T Cell Activation and Autoimmune Disease
The main focus of our research is regulation of adaptive immunity. We are particularly interested in signaling in activated and experienced T cells, as these cells influence individual susceptibility to autoimmune diseases as well as cancer.
About the group
T cells play a crucial role in our defense against infection and cancer, but these cells are also a two-edged sword. Sometimes they start to react against the body they are supposed to defend, leading to autoimmune disease.
How T cells recognize and react to foreign antigens is therefore a key to understand how T cell mediated diseases develop and how they may be prevented or treated.
The research group therefore focuses primarily on elucidating molecular mechanisms for control of T cell activation, and in particular the role of adaptor molecules in this process.