Publications - Brain Signalling

• Phillips, William A; Bachmann, Talis & Storm, Johan Frederik (2018). Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State. Frontiers in Neural Circuits.  ISSN 1662-5110.  12, s 1- 15 . doi: 10.3389/fncir.2018.00050
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2018). Distinguishing anesthetized from awake state in patients: A new approach using one second segments of raw EEG. Frontiers in Human Neuroscience.  ISSN 1662-5161.  12:40, s 1- 14 . doi: 10.3389/fnhum.2018.00040
• Storm, Johan Frederik; Boly, Melanie; Casali, Adenauer G.; Massimini, Marcello; Olcese, Umberto; Pennartz, Cyriel M.A. & Wilke, Melanie (2017). Consciousness regained: Disentangling mechanisms, brain systems, and behavioral responses. Journal of Neuroscience.  ISSN 0270-6474.  37(45), s 10882- 10893 . doi: 10.1523/JNEUROSCI.1838-17.2017 Full text in Research Archive.
• Hönigsperger, Christoph; Nigro, Maximiliano José & Storm, Johan Frederik (2017). Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. Journal of Physiology.  ISSN 0022-3751.  595(3), s 739- 757 . doi: 10.1113/JP273024 Full text in Research Archive.
• Wang, Kang; Mateos-Aparicio, Pedro; Hönigsperger, Christoph; Raghuram, Vijeta; Wu, Wendy W.; Ridder, Margreet C.; Sah, Pankaj; Maylie, James; Storm, Johan Frederik & Adelman, John P. (2015). IK1 Channels Do Not Contribute to the Slow Afterhyperpolarization in Pyramidal Neurons. eLIFE.  ISSN 2050-084X.  doi: 10.1093/toxsci/kfv245
• Hönigsperger C, Marosi M, Murphy R, Storm, Johan Fredrik. (2015) Dorsoventral differences in Kv7/M-current and its impact on resonance, temporal summation and excitability in rat hippocampal pyramidal cells. Journal of Physiology. ISSN 0022-3751. doi: 10.1113/jphysiol.2014.280826
• Nigro MJ, Mateos-Aparicio P, Storm, Johan Fredrik. (2014) Expression and functional roles of Kv7/KCNQ/M-channels in rat medial entorhinal cortex layer II stellate cells. Journal of Neuroscience.  ISSN 0270-6474. doi: 10.1523/JNEUROSCI.4153-13.2014
• Giglio AM, Storm, Johan Fredrik. (2014) Postnatal development of temporal integration, spike timing and spike threshold regulation by a dendrotoxin-sensitive K+ current in rat CA1 hippocampal cells. European Journal of Neuroscience. ISSN 0953-816X. doi: 10.1111/ejn.12385
• Mateos-Aparicio P, Murphy R, Storm, Johan Fredrik. (2014) Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells. Journal of Physiology. ISSN 0022-3751. doi: 10.1113/jphysiol.2013.267872

• Molden, Sturla; Moldestad, Olve; Storm, Johan Frederik. (2013) Estimating Extracellular Spike Waveforms from CA1 Pyramidal Cells with Multichannel Electrodes. PLoS ONE ISSN 1932-6203. doi: 10.1371/journal.pone.0082141

• Hagger-Vaughan, Nicholas & Storm, Johan Frederik (2019). Synergy of Glutamatergic and Cholinergic Modulation Induces Plateau Potentials in Hippocampal OLM Interneurons. Frontiers in Cellular Neuroscience.  ISSN 1662-5102.  13 . doi: 10.3389/fncel.2019.00508 Full text in Research Archive. Show summary

  Oriens-lacunosum moleculare (OLM) cells are hippocampal inhibitory interneurons that are implicated in the regulation of information flow in the CA1 circuit, inhibiting cortical inputs to distal pyramidal cell dendrites, whilst disinhibiting CA3 inputs to pyramidal cells. OLM cells express metabotropic cholinergic (mAChR) and glutamatergic (mGluR) receptors, so modulation of these cells via these receptors may contribute to switching between functional modes of the hippocampus. Using a transgenic mouse line to identify OLM cells, we found that both mAChR and mGluR activation caused the cells to exhibit long-lasting depolarizing plateau potentials following evoked spike trains. Both mAChR- and mGluR-induced plateau potentials were eliminated by blocking transient receptor potential (TRP) channels, and were dependent on intracellular calcium concentration and calcium entry. Pharmacological tests indicated that Group I mGluRs are responsible for the glutamatergic induction of plateaus. There was also a pronounced synergy between the cholinergic and glutamatergic modulation, plateau potentials being generated by agonists applied together at concentrations too low to elicit any change when applied individually. This synergy could enable OLM cells to function as coincidence detectors of different neuromodulatory systems, leading to their enhanced and prolonged activation and a functional change in information flow within the hippocampus.

