Manuela Zucknick

Associate Professor - Department of Biostatistics
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Phone +47 22851193
Mobile phone +47 90812078
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Academic interests

Statistical learning for translational and clinical cancer research, in particular for personalised cancer therapies. Integration of multi-omics data and other data sources for prediction of drug response and synergies in pharmacogenomic screens and of prognosis and treatment response in patients.

  • Statistical machine learning in molecular medicine
  • Structured high-dimensional regressions (for "large p, small n")
  • Regularization (using penalized likelihood and Bayesian methods)
  • Bayesian methods for integrating heterogeneous data sources (e.g. multi-omics) and for incorporating prior biological knowledge in risk prediction models

Background

  • Since 2015   Associate professor, Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo
  • 04/2014 – 09/2014   Visiting lecturer, Faculty of Statistics, TU Dortmund University, Germany
  • 2008 – 2014   Postdoc, Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany
    • 2013 – 2014   Working group «Bayesian statistics for integrative genomics» (team leader)
    • 2008 – 2013   Working group «Statistics for translational oncology»
  • 2004 – 2008   PhD Biostatistics, Department of Epidemiology and Public Health, Imperial College London, United Kingdom
  • 2003 – 2004   MSc Bioinformatics, Centre for Bioinformatics, Imperial College London, United Kingdom
  • 1998 – 2003   Diplom Statistik, Department of Statistics, University of Dortmund, Germany
Tags: Biostatistics, Cancer, Risk prediction, Integrative genomics, Epidemiology, Personalised Medicine, Precision Medicine

Publications

  • Heinicke, Fatima; Zhong, Xiangfu; Flåm, Siri Tennebø; Breidenbach, Johannes; Leithaug, Magnus; Mæhlen, Marthe Thoresen; Lillegraven, Siri; Aga, Anna-Birgitte; Norli, Ellen Sauar; Mjaavatten, Maria Dahl; Haavardsholm, Espen Andre; Zucknick, Manuela; Rayner, Simon & Lie, Benedicte Alexandra (2021). MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients. Frontiers in Immunology.  ISSN 1664-3224. . doi: 10.3389/fimmu.2021.663736
  • Kristiansen, Oddrun; Zucknick, Manuela; Reine, Trine M.; Kolset, Svein Olav; Jansson, Thomas; Powell, Theresa L.; Haugen, Guttorm; Henriksen, Tore & Michelsen, Trond Melbye (2021). Mediators Linking Maternal Weight to Birthweight and Neonatal Fat Mass in Healthy Pregnancies. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X. . doi: 10.1210/clinem/dgab166
  • Bragstad, Line Kildal; Hjelle, Ellen Gabrielsen; Zucknick, Manuela; Sveen, Unni; Thommessen, Bente; Bronken, Berit Arnesveen; Martinsen, Randi; Kitzmüller, Gabriele; Mangset, Margrete; Kvigne, Kari Johanne; Hilari, Katerina; Lightbody, C. Elizabeth & Kirkevold, Marit (2020). The effects of a dialogue-based intervention to promote psychosocial well-being after stroke: a randomized controlled trial. Clinical Rehabilitation.  ISSN 0269-2155.  34(8), s 1056- 1071 . doi: 10.1177/0269215520929737 Full text in Research Archive. Show summary
  • Epting, Daniel; Senaratne, Lokuliyanage Dona Samudita; Ott, Elisabeth; Holmgren, Asbjørn; Sumathipala, Dulika Sanjeewani; Larsen, Selma Mujezinovic; Wallmeier, Julia; Bracht, Diana; Frikstad, Kari-Anne; Crowley, Suzanne; SIKIRIC, ALMA; Barøy, Tuva; Käsmann‐Kellner, Barbara; Decker, Eva; Decker, Christian; Bachmann, Nadine; Patzke, Sebastian; Phelps, Ian G.; Katsanis, Nicholas; Giles, Rachel; Schmidts, Miriam; Zucknick, Manuela; Lienkamp, Soeren S.; Omran, Heymut; Davis, Erica E.; Doherty, Dan; Strømme, Petter; Frengen, Eirik; Bergmann, Carsten & Misceo, Doriana (2020). Loss of CBY1 results in a ciliopathy characterized by features of Joubert syndrome.. Human Mutation.  ISSN 1059-7794.  s 1- 16 . doi: 10.1002/humu.24127 Full text in Research Archive.
