Anne Spurkland

• Abrahamsen, Greger; Gjerstad, Vibeke Sundvold; Mekonnen, Meseret; Bogen, Bjarne & Spurkland, Anne (2018). Polarity of CD4+ T cells towards the antigen presenting cell is regulated by the Lck adapter TSAd. Scientific Reports.  ISSN 2045-2322.  8:13319, s 1- 13 . doi: 10.1038/s41598-018-31510-6
• Mekonnen, Meseret Habtamu; Abebe, Markos; Aseffa, Abraham; Dyrhol-Riise, Anne Ma; Spurkland, Anne & Abrahamsen, Greger (2018). In vitro analysis of antigen induced T cell-monocyte conjugates by imaging flow cytometry. JIM - Journal of Immunological Methods.  ISSN 0022-1759.  460, s 93- 100 . doi: 10.1016/j.jim.2018.06.014
• Hem, Cecilie Anne Dahl; Ekornhol, Marianne; Granum, Stine; Gjerstad, Vibeke Sundvold & Spurkland, Anne (2017). CD6 and Linker of Activated T Cells are Potential Interaction Partners for T Cell-Specific Adaptor Protein. Scandinavian Journal of Immunology.  ISSN 0300-9475.  85(2), s 104- 112 . doi: 10.1111/sji.12513
• Berge, Tone; Leikfoss, Ingvild Sørum; Brorson, Ina Skaara; Bos, Steffan Daniel; Page, Christian; Gustavsen, Marte Wendel; Bjølgerud, Anja; Holmøy, Trygve; Celius, Elisabeth Gulowsen; Damoiseaux, J.; Smolders, J; Harbo, Hanne Flinstad & Spurkland, Anne (2016). The multiple sclerosis susceptibility genes TAGAP and IL2RA are regulated by Vitamin D in CD4+ T cells. Genes and Immunity.  ISSN 1466-4879.  17(2), s 118- 127 . doi: 10.1038/gene.2015.61
• Gordon, Emma; Fukuhara, D.; Weström, S.; Padhan, N.; Sjöström, Elisabeth; van Meeteren, L.; He, Liqun; Orsenigo, F.; Dejana, E.; Bentley, K.; Spurkland, Anne & Claesson-Welsh, Lena (2016). The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Science Signaling.  ISSN 1937-9145.  9(437) . doi: 10.1126/scisignal.aad9256
• Enqvist, Monika; Ask, Eivind Heggernes; Forslund, Elin; Carlsten, Mattias; Abrahamsen, Greger; Béziat, Vivien; Andersson, Sandra; Schaffer, Marie; Spurkland, Anne; Bryceson, Yenan; Önfelt, Björn & Malmberg, Karl-Johan (2015). Coordinated expression of DNAM-1 and LFA-1 in educated NK cells. Journal of Immunology.  ISSN 0022-1767.  194(9), s 4518- 4527 . doi: 10.4049/jimmunol.1401972
• Eriksen, Agnete Bratsberg; Berge, Tone; Gustavsen, Marte Wendel; Leikfoss, Ingvild Sørum; Bos, Steffan Daniel; Spurkland, Anne; Harbo, Hanne Flinstad & Blomhoff, Heidi Kiil (2015). Retinoic acid enhances the levelels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  278, s 11- 18 . doi: 10.1016/j.jneuroim.2014.11.019
• Eriksen, Agnete Bratsberg; Torgersen, Maria Lyngaas; Lillebø Holm, Kristine; Abrahamsen, Greger; Spurkland, Anne; Moskaug, Jan Øivind; Simonsen, Anne & Blomhoff, Heidi Kiil (2015). Retinoic acid-induced IgG Production in TLR-activated human primary B cells involves ULK1-mediated autophagy. Autophagy.  ISSN 1554-8627.  11(3), s 460- 471 . doi: 10.1080/15548627.2015.1009797
• Hem, Cecilie Anne Dahl; Gjerstad, Vibeke Sundvold; Granum, Stine; Koll, Lise; Abrahamsen, Greger; Buday, Laszlo & Spurkland, Anne (2015). T cell specific adaptor protein (TSAd) promotes interaction of Nck with Lck and SLP-76 in T cells. Cell Communication and Signaling.  ISSN 1478-811X.  13(1) . doi: 10.1186/s12964-015-0109-7
• Leikfoss, Ingvild Sørum; Keshari, Pankaj Kumar; Gustavsen, Marte Wendel; Bjølgerud, Anja; Brorson, Ina Skaara; Celius, Elisabeth Gulowsen; Spurkland, Anne; Bos, Steffan Daniel; Harbo, Hanne Flinstad & Berge, Tone (2015). Multiple sclerosis risk allele in CLEC16A acts as an expression quantitative trait locus for CLEC16A and SOCS1 in CD4+ T cells. PLoS ONE.  ISSN 1932-6203.  10>e0132957(7) . doi: 10.1371/journal.pone.0132957 Fulltekst i vitenarkiv.
• Moussa, P; Abrahamsen, Greger; Fodil, N; Gopalakrishnan, Ramakrishna Prabhu; Mancini, M; Dissen, Erik; Sæther, Per Christian; Wiltshire, SA; Boivin, GA; Caignard, G; Spurkland, Anne & Vidal, SM (2015). Reduced MCMV Δm157 viral clearance in the absence of TSAd. Scientific Reports.  ISSN 2045-2322.  5 . doi: 10.1038/srep09219 Fulltekst i vitenarkiv.
