Manuela Zucknick

Image of Manuela Zucknick
Norwegian version of this page
Phone +47 22851193
Mobile phone +47 90812078
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1122 Blindern 0317 Oslo

Academic interests

Statistical learning for translational and clinical cancer research, in particular for personalised cancer therapies. Integration of multi-omics data and other data sources for prediction of drug response and synergies in pharmacogenomic screens and of prognosis and treatment response in patients.

  • Statistical machine learning in molecular medicine
  • Structured high-dimensional regressions (for "large p, small n")
  • Regularization (using penalized likelihood and Bayesian methods)
  • Bayesian methods for integrating heterogeneous data sources (e.g. multi-omics) and for incorporating prior biological knowledge in risk prediction models

Background

  • From 09/2023   Director, Oslo Centre for Biostatistics and Epidemiology, University of Oslo and Oslo University Hospital 
  • From 05/2022   Professor, Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo
  • 2015 - 2022   Associate professor, Oslo Centre for Biostatistics and Epidemiology, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo
  • 04/2014 – 09/2014   Visiting lecturer, Faculty of Statistics, TU Dortmund University, Germany
  • 2008 – 2014   Postdoc, Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany
    • 2013 – 2014   Working group «Bayesian statistics for integrative genomics» (team leader)
    • 2008 – 2013   Working group «Statistics for translational oncology»
  • 2004 – 2008   PhD Biostatistics, Department of Epidemiology and Public Health, Imperial College London, United Kingdom
  • 2003 – 2004   MSc Bioinformatics, Centre for Bioinformatics, Imperial College London, United Kingdom
  • 1998 – 2003   Diplom Statistik, Department of Statistics, University of Dortmund, Germany
Tags: Biostatistics, Cancer, Risk prediction, Integrative genomics, Personalised Medicine, Precision Medicine

Publications

  • Zhao, Zhi; Zobolas, John; Zucknick, Manuela & Aittokallio, Tero Antero (2024). Tutorial on survival modeling with applications to omics data. Bioinformatics. ISSN 1367-4803. doi: 10.1093/bioinformatics/btae132.
  • Brynjulvsen, Marit; Solli, Elise; Walewska, Maria; Zucknick, Manuela; Djirackor, Luna & Langmoen, Iver Arne [Show all 10 contributors for this article] (2023). Functional and Molecular Heterogeneity in Glioma Stem Cells Derived from Multiregional Sampling. Cancers. ISSN 2072-6694. 15(24). doi: 10.3390/cancers15245826. Full text in Research Archive
  • Vilming, Bente ; Dahl, Jørgen Fallås; Bentzen, Anne Gry; Ingebrigtsen, Vibeke Anett; Nilsen, Elisabeth Berge & Vistad, Ingvild [Show all 12 contributors for this article] (2023). Real-world data on niraparib maintenance treatment in patients with non-gBRCA mutated platinum-sensitive recurrent ovarian cancer. International Journal of Gynecological Cancer. ISSN 1048-891X. 33(12), p. 1898–1905. doi: 10.1136/ijgc-2023-004484. Full text in Research Archive
  • Zhao, Zhi; Banterle, Marco; Lewin, Alex & Zucknick, Manuela (2023). Multivariate Bayesian structured variable selection for pharmacogenomic studies. The Journal of the Royal Statistical Society, Series C (Applied Statistics). ISSN 0035-9254. 73(2), p. 420–443. doi: 10.1093/jrsssc/qlad102. Full text in Research Archive
  • Hsieh, Ping-Han; Lopes-Ramos, Camila Miranda; Zucknick, Manuela; Sandve, Geir Kjetil Ferkingstad; Glass, Kimberly & Kuijjer, Marieke (2023). Adjustment of spurious correlations in co-expression measurements from RNA-Sequencing data. Bioinformatics. ISSN 1367-4803. 39(10). doi: 10.1093/bioinformatics/btad610. Full text in Research Archive
  • Schmutz, Maximilian; Zucknick, Manuela; Schlenk, Richard F.; Mertens, Daniel; Benner, Axel & Weichenhan, Dieter [Show all 11 contributors for this article] (2023). Predictive value of DNA methylation patterns in AML patients treated with an azacytidine containing induction regimen. Clinical Epigenetics. ISSN 1868-7075. 15(1). doi: 10.1186/s13148-023-01580-z. Full text in Research Archive
