED1100)

Oligodendrocyte lab

We study the interactions between oligodendrocytes and neurons in the healthy brain and their role in cell injury and repair in disease.

The white matter comprises nearly 50% of the human brain. It is composed of nerve cell axons wrapped in myelin, a specialized membrane formed by oligodendrocytes. Myelin is required for fast and reliable action potential propagation and long-term survival of neurons. Consequently, a loss of myelin can cause mental and physical handicap.

Our group is interested in the general properties of oligodendrocytes and their role in brain injury and repair in conditions such as stroke and dementia. We also study how lactate, which is produced during physical exercise, can influence the brain's ability for repair. We use a combination of in vivo mouse models, human brain organoids and organotypic mouse brain slices. Our methods include live confocal and multiphoton imaging, viral expression, RNA sequencing, immunohistochemistry and electron microscopy.

GFP-expressing oligodendrocytes in the mouse neocortex. Myelin is labeled magenta in the right hand image.

Projects

  • The role of physical exercise and lactate in ischemic brain injury and repair
  • A human brain organoid model of cerebral ischemia
  • The metabolic properties of oligodendrocytes
  • Oxidation Resistance 1 (OXR1) in brain development and behavior
klatrepark
Teambuilding in Oslo Climbing Park 2020

 

Tags: Brain and nervous system, Myelin, Energy, Metabolism, Mitocondria, White matter, Lactate

