Thomas Olsen

• Dhar, Indu; Siddique, Sumia; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Lysne, Vegard; Olsen, Thomas; Nilsen, Dennis W.T.; Nordrehaug, Jan Erik; Midttun, Øivind; Ueland, Per Magne; Tell, Grethe S. & Nygård, Ottar (2020). Lipid parameters and vitamin A modify cardiovascular risk prediction by plasma neopterin Coronary artery disease. Heart.  ISSN 1355-6037. . doi: 10.1136/heartjnl-2019-316165
• Lee-Ødegård, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas; Refsum, Helga; Jensen, Jørgen; Birkeland, Kåre I. & Drevon, Christian A (2020). Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men. Diabetologia.  ISSN 0012-186X.  s 1- 14 . doi: 10.1007/s00125-020-05296-0
• Olsen, Thomas; Sollie, Ove; Nurk, Eha; Turner, Cheryl; Jernerén, Fredrik; Ivy, John L.; Vinknes, Kathrine; Clauss, Matthieu; Refsum, Helga Margaretha & Jensen, Jørgen (2020). Exhaustive Exercise and Post-exercise Protein Plus Carbohydrate Supplementation Affect Plasma and Urine Concentrations of Sulfur Amino Acids, the Ratio of Methionine to Homocysteine and Glutathione in Elite Male Cyclists. Frontiers in Physiology.  ISSN 1664-042X. . doi: 10.3389/fphys.2020.609335 Full text in Research Archive. Show summary

  Plasma and tissue sulfur amino acid (SAA) availability are crucial for intracellular methylation reactions and cellular antioxidant defense, which are important processes during exercise and in recovery. In this randomized, controlled crossover trial among eight elite male cyclists, we explored the effect of exhaustive exercise and post-exercise supplementation with carbohydrates and protein (CHO+PROT) vs. carbohydrates (CHO) on plasma and urine SAAs, a potential new marker of methylation capacity (methionine/total homocysteine ratio [Met/tHcy]) and related metabolites. The purpose of the study was to further explore the role of SAAs in exercise and recovery. Athletes cycled to exhaustion and consumed supplements immediately after and in 30 min intervals for 120 min post-exercise. After ~18 h recovery, performance was tested in a time trial in which the CHO+PROT group cycled 8.5% faster compared to the CHO group (41:53 ± 1:51 vs. 45:26 ± 1:32 min, p

• Olsen, Thomas; Turner, Cheryl; Øvrebø, Bente; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2020). Postprandial effects of a meal low in sulfur amino acids and high in polyunsaturated fatty acids compared to a meal high in sulfur amino acids and saturated fatty acids on stearoyl CoA-desaturase indices and plasma sulfur amino acids: a pilot study. BMC Research Notes.  ISSN 1756-0500.  13 . doi: 10.1186/s13104-020-05222-y
• Olsen, Thomas; Øvrebø, Bente; Haj Yasein, Nadia; Lee-Ødegård, Sindre; Svendsen, Karianne; Hjorth, Marit; Bastani, Nasser Ezzatkhah; Norheim, Frode; Drevon, Christian A; Refsum, Helga Margaretha & Vinknes, Kathrine (2020). Effects of dietary methionine and cysteine restriction on plasma biomarkers, serum fibroblast growth factor 21, and adipose tissue gene expression in women with overweight or obesity: a double-blind randomized controlled pilot study. Journal of Translational Medicine.  ISSN 1479-5876.  18(122) . doi: 10.1186/s12967-020-02288-x Full text in Research Archive.
• Svendsen, Karianne; Olsen, Thomas; Rusvik, Tove C. N.; Ulven, Stine Marie; Holven, Kirsten Bjørklund; Retterstøl, Kjetil & Telle-Hansen, Vibeke (2020). Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health. Lipids in Health and Disease.  ISSN 1476-511X. . doi: 10.1186/s12944-020-01282-y Full text in Research Archive.
• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). https://doi.org/10.1093/eurjpc/zwaa008. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873. . doi: 10.1093/eurjpc/zwaa008
• Koivisto, Anu; Olsen, Thomas; Paur, Ingvild; Paulsen, Gøran; Bastani, Nasser Ezzatkhah; Garthe, Ina; Raastad, Truls; Matthews, Jason; Blomhoff, Rune & Bøhn, Siv Kjølsrud (2019). Effects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trial. PLOS ONE.  ISSN 1932-6203.  14(6) . doi: 10.1371/journal.pone.0217895 Full text in Research Archive. Show summary