  • Guldvik, Ingrid Jenny; Zuber, Verena; Braadland, Peder Rustøen; Grytli, Helene Hartvedt; Ramberg, Håkon Andre; Lilleby, Wolfgang; Thiede, Bernd; Zucknick, Manuela; Saatcioglu, Fahri; Gislefoss, Randi Elin; Kvåle, Rune; George, Anne; Grönberg, Henrik; Wiklund, Fredrik; Neal, David E.; Gnanapragasam, Vincent J.; Tasken, Kristin Austlid & Mills, Ian Geoffrey (2020). Identification and Validation of Leucine-rich alpha-2-glycoprotein 1 as a Noninvasive Biomarker for Improved Precision in Prostate Cancer Risk Stratification.. European Urology Open Science.  ISSN 2666-1691.  21, s 51- 61 . doi: 10.1016/j.euros.2020.08.007 Full text in Research Archive.
  • Heinicke, Fatima; Zhong, Xiangfu; Zucknick, Karola Manuela; Breidenbach, Johannes; Sundaram, Arvind Yegambaram Meenakshi; Flåm, Siri Tennebø; Leithaug, Magnus; Dalland, Marianne; Rayner, Simon; Lie, Benedicte Alexandra & Gilfillan, Gregor (2020). An extension to: Systematic assessment of commercially available low-input miRNA library preparation kits. RNA Biology.  ISSN 1547-6286.  17(9), s 1284- 1292 . doi: 10.1080/15476286.2020.1761081 Full text in Research Archive. Show summary
  • Helset, Elin; Nordøy, Ingvild; Sporsem, Hilde Margrete; Bakke, Victoria Desiree; Bugge, Jan F; Gammelsrud, Karianne Wiger; Zucknick, Karola Manuela & Lippe, Elisabeth von der (2020). Factors increasing the risk of inappropriate vancomycin therapy in ICU patients: A prospective observational study. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  64(9), s 1295- 1304 . doi: 10.1111/aas.13658 Full text in Research Archive.
  • Joshi, Sarita; De Angelis, Paula; Zucknick, Manuela; Schjølberg, Aasa Rambæk; Andersen, Solveig Norheim & Clausen, Ole Petter Fraas (2020). Role of the Wnt signaling pathway in keratoacanthoma. Cancer Reports.  ISSN 2573-8348.  3(2), s 1- 11 . doi: 10.1002/cnr2.1219
  • Langseth, Miriam Sjåstad; Andersen, Geir Øystein; Husebye, Trygve Guttorm; Arnesen, Harald; Zucknick, Manuela; Solheim, Svein; Eritsland, Jan; Seljeflot, Ingebjørg; Opstad, Trine Baur & Helseth, Ragnhild (2020). Neutrophil extracellular trap components and myocardial recovery in post-ischemic acute heart failure. PLOS ONE.  ISSN 1932-6203.  15:e0241333(10), s 1- 14 . doi: 10.1371/journal.pone.0241333 Full text in Research Archive.
  • Maros, Máté E.; Capper, David; Jones, David T.; Hovestadt, Volker; von Deimling, Andreas; Pfister, Stefan M; Benner, Axel; Zucknick, Karola Manuela & Sill, Martin (2020). Machine learning workflows to estimate class probabilities for precision cancer diagnostics on DNA methylation microarray data. Nature Protocols.  ISSN 1754-2189.  15, s 479- 512 . doi: 10.1038/s41596-019-0251-6 Full text in Research Archive.
