Sergei Ponomartcev

Stable maintenance of de novo assembled human artificial chromosomes in embryonic
stem cells and their differentiated progeny in mice. Liskovykh, M., Ponomartsev, S.,
Popova, Bader, M., Kouprina, N., Larionov, V., Alenina, N., Tomilin, A. 2015. Cell Cycle

Neural crest contribution to the avian shoulder girdle and implications to girdle
evolution in vertebrates. Ponomartsev, S., Valasek, P., Patel, K., et al., 2017. Biological
Communications

Transfer of Synthetic Human Chromosome into Human Induced Pluripotent Stem Cells
for Biomedical Applications. Sinenko, S.A. ; Skvortsova, E.V., Liskovykh, M. A.,
Ponomartsev, S.V., Kuzmin, A.A., Khudiakov, A.A., Malashicheva, A.B., Alenina, A.,
Larionov, V., Kouprina N. and Tomilin, A.N. 2018. Cells

Genetic tool for fate mapping of Oct4 (Pou5f1)-expressing cells and their progeny past
the pluripotency stage. Kuzmin, A.A., Ermakova, V.V., Sinenko, S.A., Ponomartsev, S.V.,
Starkova, T.Y., Skvortsova, E.V., Cherepanova O., Tomilin A.N. 2019. Stem Cell Research
and Therapy

Human artificial chromosomes for pluripotent stem cell-based tissue replacement
therapy. Sinenko, S.A., Ponomartsev, S.V., Tomilin, A.N., 2020. Experimental Cell
Research

Derivation and characterization of Pcbp1-deficient mouse embryonic stem cells. E.I.
Bakhmet, S.V. Ponomartsev, P.A. Dyban et al., 2020. Cell and Tissue Biology

Human AlphoidtetO Artificial Chromosome as a Gene Therapy Vector for the Developing
Hemophilia A Model in Mice. Sergey V. Ponomartsev, Sergey A. Sinenko,, Elena V.
Skvortsova, Mikhail A. Liskovykh , Ivan N. Voropaev, Maria M. Savina et al., 2020. Cells

Pluripotent Stem Cell-Based Gene Therapy Approach: Human de novo Synthesized
Chromosomes. Sinenko S.A., Ponomartsev S.V., Tomilin A.N., 2020. Cell and Molecular
life sciences

• Ho, Richard David Jun-Geet; Mossige, Joachim; Ponomartcev, Sergei; Natalia, Smirnova,; Sunny, Dai, Keqing & Hu, Xian [Show all 9 contributors for this article] (2025). [2509.08929] Spontaneous elongation of 3D gastruloids from local cell polarity alignment. arXiv. doi: https:/arxiv.org/abs/2509.08929. Full text in Research Archive Show summary

  Gastruloids are 3D stem cell aggregate models for early embryogenesis that provide a unique platform to study how collective cell dynamics drive tissue symmetry breaking and axial elongation. Using 3D light sheet imaging, we show that a pulse of Chiron, a Wnt activator, induces coherent alignment of cell polarity during elongation. While nuclear elongation occurs with or without treatment, only Chiron-treated gastruloids exhibit quasi-long-range alignment of nuclear axes, linking cell polarity coherence to tissue-scale remodeling. A minimal physical model of polarized cells, incorporating alignment-dependent torques and polarity-mediated adhesion, reproduces symmetry breaking and elongation, demonstrating that local cell polarity alignment alone can drive tissue-scale convergence-extension flows.

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