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Xenobiotics and metabolism

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Humans are daily exposed to a great number of xenobiotics (chemicals that cannot be produced naturally). By studying xenobiotics signaling, the Ruzzin laboratory aims to 1) discover novel mechanisms regulating diseases and 2) develop innovative therapeutics.

We use engineered mouse models and organ/cell culture with cutting-edge biochemistry tools. In addition, human cohorts/samples are used to determine the relevance of our experimental research.

Our main research activities are focused on:

►TYPE 1 DIABETES: We are interested by understanding how persistent organic pollutants (POPs) can affect pancreatic beta-cells and insulin production.

►TYPE 2 DIABETES: We are interested by understanding how environmental pollutants can disrupt the insulin signaling pathway and contribute to the development of type 2 diabetes. We are currently exploring the impacts of xenobiotics on intestinal inflammation.

►SKELETAL MUSCLE ATROPHY: Our investigations on xenobiotics signaling led us to study the role of fibroblast growth factor 19 (FGF19) on skeletal muscle biology. We are currently investigating how to prevent skeletal muscle wasting. 


Scientific publications are available here.

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Mailing address
P.O.Box 1112 Blindern
0317 Oslo

Visiting address
Domus Medica, Gaustad
Sognsvannsveien 9
0372 Oslo

Published May 30, 2022 1:04 PM - Last modified May 30, 2022 1:11 PM