  • Pietka, Wojciech; Sundnes, Olav; Hammarström, Clara Louise; Zucknick, Manuela; Khnykin, Denis & Haraldsen, Guttorm (2020). Lack of interleukin-33 and its receptor does not prevent calcipotriol-induced atopic dermatitis-like inflammation in mice. Scientific Reports.  ISSN 2045-2322.  10:6451, s 1- 8 . doi: 10.1038/s41598-020-63410-z Full text in Research Archive.
  • Zhao, Zhi & Zucknick, Manuela (2020). Structured penalized regression for drug sensitivity prediction. The Journal of the Royal Statistical Society, Series C (Applied Statistics).  ISSN 0035-9254.  69(3), s 525- 545 . doi: 10.1111/rssc.12400 Full text in Research Archive.
  • Nguyen, Chinh BKrong; Kumar, Surendra; Zucknick, Manuela; Kristensen, Vessela N.; Gjerstad, Johannes; Nilsen, Hilde Loge & Wyller, Vegard Bruun Bratholm (2019). Associations between clinical symptoms, plasma norepinephrine and deregulated immune gene networks in subgroups of adolescent with Chronic Fatigue Syndrome. Brain, behavior, and immunity.  ISSN 0889-1591.  76, s 82- 96 . doi: 10.1016/j.bbi.2018.11.008 Full text in Research Archive. Show summary
  • Heinicke, Fatima; Zhong, Xiangfu; Zucknick, Manuela; Breidenbach, Johannes; Sundaram, Arvind Yegambaram Meenakshi; Flåm, Siri Tennebø; Leithaug, Magnus; Dalland, Marianne; Farmer, Andrew; Henderson, Jordana M.; Hussong, Melanie A.; Moll, Pamela; Nguyen, Loan; McNulty, Amanda; Shaffer, Jonathan M.; Shore, Sabrina; Yip, Hoichong Karen; Vitkovska, Jana; Rayner, Simon; Lie, Benedicte Alexandra & Gilfillan, Gregor Duncan (2019). Systematic assessment of commercially available low-input miRNA library preparation kits. RNA Biology.  ISSN 1547-6286.  17(1), s 75- 86 . doi: 10.1080/15476286.2019.1667741 Full text in Research Archive. Show summary
  • Hjelle, Ellen Gabrielsen; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen; Martinsen, Randi; Kvigne, Kari Johanne; Kitzmüller, Gabriele; Mangset, Margrete; Thommessen, Bente & Sveen, Unni (2019). Effect of a dialogue-based intervention on psychosocial well-being 6 months after stroke in Norway: A randomized controlled trial. Journal of Rehabilitation Medicine.  ISSN 1650-1977.  51(8), s 557- 565 . doi: 10.2340/16501977-2585 Full text in Research Archive. Show summary
  • Hjelle, Ellen Gabrielsen; Bragstad, Line Kildal; Zucknick, Manuela; Kirkevold, Marit; Thommessen, Bente & Sveen, Unni (2019). The General Health Questionnaire-28 (GHQ-28) as an outcome measurement in a randomized controlled trial in a Norwegian stroke population. BMC Psychology.  ISSN 2050-7283.  7(18) . doi: 10.1186/s40359-019-0293-0 Full text in Research Archive.
  • Menden, Michael P.; Wang, Dennis; Mason, Mike J.; Szalai, Bence; Bulusu, Krishna C.; Guan, Yuanfang; Yu, Thomas; Kang, Jaewoo; Jeon, Minji; Wolfinger, Russ; Nguyen, Tin; Zaslavskiy, Mikhail; Jang, In Sock; Ghazoui, Zara; Ahsen, Mehmet Eren; Vogel, Robert; Neto, Elias Chaibub; Norman, Thea; Tang, Eric K.Y.; Garnett, Mathew J.; Di Veroli, Giovanni Y.; Fawell, Stephen; Stolovitzky, Gustavo; Zucknick, Manuela; Guinney, Justin; Dry, Jonathan R. & Saez-Rodriguez, Julio (2019). Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen. Nature Communications.  ISSN 2041-1723.  10:2674, s 1- 17 . doi: 10.1038/s41467-019-09799-2 Full text in Research Archive.
