Public defence: Sveinung Lillehaug
MD Sveinung Lillehaug at Institute of Basic Medical Sciences will be defending the thesis “Brain-wide mapping of transgene expression in mouse models of neurodegenerative disease” for the degree of PhD (Philosophiae Doctor).
Trial Lecture – time and place
See Trial Lecture.
- First opponent: Professor Huu Phuc Nguyen, Ruhr-University Bochum, Germany
- Second opponent: Associate professor Marianne Hafting Fyhn, University of Oslo
- Third member and chair of the evaluation committee: Professor emeritus Arild Njå, University of Oslo
Chair of the Defence
Professor Mahmood Amiry-Moghaddam, University of Oslo
Professor Trygve B. Leergaard, University of Oslo
Genetically modified mice are important tools in the effort to understand neurodegenerative conditions and identify potential therapeutic targets. A wide range of transgenic mouse models have been developed, but since each model only replicates certain aspects of the human disease, it is essential to choose the most appropriate model for a particular study. Finding the most suitable model requires careful assessment of phenotype data, including empirical descriptions of the level and anatomical location of transgene expression.
Lillehaug and colleagues have utilized tools and infrastructure developed in context of the EU Human Brain Project to establish, optimize and test workflows for analysis of morphological features in transgenic mouse models for neurodegenerative disease. They have demonstrated how the anatomical location and variance of transgene expression can be quantitatively assessed and how comparison of cellular labeling in mouse brains can be improved by spatially relating microscopic images to a three-dimensional mouse brain atlas framework. Finally, they have demonstrated how large collections of histological image data can be publicly shared in accordance with the F.A.I.R. principles (Wilkinson et al. 2016), ensuring that the data are Findable, Accessible, Interoperable, and Reusable.
Contact the research support staff.