Sandip Kanse

Image of Sandip Kanse
Norwegian version of this page
Phone +47-22851464
Room 1256
Username
Visiting address Sognsvannsveien 9 Domus Medica 0372 OSLO
Postal address Postboks 1112 Blindern 0317 OSLO
Other affiliations Division of Biochemistry

Academic Interests

  • Proteases in vascular biology
  • Atherosclerosis/stroke/myocardial Infarction
  • Thrombosis/haemostasis
  • Inflammation

Courses taught

  • Medical Biochemistry

Background

Academic background

  • Habilitation, University of Giessen, Germany, 2003
  • PhD, University of London, UK, 1986-1991
  • BSc Biochemistry, University of London, UK 1983-1986

Previous positions held

  • Member of the Excellence Cluster in Cardiopulmonary Sciences (ECCPS), University of Giessen, Germany (2007-2014)
  • Member of the Sonderforschungsbereich SFB-547 University of Giessen, Germany (2006-2009)
  • Faculty Member, University of Giessen, Germany, 1999-2011
  • Postdoctoral Fellow, Max Planck Institute, Bad Nauheim, Germany, 1994-1998
  • Postdoctoral Fellow, Thrombosis Research Institute, London, UK 1992-1993

Collaboration

  • Jan Marcus Daniel, Giessen, Germany
  • Joerg Herold, Magdeburg, Germany
  • Christina Jern, Gothenburg, Sweden
  • Paul Declerck, Leuven, Belgium
  • Ralf Weiskirchen, Aachen, Germany
  • Michael Etscheid, Langen, Germany
  • Markus Huber-Lang, Ulm, Germany
  • Marcus Krueger, Bad Nauheim, Germany
  • Christoph Reichel, Munich Germany
  • Denis Vivien, Caen, France
  • Radislav Sedlacek, Prague, The Czech Republic
  • Per Morten Sandset, Oslo, Norway
  • Geir Åge Løset, Oslo, Norway
  • Jens Preben Morth, Oslo, Norway
Tags: Coagulation, Heart vascular and lungs, Inflammation, Proteases, Blood and immunology, Atherosclerosis, Cardiovascular disease, Thrombosis, Fibrinolysis