  • Schulze-Edinghausen, Lena; Dürr, Claudia; Öztürk, Selcen; Zucknick, Manuela; Benner, Axel; Kalter, Verena; Ohl, Sibylle; Close, Viola; Wuchter, Patrick; Stilgenbauer, Stephan; Lichter, Peter & Seiffert, Martina (2019). Dissecting the Prognostic Significance and Functional Role of Progranulin in Chronic Lymphocytic Leukemia. Cancers.  ISSN 2072-6694.  11(6), s 822 . doi: 10.3390/cancers11060822 Full text in Research Archive.
  • Volchenkov, Roman; Matthews, Jason; Zucknick, Manuela & Skålhegg, Bjørn Steen (2019). Shared epitope is associated with the reactivity of Th17 cells to cigarette smoke extract regardless of smoking history. Cellular & Molecular Immunology.  ISSN 1672-7681.  16(7), s 674- 675 . doi: 10.1038/s41423-019-0230-4 Full text in Research Archive.
  • Øystese, Kristin Astrid Berland; Hisanawi, Sheren; Zucknick, Manuela; Bollerslev, Jens & Ringstad, Geir (2019). Are volume measurements of non-functioning pituitary adenomas reliable?. Endocrine.  ISSN 1355-008X.  63(1), s 171- 176 . doi: 10.1007/s12020-018-1752-8
  • Dürr, Claudia; Hanna, Bola S.; Schulz, Angela; Lucas, Fabienne; Zucknick, Manuela; Benner, Axel; Clear, Andrew; Ohl, Sibylle; Öztürk, Selcen; Zenz, Thorsten; Stilgenbauer, Stephan; Li-Weber, Min; Krammer, Peter H.; Gribben, John G.; Lichter, Peter & Seiffert, Martina (2018). Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin. Haematologica.  ISSN 0390-6078.  103(4), s 688- 697 . doi: 10.3324/haematol.2017.177808 Full text in Research Archive.
  • Henriksen, Hege; Berntsen, Sveinung; Paur, Ingvild; Zucknick, Manuela; Skjetne, Anne Juul; Bøhn, Siv Kjølsrud; Henriksen, Christine; Smeland, Sigbjørn; Carlsen, Monica Hauger & Blomhoff, Rune (2018). Validation of two short questionnaires assessing physical activity in colorectal cancer patients. BMC sports science, medicine and rehabilitation.  ISSN 2052-1847.  10:8(8), s 1- 12 . doi: 10.1186/s13102-018-0096-2 Full text in Research Archive.
  • Ickstadt, Katja; Schäfer, Martin & Zucknick, Manuela (2018). Toward Integrative Bayesian Analysis in Molecular Biology. Annual Review of Statistics and Its Application.  ISSN 2326-8298.  5, s 141- 167 . doi: 10.1146/annurev-statistics-031017-100438
  • Jabeen, Shakila; Espinoza, Jaime; Torland, Lilly Anne; Zucknick, Manuela; Kumar, Surendra; Haakensen, Vilde Drageset; Luders, Torben; Engebraaten, Olav; Børresen-Dale, Anne-Lise; Kyte, Jon A; Gromov, Pavel; Naume, Bjørn; Kristensen, Vessela N.; Gromova, Irina & Tekpli, Xavier (2018). Noninvasive profiling of serum cytokines in breast cancer patients and clinicopathological characteristics.. Oncoimmunology.  ISSN 2162-4011.  :e1537691 . doi: 10.1080/2162402X.2018.1537691 Full text in Research Archive.