  Background Various altitude training regimes, systematically used to improve oxygen carrying capacity and sports performance, have been associated with increased oxidative stress and inflammation. We investigated whether increased intake of common antioxidant-rich foods attenuates these processes. Methods In a randomized controlled trial, 31 elite endurance athletes (23 ± 5 years), ingested antioxidant-rich foods (n = 16), (> doubling their usual intake), or eucaloric control foods (n = 15) during a 3-week altitude training camp (2320 m). Fasting blood and urine samples were collected 7 days pre-altitude, after 5 and 18 days at altitude, and 7 days post-altitude. Change over time was compared between the groups using mixed models for antioxidant capacity [uric acid-free (ferric reducing ability of plasma (FRAP)], oxidative stress (8-epi-PGF2α) and inflammatory biomarkers (IFNγ, IL1α, IL1RA, IL1β, IL2, IL5, IL6, IL7, IL10, IL12p70, IL13, IL17, TNFα, MCP-1 and micro-CRP). The cytokine response to a stress-test (VO2max ramp test or 100 m swimming) was assessed at pre- and post-altitude. Results FRAP increased more in the antioxidant compared to the control group (p = 0.034). IL13 decreased in the antioxidant group, while increasing in the controls (p = 0.006). A similar trend was seen for IL6 (p = 0.062). A larger decrease in micro-CRP was detected in the antioxidant group compared to controls (β: -0.62, p = 0.02). We found no group differences for the remaining cytokines. 8-epi-PGF2α increased significantly in the whole population (p = 0.033), regardless group allocation. The stress response was significantly larger post-altitude compared with pre-altitude for IL1β, IL6, IL7, IL13, IL12p70 and TNFα, but we found no group differences. Conclusions Increased intake of antioxidant-rich foods elevated the antioxidant capacity and attenuated some of the altitude-induced systemic inflammatory biomarkers in elite athletes. The antioxidant intervention had no impact on the altitude-induced oxidative stress or changes in acute cytokine responses to exercise stress-tests.

