OCBE newsletter, May 2025

This month we showcase recent publications on physical activity in cancer patients, results of rheumatoid arthritis clinical trials and much more.

We aimed to describe the prevalence of self-reported lower extremity lymphedema (LEL) by different physical activity (PA) levels and examine if higher levels of PA are associated with lower odds of self-reported LEL among endometrial cancer survivors. Among 1077 included women, the prevalence of LEL was 48 %, 32 %, and 32 % among the low active, active, and high active survivors, respectively. Compared to the low active, the active survivors had 40 % lower odds of LEL (OR 0.60, 95 % CI 0.44-0.81), but no further reduction was observed among the high active survivors (OR 0.71, 95 % CI 0.47-1.06). Findings suggest that regular PA according to the current PA guidelines is associated with decreased the odds of self-reported LEL among endometrial cancer survivors; however, causality of association needs to be verified in a longitudinal setting.

 

In this paper, we are interested in variable selection with Type I error control in lasso regression when we have different sources of input data (e.g. different types of omics data). It has earlier been shown that the IPF-lasso is able to improve prediction error in certain situations under this setup, compared to regular lasso, and we show that the IPF-lasso also gives higher power for variable selection in more or less the same situations.

 

Study of the association between pre-diagnosis physical activity (most recent level and long-term trajectories) and melanoma-specific, other-cause, and overall mortality.

 

 

Patient reported outcome measures (PROMs) could expose meaningful differences but are scarcely investigated in acute stroke trials. We sought to investigate the association of reperfusion treatment after acute ischemic stroke (AIS) on PROMs, 1-year post-stroke.

 

 

This is the three-year follow-up analysis of the ARCTIC REWIND trial to assess the effect of tapering tumour-necrosis factor inhibitors to withdrawal or continue stable treatment on flare-free survival and radiographic progression. The conclusion was that it was very few who remained flare free over three years in the withdrawal group, with a 9.3 (95% CI 3.9 – 22.8) hazard ratio compared to stable treatment. The comparison on radiographic progression did not reach a conclusion.

 

 

Research on individuals at risk for psychosis shows that psychosocial factors are critical in psychosis development, but studies of these factors and the relationship between psychosocial factors and the severity of ASEs are lacking. The present study aims to investigate the extent to which mood, social relationships, and psychosocial factors contribute to the development of BSD in adolescents at risk for psychosis.

 

 

Protocol for a study investigating lipid profile during breastfeeding in women with and without hypercholesterolemia, and concentrations of statins in breastmilk

 

 

This was an assessment of the difference between two treatment strategies, triple therapy (methotrexate, sulphasalazine, hydroxychloroquine) and intra-articular glucocorticoid injections  versus methotrexate and oral glucocorticoid injections in the treatment of rheumatoid arthritis patients. This was a non-randomised comparison within the active conventional treatment arm of the NORD-STAR study. The results indicated a better effect of triple therapy and injections on clinical outcomes but with the opposite effect on radiographic measures.

Published June 2, 2025 12:30 PM - Last modified June 12, 2026 2:43 PM
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