Publications

  • Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M and Preissner KT. Staphylococcus aureus extracellular adherence protein serves as anti- inflammatory factor by inhibiting the recruitment of host leukocytes. Nature Medicine. 2002;8:687-93.
  • Deindl E, Ziegelhoffer T, Kanse SM, Fernandez B, Neubauer E, Carmeliet P, Preissner KT and Schaper W. Receptor-independent role of the urokinase-type plasminogen activator during arteriogenesis. FASEB Journal. 2003;17:1174-6.
  • Kannemeier C, Al-Fakhri N, Preissner KT and Kanse SM. Factor VII activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells. FASEB Journal. 2004;18:728-30.
  • Sedding D, Daniel JM, Muhl L, Hersemeyer K, Brunsch H, Kemkes-Matthes B, Braun-Dullaeus RC, Tillmanns H, Weimer T, Preissner KT and Kanse SM. The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation. The Journal of Experimental Medicine. 2006;203:2801-7.
  • Shibamiya A, Muhl L, Tannert-Otto S, Preissner KT and Kanse SM. Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation. The Biochemical Journal. 2007;404:45-50.
  • Parahuleva MS, Kanse SM, Parviz B, Barth A, Tillmanns H, Bohle RM, Sedding DG and Holschermann H. Factor Seven Activating Protease (FSAP) expression in human monocytes and accumulation in unstable coronary atherosclerotic plaques. Atherosclerosis. 2008;196:164-71.
  • Roderfeld M, Weiskirchen R, Atanasova S, Gressner AM, Preissner KT, Roeb E and Kanse SM. Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells. Liver International. 2009;29:686.
  • Shibamiya A, Hersemeyer K, Schmidt Woll T, Sedding D, Daniel JM, Bauer S, Koyama T, Preissner KT and Kanse SM. A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells. Blood. 2009;113:714-22.
  • Wasmuth HE, Tag CG, Van de Leur E, Hellerbrand C, Mueller T, Berg T, Puhl G, Neuhaus P, Samuel D, Trautwein C, Kanse SM and Weiskirchen R. The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB. Hepatology. 2009;49:775-80.
  • Reichel CA, Uhl B, Lerchenberger M, Puhr-Westerheide D, Rehberg M, Liebl J, Khandoga A, Schmalix W, Zahler S, Deindl E, Lorenzl S, Declerck PJ, Kanse S and Krombach F. Urokinase-type plasminogen activator promotes paracellular transmigration of neutrophils via mac-1, but independently of urokinase-type plasminogen activator receptor. Circulation. 2011;124:1848-59.
  • Hanson E, Kanse SM, Joshi A, Jood K, Nilsson S, Blomstrand C and Jern C. Plasma factor VII-activating protease antigen levels and activity are increased in ischemic stroke. Journal of Thrombosis and Haemostasis. 2012;10:848-56.
  • Kanse SM, Declerck PJ, Ruf W, Broze G and Etscheid M. Factor VII-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32:427-33.
  • Kanse SM, Gallenmueller A, Zeerleder S, Stephan F, Rannou O, Denk S, Etscheid M, Lochnit G, Krueger M and Huber-Lang M. Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a. Journal of Immunol. 2012;188:2858-65.
  • Borkham-Kamphorst E, Zimmermann HW, Gassler N, Bissels U, Bosio A, Tacke F, Weiskirchen R and Kanse SM. Factor VII activating protease (FSAP) exerts anti-inflammatory and anti-fibrotic effects in liver fibrosis in mice and men. Journal of Hepatology. 2013;58:104-11.
  • Parahuleva MS, Maj R, Holschermann H, Parviz B, Abdallah Y, Erdogan A, Tillmanns H and Kanse SM. Regulation of monocyte/macrophage function by factor VII activating protease (FSAP). Atherosclerosis. 2013;230:365-72.
  • Roedel EK, Schwarz E and Kanse SM. The Factor VII-activating protease (FSAP) enhances the activity of bone morphogenetic protein-2 (BMP-2). The Journal of Biological Chemistry. 2013;288:11.
  • Byskov, Kristina; Boettger, Thomas; Ruehle, Paul F.; Nielsen, Nis Valentin; Etscheid, Michael & Kanse, Sandip (2017). Factor VII activating protease (FSAP) regulates the expression of inflammatory genes in vascular smooth muscle and endothelial cells. Atherosclerosis.  ISSN 0021-9150.  265, s 133- 139 . doi: 10.1016/j.atherosclerosis.2017.08.029 Full text in Research Archive.
  • Cui, Xue-Yan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Sahlberg, Kristine Kleivi; Kanse, Sandip; Iversen, Nina & Sandset, Per Morten (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7. Thrombosis Research.  ISSN 0049-3848.  157, s 111- 116 . doi: 10.1016/j.thromres.2017.07.013
  • Cui, Xueyan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip; Iversen, Nina & Sandset, Per Morten (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in breast cancer. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  1, s 395- 395
  • Espada Serrano, Sandra; Stavik, Benedicte; Holm, Sverre; Sagen, Ellen Lund; Bjerkeli, Vigdis; Skjelland, Mona; Dahl, Tuva Børresdatter; Espevik, Terje; Kanse, Sandip; Sandset, Per Morten; Skretting, Grethe & Halvorsen, Bente (2017). Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  491(2), s 442- 448 . doi: 10.1016/j.bbrc.2017.07.070 Show summary
  • Grasso, Simona; Neumann, A; Lang, IM; Etscheid, Michael; von Köckritz-Blickwede, M & Kanse, Sandip (2017). Interaction of factor VII activating protease (FSAP) with neutrophil extracellular traps (NETs).. Thrombosis Research.  ISSN 0049-3848.  161, s 36- 42 . doi: 10.1016/j.thromres.2017.11.012 Full text in Research Archive.
  • Herold, Joerg; Nowak, Steven; Kostin, Sawa; Daniel, Jan-Marcus; Francke, Alexander; Subramaniam, Saravanan; Braun-Dullaeus, Ruediger C. & Kanse, Sandip (2017). Factor VII activating protease (FSAP) influences vascular remodeling in the mouse hind limb ischemia model. American journal of translational research.  ISSN 1943-8141.  9(6), s 3084- 3095
  • Kara, Emrah; Manna, Dipankar; Løset, Geir Åge; Schneider, E L; Craik, C S & Kanse, Sandip (2017). Analysis of the substrate specificity of Factor VII activating protease (FSAP) and design of specific and sensitive peptide substrates. Thrombosis and Haemostasis.  ISSN 0340-6245. . doi: 10.1160/TH17-02-0081 Full text in Research Archive.
  • Reiterer-Farhan, Veronika; Figueras‐Puig, Cristina; Le Guerroue,, Francois; Confalonieri, Stefano; Vecchi, Manuela; Jalapothu, Dasaradha; Kanse, Sandip; Deshaies, Raymond J; Di Fiore, Pier Paolo; Behrends, Christian & Farhan, Hesso (2017). The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function. EMBO Journal.  ISSN 0261-4189.  36(3), s 260- 273 . doi: 10.15252/embj.201694795

View all works in Cristin

  • Kara, Emrah; Manna, Dipankar; Løset, Geir Åge; Schneider, Eric L.; Craik, Charles S. & Kanse, Sandip (2017). Analysis of the Substrate Specificity of Factor VII Activating Protease (FSAP) and Design of a Specific and Sensitive Peptide Substrate. Res Pract Thromb Haemost.  s 560- 560 . doi: 10.1002/rth2.12012
  • Nielsen, Nis Valentin; Manna, Dipankar; J. Preben, Morth; Roedel, Elfie; Etscheid, Michael & Kanse, Sandip (2017). Factor VII Activating Protease (FSAP) and Marburg I (G534E) Polymorphism; How One Amino Acid Determines Function. Res Pract Thromb Haemost.  s 358- 359 . doi: 10.1002/rth2.12012

View all works in Cristin

Published Jan. 12, 2012 2:25 PM - Last modified June 2, 2014 9:03 AM

Research groups