• Moutsianas, Loukas; Jostins, Luke; Beecham, Ashley H.; Dilthey, Alexander T.; Xifara, Dionysia K.; Ban, Maria; Shah, Tejas S.; Patsopoulos, Nikolaos A.; Alfredsson, Lars; Anderson, Carl A.; Attfield, Katherine E.; Baranzini, Sergio E.; Barrett, Jeffrey; Binder, Thomas M.C.; Booth, David; Buck, Dorothea; Celius, Elisabeth Gulowsen; Cotsapas, Chris; D'Alfonso, Sandra; Dendrou, Calliope A.; Donnelly, Peter; Dubois, Bénédicte; Fontaine, Bertrand; Fugger, Lars; Goris, An; Gourraud, Pierr-Antoine; Graetz, Christiane; Hemmer, Bernhard; Hillert, Jan; Kockum, Ingrid; Leslie, Stephen; Lill, Christina M.; Martinelli-Boneschi, Filippo; Oksenberg, Jorge R.; Olsson, Tomas; Oturai, Annette; Saarela, Janna; Søndergaard, Helle Bach; Spurkland, Anne; Taylor, Bruce; Winkelmann, Juliane; Zipp, Frauke; Haines, Jonathan L.; Pericak-Vance, Margaret A.; Spencer, Chris C.A.; Stewart, Graeme; Hafler, David A; Ivinson, Adrian J.; Harbo, Hanne Flinstad; Hauser, Stephen L.; De Jager, Philip L.; Compston, Alastair; McCauley, Jacob L.; Sawcer, Stephen & McVean, Gil (2015). Class II HLA interactions modulate genetic risk for multiple sclerosis. Nature Genetics.  ISSN 1061-4036.  47(10), s 1107- 1113 . doi: 10.1038/ng.3395
• Andersen, Thorny Cesilie Bie; Lindsjø, Kjersti; Hem, Cecilie Anne Dahl; Koll, Lise; Kristiansen, Per Eugen; Skjeldal, Lars; Andreotti, Amy H. & Spurkland, Anne (2014). Solubility of recombinant Src homology 2 domains expressed in E. coli can be predicted by TANGO. BMC Biotechnology.  ISSN 1472-6750.  14(3) . doi: 10.1186/1472-6750-14-3 Fulltekst i vitenarkiv.
• Damotte, V; Guillot-Noel, Lena; Patsopoulos, Nikolaos A.; Madireddy, L; Behi, M El; Ban, Maria; Baranzini, Sergio; Barcellos, Lisa; Beecham, Gary; Beecham, Ashley; Bernardinelli, L; Booth, David; Bos, Steffan Daniel; Buck, Dorothea; Bush, William; Comabella, Manuel; Compston, Alastair; Cotsapas, Chris; Cournu-rebeixisabelle, Isabelle; Cree, Bruce; d'Alfonso, Sandra; Daly, Mark; Damotte, Vincent; Davis, Mary; Bakker, Paul de; De Jager, Philip L; Dubois, Benedicte; Esposito, Federica; Fontaine, Bertrand; Goris, An; Gourraud, Pierre-Antoine; Green, Todd; Celius, Elisabeth Gulowsen; Hadjixenofontos, Athena; Hafler, David; Haines, Jonathan; Harbo, Hanne Flinstad; Hauser, Stephen; Hawkins, Clive; Hemmer, Bernhard; Hillert, Jan; Hintzen, Rogier; Horáková, Dana; Ivinson, Adrian J; Kemppinen, Anu; Kira, Jun-ichi; Kockum, Ingrid; Lincoln, Robin; Martin, Roland; Boneschi, Filippo martinelli; McCauley, Jacob L.; Mero, Inger-Lise; Oksenberg, Jorge; Olsson, Tomas; Oturai, Annette; Palotie, Aarno; Pericak-Vance, Margaret; Rioux, John; Saarela, Janna; Sawcer, Stephen; Schnetz-boutaud, Nathalie; Sellebjerg, Finn; Soendergaard, Helle; Sorensen, Per Soelberg; Spurkland, Anne; Stankovich, Jim; Stewart, Graeme; Taylor, Bruce; Ticca, Anna; West, Sandra; Zipp, Frauke; Blackwell, Jenefer m; Bramon, Elvira; Brown, Matthew A; Casas, Juan Pablo; Corvin, Aiden; Jankowski, Janusz; Markus, Hugh s; Mathew, Christopher G.; Palmer, Colin NA; Plomin, Robert; Rautanen, Anna; Trembath, Richard c; Viswanathan, Ananth c; Wood, Nicholas W.; Spencer, Chris ca; Band, Gavin; Bellenguez, Celine; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Pearson, Richard; Strange, Amy; Su, Zhan; Vukcevic, Damjan; Donnelly, Peter; Langford, Cordelia; Hunt, Sarah E; Edkins, Sarah; Gwilliam, Rhian; Blackburn, Hannah; Bumpstead, Suzannah J.; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; Mccann, Owen t; Liddle, Jennifer; Potter, Simon C; Ravindrarajah, Rathi; Ricketts, Michelle; Waller, Matthew J; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Barroso, Ines; Deloukas, Panos; Dilthey, Alexander; Leslie, Stephen; Moutsianas, Loukas; Perez, Marc l; Mcvean, Gil; Mccarthy, Mark i; Baranzini, SE; Cournu-Rebeix, I & Fontaine, B. (2014). A gene pathway analysis highlights the role of cellular adhesion molecules in multiple sclerosis susceptibility. Genes and Immunity.  ISSN 1466-4879.  15, s 126- 132 . doi: 10.1038/gene.2013.70
• Goris, An; Van Setten, Jessica; Diekstra, Frank; Ripke, Stephan; Patsopoulos, Nikolaos A.; Sawcer, Stephen; Ban, Maria; Baranzini, Sergio; Barcellos, Lisa; Beecham, Gary; Beecham, Ashley; Bernardinelli, L; Booth, David; Bos, Steffan Daniel; Buck, Dorothea; Bush, William; Comabella, Manuel; Compston, Alastair; Cotsapas, Chris; Cournu-Rebeix, Isabelle; Cree, Bruce; d'Alfonso, Sandra; Daly, Mark; Damotte, Vincent; Davis, Mary; Bakker, Paul de; De Jager, Philip L; Dubois, Benedicte; Esposito, Federica; Fontaine, Bertrand; Gourraud, Pierre-Antoine; Green, Todd; Celius, Elisabeth Gulowsen; Hadjixenofontos, Athena; Hafler, David; Haines, Jonathan; Harbo, Hanne Flinstad; Hauser, Stephen; Hawkins, Clive; Hemmer, Bernhard; Hillert, Jan; Hintzen, Rogier; Horáková, Dana; Ivinson, Adrian