  • Vigeland, Maria Dehli; Flåm, Siri Tennebø; Vigeland, Magnus Dehli; Espeland, Ansgar; Zucknick, Manuela & Wigemyr, Monica [Show all 14 contributors for this article] (2023). Long-Term Use of Amoxicillin Is Associated with Changes in Gene Expression and DNA Methylation in Patients with Low Back Pain and Modic Changes. Antibiotics. ISSN 2079-6382. 12(7). doi: 10.3390/antibiotics12071217. Full text in Research Archive
  • Alavi, Dena Treider; Henriksen, Hege Berg; Lauritzen, Peter Mæhre; Zucknick, Manuela; Bøhn, Siv Kjølsrud & Henriksen, Christine [Show all 9 contributors for this article] (2023). Effect of a one-year personalized intensive dietary intervention on body composition in colorectal cancer patients: Results from a randomized controlled trial. Clinical Nutrition ESPEN. ISSN 2405-4577. 57, p. 414–422. doi: 10.1016/j.clnesp.2023.06.037. Full text in Research Archive
  • Rønneberg, Leiv; Kirk, Paul D. W. & Zucknick, Manuela (2023). Dose–response prediction for in-vitro drug combination datasets: a probabilistic approach. BMC Bioinformatics. ISSN 1471-2105. 24. doi: 10.1186/s12859-023-05256-6. Full text in Research Archive
  • Klevberg, Gunvor Lilleholt; Zucknick, Manuela; Jahnsen, Reidun Birgitta & Eliasson, Ann-Christin (2023). Development of Hand Use with and Without Intensive Training Among Children with Unilateral Cerebral Palsy in Scandinavia. Developmental Neurorehabilitation. ISSN 1751-8423. 26(3), p. 163–171. doi: 10.1080/17518423.2023.2193256. Full text in Research Archive
  • Hanes, Robert; Ayuda-Duran, Maria del Pilar; Rønneberg, Leiv; Nakken, Sigve; Hovig, Eivind & Zucknick, Manuela [Show all 7 contributors for this article] (2022). screenwerk: a modular tool for the design and analysis of drug combination screens. Bioinformatics. ISSN 1367-4803. 39(1). doi: 10.1093/bioinformatics/btac840. Full text in Research Archive
  • Vitelli, Valeria; Fleischer, Thomas; Ankill, Jørgen; Arjas, Elja; Frigessi, Arnoldo & Kristensen, Vessela N. [Show all 7 contributors for this article] (2022). Transcriptomic pan-cancer analysis using rank-based Bayesian inference. Molecular Oncology. ISSN 1574-7891. 00(0), p. 1–16. doi: 10.1002/1878-0261.13354. Full text in Research Archive
  • Leblanc, Marissa Erin; Rueegg, Corina Silvia; Bekiroğlu, Nural; Esterhuizen, Tonya M.; Fagerland, Morten Wang & Falk, Ragnhild Sørum [Show all 20 contributors for this article] (2022). Statistical advising: Professional development opportunities for the biostatistician. Statistics in Medicine. ISSN 0277-6715. 41(5). doi: 10.1002/sim.9290. Full text in Research Archive
  • Kolan, Shrikant; Li, Gaoyang; Grimolizzi, Franco; Sexton, Joseph; Kvien, Tore Kristian & Goll, Guro Løvik [Show all 11 contributors for this article] (2022). Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis. Frontiers in Pharmacology. ISSN 1663-9812. 13. doi: 10.3389/fphar.2022.1075603. Full text in Research Archive
  • Zhao, Zhi; Zucknick, Manuela & Aittokallio, Tero Antero (2022). EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets. Bioinformatics Advances. ISSN 2635-0041. 2(1). doi: 10.1093/bioadv/vbac073. Full text in Research Archive
  • Mørk, Marianne; Hoksrud, Aasne Fenne; Søberg, Helene L.; Zucknick, Manuela; Heide, Marte & Groven, Karen Synne [Show all 7 contributors for this article] (2022). “Psychometric properties of the Norwegian foot function index revised short form”. BMC Musculoskeletal Disorders. ISSN 1471-2474. 23(1), p. 1–10. doi: 10.1186/s12891-022-05374-x. Full text in Research Archive
  • Kristiansen, Oddrun; Roland, Marie Cecilie; Zucknick, Manuela; Reine, Trine M.; Kolset, Svein Olav & Henriksen, Tore [Show all 8 contributors for this article] (2022). Maternal body mass index and placental weight: a role for fetal insulin, maternal insulin and leptin. Journal of Endocrinological Investigation. ISSN 0391-4097. 45, p. 2105–2121. doi: 10.1007/s40618-022-01842-2.