  • Jabeen, Shakila; Zucknick, Manuela; Nome, Marianne Eikhom; dannenfelser, ruth; Fleischer, Thomas; Kumar, Surendra; Luders, Torben; Gythfeldt, Hedda; Troyanskaya, Olga; Kyte, Jon A; Børresen-Dale, Anne-Lise; Naume, Bjørn; Tekpli, Xavier; Engebråten, Olav & Kristensen, Vessela N. (2018). Serum cytokine levels in breast cancer patients during neoadjuvant treatment with bevacizumab. Oncoimmunology.  ISSN 2162-4011.  7(11), s e1457598-1- e1457598-15 . doi: 10.1080/2162402X.2018.1457598
  • Klevberg, Gunvor Lilleholt; Elvrum, Ann-Kristin; Zucknick, Manuela; Elkjær, Sonja; Østensjø, Sigrid; Krumlinde-Sundholm, Lena; Kjeken, Ingvild & Jahnsen, Reidun Birgitta (2018). Development of bimanual performance in young children with cerebral palsy. Developmental Medicine & Child Neurology.  ISSN 0012-1622.  60(5), s 490- 497 . doi: 10.1111/dmcn.13680 Full text in Research Archive.
  • LeBlanc, Marissa; Nustad, Haakon Egdetveit; Zucknick, Manuela & Page, Christian (2018). Quality control for Illumina 450K methylation data in the absence of iDat files using correlation structure in pedigrees and repeated measures. BMC Genetics.  ISSN 1471-2156.  19 . doi: 10.1186/s12863-018-0636-5 Full text in Research Archive.
  • Nustad, Haakon Egdetveit; Page, Christian; Reiner, Andrew Henry; Zucknick, Manuela & LeBlanc, Marissa (2018). A Bayesian mixed modeling approach for estimating heritability. BMC Proceedings.  ISSN 1753-6561.  12, s 117- 122 . doi: 10.1186/s12919-018-0131-z Full text in Research Archive. Show summary
  • Opheim, Gun Lisbeth; Zucknick, Manuela; Henriksen, Tore & Haugen, Guttorm (2018). A maternal meal affects clinical Doppler parameters in the fetal middle cerebral artery. PLOS ONE.  ISSN 1932-6203.  13(12) . doi: 10.1371/journal.pone.0209990 Full text in Research Archive.
  • Tanbo, Tom Gunnar; Zucknick, Manuela & Eskild, Anne (2018). Maternal concentrations of human chorionic gonadotrophin in very early IVF pregnancies and duration of pregnancy: a follow-up study.. Reproductive Biomedicine Online.  ISSN 1472-6483.  37(2), s 208- 215 . doi: 10.1016/j.rbmo.2018.04.048 Full text in Research Archive.
  • Wolf, Christine; Garding, Angela; Filarsky, Katharina; Bahlo, Jasmin; Robrecht, Sandra; Becker, Natalia; Zucknick, Manuela; Rouhi, Arefeh; Weigel, Anja; Claus, Rainer; Weichenhan, Dieter; Eichhorst, Barbara; Fischer, Kirsten; Hallek, Michael; Kuchenbauer, Florian; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter & Mertens, Daniel (2018). NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib. International Journal of Cancer.  ISSN 0020-7136.  142(2), s 322- 333 . doi: 10.1002/ijc.31057
  • Zimmo, Kaled; Laine, Hely Katariina; Fosse, Erik; Zimmo, Mohammed; Ali-Masri, Hadil Y.; Zucknick, Karola Manuela; Vikanes, Åse Vigdis & Sahar, Hassan (2018). Episiotomy practice in six Palestinian hospitals: a population-based cohort study among singleton vaginal births. BMJ Open.  ISSN 2044-6055. . doi: 10.1136/bmjopen-2018-021629
  • Zimmo, Kaled; Laine, Katariina; Fosse, Erik; Zimmo, Mohammed; Ali, Hadil; Zucknick, Manuela; Vikanes, Åse Vigdis & Hassan, Sahar J. A. (2018). Episiotomy practice in six Palestinian hospitals: a population-based cohort study among singleton vaginal births. BMJ Open.  ISSN 2044-6055.  8(7) . doi: 10.1136/bmjopen-2018-021629 Full text in Research Archive.
