Seham Skah

Postdoctoral Fellow - Cell Cycle and Apoptosis Group
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Visiting address Sognsvannsveien 9 Domus Medica 0372 Oslo
Postal address Postboks 1112 Blindern 0317 Oslo

Academic interests

Cyclic AMP-signaling in development and treatment of BCP-ALL

Relationship between autophagy, cAMP signaling and DNA damage response

Background

2012: PhD in Sciences Technologies and Health, Specialized in Life Sciences at the École Normale Supérieure of Lyon, France. Dissertation subject: Functional relationships between the pathways of thyroid hormones and Wnt in the intestinal physiopathology: Study of sFRP2 function. 

2008: Master in Cell Genetics and Biology, Cellular Function and Pathology at the University Claude Bernard of Lyon 1, France. Subject of research: Validation of a transgenic mouse model conditionally over-expressing the nuclear receptor of the thyroid hormones TRalpha1, specifically in the intestinal epithelium.

Publications                                                                                                                        

Richartz N, Duthil E, Ford A, Naderi EH, Bhagwat S, Gilljam KM, Burman MM, Ruud E, Blomhoff HK, Skah S. “Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model”. Blood Adv. 2019 Nov 12;3(21):3181-3190. doi: 10.1182/bloodadvances.2019000473.

Skah S, Richartz N, Duthil E, Gilljam KM, Bindesbøll C, Naderi EH, Eriksen AB, Ruud E, Dirdal MM, Simonsen A, Blomhoff HK. “cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53”. Oncotarget. 2018 Jul 13;9(54):30434-30449. doi: 10.18632/oncotarget.25758. eCollection 2018 Jul 13.

Skah S, Uchuya-Castillo J, Sirakov M, Plateroti M. “The thyroid hormone nuclear receptors and the Wnt/β-catenin pathway: An intriguing liaison”. Dev Biol. 2017 Feb 15;422(2):71-82. doi: 10.1016/j.ydbio.2017.01.003. Epub 2017 Jan 6. Review.

Naderi EH, Skah S, Ugland H, Myklebost O, Sandnes DL, Torgersen ML, Josefsen D, Ruud E, Naderi S, Blomhoff HK. “Bone marrow stroma-derived PGE2 protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death”. Mol Cancer 2015 27;14:14. Epub 2015 Jan 27.

Skah S, Nadjar J, Sirakov M, Plateroti M. “The secreted Frizzled-Related Protein 2 modulates cell fate and the Wnt pathway in the murine intestinal epithelium”. Exp Cell Res 2015 Jan 24;330 (1):56-65. Epub 2014 Oct 24.

Berthon A, Drelon C, Ragazzon B, Tissier F, Boulkroun S, Amar L, Samson-Couterie B, Zennaro MC, Plouin PF, Skah S, Plateroti M, Lefèbvre H, Sahut-Barnola I, Batisse M, Assié G, Lefrançois-Martinez AM, Bertherat J, Martinez A, Val P. “WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production”. Hum Mol Genet 2014 Feb 1;23 (4):889-905. Epub 2013 Oct 1.

Sirakov M, Skah S, Nadjar J, Plateroti M. “Thyroid hormone's action on progenitor/stem cell biology: New challenge for a classic hormone?” Biochim Biophys Acta 2013 Jul 7;1830 (7):3917-27. Epub 2012 Aug 7.

Sirakov M, Skah S, Lone IN, Nadjar J, Angelov D, Plateroti M. “Multi-level interactions between the nuclear receptor TRa1 and the WNT effectors b-catenin/Tcf4 in the intestinal epithelium”. PLoS One 2012 3;7 (4):e34162. Epub 2012 Apr 3.

Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M., “The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation”. J Cell Sci 2010 Oct 7;123(Pt 19):3256-65. Epub 2010 Sep 7.

Kress E, Skah S, Sirakov M, Nadjar J, Gadot N, Scoazec JY, Samarut J, Plateroti M., “Cooperation between the thyroid hormone receptor TRalpha1 and the WNT pathway in the induction of intestinal tumorigenesis”. Gastroenterology 2010 May 28;138 (5):1863-74. Epub 2010 Jan 28.

Tags: Life science, cancer research, cAMP-signaling, autophagy, DNA damage, p53, apoptosis

Publications

  • Richartz, Nina; Duthil, Eva; Ford, Anthony; Naderi, Elin Hallan; Bhagwat, Sampada; Gilljam, Karin Margaretha; Dirdal, Marta Maria; Ruud, Ellen; Blomhoff, Heidi Kiil & Skah, Seham (2019). Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. Blood Advances.  ISSN 2473-9529.  3(21), s 3181- 3190 . doi: 10.1182/bloodadvances.2019000473
  • Skah, Seham; Richartz, Nina; Duthil, Eva; Gilljam, Karin Margaretha; Bindesbøll, Christian; Naderi, Elin Hallan; Eriksen, Agnete Bratsberg; Ruud, Ellen; Dirdal, Marta Maria; Simonsen, Anne & Blomhoff, Heidi Kiil (2018). cAMP-mediated autophagy inhibits DNA damage-induced death of leukemia cells independent of p53. OncoTarget.  ISSN 1949-2553.  9(54), s 30434- 30449 . doi: 10.18632/oncotarget.25758 Full text in Research Archive.
  • Naderi, Elin Hallan; Skah, Seham; Ugland, Hege Katrin; Myklebost, Ola; Sandnes, Dagny Lise; Torgersen, Maria Lyngaas; Josefsen, Dag; Ruud, Ellen; Naderi, Soheil & Blomhoff, Heidi Kiil (2015). Bone marrow stroma-derived PGE<sub>2</sub> protects BCP-ALL cells from DNA damage-induced p53 accumulation and cell death. Molecular Cancer.  ISSN 1476-4598.  14(1) . doi: 10.1186/s12943-014-0278-9 Full text in Research Archive.

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Published Sep. 6, 2013 10:55 AM - Last modified Dec. 5, 2019 5:06 PM

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