  • Degnes, Maren-Helene Langeland; Westerberg, Ane Cecilie; Zucknick, Manuela; Powell, Theresa L.; Jansson, Thomas & Henriksen, Tore [Show all 8 contributors for this article] (2022). Placenta-derived proteins across gestation in healthy pregnancies—a novel approach to assess placental function? BMC Medicine. ISSN 1741-7015. 20. doi: 10.1186/s12916-022-02415-z. Full text in Research Archive
  • Zhao, Zhi; Wang, Shixiong; Zucknick, Manuela & Aittokallio, Tero Antero (2022). Tissue-specific identification of multi-omics features for pan-cancer drug response prediction. iScience. ISSN 2589-0042. 25(8). doi: 10.1016/j.isci.2022.104767. Full text in Research Archive
  • Madjar, Katrin; Zucknick, Manuela; Ickstadt, Katja & Rahnenführer, Jörg (2021). Combining heterogeneous subgroups with graph-structured variable selection priors for Cox regression. BMC Bioinformatics. ISSN 1471-2105. 22(1), p. 1–29. doi: 10.1186/s12859-021-04483-z. Full text in Research Archive
  • Zhao, Zhi; Banterle, Marco; Bottolo, Leonardo; Richardson, Sylvia; Lewin, Alexandra & Zucknick, Manuela (2021). BayesSUR: An R package for high-dimensional multivariate Bayesian variable and covariance selection in linear regression. Journal of Statistical Software. ISSN 1548-7660. 100(11), p. 1–32. doi: 10.18637/jss.v100.i11. Full text in Research Archive
  • Rønneberg, Leiv; Cremaschi, Andrea; Hanes, Robert; Enserink, Jorrit & Zucknick, Manuela (2021). bayesynergy: flexible Bayesian modelling of synergistic interaction effects in in vitro drug combination experiments. Briefings in Bioinformatics. ISSN 1467-5463. 22(6), p. 1–12. doi: 10.1093/bib/bbab251. Full text in Research Archive
  • Klevberg, Gunvor Lilleholt; Jahnsen, Reidun Birgitta; Elkjær, Sonja & Zucknick, Manuela (2021). Hand use development in children with unilateral cerebral palsy. Developmental Medicine & Child Neurology. ISSN 0012-1622. 63(12), p. 1462–1468. doi: 10.1111/dmcn.14957. Full text in Research Archive
  • Schellhorn, Till; Zucknick, Manuela; Askim, Torunn; Munthe-Kaas, Ragnhild; Ihle-Hansen, Hege & Seljeseth, Yngve Müller [Show all 13 contributors for this article] (2021). Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatrics. ISSN 1471-2318. 21:362, p. 1–10. doi: 10.1186/s12877-021-02327-2. Full text in Research Archive
  • Kristiansen, Oddrun; Zucknick, Manuela; Reine, Trine M.; Kolset, Svein Olav; Jansson, Thomas & Powell, Theresa L. [Show all 9 contributors for this article] (2021). Mediators linking maternal weight to birthweight and neonatal fat mass in healthy pregnancies. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 106(7), p. 1977–1993. doi: 10.1210/clinem/dgab166. Full text in Research Archive
  • Heinicke, Fatima; Zhong, Xiangfu; Flåm, Siri Tennebø; Breidenbach, Johannes; Leithaug, Magnus & Mæhlen, Marthe Thoresen [Show all 14 contributors for this article] (2021). MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients. Frontiers in Immunology. ISSN 1664-3224. 12. doi: 10.3389/fimmu.2021.663736. Full text in Research Archive
  • Mai, The Tien; Rønneberg, Leiv; Zhao, Zhi; Zucknick, Manuela & Corander, Jukka (2020). Learning Cancer Drug Sensitivities in Large-Scale Screens from Multi-omics Data with Local Low-Rank Structure. Lecture Notes in Computer Science (LNCS). ISSN 0302-9743. 12313, p. 67–79. doi: 10.1007/978-3-030-63061-4_7.