  • Zimmo, Kaled; Laine, Katariina; Fosse, Erik; Zimmo, Mohammed; Ali-Masri, Hadil; Böttcher, Bettina; Zucknick, Manuela; Vikanes, Åse Vigdis & Hassan, Sahar J. A. (2018). Impact of animated instruction on tablets and hands-on training in applying bimanual perineal support on episiotomy rates: an intervention study. International Urogynecology Journal.  ISSN 0937-3462.  s 1- 8 . doi: 10.1007/s00192-018-3711-6 Full text in Research Archive.
  • Øystese, Kristin Astrid Berland; Berg, Jens Petter; Normann, Kjersti Ringvoll; Zucknick, Manuela; Casar-Borota, Olivera & Bollerslev, Jens (2018). The role of E and N-cadherin in the postoperative course of gonadotroph pituitary tumours.. Endocrine.  ISSN 1355-008X.  62(2), s 351- 360 . doi: 10.1007/s12020-018-1679-0
  • Goeppert, Benjamin; Roessler, Stephanie; Becker, Natalia; Zucknick, Manuela; Vogel, Monika Nadja; Warth, Arne; Pathil‐Warth, Anita; Mehrabi, Arianeb; Schirmacher, Peter; Mollenhauer, Jan & Renner, Marcus (2017). DMBT1 expression in biliary carcinogenesis with correlation of clinicopathological data. Histopathology.  ISSN 0309-0167.  70(7), s 1064- 1071 . doi: 10.1111/his.13175
  • Henriksen, Hege; Ræder, Hanna; Bøhn, Siv Kjølsrud; Paur, Ingvild; Kværner, Ane Sørlie; Billington, Siv Åshild; Eriksen, Morten Tandberg; Wiedswang, Gro; Erlund, Iris; Færden, Arne Engebreth; Veierød, Marit Bragelien; Zucknick, Manuela; Smeland, Sigbjørn & Blomhoff, Rune (2017). The Norwegian dietary guidelines and colorectal cancer survival (CRC-NORDIET) study: A food-based multicentre randomized controlled trial. BMC Cancer.  ISSN 1471-2407.  17(1) . doi: 10.1186/s12885-017-3072-4
  • Holm, Maia Blomhoff; Bastani, Nasser Ezzatkhah; Holme, Ane Moe; Zucknick, Manuela; Jansson, Thomas; Refsum, Helga; Mørkrid, Lars; Blomhoff, Rune; Henriksen, Tore & Michelsen, Trond Melbye (2017). Uptake and release of amino acids in the fetal-placental unit in human pregnancies. PLOS ONE.  ISSN 1932-6203.  12(10) . doi: 10.1371/journal.pone.0185760 Full text in Research Archive.
  • Majak, Guri Bårdstu; Reisæter, Anna Varberg; Zucknick, Manuela; Lorentzen, Bjørg; Vangen, Siri; Henriksen, Tore & Michelsen, Trond Melbye (2017). Preeclampsia in kidney transplanted women; Outcomes and a simple prognostic risk score system. PLOS ONE.  ISSN 1932-6203.  12:e0173420(3), s 1- 11 . doi: 10.1371/journal.pone.0173420
  • Treppmann, Tabea; Ickstadt, Katja & Zucknick, Manuela (2017). Integration of multiple genomic data sources in a Bayesian Cox model for variable selection and prediction. Computational & Mathematical Methods in Medicine.  ISSN 1748-670X.  2017 . doi: 10.1155/2017/7340565 Full text in Research Archive.
