Title: The role of macrodomain-containing histone variants in chromatin regulation and cancer
Epigenetic information is written in chromatin. But how exactly do epigenetic mechanisms operate on the molecular level? How does the environment influence these processes? How does nuclear metabolism impact chromatin structure and the cell’s epigenetic memory?
These are the questions we address in the lab. We combine basic research and applied research. In our basic research, we like to dissect molecular mechanisms of chromatin regulation and evaluate if this knowledge has an application in cancer. In our more applied projects, we screen for novel drug targets for blood cancers and to understand their molecular mode of action.
We have a long-standing interest in histone variants with C-terminal linkers and macrodomains. I will present published and unpublished results that relate these unique domains to functions in heterochromatin architecture and gene regulation and discuss their relevance for cancer.
Our keywords are: histone variants, macroH2A, drug targets, combinatorial therapies, leukemia, 3D genome, chromatin regulation, myelodysplastic syndromes, … .
More: https://buschbecklab.org
This event is sponsored by UiO Lifescience.