  • Heinicke, Fatima; Zhong, Xiangfu; Zucknick, Karola Manuela; Breidenbach, Johannes; Sundaram, Arvind Yegambaram Meenakshi & Flåm, Siri Tennebø [Show all 11 contributors for this article] (2020). An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits. RNA Biology. ISSN 1547-6286. 17(9), p. 1284–1292. doi: 10.1080/15476286.2020.1761081. Full text in Research Archive
  • Guldvik, Ingrid Jenny; Zuber, Verena; Braadland, Peder Rustøen; Grytli, Helene Hartvedt; Ramberg, Håkon Andre & Lilleby, Wolfgang [Show all 18 contributors for this article] (2020). Identification and Validation of Leucine-rich alpha-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification. European Urology Open Science. ISSN 2666-1691. 21, p. 51–61. doi: 10.1016/j.euros.2020.08.007. Full text in Research Archive
  • Zhao, Zhi & Zucknick, Manuela (2020). Structured penalized regression for drug sensitivity prediction. The Journal of the Royal Statistical Society, Series C (Applied Statistics). ISSN 0035-9254. 69(3), p. 525–545. doi: 10.1111/rssc.12400. Full text in Research Archive
  • Langseth, Miriam Sjåstad; Andersen, Geir Øystein; Husebye, Trygve Guttorm; Arnesen, Harald; Zucknick, Manuela & Solheim, Svein [Show all 10 contributors for this article] (2020). Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure. PLOS ONE. ISSN 1932-6203. 15:e0241333(10), p. 1–14. doi: 10.1371/journal.pone.0241333. Full text in Research Archive
  • Epting, Daniel; Senaratne, Lokuliyanage Dona Samudita; Ott, Elisabeth; Holmgren, Asbjørn; Sumathipala, Dulika Sanjeewani & Larsen, Selma Mujezinovic [Show all 30 contributors for this article] (2020). Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome. . Human Mutation. ISSN 1059-7794. p. 1–16. doi: 10.1002/humu.24127. Full text in Research Archive
  • Helset, Elin; Nordøy, Ingvild; Sporsem, Hilde Margrete; Bakke, Victoria Desiree; Bugge, Jan F & Gammelsrud, Karianne Wiger [Show all 8 contributors for this article] (2020). Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study. Acta Anaesthesiologica Scandinavica. ISSN 0001-5172. 64(9), p. 1295–1304. doi: 10.1111/aas.13658. Full text in Research Archive
  • Bragstad, Line Kildal; Hjelle, Ellen Gabrielsen ; Zucknick, Manuela; Sveen, Unni; Thommessen, Bente & Bronken, Berit Arnesveen [Show all 13 contributors for this article] (2020). The effects of a dialogue-based intervention to promote psychosocial well-being after stroke: a randomized controlled trial. Clinical Rehabilitation. ISSN 0269-2155. 34(8), p. 1056–1071. doi: 10.1177/0269215520929737. Full text in Research Archive
  • Pietka, Wojciech; Sundnes, Olav; Hammarström, Clara Louise; Zucknick, Manuela; Khnykin, Denis & Haraldsen, Guttorm (2020). Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice. Scientific Reports. ISSN 2045-2322. 10:6451, p. 1–8. doi: 10.1038/s41598-020-63410-z. Full text in Research Archive
  • Maros, Máté E.; Capper, David; Jones, David T.; Hovestadt, Volker; von Deimling, Andreas & Pfister, Stefan M [Show all 9 contributors for this article] (2020). Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data. Nature Protocols. ISSN 1754-2189. 15, p. 479–512. doi: 10.1038/s41596-019-0251-6. Full text in Research Archive
  • Joshi, Sarita; De Angelis, Paula; Zucknick, Manuela; Schjølberg, Aasa Rambæk; Andersen, Solveig Norheim & Clausen, Ole Petter Fraas (2020). Role of the Wnt signaling pathway in keratoacanthoma. Cancer Reports. ISSN 2573-8348. 3(2), p. 1–11. doi: 10.1002/cnr2.1219.
