Rune Enger

Associate Professor - Glia
Image of Rune Enger
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Phone +47 22840261
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Visiting address Domus Medica Sognsvannsveien 9 0372 OSLO
Postal address Postboks 1105 Blindern 0317 OSLO

Academic interests

My research interests are mainly focussed on astrocyte–neuron interplay in the healthy and dysfunctioning brain. Broadly, I'm involved in projects belonging to the following categories:

  • What are the roles of astrocytic Ca2+ signals in the normal brain? Since the discovery that astrocytes can react with and communicate by local or spreading Ca2+ elevations, a range of different mechanisms have been linked to these signals. For instance, such signals have been proposed to influence neuronal network activity by release of transmitter substances in, or close by, synapses. Similarly, astrocytic Ca2+ signals have been proposed to influence vascular tone. Currently, I'm trying to outline the role of astroglial Ca2+ signals in spatial memory encoding and consolidation.
  • What are the mechanisms underlying cortical spreading depression (CSD)? CSD is the phenomenon underlying the perceptual disturbances of the migraine aura, and although first discovered over 70 years ago, key aspects of these events are still unknown. 
  • What are the roles of astrocytic Ca2+ signals in epileptic seizures and chronic epileptic brain tissue?

To answer these questions I work with advanced imaging techniques. Most importantly, two-photon microscopy in awake head-fixed mice, in combination with electrophysiology and molecular strategies.

Teaching

  • Human macroscopic and microscopic anatomy to 1. and 2. year medical students (MED1100 and MED2200).

Background

  • 2019– Associate professor, Division of Anatomy, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2017–2019 10% associate professor, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2016–2019 Postdoctoral researcher, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • Dissertation June 2016.
  • 2013–2016 Ph.d. student, Oslo University Hospital, Rikshospitalet, Department of Neurology. Erlend Nagelhus’ group, Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo.
  • 2011–2013 Medical internship in internal medicine, surgery and as a general practitioner
  • 2004–2011 Cand.med. including the medical student research programme, University of Oslo