J; Kemppinen, Anu; Kira, Jun-ichi; Kockum, Ingrid; Lincoln, Robin; Martin, Roland; Boneschi, Filippo martinelli; McCauley, Jacob L.; Mero, Inger-Lise; Oksenberg, Jorge; Olsson, Tomas; Oturai, Annette; Palotie, Aarno; Pericak-Vance, Margaret; Rioux, John; Saarela, Janna; Schnetz-boutaud, Nathalie; Sellebjerg, Finn; Soendergaard, Helle; Sorensen, Per Soelberg; Spurkland, Anne; Stankovich, Jim; Stewart, Graeme; Taylor, Bruce; Ticca, Anna; West, Sandra; Zipp, Frauke; van Es, Michael; Bahlo, M; Booth, DR; Broadley, SA; Brown, MA; Foote, SJ; Griffiths, LR; Kilpatrick, TJ; Lechner-Scott, J; Moscato, P; Perreau, VM; Rubio, JP; Scott, RJ; Stankovich, J; Taylor, BV; Wiley, J; Clarke, G; Cox, MB; Csurhes, PA; Danoy, P; Drysdale, K; Field, J; Greer, JM; Guru, P; Hadler, J; Mcmorran, BJ; Jensen, CJ; Johnson, JL; McCallum, R.; Merriman, M.; Merriman, T.; Pryce, K; Stewart, GJ; Tajouri, L; Wilkins, EJ; Browning, BL; Browning, SR; Perera, D; Broadley, S.; Butzkueven, H.; Carroll, WM; Chapman, C.; Kermode, AG; Marriott, M; Mason, D; Heard, RN; Pender, MP; Slee, M.; Tubridy, N; Willoughby, E; Andersen, Peter M.; Melki, Judith; Meininger, Vincent; Hardiman, Orla; Landers, John E; Brown, Robert H; Shatunov, Aleksey; Leigh, Nigel; Al-Chalabi, Ammar; Shaw, Christopher E; Traynor, Bryan J.; Chio, Adriano; Restagno, Gabriella; Mora, Gabriele; Ophoff, Roel A.; Oksenberg, Jorge R.; Van Damme, Philip; Robberecht, Wim; van den Berg, Leonard H.; Veldink, Jan H & de Bakker, Paul I.W. (2014). No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis. Human Molecular Genetics.  ISSN 0964-6906.  23(7), s 1916- 1922 . doi: 10.1093/hmg/ddt574
• Granum, Stine; Gjerstad, Vibeke Sundvold; Gopalakrishnan, Ramakrishna Prabhu; Berge, Tone; Koll, Lise; Abrahamsen, Greger; Sørlie, Morten & Spurkland, Anne (2014). The kinase Itk and the adaptor TSAd change the specificity of the kinase Lck in T cells by promoting the phosphorylation of Tyr192. Science Signaling.  ISSN 1937-9145.  7:ra118(355) . doi: 10.1126/scisignal.2005384
• Pandya, Abhilash D.; Leergaard, Trygve Brauns; Dissen, Erik; Haraldsen, Guttorm & Spurkland, Anne (2014). Expression of the T cell-specific adapter protein in human tissues. Scandinavian Journal of Immunology.  ISSN 0300-9475.  80(3), s 169- 179 . doi: 10.1111/sji.12199
• Sundqvist, Emilie; Buck, Dorothea; Warnke, Clemens; Albrecht, Eva; Gieger, Christian; Khademi, Mohsen; Lima Bomfim, Izaura; Fogdell-Hahn, Anna; Link, Jenny; Alfredsson, Lars; Søndergaard, Helle Bach; Hillert, Jan; Barcellos, Lisa; Booth, David; McCauley, Jacob L.; Comabella, Manuel; Compston, Alastair; d'Alfonso, Sandra; de Jager, Philip; Fontaine, Bertrand; Goris, An; Hafler, David; Haines, Jonathan; Harbo, Hanne Flinstad; Hauser, Stephen L; Hawkins, Clive; Ivinson, Adrian; Martin, Roland; Boneschi, Fillippo Martinelli; Oksenberg, Jorge; Patsopoulos, Nikolaos; Pericak-Vance, Margaret; Saarela, Janna; Sawcer, Stephen; Spurkland, Anne; Stewart, Graeme; Zipp, Frauke; Oturai, Annette B.; Hemmer, Bernhard; Kockum, Ingrid & Olsson, Tomas (2014). JC Polyomavirus Infection Is Strongly Controlled by Human Leucocyte Antigen Class II Variants. PLoS Pathogens.  ISSN 1553-7366.  10(4) . doi: 10.1371/journal.ppat.1004084
• Baranzini, SE; Celius, E.G.; Elovaara, I; Harbo, HF; Hillert, J; Myhr, Kjell-Morten; Sørensen, PS; Spurkland, A; Sawcer, S; Hauser, SL; Oksenberg, JR; Khankhanian, Pouya; Patsopoulos, Nikolaos A.; Li, Michael; Stankovich, Jim; Cotsapas, Chris; Søndergaard, Helle Bach; Ban, Maria; Barizzone, Nadia; Bergamaschi, Laura; Booth, David; Buck, Dorothea; Cavalla, Paola; Celius, Elisabeth G.; Comabella, Manuel; Comi, Giancarlo; Compston, Alastair; Cournu-Rebeix, Isabelle; D’alfonso, Sandra; Damotte, Vincent; Din, Lennox; Dubois, Benedicte; Elovaara, Irina; Esposito, Federica; Fontaine, Bertrand; Franke, Andre; Goris, An; Gourraud, Pierre-Antoine; Graetz, Christiane; Guerini, Franca R.; Guillot-Noel, Lena; Hafler, David A; Hakonarson, Hakon; Hall, Per; Hamsten, Anders; Harbo, Hanne Flinstad; Bernhard, Hemmer; Hillert, Jan; Kemppinen, Anu; Ingrid, Kockum; Koivisto, Keijo; Larsson, Malin; Lathrop, Mark; Leone, Maurizio; Lill, Christina M.; Macciardi, Fabio; Martin, Roland; Martinelli, Vittorio; Martinelli-Boneschi, Filippo; McCauley, Jacob L.; Naldi, Paoloa; Olsson, Tomas; Oturai, Annette; Pericak-Vance, Margaret A.; Perla, Franco; Reunanen, Mauri; Saarela, Janna; Saker-Delye, Safa; Salvetti, Marco; Sellebjerg, Finn; Sørensen, Per Soelberg; Spurkland, Anne; Stewart, Graeme; Taylor, Bruce; Tienari, Pentti; Winkelmann, Juliane; Wellcome Trust Case Control, Consortium 2; Zipp, Frauke; Ivinson, Adrian J; Haines, Jonathan L.; Sawcer, Stephen; DeJager, Philip; Hauser, Stephen L & Oksenberg, Jorge R. (2013). Network-based multiple sclerosis pathway analysis with GWAS data from 15,000 cases and 30,000 controls. American Journal of Human Genetics.  ISSN 0002-9297.  s 854- 865 . doi: 10.1016/j.ajhg.2013.04.019