  • Øystese, Kristin Astrid Berland; Casar-Borota, Olivera; Normann, Kjersti Ringvoll; Zucknick, Manuela; Berg, Jens Petter & Bollerslev, Jens (2017). Estrogen Receptor α, a Sex-Dependent Predictor of Aggressiveness in Nonfunctioning Pituitary Adenomas: SSTR and Sex Hormone Receptor Distribution in NFPA. Journal of Clinical Endocrinology and Metabolism.  ISSN 0021-972X.  102(9), s 3581- 3590 . doi: 10.1210/jc.2017-00792
  • Øystese, Kristin Astrid Berland; Zucknick, Manuela; Casar-Borota, Olivera; Ringstad, Geir & Bollerslev, Jens (2017). Early postoperative growth in non-functioning pituitary adenomas; A tool to tailor safe follow-up. Endocrine.  ISSN 1355-008X.  57(1), s 35- 45 . doi: 10.1007/s12020-017-1314-5
  • Joshi, Sarita; Schjølberg, Aasa Rambæk; Ekstrøm, Per Olaf; De Angelis, Paula; Zucknick, Manuela; Andersen, Solveig Norheim & Clausen, Ole Petter Fraas (2016). Tp53/p53 status in keratoacanthomas. Journal of cutaneous pathology.  ISSN 0303-6987.  43(7), s 571- 578 . doi: 10.1111/cup.12713
  • Kap, Elisabeth J; Seibold, Petra; Scherer, Dominique; Habermann, Nina; Balavarca, Yesilda; Jansen, Lina; Zucknick, Manuela; Becker, Natalia; Hoffmeister, Michael; Ulrich, Alexis; Benner, Axel; Ulrich, Cornelia M; Burwinkel, Barbara; Brenner, Hermann & Chang-Claude, Jenny (2016). SNPs in transporter and metabolizing genes as predictive markers for oxaliplatin treatment in colorectal cancer patients. International Journal of Cancer.  ISSN 0020-7136.  138(12), s 2993- 3001 . doi: 10.1002/ijc.30026
  • Kostareli, Efterpi; Hielscher, Thomas; Zucknick, Manuela; Baboci, Lorena; Wichmann, Gunnar; Holzinger, Dana; Mucke, Oliver; Pawlita, Michael; Del Mistro, Annarosa; Boscolo-Rizzo, Paolo; Da Mosto, Maria Cristina; Tirelli, Giancarlo; Plinkert, Peter; Dietz, Andreas; Plass, Christoph; Weichenhan, Dieter & Hess, Jochen (2016). Gene promoter methylation signature predicts survival of head and neck squamous cell carcinoma patients. Epigenetics.  ISSN 1559-2294.  11(1), s 61- 73 . doi: 10.1080/15592294.2015.1137414
  • Madhavan, Dharanija; Peng, Cike; Wallwiener, Markus; Zucknick, Manuela; Nees, Juliane; Schott, Sarah; Rudolph, Anja; Riethdorf, Sabine; Trumpp, Andreas; Pantel, Klaus; Sohn, Christof; Chang-Claude, Jenny; Schneeweiss, Andreas & Burwinkel, Barbara (2016). Circulating miRNAs with prognostic value in metastatic breast cancer and for early detection of metastasis. Carcinogenesis.  ISSN 0143-3334.  37(5), s 461- 470 . doi: 10.1093/carcin/bgw008
  • Mock, Andreas; Geisenberger, Christoph; Orlik, Christian; Warta, Rolf; Schwager, Christian; Jungk, Christine; Dutruel, Celine; Geiselhart, Lea; Weichenhan, Dieter; Zucknick, Manuela; Nied, Ann-Katrin; Friauf, Sara; Exner, Janina; Capper, David; Hartmann, Christian; Lahrmann, Bernd; Grabe, Niels; Debus, Jurgen; Von Deimling, Andreas; Popanda, Odilia; Plass, Christoph; Unterberg, Andreas; Abdollahi, Amir; Schmezer, Peter & Herold-Mende, Christel (2016). LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild-type glioblastoma patients. International Journal of Cancer.  ISSN 0020-7136.  139(2), s 424- 432 . doi: 10.1002/ijc.30069
  • Chen, Hongda; Zucknick, Manuela; Werner, Simone; Knebel, Phillip & Brenner, Hermann (2015). Head-to-head comparison and evaluation of 92 plasma protein biomarkers for early detection of colorectal cancer in a true screening setting. Clinical Cancer Research.  ISSN 1078-0432.  21(14), s 3318- 3326 . doi: 10.1158/1078-0432.CCR-14-3051