• Gofman, Xenia; Tocker, Gilad; Weiss, Shahaf; Boccara, Charlotte N; Lu, Li; Moser, May-Britt; Moser, Edvard Ingjald; Morris, Genela & Derdikman, Dori Moshe (2019). Dissociation between postrhinal cortex and downstream parahippocampal regions in the representation of egocentric boundaries. Current Biology.  ISSN 0960-9822.  29(16), s 2751- 2757.e4 . doi: 10.1016/j.cub.2019.07.007 Full text in Research Archive.
• Farnes, Nadine; Juel, Bjørn Erik; Nilsen, Andre Sevenius; Romundstad, Luis Georg & Storm, Johan Frederik (2019). Increased signal diversity/complexity of spontaneous EEG in humans given sub-anaesthetic doses of ketamine. biorxiv. . doi: 10.1101/508697
• Boccara, Charlotte N; Nardin, Michele; Stella, Federico; O'Neill, Joseph & Csicsvari, Jozsef (2019). The entorhinal cognitive map is attracted to goals. Science.  ISSN 0036-8075.  363(6434), s 1443- 1447 . doi: 10.1126/science.aav4837
• Nilsen, Andre Sevenius; Juel, Bjørn Erik & Marshall, William (2019). Evaluating approximations and heuristic measures of integrated information. Entropy.  ISSN 1099-4300.  21(5), s 1- 23 . doi: 10.3390/e21050525 Full text in Research Archive.
• Thürer, Benjamin; Gedemer, Sarah; Focke, Anne & Stein, Thorsten (2019). Contextual Interference Effect Is Independent of Retroactive Inhibition but Variable Practice Is Not Always Beneficial. Frontiers in Human Neuroscience.  ISSN 1662-5161.  13, s 1- 9 . doi: 10.3389/fnhum.2019.00165 Full text in Research Archive.
• Kusztor, Aniko; Raud, Liisa; Juel, Bjørn Erik; Nilsen, Andre Sevenius; Storm, Johan Frederik & Huster, Rene (2019). Sleep deprivation differentially affects subcomponents of cognitive control. Sleep.  ISSN 0161-8105.  42(4) . doi: 10.1093/sleep/zsz016
• Phillips, William A; Bachmann, Talis & Storm, Johan Frederik (2018). Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State. Frontiers in Neural Circuits.  ISSN 1662-5110.  12, s 1- 15 . doi: 10.3389/fncir.2018.00050 Full text in Research Archive.
• Halder, Sebastian; Takano, Kouji & Kansaku, Kenji (2018). Comparison of Four Control Methods for a Five-Choice Assistive Technology. Frontiers in Human Neuroscience.  ISSN 1662-5161.  12, s 1- 14 . doi: 10.3389/fnhum.2018.00228 Full text in Research Archive.
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2018). Distinguishing anesthetized from awake state in patients: A new approach using one second segments of raw EEG. Frontiers in Human Neuroscience.  ISSN 1662-5161.  12:40, s 1- 14 . doi: 10.3389/fnhum.2018.00040 Full text in Research Archive.
• Storm, Johan Frederik; Boly, Melanie; Casali, Adenauer G.; Massimini, Marcello; Olcese, Umberto; Pennartz, Cyriel M.A. & Wilke, Melanie (2017). Consciousness regained: Disentangling mechanisms, brain systems, and behavioral responses. Journal of Neuroscience.  ISSN 0270-6474.  37(45), s 10882- 10893 . doi: 10.1523/JNEUROSCI.1838-17.2017 Full text in Research Archive.