  • Volchenkov, Roman; Matthews, Jason; Zucknick, Manuela & Skålhegg, Bjørn Steen (2019). Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history. Cellular & Molecular Immunology. ISSN 1672-7681. 16(7), p. 674–675. doi: 10.1038/s41423-019-0230-4. Full text in Research Archive
  • Heinicke, Fatima; Zhong, Xiangfu; Zucknick, Manuela; Breidenbach, Johannes; Sundaram, Arvind Yegambaram Meenakshi & Flåm, Siri Tennebø [Show all 21 contributors for this article] (2019). Systematic assessment of commercially available low-input miRNA library preparation kits. RNA Biology. ISSN 1547-6286. 17(1), p. 75–86. doi: 10.1080/15476286.2019.1667741. Full text in Research Archive
  • Menden, Michael P.; Wang, Dennis; Mason, Mike J.; Szalai, Bence; Bulusu, Krishna C. & Guan, Yuanfang [Show all 27 contributors for this article] (2019). Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. Nature Communications. ISSN 2041-1723. 10:2674, p. 1–17. doi: 10.1038/s41467-019-09799-2. Full text in Research Archive
  • Hjelle, Ellen Gabrielsen ; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen & Martinsen, Randi [Show all 11 contributors for this article] (2019). Effect of a dialogue-based intervention on psychosocial well-being 6 months after stroke in Norway: A randomized controlled trial . Journal of Rehabilitation Medicine. ISSN 1650-1977. 51(8), p. 557–565. doi: 10.2340/16501977-2585. Full text in Research Archive
  • Schulze-Edinghausen, Lena; Dürr, Claudia; Öztürk, Selcen; Zucknick, Manuela; Benner, Axel & Kalter, Verena [Show all 12 contributors for this article] (2019). Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. Cancers. ISSN 2072-6694. 11(6). doi: 10.3390/cancers11060822. Full text in Research Archive
  • Hjelle, Ellen Gabrielsen; Bragstad, Line Kildal; Zucknick, Manuela; Kirkevold, Marit; Thommessen, Bente & Sveen, Unni (2019). The General Health Questionnaire-28 (GHQ-28) as an outcome measurement in a randomized controlled trial in a Norwegian stroke population. BMC Psychology. ISSN 2050-7283. 7(18). doi: 10.1186/s40359-019-0293-0. Full text in Research Archive
  • Nguyen, Chinh BKrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes & Nilsen, Hilde Loge [Show all 7 contributors for this article] (2019). Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome. Brain, Behavior, and Immunity. ISSN 0889-1591. 76, p. 82–96. doi: 10.1016/j.bbi.2018.11.008. Full text in Research Archive
  • Øystese, Kristin Astrid Berland; Hisanawi, Sheren; Zucknick, Manuela; Bollerslev, Jens & Ringstad, Geir (2019). Are volume measurements of non-functioning pituitary adenomas reliable? Endocrine. ISSN 1355-008X. 63(1), p. 171–176. doi: 10.1007/s12020-018-1752-8.
  • Zimmo, Kaled; Laine, Hely Katariina; Fosse, Erik; Zimmo, Mohammed; Ali-Masri, Hadil Y. & Zucknick, Karola Manuela [Show all 8 contributors for this article] (2018). Episiotomy practice in six Palestinian hospitals: a population-based cohort study among singleton vaginal births. BMJ Open. ISSN 2044-6055. doi: 10.1136/bmjopen-2018-021629.
  • Opheim, Gun Lisbeth; Zucknick, Manuela; Henriksen, Tore & Haugen, Guttorm (2018). A maternal meal affects clinical Doppler parameters in the fetal middle cerebral artery. PLOS ONE. ISSN 1932-6203. 13(12). doi: 10.1371/journal.pone.0209990. Full text in Research Archive
  • Jabeen, Shakila; Espinoza, Jaime; Torland, Lilly Anne; Zucknick, Manuela; Kumar, Surendra & Haakensen, Vilde Drageset [Show all 15 contributors for this article] (2018). Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics. Oncoimmunology. ISSN 2162-4011. :e1537691. doi: 10.1080/2162402X.2018.1537691. Full text in Research Archive
  • Zimmo, Kaled; Laine, Katariina; Fosse, Erik; Zimmo, Mohammed; Ali-Masri, Hadil & Böttcher, Bettina [Show all 9 contributors for this article] (2018). Impact of animated instruction on tablets and hands-on training in applying bimanual perineal support on episiotomy rates: an intervention study. International Urogynecology Journal. ISSN 0937-3462. p. 1–8. doi: 10.1007/s00192-018-3711-6. Full text in Research Archive
  • Jabeen, Shakila; Zucknick, Manuela; Nome, Marianne Eikhom; dannenfelser, ruth; Fleischer, Thomas & Kumar, Surendra [Show all 15 contributors for this article] (2018). Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab. Oncoimmunology. ISSN 2162-4011. 7(11), p. e1457598-1–e1457598-15. doi: 10.1080/2162402X.2018.1457598.
