Regulatory genomics: from basic biology to disease mechanisms
Speaker: Judith Zaugg, Group Leader, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
This biostatistics seminar is jointly organised with the Sven Furberg Seminars in Bioinformatics and Statistical Genomics. At the end of the seminar simple food and refreshments will be served.
Transcription factors (TFs) are essential for regulating all kinds of cellular processes. In addition, thousands of genome wide association studies (GWAS) that link genetic variants to complex diseases have revealed that most variants associated with diseases lie in the non-coding genome and thus likely affect regulatory elements, rather than protein coding genes. This makes TFs a particularly interesting class of proteins to study for understanding disease mechanisms.
Here I will present how we can use quantitative modeling to better understand combinatorial TF binding, how TF binding affects alternative splicing and finally how we can gain insights into disease mechanisms (e.g. for pulmonary artery hypertension) by comparing TF activities between patients and controls.
Meet the speaker
Dr. Zaugg did her PhD at the EMBL-EBI studying computational functional genomics. Then she joined the lab of Dr. Steinmetz lab at Stanford University for her postdoc where she integrated histone modification and chromatin conformation data to analyze the genetic basis of regulatory variation across healthy human individuals. She is now a Group Leader at EMBL Heidelberg. Her group aims at understanding the molecular basis of complex genetic traits and diseases using genome-wide data of various molecular phenotypes, and developing multi-omics data integration approaches.
Dr. Zaugg's lecture will be preceded by a talk given by Dr. Xavier Tekpli, postdoctoral fellow in Dr. Kristensen's group at the Institute for Cancer Research, Oslo University Hospital. He will be presenting the talk entitled "Genome wide associations between DNA methylation and gene expression unravel transcription factories in breast cancer."