• Hu, Hua & Vervaeke, Koen Gerard Alois (2017). Synaptic integration in cortical inhibitory neuron dendrites. Neuroscience.  ISSN 0306-4522.  368, s 115- 131 . doi: 10.1016/j.neuroscience.2017.06.065
• Hönigsperger, Christoph; Nigro, Maximiliano José & Storm, Johan Frederik (2017). Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E. Journal of Physiology.  ISSN 0022-3751.  595(3), s 739- 757 . doi: 10.1113/JP273024 Full text in Research Archive.
• Fayzullin, Artem; Tuvnes, Frode Alexander; Skjellegrind, Håvard; Behnan, Jinan; Mughal, Awais; Langmoen, Iver Arne & Vik-Mo, Einar O. (2016). Time-lapse phenotyping of invasive glioma cells ex vivo reveals subtype-specific movement patterns guided by tumor core signaling. Experimental Cell Research.  ISSN 0014-4827.  349(2), s 199- 213 . doi: 10.1016/j.yexcr.2016.08.001
• Wang, Kang; Mateos-Aparicio, Pedro; Hönigsperger, Christoph; Raghuram, Vijeta; Wu, Wendy W.; Ridder, Margreet C.; Sah, Pankaj; Maylie, James; Storm, Johan Frederik & Adelman, John P. (2015). IK1 Channels Do Not Contribute to the Slow Afterhyperpolarization in Pyramidal Neurons. eLIFE.  ISSN 2050-084X. . doi: 10.1093/toxsci/kfv245
• Hu, Hua; Gan, Jian & Jonas, Peter (2014). Interneurons. Fast-spiking, parvalbumin⁺ GABAergic interneurons: from cellular design to microcircuit function. Science.  ISSN 0036-8075.  345, s 1255263 . doi: 10.1126/science.1255263
• Hu, Hua & Jonas, Peter (2014). A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons.. Nature Neuroscience.  ISSN 1097-6256.  17, s 686- 693 . doi: 10.1038/nn.3678
• Pietersen, Alexander N.J.; Ward, Peter D.; Hagger-Vaughan, Nicholas; Wiggins, James; Jefferys, John G.R. & Vreugdenhil, Martin (2014). Transition between fast and slow gamma modes in rat hippocampus area CA1 in vitro is modulated by slow CA3 gamma oscillations. Journal of Physiology.  ISSN 0022-3751.  592(4), s 605- 620 . doi: 10.1113/jphysiol.2013.263889
• Kim, Sooyun; Guzman, Segundo J; Hu, Hua & Jonas, Peter (2012). Active dendrites support efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.. Nature Neuroscience.  ISSN 1097-6256.  15, s 600- 606 . doi: 10.1038/nn.3060

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• Nilsen, Andre Sevenius; Juel, Bjørn Erik; Marshall, William & Storm, Johan Frederik (2019). Estimating Integrated Information: How noise, sampling, and perturbations affect Phi.
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2018). Changes in EEG captured by Directed Transfer Function is sufficient to accurately classify the state of wakefulness in patients undergoing sevoflurane anesthesia in accordance with the clinician’s judgement.
• Juel, Bjørn Erik; Nilsen, Andre Sevenius; Murphy, Ricardo & Storm, Johan Frederik (2018). Thalamocortical model for studying the effects of neuromodulation on network properties.
• Juel, Bjørn Erik; Nilsen, Andre Sevenius; Gosseries, Olivia; Sarasso, Simone; Larsson, Pål Gunnar; Boly, Malanie; Laureys, Steven; Massimini, marcello & Storm, Johan Frederik (2018). Measures of connectivity, complexity and signal diversity in EEG distinguish conscious from unconscious state during anesthesia.
• Nilsen, Andre Sevenius & Storm, Johan Frederik (2018). Tracking conscious states: the potential of spontaneous EEG signal complexity.
• Nilsen, Andre Sevenius; Juel, Bjørn Erik & Storm, Johan Frederik (2018). Attentional Modulation on Measures of Conscious States.
• Nilsen, Andre Sevenius; Juel, Bjørn Erik; Marshall, William & Storm, Johan Frederik (2018). Calculating conscious capacity: approximations, analogues, and correlates of PHI.
• Arena, Alessandro; Comolatti, Renzo; Casali, Adenauer G. & Storm, Johan F. (2018). Cortical complexity and cause‐effect power are reduced by general anesthesia compared to wakefulness in rats.
