Sissel Eikvar

Head Engineer - Xenobiotics and metabolism

Norwegian version of this page

Email sissel.eikvar@medisin.uio.no

Phone +47 22851008

Room 3166

Available hours 9.00-14.00

Username

Visiting address Sognsvannveien 9 Domus Medica 0372 Oslo

Postal address Postboks 1112, Blindern 0317 Oslo

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Tasks performed

Lab coordinator at Tore Jahnsens lab, dep of Biochemistry and B.S.Skålheggs lab. dep of Nutrition:

molecular biology
cell biology
purchasing
accounting
laboratory course for medical students

Background

Master in biology
Employee at the University of Oslo since 1998, 6 months leave in 2005 when I worked at NIVA. Tox.dep.

Tags: Laboratory operation, Molecular biology techniques, Cell growth, Basware, Protein analysis, Teaching, Bacterial work

Aksaas, Anne Kristin; Eikvar, Sissel; Akusjervi, Goran; Skålhegg, Bjørn Steen & Kvissel, Anne Katrine (2011). Protein kinase A-dependent phosphorylation of serine 119 in the proto-oncogenic Serine/arginine-rich splicing factor 1 modulates its activity as a splicing enhancer protein. Genes, Chromosomes and Cancer. ISSN 1045-2257. 2(8), p. 841–851.
Stakkestad, Øystein; Larsen, Anja C V; Kvissel, Anne Katrine; Eikvar, Sissel; Ørstavik, Sigurd & Skålhegg, Bjørn Steen (2011). Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform. BMC Biochemistry. ISSN 1471-2091. 12. doi: 10.1186/1471-2091-12-7.
Larsen, Anja C V; Kvissel, Anne Katrine; Hafte, Tolesa Tilahun; Avellan, Cecilia I. A.; Eikvar, Sissel & Rootwelt, Terje [Show all 8 contributors for this article] (2008). Inactive forms of the catalytic subunit of protein kinase A are expressed in the brain of higher primates. The FEBS Journal. ISSN 1742-464X. 275(2), p. 250–262. doi: 10.1111/j.1742-4658.2007.06195.x.
Tollefsen, Knut-Erik; Blikstad, Camilla; Eikvar, Sissel; Finne, Eivind Farmen & Gregersen, Inger Katharina (2008). Cytotoxicity of alkylphenols and alkylated non-phenolics in a primary culture of rainbow trout (Onchorhynchus mykiss) hepatocytes. Ecotoxicology and Environmental Safety. ISSN 0147-6513. 69. doi: 10.1016/j.ecoenv.2006.12.005.
Tollefsen, Knut Erik; Blikstad, Camilla; Eikvar, Sissel; Farmen, Eivind & Gregersen, Inger Katharina (2008). Cytotoxicity of alkylphenols and alkylated non-phenolics in a primary culture of rainbow trout (Onchorhynchus mykiss) hepatocytes. Ecotoxicology and Environmental Safety. ISSN 0147-6513. 69, p. 64–73.
Kvissel, Anne Katrine; Ørstavik, Sigurd; Eikvar, Sissel; Brede, Gaute; Jahnsen, Tore & Collas, Philippe [Show all 8 contributors for this article] (2007). Involvement of the catalytic subunit of protein kinase A and of HA95 in pre-mRNA splicing. PMID: 17594903 [PubMed - in process]. Experimental Cell Research. ISSN 0014-4827. 313, p. 2795–2809. doi: 10.1016/j.yexcr.2007.05.014.
Skålhegg, Bjørn Steen; Funderud, Ane; Henanger, HH; Hafte, Tolesa Tilahun; Larsen, Anja Camilla Vogeler & Kvissel, Anne Katrine [Show all 8 contributors for this article] (2005). Protein kinase A (PKA) - A potential target for therapeutic intervention of dysfunctional immune cells. Current Drug Targets. ISSN 1389-4501. 6.
Orstavik, Sigurd; Funderud, Ane; Hafte, Tolesa Tilahun; Eikvar, Sissel; Jahnsen, Tore & Skålhegg, Bjørn Steen (2005). Identification and characterization of novel PKA holoenzymes in human T lymphocytes. The FEBS Journal. ISSN 1742-464X. 272, p. 1559–1567.
Martins, Sandra ; Eikvar, Sissel; Furukawa, K. & Collas, Philippe (2003). HA95 and LAP2β mediate a novel chromatin-nuclear envelope interaction implicated in initiation of DNA replication. Journal of Cell Biology. ISSN 0021-9525. p. 177–188.
Skålhegg, Bjørn Steen; Witczak, Oliwia; Reinton, Nils Torgny Kjelkevik; Eide, Turid; Eikvar, Sissel & Collas, Philippe [Show all 9 contributors for this article] (1999). Specific effects of cAMP are mediated by multiple isozymes of cyclic AMP-dependent protein kinase and A-kinase anchoring proteins. Journal of Molecular Microbiology and Biotechnology. ISSN 1464-1801. 1, p. 49–63. Show summary
A large number of hormones, neurotransmitters, and other signaling substances that bind to G-protein coupled cell-surface receptors, converge their signals through one sole second messenger, 3', 5'-cyclic adenosine monophosphate (cAMP). Cyclic AMP has been shown to regulate cellular processes such as cell growth and differentiation, ion channel conductivity, synaptic release of neurotransmitters, and gene transcription. The principle intracellular target for cAMP in mammalian cells is the cAMP-dependent protein kinase (PKA). The fact that this broad specificity protein kinase mediates a number of discrete physiological responses following cAMP engagement has raised the question of how specificity is maintained in the cAMP/PKA system. It has been speculated to what extent specificity in cAMP signaling may be obtained by differential stimulation of multiple PKA holoenzymes that are targeted to various sites within a single cell through specific anchoring proteins.

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Kvissel, Anne Katrine; Orstavik, S; Eikvar, Sissel; Øistad, Pia Madeleine; Punga, T & Jahnsen, Tore [Show all 9 contributors for this article] (2004). Co-localization and in vitro phosphorylation of splicing factors by cAMP-dependent protein kinase. The FASEB Journal. ISSN 0892-6638. 18, p. C259–C259.
Martins, Sandra B.; Eikvar, Sissel; Furukawa, K.; Skålhegg, Bjørn Steen & Collas, Philippe (2002). HA95, a novel protein mediating nuclear envelope-chromatin interactions.
Martins, Sandra B.; Eikvar, Sissel; Furukawa, K.; Skålhegg, Bjørn Steen & Collas, Philippe (2001). Interaction of the inner nuclear membrane protein LAP2β with chromatin-associated HA95.

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Published Apr. 13, 2011 10:59 AM - Last modified Mar. 28, 2019 2:39 PM

Research groups

cAMP and PKA