• Beecham, Ashley H.; Patsopoulos, NA; Xifara, DK; Davis, MF; Kemppinen, A; Cotsapas, C; Shah, TS; Spencer, C; Booth, D; Goris, A; Oturai, A; Saarela, J; Fontaine, B; Hemmer, B; Martin, C; Zipp, F; D'Alfonso, S; Martinelli-Boneschi, F; Taylor, B; Harbo, Hanne Flinstad; Kockum, I; Hillert, J; Olsson, T; Ban, M; Oksenberg, JR; Hintzen, R; Barcellos, LF; Agliardi, C; Alfredsson, L; Alizadeh, M; Anderson, C; Andrews, R; Sondergaard, HB; Baker, A; Band, G; Baranzini, SE; Barizzone, N; Barrett, J; Bellenguez, C; Bergamaschi, L; Bernardinelli, L; Berthele, A; Biberacher, V; Binder, TMC; Blackburn, H; Bomfim, IL; Brambilla, P; Broadley, S; Brochet, B; Brundin, L; Buck, D; Butzkueven, H; Caillier, SJ; Camu, W; Carpentier, W; Cavalla, P; Celius, Elisabeth Gulowsen; Coman, I; Comi, G; Corrado, L; Cosemans, L; Cournu-Rebeix, I; Cree, BAC; Cusi, D; Damotte, V; Defer, G; Delgado, SR; Deloukas, P; di Sapio, A; Dilthey, AT; Donnelly, P; Dubois, B; Duddy, M; Edkins, S; Elovaara, I; Esposito, F; Evangelou, N; Fiddes, B; Field, J; Franke, A; Freeman, C; Frohlich, IY; Galimberti, D; Gieger, C; Gourraud, PA; Graetz, C; Graham, A; Grummel, V; Guaschino, C; Hadjixenofontos, A; Hakonarson, H; Halfpenny, C; Hall, G; Hall, P; Hamsten, A; Harley, J; Harrower, T; Hawkins, C; Hellenthal, G; Hillier, C; Hobart, J; Hoshi, M; Hunt, SE; Jagodic, M; Jelcic, I; Jochim, A; Kendall, B; Kermode, A; Kilpatrick, T; Koivisto, K; Konidari, I; Korn, T; Kronsbein, H; Langford, C; Larsson, M; Lathrop, M; Lebrun-Frenay, C; Lechner-Scott, J; Lee, MH; Leone, MA; Leppa, V; Liberatore, G; Lie, Benedicte Alexandra; Lill, CM; Linden, M; Link, J; Luessi, F; Lycke, J; Macciardi, F; Mannisto, S; Manrique, CP; Martin, R; Martinelli, V; Mason, D; Mazibrada, G; McCabe, C; Mero, Inger-Lise; Mescheriakova, J; Moutsianas, L; Myhr, Kjell-Morten; Nagels, G; Nicholas, R; Nilsson, P; Piehl, F; Pirinen, M; Price, SE; Quach, H; Reunanen, M; Robberecht, W; Robertson, NP; Rodegher, M; Rog, D; Salvetti, M; Schnetz-Boutaud, NC; Sellebjerg, F; Selter, RC; Schaefer, C; Shaunak, S; Shen, L; Shields, S; Siffrin, V; Slee, M; Sorensen, PS; Sorosina, M; Sospedra, M; Spurkland, Anne; Strange, A; Sundqvist, E; Thijs, V; Thorpe, J; Ticca, A; Tienari, P; van Duijn, C; Visser, EM; Vucic, S; Westerlind, H; Wiley, JS; Wilkins, A; Wilson, JF; Winkelmann, J; Zajicek, J; Zindler, E; Haines, JL; Pericak-Vance, MA; Ivinson, AJ; Stewart, G; Hafler, D; Hauser, SL; Compston, A; McVean, G; De Jager, P; Sawcer, SJ & McCauley, JL (2013). Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nature Genetics.  ISSN 1061-4036.  45(11), s 1353- 1360 . doi: 10.1038/ng.2770
• Jacobsen, Johanne Tracey; Gjerstad, Vibeke Sundvold; Skjeldal, Frode Miltzow; Andersen, Jan Terje; Abrahamsen, Greger; Bakke, Oddmund; Spurkland, Anne & Bogen, Bjarne (2013). B-cell tolerance to the B-cell receptor variable regions. European Journal of Immunology.  ISSN 0014-2980.  43(10), s 2577- 2587 . doi: 10.1002/eji.201243203
• Leikfoss, Ingvild Sørum; Mero, Inger-Lise; Dahle, Maria Krudtaa; Lie, Benedicte Alexandra; Harbo, Hanne Flinstad; Spurkland, Anne & Berge, Tone (2013). Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus. Genes and Immunity.  ISSN 1466-4879.  14(1), s 62- 66 . doi: 10.1038/gene.2012.52
• Rosella, Mechelli; Renato, Umeton; Policano, Claudia; Annibali, Viviana; Giulia, Coarelli; Ricigliano, Vito A. G.; Vittori, Danila; Fornasiero, Arianna; Buscarinu, Maria Chiara; Sawcer, Stephen; Hellenthal, Garrett; Pirinen, Matti; Spencer, Chris C A; Patsopoulos, Nikolaos; Mousianas, Loukas; Dithey, Alexander; Su, Zhan; Freeman, Colin; Hunt, Sarah E; Edkins, Sarah; Gray, Emma; Booth, David R; Potter, Simon C; Goris, An; Band, Gavin; Oturai, Annette Bang; Strange, Amy; Saarela, Janna; Bellenguez, Celine; Fontaine, Bertrand; Gillman, Matthew; Hemmer, Bernhard; Gwilliam, Rhian; Zipp, Frauke; Jayakumar, Akagurevathi; Martin, Roland; Leslie, Stephen; Hawkins, Stanley; Giannolatou, Eleni; D`alfonso, Sandra; Blackburn, Hannah; Boneschi, Fillippo Martinelli; Liddle, Jennifer; Harbo, Hanne Flinstad; Perez, Marc L; Spurkland, Anne; Waller, Matthew J; Mycko, Marcin P; Ricketts, Michelle; Comabella, Manuel; Celius, Elisabeth Gulowsen; Lorentzen, Åslaug Rudjord; Mero, Inger-Lise; Myhr, Kjell-Morten & SMESTAD, CATHRINE (2013). A ‘‘candidate-interactome’’ aggregate analysis of genome-wide association data in multiple sclerosis. PLoS ONE.  ISSN 1932-6203.  8(5) . doi: 10.1371/journal.pone.0063300
• Berge, Tone; Grønningsæter, Ingrid Helene; Lorvik, Kristina Berg; Abrahamsen, Greger; Granum, Stine; Gjerstad, Vibeke Sundvold; Corthay, Alexandre; Bogen, Bjarne & Spurkland, Anne (2012). SH2D2A Modulates T Cell Mediated Protection to a B Cell Derived Tumor in Transgenic Mice. PLoS ONE.  ISSN 1932-6203.  7(10)