• Pigorini, Andrea; Arena, Alessandro; Barbero Castillo, A.; Wolff, A.; Galluzzi, A.; Raimondo, F.; Gosseries, Olivia; Fecchio, Matteo; Pazienti, A.; Gorostiza, P.; Mikulan, E.; Nieus, Thierry; Barra, A.; Laureys, Steven; Storm, Johan F.; Mattia, Maurizio; Sanchez-Vives, M.V. & Massimini, Marcello (2018). Consciousness and brain complexity: a multi-scale exploration across species and model.
• Arena, Alessandro; Comolatti, Renzo; Casali, Adenauer G. & Storm, Johan F. (2018). A New Approach For Assessing Perturbational Complexity In Rats.
• Arena, Alessandro (2018). Conscious vs. unconscious brain states in rodents.
• Murphy, Ricardo; Nilsen, Andre Sevenius; Juel, Björn E; Hill, Sean; Plesser, Hans Ekkehard; Nieus, Thierry; Massimini, Marcello & Storm, Johan Frederik (2018). Implementation of the Hill-Tononi thalamocortical network model in the neural simulator NEST.
• Halder, Sebastian; Leinfelder, Teresa; Schulz, SM & Kubler, Andrea (2018). Neural mechanisms of training an auditory perception task in a brain-computer interface context.
• Halder, Sebastian; Venkat Raghavan, L; Juel, Bjørn Erik; Nilsen, Andre Sevenius & Storm, Johan Frederik (2018). Effects of intracarotid sodium amobarbital procedure (ISAP) on cortical complexity.
• Roth, Fabian Christoph; Storm, Johan Frederik & Hu, Hua (2018). A unique subcellular distribution of HCN channels accelerates action potential propagation in GABAergic interneuron axons.
• Farnes, Nadine; Juel, Bjørn Erik; Nilsen, Andre Sevenius; Romundstad, Luis Georg; Larsson, Pål Gunnar; Engstrøm, Morten & Storm, Johan Frederik (2017). Integrated information in sub-anaesthetic ketamine measured by TMS and EEG.
• Bremnes, Thomas Rene; Juel, Bjørn Erik; Sarasso, Simone; Boly, Melanie; Casarotto, Silvia; Casali, Adenauer G.; Nilsen, Andre Sevenius; Tononi, Giulio; Larsson, Pål Gunnar; Laureys, Steven; Massimini, marcello & Storm, Johan Frederik (2017). Unresponsive states with and without report of conscious experience show distinct patterns of EEG-based effective brain connectivity in humans.
• Nilsen, Andre Sevenius; Arena, Alessandro; Juel, Bjørn Erik; Storm, Johan Frederik; Murphy, Ricardo; Hu, Hua & Hagger-Vaughan, Nicholas (2017). Forsknigstorget: Hvordan kan hjernen skape bevissthet.
• Juel, Bjørn Erik; Bremnes, Thomas Rene; Larsson, Pål Gunnar & Storm, Johan Frederik (2017). Classifying states of (un)consciousness based on one second of raw EEG.
• Nilsen, Andre Sevenius (2017). The Hill Tononi Thalamo Cortical Model implemented in NEST.
• Juel, Bjørn Erik; Kusztor, Aniko; Nilsen, Andre Sevenius; Farnes, Nadine; Larsson, Pål Gunnar; Romundstad, Luis Georg & Storm, Johan Frederik (2017). Changes in electrophysiological markers of consciousness in response to various anesthetics.
• Nilsen, Andre Sevenius; Storm, Johan Frederik & Juel, Bjørn Erik (2017). Attentional Modulation on Measures of Conscious States.
• Nilsen, Andre Sevenius; Juel, Bjørn Erik; Storm, Johan Frederik; Romundstad, Luis Georg & Larsson, Pål Gunnar (2017). Markers of consciousness before, during, and after anesthesia.
• Nilsen, Andre Sevenius (2017). Markers of Consciousness before, during, and after anesthesia.
• Nilsen, Andre Sevenius; Juel, Bjørn Erik; Storm, Johan Frederik; Murphy, Ricardo; Plesser, Hans Ekkehard; Hill, Sean; Nieus, Thierry & marcello, massimini (2017). Implementation of the Hill-Tononi thalamocortical network model in the neural simulator NEST.