Publications

  • Eilert-Olsen, Martine; Hjukse, Jarand Berg; Thoren, Anna; Tang, Wannan; Enger, Rune; Jensen, Vidar; Pettersen, Klas Henning & Nagelhus, Erlend Arnulf (2019). Astroglial endfeet exhibit distinct Ca2+ signals during hypoosmotic conditions. Glia.  ISSN 0894-1491.  67(12), s 2399- 2409 . doi: 10.1002/glia.23692 Full text in Research Archive.
  • Hasan-Olive, Md Mahdi; Enger, Rune; Hansson, Hans-Arne; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2019). Pathological mitochondria in neurons and perivascular astrocytic endfeet of idiopathic normal pressure hydrocephalus patients. Fluids and Barriers of the CNS.  ISSN 2045-8118.  16:39, s 1- 16 . doi: 10.1186/s12987-019-0160-7 Full text in Research Archive.
  • Hasan-Olive, Md Mahdi; Hansson, Hans-Arne; Enger, Rune; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2019). Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension. Journal of Neuropathology and Experimental Neurology.  ISSN 0022-3069.  78(9), s 808- 818 . doi: 10.1093/jnen/nlz063
  • Rosic, Brana; Dukefoss, Didrik Bakke; Åbjørsbråten, Knut Sindre; Tang, Wannan; Jensen, Vidar; Ottersen, Ole Petter; Enger, Rune & Nagelhus, Erlend Arnulf (2019). Aquaporin-4-independent volume dynamics of astroglial endfeet during cortical spreading depression. Glia.  ISSN 0894-1491.  67(6), s 1113- 1121 . doi: 10.1002/glia.23604 Full text in Research Archive. Show summary
  • Hasan-Olive, Md Mahdi; Enger, Rune; Hansson, Hans-Arne; Nagelhus, Erlend Arnulf & Eide, Per Kristian (2018). Loss of perivascular aquaporin-4 in idiopathic normal pressure hydrocephalus. Glia.  ISSN 0894-1491.  67, s 91- 100 . doi: 10.1002/glia.23528
  • Heuser, Kjell; Nome, Cecilie; Pettersen, Klas; Åbjørsbråten, Knut Sindre; Jensen, Vidar; Tang, Wannan; Sprengel, Rolf; Taubøll, Erik; Nagelhus, Erlend Arnulf & Enger, Rune (2018). Ca2+ signals in astrocytes facilitate spread of epileptiform activity. Cerebral Cortex.  ISSN 1047-3211.  28(11), s 4036- 4048 . doi: 10.1093/cercor/bhy196 Full text in Research Archive.
  • Eidsvaag, Vigdis Andersen; Enger, Rune; Hansson, Hans-Arne; Eide, Per Kristian & Nagelhus, Erlend Arnulf (2017). Human and mouse cortical astrocytes differ in aquaporin-4 polarization toward microvessels. Glia.  ISSN 0894-1491.  65(6), s 964- 973 . doi: 10.1002/glia.23138 Full text in Research Archive.
  • Enger, Rune (2017). Automated gold particle quantification of immunogold labeled micrographs. Journal of Neuroscience Methods.  ISSN 0165-0270.  286, s 31- 37 . doi: 10.1016/j.jneumeth.2017.05.018 Full text in Research Archive.
  • Enger, Rune; Dukefoss, Didrik Bakke; Tang, Wannan; Pettersen, Klas; Bjørnstad, Daniel Marelius; Helm, Paul Johannes; Jensen, Vidar; Sprengel, Rolf; Vervaeke, Koen Gerard Alois; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2016). Deletion of aquaporin-4 curtails extracellular glutamate elevation in cortical spreading depression in awake mice. Cerebral Cortex.  ISSN 1047-3211. . doi: 10.1093/cercor/bhw359
  • Enger, Rune; Tang, Wannan; Vindedal, Gry Fluge; Jensen, Vidar; Helm, Paul Johannes; Sprengel, Rolf; Looger, Loren L. & Nagelhus, Erlend Arnulf (2015). Dynamics of ionic shifts in cortical spreading depression. Cerebral Cortex.  ISSN 1047-3211.  25(11), s 4469- 4476 . doi: 10.1093/cercor/bhv054 Show summary
  • Szokol, Karolina; Heuser, Kjell; Tang, Wannan; Jensen, Vidar; Enger, Rune; Bedner, Peter; Steinhäuser, Christian; Taubøll, Erik; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2015). Augmentation of Ca<sup>2+</sup> signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Frontiers in Cellular Neuroscience.  ISSN 1662-5102.  9 . doi: 10.3389/fncel.2015.00049 Full text in Research Archive. Show summary
  • Tang, Wannan; Szokol, Karolina; Jensen, Vidar; Enger, Rune; Trivedi, Chintan A.; Hvalby, Øyvind Christian dødsbo; Helm, Paul Johannes; Looger, Loren L.; Sprengel, Rolf & Nagelhus, Erlend Arnulf (2015). Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP. Journal of Neuroscience.  ISSN 0270-6474.  35(7), s 3016- 3021 . doi: 10.1523/JNEUROSCI.3319-14.2015 Show summary
  • Eilert-Olsen, Martine; Haj Yasein, Nadia Nabil; Vindedal, Gry Fluge; Enger, Rune; Gundersen, Georg Andreas; Hoddevik, Eystein Hellstrøm; Petersen, Petur Henry; Haug, Finn-Mogens Smejda; Skare, Øivind; Adams, Marvin E.; Froehner, Stanley C.; Burkhardt, John Michael; Thoren, Anna & Nagelhus, Erlend Arnulf (2012). Deletion of aquaporin-4 changes the perivascular glial protein scaffold without disrupting the brain endothelial barrier. Glia.  ISSN 0894-1491.  60(3), s 432- 440 . doi: 10.1002/glia.22277
  • Enger, Rune; Gundersen, Georg Andreas; Haj-Yasein, Nadia Nabil; Eilert-Olsen, Martine; Thoren, Anna; Vindedal, Gry Fluge; Petersen, Petur Henry; Skare, Øivind; Nedergaard, Maiken; Ottersen, Ole Petter & Nagelhus, Erlend Arnulf (2012). Molecular scaffolds underpinning macroglial polarization: An analysis of retinal Muller cells and brain astrocytes in mouse. Glia.  ISSN 0894-1491.  60(12), s 2018- 2026 . doi: 10.1002/glia.22416 Show summary
  • Thrane, Alexander Stanley; Rappold, Philip M; Fujita, Takumi; Torres, Arnulfo; Bekar, Lane K; Takano, Takahiro; Peng, Weiguo; Wang, Fushun; Thrane Rangroo, Vinita; Enger, Rune; Haj Yasein, Nadia Nabil; Skare, Øivind; Holen, Torgeir; Klungland, Arne; Ottersen, Ole Petter; Nedergaard, Maiken & Nagelhus, Erlend Arnulf (2011). Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  108(2), s 846- 851 . doi: 10.1073/pnas.1015217108
  • Nase, Gabriele; Helm, Paul Johannes; Enger, Rune & Ottersen, Ole Petter (2008). Water entry into astrocytes during brain edema formation. Glia.  ISSN 0894-1491.  56, s 895- 902 . doi: 10.1002/glia.20664

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Published Jan. 29, 2014 1:44 PM - Last modified Dec. 4, 2019 4:20 PM

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