  • Zimmo, Kaled; Laine, Katariina; Fosse, Erik; Zimmo, Mohammed; Ali, Hadil & Zucknick, Manuela [Show all 8 contributors for this article] (2018). Episiotomy practice in six Palestinian hospitals: a population-based cohort study among singleton vaginal births. BMJ Open. ISSN 2044-6055. 8(7). doi: 10.1136/bmjopen-2018-021629. Full text in Research Archive
  • Øystese, Kristin Astrid Berland; Berg, Jens Petter; Normann, Kjersti Ringvoll; Zucknick, Manuela; Casar-Borota, Olivera & Bollerslev, Jens (2018). The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours. Endocrine. ISSN 1355-008X. 62(2), p. 351–360. doi: 10.1007/s12020-018-1679-0.
  • LeBlanc, Marissa; Nustad, Haakon Egdetveit; Zucknick, Manuela & Page, Christian (2018). Quality control for Illumina 450K methylation data in the absence of iDat files using correlation structure in pedigrees and repeated measures. BMC Genetics. ISSN 1471-2156. 19. doi: 10.1186/s12863-018-0636-5. Full text in Research Archive
  • Nustad, Haakon Egdetveit; Page, Christian; Reiner, Andrew Henry; Zucknick, Manuela & LeBlanc, Marissa (2018). A Bayesian mixed modeling approach for estimating heritability. BMC Proceedings. ISSN 1753-6561. 12, p. 117–122. doi: 10.1186/s12919-018-0131-z. Full text in Research Archive
  • Ickstadt, Katja; Schäfer, Martin & Zucknick, Manuela (2018). Toward Integrative Bayesian Analysis in Molecular Biology. Annual Review of Statistics and Its Application. ISSN 2326-8298. 5, p. 141–167. doi: 10.1146/annurev-statistics-031017-100438.
  • Henriksen, Hege; Berntsen, Sveinung; Paur, Ingvild; Zucknick, Manuela; Skjetne, Anne Juul & Bøhn, Siv Kjølsrud [Show all 10 contributors for this article] (2018). Validation of two short questionnaires assessing physical activity in colorectal cancer patients. BMC sports science, medicine and rehabilitation. ISSN 2052-1847. 10:8(8), p. 1–12. doi: 10.1186/s13102-018-0096-2. Full text in Research Archive
  • Tanbo, Tom Gunnar; Zucknick, Manuela & Eskild, Anne (2018). Maternal concentrations of human chorionic gonadotrophin in very early IVF pregnancies and duration of pregnancy: a follow-up study. Reproductive Biomedicine Online. ISSN 1472-6483. 37(2), p. 208–215. doi: 10.1016/j.rbmo.2018.04.048. Full text in Research Archive
  • Klevberg, Gunvor Lilleholt; Elvrum, Ann-Kristin; Zucknick, Manuela; Elkjær, Sonja; Østensjø, Sigrid & Krumlinde-Sundholm, Lena [Show all 8 contributors for this article] (2018). Development of bimanual performance in young children with cerebral palsy. Developmental Medicine & Child Neurology. ISSN 0012-1622. 60(5), p. 490–497. doi: 10.1111/dmcn.13680. Full text in Research Archive
  • Dürr, Claudia; Hanna, Bola S.; Schulz, Angela; Lucas, Fabienne; Zucknick, Manuela & Benner, Axel [Show all 16 contributors for this article] (2018). Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin. Haematologica. ISSN 0390-6078. 103(4), p. 688–697. doi: 10.3324/haematol.2017.177808. Full text in Research Archive
  • Wolf, Christine; Garding, Angela; Filarsky, Katharina; Bahlo, Jasmin; Robrecht, Sandra & Becker, Natalia [Show all 20 contributors for this article] (2018). NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. International Journal of Cancer. ISSN 0020-7136. 142(2), p. 322–333. doi: 10.1002/ijc.31057.
  • Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens (2017). Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA. Journal of Clinical Endocrinology and Metabolism (JCEM). ISSN 0021-972X. 102(9), p. 3581–3590. doi: 10.1210/jc.2017-00792.