• Sun, Zuyue; Li, Xiujuan; Massena, Sara; Kutschera, Simone; Padhan, Narendra; Gualandi, Laura; Gjerstad, Vibeke Sundvold; Gustafsson, Karin; Choy, Wing Wen; Zang, Guangxiang; Quach, My; Jansson, Leif; Phillipson, Mia; Abid, Md Ruhul; Spurkland, Anne & Claesson-Welsh, Lena (2012). VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd. Journal of Experimental Medicine.  ISSN 0022-1007.  209(7), s 1363- 1377 . doi: 10.1084/jem.20111343
• Harbo, Hanne Flinstad; Lorentzen, Åslaug Rudjord; Lie, Benedicte Alexandra; Celius, Elisabeth Gulowsen & Spurkland, Anne (2011). Nytt genkart for multippel sklerose. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  131(21), s 2126- 2130
• Mero, Inger-Lise; Ban, Maria; Lorentzen, Åslaug Rudjord; SMESTAD, CATHRINE; Celius, Elisabeth Gulowsen; Sæther, Hanne Skarpodde; Saeedi, Haleh; Viken, Marte K; Skinningsrud, Beate; Undlien, Dag Erik; Aarseth, Jan Harald; Myhr, Kjell-Morten; Granum, Stine; Spurkland, Anne; Sawcer, Stephen; Compston, Alastair; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2011). Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus. Genes and Immunity.  ISSN 1466-4879.  12(3), s 191- 198 . doi: 10.1038/gene.2010.59
• Sawcer, S; Hellenthal, G; Pirinen, M; Spencer, CCA; Patsopoulos, NA; Moutsianas, L; Dilthey, A; Su, Z; Freeman, C; Hunt, SE; Edkins, S; Gray, E; Booth, DR; Potter, SC; Goris, A; Band, G; Oturai, AB; Strange, A; Saarela, J; Bellenguez, C; Fontaine, B; Gillman, M; Hemmer, B; Gwilliam, R; Zipp, F; Jayakumar, A; Martin, R; Leslie, S; Hawkins, S; Giannoulatou, E; D'alfonso, S; Blackburn, H; Boneschi, FM; Liddle, J; Harbo, Hanne Flinstad; Perez, ML; Spurkland, Anne; Waller, MJ; Mycko, MP; Ricketts, M; Comabella, M; Hammond, N; Kockum, I; McCann, OT; Ban, M; Whittaker, P; Kemppinen, A; Weston, P; Hawkins, C; Widaa, S; Zajicek, J; Dronov, S; Robertson, N; Bumpstead, SJ; Barcellos, LF; Ravindrarajah, R; Abraham, R; Alfredsson, L; Ardlie, K; Aubin, C; Baker, A; Baker, K; Baranzini, SE; Bergamaschi, L; Bergamaschi, R; Bernstein, A; Berthele, A; Boggild, M; Bradfield, JP; Brassat, D; Broadley, SA; Buck, D; Butzkueven, H; Capra, R; Carroll, WM; Cavalla, P; Celius, Elisabeth Gulowsen; Cepok, S; Chiavacci, R; Clerget-Darpoux, F; Clysters, K; Comi, G; Cossburn, M; Cournu-Rebeix, I; Cox, MB; Cozen, W; Cree, BAC; Cross, AH; Cusi, D; Daly, MJ; Davis, E; de Bakker, PIW; Debouverie, M; D'hooghe, MB; Dixon, K; Dobosi, R; Dubois, B; Ellinghaus, D; Elovaara, I; Esposito, F; Fontenille, C; Foote, S; Franke, A; Galimberti, D; Ghezzi, A; Glessner, J; Gomez, R; Gout, O; Graham, C; Grant, SFA; Guerini, FR; Hakonarson, H; Hall, P; Hamsten, A; Hartung, HP; Heard, RN; Heath, S; Hobart, J; Hoshi, M; Infante-Duarte, C; Ingram, G; Ingram, W; Islam, T; Jagodic, M; Kabesch, M; Kermode, AG; Kilpatrick, TJ; Kim, C; Klopp, N; Koivisto, K; Larsson, M; Lathrop, M; Lechner-Scott, JS; Leone, MA; Leppa, V; Liljedahl, U; Bomfim, IL; Lincoln, RR; Link, J; Liu, JJ; Lorentzen, Åslaug Rudjord; Lupoli, S; Macciardi, F; Mack, T; Marriott, M; Martinelli, V; Mason, D; McCauley, JL; Mentch, F; Mero, Inger-Lise; Mihalova, T; Montalban, X; Mottershead, J; Myhr, Kjell-Morten; Naldi, P; Ollier, W; Page, A; Palotie, A; Pelletier, J; Piccio, L; Pickersgill, T; Piehl, F; Pobywajlo, S; Quach, HL; Ramsay, PP; Reunanen, M; Reynolds, R; Rioux, J; Rodegher, M; Roesner, S; Rubio, JP; Ruckert, IM; Salvetti, M; Salvi, E; Santaniello, A; Schaefer, CA; Schreiber, S; Schulze, C; Scott, RJ; Sellebjerg, F; Selmaj, KW; Sexton, D; Shen, L; Simms-Acuna, B; Skidmore, S; Sleiman, PMA; SMESTAD, CATHRINE; Sorensen, PS; Sondergaard, HB; Stankovich, J; Strange, RC; Sulonen, AM; Sundqvist, E; Syvanen, AC; Taddeo, F; Taylor, B; Blackwell, JM; Tienari, P; Bramon, E; Tourbah, A; Brown, MA; Tronczynska, E; Casas, JP; Tubridy, N; Corvin, A; Vickery, J; Jankowski, J; Villoslada, P; Markus, HS; Wang, K; Mathew, CG; Wason, J; Palmer, CNA; Wichmann, HE; Plomin, R; Willoughby, E; Rautanen, A; Winkelmann, J; Wittig, M; Trembath, RC; Yaouanq, J; Viswanathan, AC; Zhang, HT; Wood, NW; Zuvich, R; Deloukas, P; Langford, C; Duncanson, A; Oksenberg, JR; Pericak-Vance, MA; Haines, JL; Olsson, T; Hillert, J; Ivinson, AJ; De Jager, PL; Peltonen, L; Stewart, GJ; Hafler, DA; Hauser, SL; McVean, G; Donnelly, Peter & Compston, Alastair (2011). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature.  ISSN 0028-0836.  476(7359), s 214- 219 . doi: 10.1038/nature10251
• Berge, Tone; Gjerstad, Vibeke Sundvold; Granum, Stine; Andersen, Thorny Cesilie Bie; Holthe, Gunn Bodil; Claesson-Welsh, L; Andreotti, Amy H.; Inngjerdingen, Marit & Spurkland, Anne (2010). T Cell Specific Adapter Protein (TSAd) Interacts with Tec Kinase ITK to Promote CXCL12 Induced Migration of Human and Murine T Cells. PLoS ONE.  ISSN 1932-6203.  5(3) . doi: 10.1371/journal.pone.0009761
