The Dynamic Connectome
Special Seminar in Neuroscience by Hollis Cline, Scripps Research Institute in La Jolla.
Professor Hollis Cline
Hollis Cline is Hahn Professor of Neuroscience in the Departments of Molecular and Cellular Neuroscience, and of Chemical Physiology at The Scripps Research Institute in La Jolla, and current President of the Society for Neuroscience. She is a recipient of the prestigious NIH Director’s Pioneer Award. Her work focuses on the mechanisms by which sensory experience affect the development of brain structure and function, using the visual system of Xenopus as principal model. Her early groundbreaking studies demonstrated the central role of NMDA receptors in mediating the synaptic competition that underlies the establishment and refinement of retinotopic maps. Since then she and her coworkers have performed numerous and elegant investigations of how activity-dependent mechanisms control the structural plasticity of dendrites and axons, synaptic maturation and topographic map formation. Central to these efforts has been the establishment of experimental approaches to study the dynamics of presynaptic and postsynaptic elements in the living organism. Key insights gained from these studies are that circuit formation in vivo is continuously guided by experience, and that the basic mechanisms governing brain development, plasticity, information processing and neural circuit organization are highly conserved across vertebrates.
See her lab webpage for a more comprehensive account of research activities.
Refreshments will be served after the seminar.