  • Treppmann, Tabea; Ickstadt, Katja & Zucknick, Manuela (2017). Integration of multiple genomic data sources in a Bayesian Cox model for variable selection and prediction. Computational & Mathematical Methods in Medicine. ISSN 1748-670X. 2017. doi: 10.1155/2017/7340565. Full text in Research Archive
  • Holm, Maia Blomhoff; Bastani, Nasser Ezzatkhah; Holme, Ane Moe; Zucknick, Manuela; Jansson, Thomas & Refsum, Helga [Show all 10 contributors for this article] (2017). Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLOS ONE. ISSN 1932-6203. 12(10). doi: 10.1371/journal.pone.0185760. Full text in Research Archive
  • Øystese, Kristin Astrid Berland; Zucknick, Manuela; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2017). Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up. Endocrine. ISSN 1355-008X. 57(1), p. 35–45. doi: 10.1007/s12020-017-1314-5.
  • Goeppert, Benjamin; Roessler, Stephanie; Becker, Natalia; Zucknick, Manuela; Vogel, Monika Nadja & Warth, Arne [Show all 11 contributors for this article] (2017). DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data. Histopathology. ISSN 0309-0167. 70(7), p. 1064–1071. doi: 10.1111/his.13175.
  • Majak, Guri Bårdstu; Reisæter, Anna Varberg; Zucknick, Manuela; Lorentzen, Bjørg; Vangen, Siri & Henriksen, Tore [Show all 7 contributors for this article] (2017). Preeclampsia in kidney transplanted women; Outcomes and a simple prognostic risk score system. PLOS ONE. ISSN 1932-6203. 12:e0173420(3), p. 1–11. doi: 10.1371/journal.pone.0173420.
  • Henriksen, Hege; Ræder, Hanna; Bøhn, Siv Kjølsrud; Paur, Ingvild; Kværner, Ane Sørlie & Billington, Siv Åshild [Show all 14 contributors for this article] (2017). The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: A food-based multicentre randomized controlled trial. BMC Cancer. ISSN 1471-2407. 17(1). doi: 10.1186/s12885-017-3072-4.
  • Joshi, Sarita; Schjølberg, Aasa Rambæk; Ekstrøm, Per Olaf; De Angelis, Paula; Zucknick, Manuela & Andersen, Solveig Norheim [Show all 7 contributors for this article] (2016). Tp53/p53 status in keratoacanthomas. Journal of cutaneous pathology. ISSN 0303-6987. 43(7), p. 571–578. doi: 10.1111/cup.12713.
  • Mock, Andreas; Geisenberger, Christoph; Orlik, Christian; Warta, Rolf; Schwager, Christian & Jungk, Christine [Show all 25 contributors for this article] (2016). LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients. International Journal of Cancer. ISSN 0020-7136. 139(2), p. 424–432. doi: 10.1002/ijc.30069.
  • Madhavan, Dharanija; Peng, Cike; Wallwiener, Markus; Zucknick, Manuela; Nees, Juliane & Schott, Sarah [Show all 14 contributors for this article] (2016). Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis. ISSN 0143-3334. 37(5), p. 461–470. doi: 10.1093/carcin/bgw008.
  • Kap, Elisabeth J; Seibold, Petra; Scherer, Dominique; Habermann, Nina; Balavarca, Yesilda & Jansen, Lina [Show all 15 contributors for this article] (2016). SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients. International Journal of Cancer. ISSN 0020-7136. 138(12), p. 2993–3001. doi: 10.1002/ijc.30026.
  • Kostareli, Efterpi; Hielscher, Thomas; Zucknick, Manuela; Baboci, Lorena; Wichmann, Gunnar & Holzinger, Dana [Show all 17 contributors for this article] (2016). Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients. Epigenetics. ISSN 1559-2294. 11(1), p. 61–73. doi: 10.1080/15592294.2015.1137414.
  • Yang, Rongxi; Pfütze, Katrin; Zucknick, Manuela; Sutter, Christian; Wappenschmidt, Barbara & Marme, Frederik [Show all 20 contributors for this article] (2015). DNA methylation array analyses identified breast cancer‐associated HYAL2 methylation in peripheral blood. International Journal of Cancer. ISSN 0020-7136. 136(8), p. 1845–1855. doi: 10.1002/ijc.29205.
  • Goeppert, Benjamin; Frauenschuh, Lena; Zucknick, Manuela; Roessler, Stephanie; Mehrabi, Arianeb & Hafezi, Mohammadreza [Show all 12 contributors for this article] (2015). Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer. British Journal of Cancer. ISSN 0007-0920. 113(9), p. 1343–1349. doi: 10.1038/bjc.2015.337.