  • Goeppert, Benjamin; Frauenschuh, Lena; Zucknick, Manuela; Roessler, Stephanie; Mehrabi, Arianeb; Hafezi, Mohammadreza; Stenzinger, Albrecht; Warth, Arne; Pathil, Anita; Renner, Marcus; Schirmacher, Peter & Weichert, Wilko (2015). Major histocompatibility complex class I expression impacts on patient survival and type and density of immune cells in biliary tract cancer. British Journal of Cancer.  ISSN 0007-0920.  113(9), s 1343- 1349 . doi: 10.1038/bjc.2015.337
  • Yang, Rongxi; Pfütze, Katrin; Zucknick, Manuela; Sutter, Christian; Wappenschmidt, Barbara; Marme, Frederik; Qu, Bin; Cuk, Katarina; Engel, Christoph; Schott, Sarah; Schneeweiss, Andreas; Brenner, Hermann; Claus, Rainer; Plass, Christoph; Bugert, Peter; Hoth, Markus; Sohn, Christof; Schmutzler, Rita; Bartram, Claus R & Burwinkel, Barbara (2015). DNA methylation array analyses identified breast cancer‐associated HYAL2 methylation in peripheral blood. International Journal of Cancer.  ISSN 0020-7136.  136(8), s 1845- 1855 . doi: 10.1002/ijc.29205
  • Zucknick, Manuela; Saadati, Maral & Benner, Axel (2015). Nonidentical twins: Comparison of frequentist and Bayesian lasso for Cox models. Biometrical Journal.  ISSN 0323-3847.  57(6), s 959- 981 . doi: 10.1002/bimj.201400160

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  • Hjelle, Ellen Gabrielsen; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen; Martinsen, Randi; Kvigne, Kari Johanne; Kitzmüller, Gabriele; Mangset, Margrete; Thommessen, Bente & Sveen, Unni (2019). The effect of a psychosocial intervention on well-being 6 months after stroke – a multicentre prospective randomized controlled trial.
  • Hjelle, Ellen Gabrielsen Hjelle; Bragstad, Line Kildal; Kirkevold, Marit; Zucknick, Manuela; Bronken, Berit Arnesveen; Martinsen, Randi; Kvigne, Kari Johanne; Kitzmüller, Gabriele; Mangset, Margrete; Thommessen, Bente & Sveen, Unni (2019). The complexities of an intervention to promote psychosocial well-being after stroke: Implications for trial outcome.
  • Filarsky, Katharina; Garding, Angela; Becker, Natalia; Wolf, Christine; Zucknick, Manuela; Claus, Rainer; Weichenhan, Dieter; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter & Mertens, Daniel (2016). Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of NOTCH signaling. Haematologica.  ISSN 0390-6078.  101(6), s e249- e253 . doi: 10.3324/haematol.2015.138172
  • Hellton, Kristoffer Herland & Zucknick, Manuela (2016). Drug synergy prediction for personalized therapy.
  • Lipka, Daniel B.; Witte, Tania; Wiesenfarth, Manuel; Zucknick, Manuela; Konermann, Carolin; Gu, Lei; Claus, Rainer; Nöllke, Peter; Niemeyer, Charlotte M; Flotho, Christian & Plass, Christoph (2015). Genome-wide DNA methylation profiling reveals two prognostically distinct subgroups of juvenile myelomonocytic leukemia. Experimental Hematology.  ISSN 0301-472X.  43(9), s S47
  • Maierthaler, Melanie; Mennesson, Eric; Cuk, Katarina; Madhavan, Dharanija; Zucknick, Manuela; Fixe, Isabelle; Foucher, Alexandra; Wallwiener, Markus; Schneeweiss, Andreas; Normand, Nadia & Burwinkel, Barbara (2015). Comparison of different highly sensitive miRNA array platforms for the investigation of circulating cell-free microRNAs in blood. Cancer Research.  ISSN 0008-5472.  75(15), s 3973- 3973

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Published Jan. 5, 2015 12:33 PM - Last modified Nov. 15, 2020 3:01 AM