A pan-cancer compendium of chromosomal instability
Florian Markowetz, Group Leader, Integrative Cancer Biology Team, Cancer Research UK Cambridge Institute, University of Cambridge, UK.
This biostatistics seminar is jointly organised with the Sven Furberg Seminars in Bioinformatics and Statistical Genomics.
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Meeting ID: 637 7267 9340
Chromosomal instability (CIN) is one of the earliest molecular characteristics to be described in cancer. Since its detection using light microscopy in the late 19th century technological advances have facilitated observation at increasing resolution. This has revealed extreme genomic complexity which we are only starting to understand. Here, using genomic profiling of a large cohort of patient tumours, we present a comprehensive compendium of CIN in cancer. We show that 80% of all tumours have detectable CIN which is predominantly caused by mitotic errors or impaired homologous recombination. We provide a framework in which to interrogate and quantify different types of CIN in cancer in order to facilitate improved understanding of this fundamental feature of cancer.