  • Chen, Hongda; Zucknick, Manuela; Werner, Simone; Knebel, Phillip & Brenner, Hermann (2015). Head-to-head comparison and evaluation of 92 plasma protein biomarkers for early detection of colorectal cancer in a true screening setting. Clinical Cancer Research. ISSN 1078-0432. 21(14), p. 3318–3326. doi: 10.1158/1078-0432.CCR-14-3051.
  • Zucknick, Manuela; Saadati, Maral & Benner, Axel (2015). Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models. Biometrical Journal. ISSN 0323-3847. 57(6), p. 959–981. doi: 10.1002/bimj.201400160.

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  • Frigessi, Arnoldo; Smajdor, Anna & Zucknick, Manuela (2023). The Importance of Reward Functions in Machine Learning Algorithms and Why These Should be Regulated.
  • Andresen, Ina Jungersen; Degnes, Maren-Helene Langeland; Zucknick, Manuela; Powell, Theresa L; Jansson, Thomas & Henriksen, Tore [Show all 8 contributors for this article] (2022). Protein biomarkers of late-onset preeclampsia.
  • Degnes, Maren-Helene Langeland; Westerberg, AC; Andresen, Ina Jungersen; Zucknick, Manuela; Powell, Theresa L & Jansson, Thomas [Show all 9 contributors for this article] (2022). Six placenta-derived proteins as markers of placental function.
  • Westerberg, AC; Degnes, Maren-Helene Langeland; Andresen, Ina Jungersen; Zucknick, Manuela; Powell, Theresa L & Jansson, Thomas [Show all 9 contributors for this article] (2022). Pleiotrophin and Fatty-acid Amide Hydrolase 2 – Placenta-derived Biomarkers of Preeclampsia?
  • Ross Raftemo, Anne Elisabeth; Jahnsen, Reidun Birgitta; Brandvik, Siri; Hollung, Sandra Julsen; Zucknick, Manuela & Andersen, Guro Lillemoen (2022). Spasticity treatments and orthopedic surgeries in lower extremities in children with cerebral palsy – a longitudinal population based study.
  • Madjar, Katrin; Zucknick, Manuela; Ickstadt, Katja & Rahnenführer, Jörg (2022). Correction to: Combining heterogeneous subgroups with graph-structured variable selection priors for Cox regression (BMC Bioinformatics, (2021), 22, 1, (586), 10.1186/s12859-021-04483-z). BMC Bioinformatics. ISSN 1471-2105. 23(1). doi: 10.1186/s12859-021-04552-3.
  • Hjelle, Ellen Gabrielsen ; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen & Martinsen, Randi [Show all 11 contributors for this article] (2019). The effect of a psychosocial intervention on well-being 6 months after stroke – a multicentre prospective randomized controlled trial .
  • Hjelle, Ellen Gabrielsen Hjelle; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen & Martinsen, Randi [Show all 11 contributors for this article] (2019). The complexities of an intervention to promote psychosocial well-being after stroke: Implications for trial outcome .
  • Hellton, Kristoffer Herland & Zucknick, Manuela (2016). Drug synergy prediction for personalized therapy.
  • Filarsky, Katharina; Garding, Angela; Becker, Natalia; Wolf, Christine; Zucknick, Manuela & Claus, Rainer [Show all 12 contributors for this article] (2016). Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling. Haematologica. ISSN 0390-6078. 101(6), p. e249–e253. doi: 10.3324/haematol.2015.138172.
  • Maierthaler, Melanie; Mennesson, Eric; Cuk, Katarina; Madhavan, Dharanija; Zucknick, Manuela & Fixe, Isabelle [Show all 11 contributors for this article] (2015). Comparison of different highly sensitive miRNA array platforms for the investigation of circulating cell-free microRNAs in blood. Cancer Research. ISSN 0008-5472. 75(15), p. 3973–3973.
  • Lipka, Daniel B.; Witte, Tania; Wiesenfarth, Manuel; Zucknick, Manuela; Konermann, Carolin & Gu, Lei [Show all 11 contributors for this article] (2015). Genome-wide DNA methylation profiling reveals two prognostically distinct subgroups of juvenile myelomonocytic leukemia. Experimental Hematology. ISSN 0301-472X. 43(9).

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Published Jan. 5, 2015 12:33 PM - Last modified Jan. 19, 2024 6:52 PM