Selected publications

Research on neuroprotection:

  • Falck, Mari; Osredkar, Damjan; Maes, Elke; Flatebø, Torun; Wood, Thomas Ragnar; Walløe, Lars; Sabir, Hemmen & Thoresen, Marianne (2018). Hypothermia is neuroprotective after severe hypoxic-ischaemic brain injury in neonatal rats pre-exposed to PAM3CSK4. Developmental Neuroscience.  ISSN 0378-5866. doi:
  • Sabir, Hemmen; Dingley, John; Scull-Brown, Emma; Chakkarapani, Ela & Thoresen, Marianne (2018). Fentanyl induces cerebellar internal granular cell layer apoptosis in healthy newborn pigs. Frontiers in Neurology.  ISSN 1664-2295.  9(MAY) . doi: 10.3389/fneur.2018.00294 Full text in Research Archive.
  • Falck, Mari; Osredkar, Damjan; Maes, Elke; Flatebø, Torun; Wood, Thomas Ragnar; Sabir, Hemmen & Thoresen, Marianne (2017). Hypothermic neuronal rescue from infection-sensitised hypoxic-ischaemic brain injury is pathogen dependent. Developmental Neuroscience.  ISSN 0378-5866.  39(1-4), s 238- 247 . doi: 10.1159/000455838
  • Wood, Thomas Ragnar; Hobbs, C; Brun, AC; Falck, Mari; Løberg, Else Marit & Thoresen, Marianne (2017). Rectal temperature in the first five hours after hypoxia-ischaemia critically affetcs neuropathological outcomes in neonatale rats. Pediatric Research.  ISSN 0031-3998. . doi: 10.1038/pr.2017.51
  • Sabir, Hemmen; Osredkar, Damjan; Maes, Elke; Wood, Thomas Ragnar & Thoresen, Marianne (2016). Xenon combined with therapeutic hypothermia is not neuroprotective after severe hypoxia-ischemia in neonatal rats. PLoS ONE.  ISSN 1932-6203.  11(6) . doi: 10.1371/journal.pone.0156759
  • Wood, Thomas Ragnar; Osredkar, Damjan; Puchades, Maja Amedjkouh; Maes, Elke; Falck, Mari; Flatebø, Torun; Walløe, Lars; Sabir, Hemmen & Thoresen, Marianne (2016). Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep23430 Full text in Research Archive.
  • Wood, Thomas Ragnar; Smit, Elisa; Maes, Elke; Osredkar, Damjan; Falck, Mari; Elstad, Maja & Thoresen, Marianne (2016). Monitoring of cerebral blood flow during hypoxia-ischemia and resuscitation in the neonatal rat using laser speckle imaging. Physiological Reports.  ISSN 2051-817X.  4(7), s 1- 14 . doi: 10.14814/phy2.12749 Full text in Research Archive.
  • Osredkar, Damjan; Sabir, Hemmen; Falck, Mari; Wood, Thomas Ragnar; Maes, Elke; Flatebø, Torun; Puchades, Maja Amedjkouh & Thoresen, Marianne (2015). Hypothermia Does Not Reverse Cellular Responses Caused by Lipopolysaccharide in Neonatal Hypoxic-Ischaemic Brain Injury. Developmental Neuroscience.  ISSN 0378-5866.  37(4-5), s 390- 397 . doi: 10.1159/000430860
  • Thoresen, Marianne & Sabir, Hemmen (2015). Epilepsy: Neonatal seizures still lack safe and effective treatment. Nature Reviews Neurology.  ISSN 1759-4758.  11(6), s 311- 312 . doi: 10.1038/nrneurol.2015.74
  • Osredkar, Damjan; Thoresen, Marianne; Maes, Elke; Flatebø, Torun; Elstad, Maja & Sabir, Hemmen (2014). Hypothermia is not neuroprotective after infection-sensitized neonatal hypoxic-ischemic brain injury. Resuscitation.  ISSN 0300-9572.  85(4), s 567- 572 . doi: 10.1016/j.resuscitation.2013.12.006
  • Skranes, Janne Helen; Elstad, Maja; Thoresen, Marianne; Cowan, Frances; Stiris, Tom & Fugelseth, Drude (2014). Hypothermia Makes Cerebral Resistance Index a Poor Prognostic Tool in Encephalopathic Newborns. Neonatology.  ISSN 1661-7800.  106(1), s 17- 23 . doi: 10.1159/000358229
  • Sabir H, Bishop S, Cohen N, Maes E, Liu X, Dingley J, Thoresen M. Neither Xenon nor Fentanyl Induces Neuroapoptosis in the Newborn Pig Brain. Anesthesiology. 2013 Aug;119(2):345-357. PubMed PMID: 23591070.
  • Chakkarapani E, Dingley J, Aquilina K, Osredkar D, Liu X, Thoresen M. Effects  of xenon and hypothermia on cerebrovascular pressure reactivity in newborn global hypoxic-ischemic pig model. J Cereb Blood Flow Metab. 2013 Jul 31. doi: 10.1038/jcbfm.2013.123. PubMed PMID: 23899927.
  • Liu X, Chakkarapani E, Stone J, Thoresen M. Effect of cardiac compressions and hypothermia treatment on cardiac troponin I in newborns with perinatal asphyxia.  Resuscitation. 2013 Jul 12. doi:pii: S0300-9572(13)00353-5. 10.1016/j.resuscitation.2013.07.003. PubMed PMID: 23856603.
  • Aquilina K, Chakkarapani E, Thoresen M. Early deterioration of cerebrospinal fluid dynamics in a neonatal piglet model of intraventricular hemorrhage and posthemorrhagic ventricular dilation. J Neurosurg Pediatr. 2012 Dec;10(6):529-37. doi: 10.3171/2012.8.PEDS11386. Epub 2012 Sep 28. PubMed PMID: 23020227.
  • Sabir H, Scull-Brown E, Liu X, Thoresen M. Immediate hypothermia is not neuroprotective after severe hypoxia-ischemia and is deleterious when delayed by  12 hours in neonatal rats. Stroke. 2012 Dec;43(12):3364-70. doi: 10.1161/STROKEAHA.112.674481. Epub 2012 Sep 20. PubMed PMID: 22996953.
  • Thoresen M, Liu X, Jary S, Brown E, Sabir H, Stone J, Cowan F, Karlsson M. Lactate dehydrogenase in hypothermia-treated newborn infants with hypoxic-ischaemic encephalopathy. Acta Paediatr. 2012 Oct;101(10):1038-44. doi: 10.1111/j.1651-2227.2012.02778.x. Epub 2012 Jul 27. PubMed PMID: 22775455.
  • Sabir H, Jary S, Tooley J, Liu X, Thoresen M. Increased inspired oxygen in the first hours of life is associated with adverse outcome in newborns treated for perinatal asphyxia with therapeutic hypothermia. J Pediatr. 2012 Sep;161(3):409-16. doi: 10.1016/j.jpeds.2012.03.007. Epub 2012 Apr 18. PubMed PMID: 22521111.
  • Dalen ML, Liu X, Elstad M, Løberg EM, Saugstad OD, Rootwelt T, Thoresen M. Resuscitation with 100% oxygen increases injury and counteracts the neuroprotective effect of therapeutic hypothermia in the neonatal rat. Pediatr Res. 2012 Mar;71(3):247-52. doi: 10.1038/pr.2011.43. Epub 2012 Jan 11. PubMed PMID: 22337259.
  • Liu X, Tooley J, Løberg EM, Suleiman MS, Thoresen M. Immediate hypothermia reduces cardiac troponin I after hypoxic-ischemic encephalopathy in newborn pigs. Pediatr Res. 2011 Oct;70(4):352-6. doi: 10.1038/pr.2011.577. PubMed PMID: 21691250; PubMed Central PMCID: PMC3173864.