Publications

  • Lauritzen, Knut H.; Olsen, Maria Belland; Ahmed, Mohammed Shakil; Yang, Kuan; Rinholm, Johanne Egge & Bergersen, Linda H. [Show all 13 contributors for this article] (2021). Instability in nad+ metabolism leads to impaired cardiac mitochondrial function and communication. eLIFE. ISSN 2050-084X. 10, p. 1–23. doi: 10.7554/ELIFE.59828. Full text in Research Archive
  • Yang, Mingyi; Lin, Xiaolin; Segers, Filip; Suganthan, Rajikala; Hildrestrand, Gunn Annette & Rinholm, Johanne Egge [Show all 21 contributors for this article] (2020). OXR1A, a Coactivator of PRMT5 Regulating Histone Arginine Methylation. Cell reports. ISSN 2211-1247. 30(12), p. 4165–4178. doi: 10.1016/j.celrep.2020.02.063. Full text in Research Archive
  • Kennedy, Lauritz Hagen & Rinholm, Johanne Egge (2017). Visualization and live imaging of oligodendrocyte organelles in organotypic brain slices using adeno-associated virus and confocal microscopy. Journal of Visualized Experiments. ISSN 1940-087X. doi: 10.3791/56237.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nature Communications. ISSN 2041-1723. 8. doi: 10.1038/ncomms15557. Full text in Research Archive
  • Rinholm, Johanne Egge; Vervaeke, Koen Gerard Alois; Tadross, Michael; Tkachuk, Ariana; Kopek, Benjamin & Brown, Timothy A [Show all 8 contributors for this article] (2016). Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths. Glia. ISSN 0894-1491. 64(5), p. 810–825. doi: 10.1002/glia.22965.
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2014). White matter lactate - Does it matter? Neuroscience. ISSN 0306-4522. 276, p. 109–116. doi: 10.1016/j.neuroscience.2013.10.002.
  • Nordengen, Kaja; Heuser, Christoph; Rinholm, Johanne Egge; Matalon, Reuben & Gundersen, Vidar (2013). Localisation of N-acetylaspartate in oligodendrocytes/myelin. Brain Structure and Function. ISSN 1863-2653. doi: 10.1007/s00429-013-0691-7.
  • Ersland, Kari Merete; Håvik, Bjarte; Rinholm, Johanne Egge; Gundersen, Vidar; Stansberg, Christine & Steen, Vidar Martin (2013). LOC689986, a unique gene showing specific expression in restricted areas of the rodent neocortex. BMC Neuroscience. ISSN 1471-2202. 14. doi: 10.1186/1471-2202-14-68.
  • Medin, Tirill; Rinholm, Johanne Egge; Owe, Simen Gylterud; Sagvolden, Terje; Gjedde, A. & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2013). LOW DOPAMINE D5 RECEPTOR DENSITY IN HIPPOCAMPUS IN AN ANIMAL MODEL OF ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD). Neuroscience. ISSN 0306-4522. 242, p. 11–20. doi: 10.1016/j.neuroscience.2013.03.036.
  • Bergersen, Linda Hildegard; Morland, Cecilie; Ormel, Lasse; Rinholm, Johanne Egge; Larsson, Max David & Wold, Johan Fredrik Hustad [Show all 13 contributors for this article] (2012). Immunogold Detection of L-glutamate and D-serine in Small Synaptic-Like Microvesicles in Adult Hippocampal Astrocytes. Cerebral Cortex. ISSN 1047-3211. 22(7), p. 1690–1697. doi: 10.1093/cercor/bhr254.
  • Medin, Tirill; Owe, Simen Gylterud; Rinholm, Johanne Egge; Larsson, Max; Sagvolden, Terje & Storm-Mathisen, Jon [Show all 7 contributors for this article] (2011). Dopamine D5 receptors are localized at asymmetric synapses in the rat hippocampus. Neuroscience. ISSN 0306-4522. 192, p. 164–171. doi: 10.1016/j.neuroscience.2011.06.056.
  • Rinholm, Johanne Egge; Hamilton, Nicola; Kessaris, Nicoletta; Richardson, William D.; Bergersen, Linda Hildegard & Attwell, David (2011). Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate. Journal of Neuroscience. ISSN 0270-6474. 31(2), p. 538–548. doi: 10.1523/JNEUROSCI.3516-10.2011.
  • Jensen, Vidar; Rinholm, Johanne Egge; Johansen, Tine Jeanette; Medin, Tirill; Storm-Mathisen, Jon & Sagvolden, Terje [Show all 8 contributors for this article] (2009). N-methyl-d-aspartate receptor subunit dysfunction at hippocampal glutamatergic synapses in an animal model of attention-deficit/hyperactivity disorder. Neuroscience. ISSN 0306-4522. 158(1), p. 353–364. doi: 10.1016/j.neuroscience.2008.05.016.
  • MacAskill, Andrew F.; Rinholm, Johanne Egge; Twelvetrees, Alison E.; Arancibia-Carcamo, I. Lorena; Muir, James & Fransson, Asa [Show all 9 contributors for this article] (2009). Miro1 is a calcium sensor for glutamate receptor-dependent localization of mitochondria at synapses. Neuron. ISSN 0896-6273. 61(4), p. 541–555.
  • Rinholm, Johanne Egge; Slettaløkken, Gunnar; Marcaggi, Paikan; Skare, Øivind; Storm-Mathisen, Jon & Bergersen, Linda Hildegard (2007). Subcellular localization of the glutamate transporters GLAST and GLT at the neuromuscular junction in rodents. Neuroscience. ISSN 0306-4522. 145. doi: 10.1016/j.neuroscience.2006.12.041.

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  • Andersson, Krister; Morland, Cecilie; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 21 contributors for this article] (2017). Exercise benefits brain through the lactate receptor HCAR1, increasing VEGF and capillary density in hippocampus and cortex.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). A novel mechanism for cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Morland, Cecilie; Andersson, Krister; Haugen, Øyvind Pernell; Hadzic, Alena; Kleppa, Liv & Gille, Andreas [Show all 18 contributors for this article] (2016). Exercise induces cerebral angiogenesis via lactate receptor HCAR1 at pial vessels.
  • Rinholm, Johanne Egge & Bergersen, Linda Hildegard (2012). The wrap that feeds neurons. Nature. ISSN 0028-0836. 487(7408), p. 435–436. doi: 10.1038/487435a.
  • Rinholm, Johanne Egge; Hamilton, NB; Ianarelli, P; Kessaris, N; Richardson, WD & Bergersen, Linda Hildegard [Show all 7 contributors for this article] (2009). LACTATE TRANSPORTERS IN DEVELOPING OLIGODENDROCYTES. Glia. ISSN 0894-1491. 57(13), p. S113–S113.

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Published June 2, 2021 10:15 AM - Last modified Jan. 26, 2022 11:06 AM

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