• Esposito, Floriana; Patsopoulos, NA; Cepok, Sabine; Kockum, I; Leppa, V; Booth, DR; Heard, RN; Stewart, GJ; Cox, M; Scott, RJ; Lechner-Scott, J; Goris, A; Dobosi, R; Dubois, B; Rioux, JD; Oturai, AB; Søndergaard, HB; Sellebjerg, F; Sørensen, PS; Reunanen, M; Koivisto, K; Cournu-Rebeix, I; Fontaine, B; Winkelmann, J; Gieger, C; Infante-Duarte, C; Zipp, F; Bergamaschi, L; Leone, M; Bergamaschi, R; Cavalla, P; Lorentzen, ÅR; Mero, Inger-Lise; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad; Spurkland, Anne; Comabella, M; Brynedal, B; Alfredsson, L; Bernardinelli, L; Robertson, NB; Hawkins, CP; Barcellos, LF; Beecham, G; Bush, W; Cree, BAC; Daly, MJ; Ivinson, AJ; Aublin, C; Compston, A; D´Alfonso, S; Haines, JL; Hauser, SL; Hemmer, B; Hillert, J; McMcauley, JL; Oksenberg, Jorge; Olsson, T; Palotie, A; Peltonen, L; Pericak-Vance, MA; Saarela, J; Sawcer, SJ; Stranger, B; Boneschi, FM; Comi, G; Hafler, DA; de Bakker, PIW & De Jaeger, PL (2010). IL12A, MPHOSPH9/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci. Genes and Immunity.  ISSN 1466-4879.  11(5), s 397- 405 . doi: 10.1038/gene.2010.28
• Kolltveit, Kristin Melkevik; Schreurs, Olav Joseph F; Østrem, Janet M; Søland, Tine Merete; Khuu, Cuong; Berge, Tone; Messelt, Edvard Berger; Hayashi, Katsuhiko; Granum, Stine; Spurkland, Anne & Schenck, Karl (2010). Expression of the T-cell-specific adapter protein in oral epithelium. European Journal of Oral Sciences.  ISSN 0909-8836.  118(2), s 159- 167 Vis sammendrag

  The multifunctional T-cell-specific adapter protein (TSAd) was originally described in T cells but is also expressed in epithelial cells from the respiratory tract and in endothelium. In this study, we found expression of TSAd messenger RNA (mRNA) and protein in both human and murine oral mucosal epithelium as well as in human primary oral keratinocyte cell cultures. In TSAd(-/-) mice, the mucosa and skin appeared macroscopically normal, but severe disturbances were observed in the fine structures of the basal membrane and intercellular epithelial spaces upon analysis using transmission electron microscopy. Oral epithelial cells from TSAd(-/-) mice displayed decreased migration compared with cells from wild-type mice, whereas overexpression of TSAd in a human epithelial cell line resulted in impaired proliferation. This study is the first to show that TSAd is expressed in normal oral mucosa, that it is important for the normal ultrastructural morphology of the epithelium and the basal membrane, and that it is involved in the migration and proliferation of oral keratinocytes.

• Mero, Inger-Lise; Lorentzen, Åslaug Rudjord; SMESTAD, CATHRINE; Ban, Maria; Celius, Elisabeth Gulowsen; Aarseth, Jan; Myhr, Kjell-Morten; Link, Jenny; Olsson, Tomas; Hillert, Jan; Kockum, Ingrid; Masterman, T; Oturai, AB; Sondergaard, HB; Sellebjerg, F; Saarela, J; Kemppinen, A; Elovaara, I; Spurkland, Anne; Dudbridge, F; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2010). A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. European Journal of Human Genetics.  ISSN 1018-4813.  18(4), s 502- 504 . doi: 10.1038/ejhg.2009.195
• Lorentzen, Åslaug Rudjord; Karlsen, TH; Olsson, M; Smestad, C; Mero, IL; Woldseth, B; Sun, JY; Senitzer, D; Celius, EG; Thorsby, E; Spurkland, Anne; Lie, BA & Harbo, Hanne Flinstad (2009). Killer Immunoglobulin-like Receptor Ligand HLA-Bw4 Protects Against Multiple Sclerosis. Annals of Neurology.  ISSN 0364-5134.  65(6), s 658- 666 . doi: 10.1002/ana.21695
• Mero, Inger Lise; Lorentzen, Åslaug Rudjord; Ban, Maria; SMESTAD, CATHRINE; Celius, Elisabeth G; Aarseth, Jan; Myhr, Kjell Morten; Link, Jenny; Hillert, Jan; Olsson, Tomas; Kochum, Ingrid; Masterman, T; Oturai, A; Søndergaard, HB; Sellebjerg, Finn; Saaerla, Janna; Kemppinen, Anu; Spurkland, Anne; Dubridge, F; Lie, BA & Harbo, Hanne Flinstad (2009). A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis. European Journal of Human Genetics.  ISSN 1018-4813. . doi: 10.1038/ejhg.2009.195
• Ban, M; Goris, A; Lorentzen, Åslaug Rudjord; Baker, A; Mihalova, T; Ingram, G; Booth, DR; Heard, RN; Stewart, GJ; Bogaert, E; Dubois, B; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Spurkland, Anne; Strange, R; Hawkins, C; Robertson, NP; Dudbridge, F; Wason, J; De Jager, PL; Hafler, D; Rioux, JD; Ivinson, AJ; McCauley, JL; Pericak-Vance, M; Oksenberg, JR; Hauser, SL; Sexton, D; Haines, J; Sawcer, S & Compston, A (2009). Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human Genetics.  ISSN 1018-4813.  17(10), s 1309- 1313 . doi: 10.1038/ejhg.2009.41