• Lee-Ødegård, Sindre; Olsen, Thomas; Vinknes, Kathrine; Refsum, Helga; Gulseth, Hanne Løvdal; Birkeland, Kåre I. & Drevon, Christian A (2019). Plasma Sulphur-Containing Amino Acids, Physical Exercise and Insulin Sensitivity in Overweight Dysglycemic and Normal Weight Normoglycemic Men. Nutrients.  ISSN 2072-6643.  11(1) . doi: 10.3390/nu11010010 Full text in Research Archive.
• Olsen, Thomas & Blomhoff, Rune (2019). Retinol, Retinoic Acid, and Retinol-Binding Protein 4 are Differentially Associated with Cardiovascular Disease, Type 2 Diabetes, and Obesity: An Overview of Human Studies. Advances in Nutrition.  ISSN 2161-8313. . doi: 10.1093/advances/nmz131 Full text in Research Archive.
• Olsen, Thomas; Vinknes, Kathrine; Blomhoff, Rune; Lysne, Vegard; Midttun, Øivind; Dhar, Indu; Ueland, Per Magne; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Drevon, Christian A; Refsum, Helga & Nygård, Ottar (2019). Creatinine, total cysteine and uric acid are associated with serum retinol in patients with cardiovascular disease. European Journal of Nutrition.  ISSN 1436-6207. . doi: 10.1007/s00394-019-02086-2 Full text in Research Archive.
• Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Dhar, Indu; Tell, Grethe S.; Blomhoff, Rune; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga & Nygård, Ottar (2018). The risk association of plasma total homocysteine with acute myocardial infarction is modified by serum vitamin A. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873.  25(15), s 1612- 1620 . doi: 10.1177/2047487318788587 Full text in Research Archive.
• Olsen, Thomas; Øvrebø, Bente; Turner, Cheryl; Bastani, Nasser Ezzatkhah; Refsum, Helga & Vinknes, Kathrine (2018). Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial. Nutrients.  ISSN 2072-6643.  10(12), s 1- 15 . doi: 10.3390/nu10121822 Full text in Research Archive.
• Olsen, Thomas; Vinknes, Kathrine; Svingen, Gard Frodahl Tveitevåg; Pedersen, Eva Ringdal; Tell, Grethe S.; Blomhoff, Rune; Drevon, Christian A; Ueland, Per Magne; Midttun, Øivind; Refsum, Helga & Nygård, Ottar (2017). Cardiovascular disease risk associated with serum apolipoprotein B is modified by serum vitamin A. Atherosclerosis.  ISSN 0021-9150.  (265), s 325- 330 . doi: 10.1016/j.atherosclerosis.2017.07.020
• Strand, Elin; Pedersen, Eva Ringdal; Svingen, Gard Frodahl Tveitevåg; Olsen, Thomas; Bjørndal, Bodil; Karlsson, Therese; Dierkes, Jutta; Njølstad, Pål Rasmus; Mellgren, Gunnar; Tell, Grethe S.; Berge, Rolf Kristian; Svardal, Asbjørn M. & Nygård, Ottar (2017). Serum acylcarnitines and risk of cardiovascular death and acute myocardial infarction in patients with stable angina pectoris. Journal of the American Heart Association.  ISSN 2047-9980.  6:e003620(2), s 1- 28 . doi: 10.1161/JAHA.116.003620 Full text in Research Archive.
• Lysne, Vegard; Strand, Elin; Svingen, Gard Frodahl Tveitevåg; Bjørndal, Bodil; Pedersen, Eva Ringdal; Midttun, Øivind; Olsen, Thomas; Ueland, Per Magne; Berge, Rolf Kristian & Nygård, Ottar (2016). Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. Nutrients.  ISSN 2072-6643.  8(1) . doi: 10.3390/nu8010026 Full text in Research Archive.
• Mathisen, Therese Fostervold & Olsen, Thomas (2016). Når kroppsfokus blir patologisk: Sosiale medier, fitness og spiseforstyrret atferd. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (3), s 6- 11

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• Svendsen, Karianne; Vinknes, Kathrine; Retterstøl, Kjetil & Olsen, Thomas (2020). Why we can probably trust public policy dietary guidelines for prevention. European Journal of Preventive Cardiology (EJPC).  ISSN 2047-4873. . doi: 10.1093/EURJPC/ZWAA008
• Lysne, Vegard & Olsen, Thomas (2018). Feilkilder i ernæringsepidemiologi. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.
• Lysne, Vegard; Olsen, Thomas; Christensen, Jacob J. & Arnesen, Erik (2018). Ja, det er et poeng å bytte til lettbrus!. Dagbladet.  ISSN 0805-3766.
• Olsen, Thomas; Lysne, Vegard & Dahl, Helene (2018). Bedre mot overvekt, bedre for tennene. Kunstig sukker er et folkehelsetiltak.. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Olsen, Thomas; Øvrebø, Bente; Arnesen, Erik & Lysne, Vegard (2018). Ikke skrot BMI!. NRK Ytring.
• Lysne, Vegard & Olsen, Thomas (2017). Konfidensintervaller – hva kan de fortelle deg?. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (1), s 28- 31
• Øvrebø, Bente; Olsen, Thomas & Vinknes, Kathrine (2017). Stearoyl-CoA desaturase og energimetabolisme – et prosjekt ved Universitetet i Oslo. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (4), s 20- 22
• Lysne, Vegard & Olsen, Thomas (2016). P-verdier. Veiledende eller villedende? En simulert studie. Norsk Tidsskrift for Ernæring.  ISSN 1503-5034.  (4), s 28- 31

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