• Arena, Alessandro (2017). Toward exploration of cortical complexity in rats.
• Juel, Bjørn Erik; Nilsen, Andre Sevenius; Farnes, Nadine & Storm, Johan Frederik (2017). Comparing electrophysiological markers of consciousness between physiologically distinct states of wakefulness.
• Arena, Alessandro & Storm, Johan Frederik (2017). TOWARD THE EXPLORATION OF COMPLEXITY IN RATS.
• Nilsen, Andre Sevenius; Juel, Bjørn Erik & Storm, Johan Frederik (2017). Proxies for integrated information of microscale networks Is it possible to predict PHI?.
• Murphy, Ricardo; Nilsen, Andre Sevenius; Juel, Bjørn Erik; Plesser, Hans Ekkehard; Hill, Sean; Nieus, Thierry; Massimini, Marcello & Storm, Johan Frederik (2017). Implementation of the Hill-Tononi thalamocortical network model in the neural simulator NEST.
• Nilsen, Andre Sevenius; Murphy, Ricardo; Juel, Bjørn Erik; Plesser, Hans Ekkehard; Hill, Sean; Nieus, Thierry; Massimini, Marcello & Storm, Johan Frederik (2017). Simulating deep sleep and awake states in a mammalian thalamocortical model.
• Hagger-Vaughan, Nicholas; Klaus, Carolin & Storm, Johan Frederik (2017). Dual adrenergic modulation of HCN channels in hippocampal and neocortical pyramidal neurons.
• Hagger-Vaughan, Nicholas & Storm, Johan Frederik (2017). Differential basal properties and metabotropic modulation responses between OLM and Martinotti cells.
• Juel, Bjørn Erik; Bremnes, Thomas Rene; Larsson, Pål Gunnar & Storm, Johan Frederik (2016). Comparing Potential Objective Measures of Human Consciousness: the Perturbational Complexity Index and the Directed Transfer Function.
• Storm, Johan Frederik; Murphy, Ricardo & Mateos-Aparicio, Pedro (2016). Kv7/M-current function in axons: high-pass filtering of plateau potentials promotes full action potentials, also during cholinergic activation.
• Hagger-Vaughan, Nicholas & Storm, Johan Frederik (2016). CA1 OLM cells exhibit plateau potentials in response to metabotropic glutamate receptor activation.
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2016). Differences in effective connectivity can be used to separate conscious from unconscious states in patients undergoing general anesthesia..
• Jonas, Peter & Hu, Hua (2016). Energy-efficient action potential signaling in inhibitory interneuron axons.
• Hu, Hua & Jonas, Peter (2016). Energy efficient action potential signaling in GABAergic inhibitory axons.
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2015). Can We Monitor Consciousness in Real Time with EEG?.
• Juel, Bjørn Erik; Romundstad, Luis Georg; Kolstad, Frode; Storm, Johan Frederik & Larsson, Pål Gunnar (2015). Monitoring Brain Connectivity to Predict Patients’ Level of Awareness.
• Nilsen, Andre Sevenius; Endestad, Tor & Alnæs, Dag (2014). Right Inferior Frontal Gyrus and Motor Response Inhibition A Real-Time FMRI Neurofeedback Study.
• Mateos-Aparicio, Pedro; Murphy, Ricardo & Storm, Johan Frederik (2014). Dentate granule cell: mAHP & sAHP; SK & Kv7/M channels. [www /  CD]. Show summary

  The model is based on that of Aradi & Holmes (1999; Journal of Computational Neuroscience 6, 215-235). It was used to help understand the contribution of M and SK channels to the medium afterhyperpolarization (mAHP) following one or seven spikes, as well as the contribution of M channels to the slow afterhyperpolarization (sAHP). We found that SK channels are the main determinants of the mAHP, in contrast to CA1 pyramidal cells where the mAHP is primarily caused by the opening of M channels. The model reproduced these experimental results, but we were unable to reproduce the effects of the M-channel blocker XE991 on the sAHP. It is suggested that either the XE991-sensitive component of the sAHP is not due to M channels, or that when contributing to the sAHP, these channels operate in a mode different from that associated with the mAHP.

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