• Ban, Maria; Booth, David R; Heard, Robert N; Stewart, Graeme J; Goris, An; Dobosi, Rita; Lorentzen, Åslaug Rudjord; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad; Spurkland, Anne; Dubois, Benedicte; Olsson, Tomas; Hillert, Jan; Kockum, Ingrid; Link, Jenny; Baker, Amie; Sawcer, Stephen; Compston, Alastair; Mihalova, Tania; Strange, Richard; Hawkins, Clive; Ingram, Gillian; Robertson, Neil P; De Jager, Philip L; Hafler, David A; Barcellos, Lisa F; Ivinson, Adrian; Periack-Vance, Margaret; Oksenberg, Jorge R; Hauser, Stephen L; McCauley, Jacob L; Sexton, David & Haines, Jonathan (2009). The expanding genetic overlap between multiple sclerosis and type I diabetes. Genes and Immunity.  ISSN 1466-4879.  10(1), s 11- 14 . doi: 10.1038/gene.2008.83 Vis sammendrag

  Familial clustering of autoimmune disease is well recognized and raises the possibility that some susceptibility genes may predispose to autoimmunity in general. In light of this observation, it might be expected that some of the variants of established relevance in one autoimmune disease may also be relevant in other related conditions. On the basis of this hypothesis, we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10,296 unrelated controls. Two of these seven SNPs showed evidence of association with multiple sclerosis; that is rs12708716 from the CLEC16A gene (P=1.6 x 10(-16)) and rs763361 from the CD226 gene (P=5.4 x 10(-8)). These findings thereby identify two additional multiple sclerosis susceptibility genes and lend support to the notion of autoimmune susceptibility genes.

• Holmøy, Trygve; Harbo, hanne F.; Vartdal, Frode & Spurkland, Anne (2009). Genetic and Molecular Approaches to the Immunopathogenesis of Multiple Sclerosis: An Update. Current molecular medicine.  ISSN 1566-5240.  9(5), s 591- 611
• Jagodic, Maja; Colacios, Celine; Nohra, Rita; Dejean, Anne S.; Beyeen, Amennai Daniel; Khademi, Mohsen; Casemayou, Audrey; Lamouroux, Lucille; Duthoit, Christine; Papapietro, Olivier; Sjöholm, Louise; Bernard, Isabelle; Lagrange, Dominique; Dahlman, Ingrid; Lundmark, Frida; Oturai, Annette Bang; Soendergaard, Helle B; Kemppinen, Anu; Saarela, Janna; Tienari, Pentti J.; Harbo, Hanne Flinstad; Spurkland, Anne; Ramagopalan, Sreeram V.; Sadovnick, Dessa A.; Ebers, George C.; Seddighzadeh, Maria; Klareskog, Lars; Alfredsson, Lars; Padyukov, Leonid; Hillert, Jan; Clanet, Michel; Edan, Gilles; Fontaine, Bertrand; Fournie, Gilbert J.; Kockum, Ingrid; Saoudi, Abdelhadi & Olsson, Tomas (2009). A Role for VAV1 in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis. Science Translational Medicine.  ISSN 1946-6234.  1(10) . doi: 10.1126/scitranslmed.3000278
• Lorentzen, Åslaug R; Smestad, Cathrine; Lie, Benedicte A; Lie, BA; Oturai, AB; Oturai, Annette; Åkesson, Eva; Akesson, E; Saarela, Janna; Myhr, Kjell-Morten; Vartdal, Frode; Celius, Elisabeth G; Sorensen, PS; Sørensen, Per S; Hillert, Jan; Spurkland, Anne; Harbo, Hanne F & Harbo, HF (2008). The SH2D2A gene and susceptibility to multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  197, s 152- 158 . doi: 10.1016/j.jneuroim.2008.04.037
• Granum, Stine; Andersen, Thorny C. B.; Sørlie, Morten; Jørgensen, Marit; Koll, Lise; Berge, Tone; Lea, Tor; Fleckenstein, Burkhard; Spurkland, Anne & Sundvold-Gjerstad, Vibeke (2008). Modulation of Lck function through multisite docking to T cell-specific adapter protein. Journal of Biological Chemistry.  ISSN 0021-9258.  283(32), s 21909- 21919 Vis sammendrag

  T cell-specific adapter protein (TSAd), encoded by the SH2D2A gene, interacts with Lck through its C terminus and thus modulates Lck activity. Here we mapped Lck phosphorylation and interaction sites on TSAd and evaluated their functional importance. The three C-terminal TSAd tyrosines Tyr(280), Tyr(290), and Tyr(305) were phosphorylated by Lck and functioned as docking sites for the Lck Src homology 2 (SH2) domain. Binding affinities of the TSAd Tyr(P)(280) and Tyr(P)(290) phosphopeptides to the isolated Lck SH2 domain were similar to that observed for the Lck Tyr(P)(505) phosphopeptide, whereas the TSAd Tyr(P)(305) peptide displayed a 10-fold higher affinity. The proline-rich Lck SH3-binding site on TSAd as well as the Lck SH2 domain were required for efficient tyrosine phosphorylation of TSAd by Lck. Interaction sites on TSAd for both Lck SH2 and Lck SH3 were necessary for TSAd-mediated modulation of proximal TCR signaling events. We found that 20-30% of TSAd molecules are phosphorylated in activated T cells and that the proportion of TSAd to Lck molecules in such cells is similar to 1:1. Therefore, in activated T cells, a considerable number of Lck molecules may potentially be engaged by TSAd. In conclusion, Lck binds to TSAd prolines and phosphorylates and interacts with the three C-terminal TSAd tyrosines. We propose that through multivalent interactions with Lck, TSAd diverts Lck from phosphorylating other substrates, thus modulating its functional activity through substrate competition.