Research on cardiovascular physiology:

  • Elstad, Maja; Liu, Xun & Thoresen, Marianne (2016). Heart rate response to therapeutic hypothermia in infants with hypoxic–ischaemic encephalopathy. Resuscitation.  ISSN 0300-9572.  106, s 53- 57 . doi: 10.1016/j.resuscitation.2016.06.023
  • Elstad, Maja; Walløe, Lars; Holme, Nathalie; Maes, Elke & Thoresen, Marianne (2014). Respiratory sinus arrhythmia stabilizes mean arterial blood pressure at high-frequency interval in healthy humans. European Journal of Applied Physiology.  ISSN 1439-6319.  115(3), s 521- 530 . doi: 10.1007/s00421-014-3042-3
  • Elstad, Maja (2012). Respiratory variations in pulmonary and systemic blood flow in healthy humans. Acta Physiologica.  ISSN 1748-1708.  205(3), s 341- 348 . doi: 10.1111/j.1748-1716.2012.02419.x
  • Elstad, Maja; Walløe, Lars; Chon, Ki H. & Toska, Karin (2011). Low-frequency fluctuations in heart rate, cardiac output and mean arterial pressure in humans: what are the physiological relationships?. Journal of Hypertension.  ISSN 0263-6352.  29(7), s 1327- 1336 . doi:10.1097/HJH.0b013e328347a17a
  • Elstad, Maja; Nådland, Inger Helene; Toska, Karin & Walløe, Lars (2009). Stroke volume decreases during mild dynamic and static exercise in supine humans. Acta Physiologica.  ISSN 1748-1708.  195(2), s 289- 300 . doi: 10.1111/j.1748-1716.2008.01887.x
  • Rein, Erling Bekkestad; Filtvedt, Marius; Walløe, Lars & Ræder, Johan (2007). Hypothermia during laparotomy can be prevented by locally applied warm water and pulsating negative pressure. British Journal of Anaesthesia.  ISSN 0007-0912.  98(3), s 331- 336 . doi: 10.1093/bia/ael369
  • Elstad, Maja; Toska, Karin & Walløe, Lars (2002). Model simulations of cardiovascular changes at the onset of moderate exercise in humans. Journal of Physiology.  ISSN 0022-3751.  543(2), s 719- 728
  • Elstad, Maja; Toska, Karin; Chon, Ki H.; Raeder, Ernst A. & Cohen, Richard J. (2001). Respiratory sinus arrhythmia: opposite effects on systolic and mean arterial pressure in supine humans. Journal of Physiology.  ISSN 0022-3751.  536(1), s 251- 259
  • Nådland, Inger Helene; Walløe, Lars & Toska, Karin (2009). Effect of the leg muscle pump on the rise in muscle perfusion during muscle work in humans. European Journal of Applied Physiology.  ISSN 1439-6319.  105(6), s 829- 841 . doi: 10.1007/s00421-008-0965-6
Published Aug. 22, 2013 1:10 PM - Last modified Feb. 20, 2019 7:08 PM