• Granum, Stine; Andersen, Thorny Cesilie Bie; Sørlie, Morten; Jorgensen, M; Koll, Lise; Berge, Tone; Lea, Tor Erling; Fleckenstein, B; Spurkland, Anne & Gjerstad, Vibeke Sundvold (2008). Modulation of Lck function through multisite docking to T cell-specific adapter protein. Journal of Biological Chemistry.  ISSN 0021-9258.  283, s 21909- 21919 . doi: 10.1074/jbc.M800871200
• Kolltveit, Kristin Melkevik; Granum, Stine; Aasheim, HC; Forsbring, Monika; Gjerstad, Vibeke Sundvold; Dai, KZ; Molberg, Øyvind; Schjetne, KW; Bogen, B; Shapiro, VS; Johansen, Finn Eirik; Schenck, Karl & Spurkland, Anne (2008). Expression of SH2D2A in T-cells is regulated both at the transcriptional and translational level. Molecular Immunology.  ISSN 0161-5890.  45 . doi: 10.1016/j.molimm.2007.11.005
• Datta, Pameli; Harbo, Hanne F; Ryder, Lars P.; Akesson, E; Åkesson, Elisabeth; Benedikz, John; Celius, Elisabeth G; Andersen, Oluf; Myhe, KM; Myhr, Kjell-Morten; Sandberg-Wollheim, Magnhild; Hillert, Jan; Svejgaard, Arne; Sørensen, Per Soelberg; Sorensen, PS; Spurkland, Anne & Oturai, Annette (2007). A follow-up study of Nordic multiple sclerosis candidate gene regions. Multiple Sclerosis.  ISSN 1352-4585.  13(5), s 584- 589 . doi: 10.1177/1352458506071790
• Knudsen, Gun Peggy Strømstad; Harbo, Hanne Flinstad; Smestad, C; Celius, EG; Akesson, E; Oturai, A; Ryder, LP; Spurkland, Anne & Ørstavik, Karen Helene (2007). X chromosome inactivation in females with multiple sclerosis. European Journal of Neurology.  ISSN 1351-5101.  14, s 1392- 1396 . doi: 10.1111/j.1468-1331.2007.01987.x
• Smestad, C; Brynedal, B; Jonasdottir, G; Lorentzen, Åslaug Rudjord; Masterman, T; Akesson, E; Spurkland, Anne; Lie, BA; Palmgren, J; Celius, EG; Hillert, J & Harbo, Hanne Flinstad (2007). The impact of HLA-A and-DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. European Journal of Neurology.  ISSN 1351-5101.  14, s 835- 840 . doi: 10.1111/j.1468-1331.2007.01825.x
• Gjerstad, Vibeke Sundvold; Granum, Stine; Berge, Tone; Andersen, Thorny Cesilie Bie; Kolltveit, Kristin Melkevik & Spurkland, Anne (2007). T cell specific adapter protein in cell signalling and autoimmunity, In Noah Isakov (ed.),  Lymphocyte Activation and Signal Transduction.  Transworld Research Network.  ISBN 978-81-7895-281-9.  12.  s 211 - 220
• Harbo, HF & Spurkland, Anne (2007). Genetics in multiple sclerosis: past and future perspectives. Acta Neurologica Scandinavica.  ISSN 0001-6314.  115
• Lie, BA; Dupuy, Berit Myhre; Spurkland, Anne; Fernandez-Vina, MA; Hagelberg, Erika & Thorsby, Erik (2007). Molecular genetic studies of natives on Easter Island: evidence of an early European and Amerindian contribution to the Polynesian gene pool. Tissue Antigens.  ISSN 0001-2815.  69, s 10- 18 . doi: 10.1111/j.1399-0039.2006.00717.x
• Wiencke, Kristine; Karlsen, Hemming Tom; Boberg, Kirsten Muri; Thorsby, Erik; Schrumpf, Erik; Lie, Benedicte Alexandra & Spurkland, Anne (2007). Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes. Tissue Antigens.  ISSN 0001-2815.  69, s 161- 169 . doi: 10.1111/j.1399-0039.2006.00738.x
• Harbo, Hanne Flinstad; Ekstrom, PO; Lorentzen, Åslaug Rudjord; Gjerstad, Vibeke Sundvold; Celius, EG; Sawcer, Stephen & Spurkland, Anne (2006). Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis. Journal of Neuroimmunology.  ISSN 0165-5728.  177, s 40- 45
• Granum, Stine; Gjerstad, Vibeke Sundvold; Dai, Kezheng; Kolltveit, Kristin Melkevik; Hildebrand, Kjersti; Huitfeldt, Henrik; Lea, T & Spurkland, Anne (2006). Structure function analysis of SH2D2A isoforms expressed in T cells reveals a crucial role for the proline rich region encoded by SH2D2A exon 7. BMC Immunology.  ISSN 1471-2172.  7, s 15
• Spurkland, Anne & Sollid, Ludvig Magne (2006). Mapping genes and pathways in autoimmune disease. Trends in immunology.  ISSN 1471-4906.  27, s 336- 342
• Wiencke, Kristine; Boberg, Kirsten Muri; Donaldson, P; Harbo, Hanne Flinstad; Ling, V; Schrumpf, Erik & Spurkland, Anne (2006). No major effect of the CD28/CTLA4/ICOS gene region on susceptibility to primary sclerosing cholangitis. Scandinavian Journal of Gastroenterology.  ISSN 0036-5521.  41
• Matsumoto, T; Bohman, S; Dixelius, J; Berge, Tone; Dimberg, A; Magnusson, P; Wang, L; Wikner, C; Qi, JH; Wernstedt, C; Wu, J; Bruheim, Skjalg; Mugishima, H; Mukhopadhyay, D; Spurkland, Anne & Claesson-Welsh, L (2005). VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. EMBO Journal.  ISSN 0261-4189.  24 Vis sammendrag

  Vascular endothelial growth factor receptor-2 (VEGFR-2) activation by VEGF-A is essential in vasculogenesis and angiogenesis. We have generated a pan-phosphorylation site map of VEGFR-2 and identified one major tyrosine phosphorylation site in the kinase insert (Y951), in addition to two major sites in the C-terminal tail (Y1175 and Y1214). In developing vessels, phosphorylation of Y1175 and Y1214 was detected in all VEGFR-2-expressing endothelial cells, whereas phosphorylation of Y951 was identified in a subset of vessels. Phosphorylated Y951 bound the T-cell-specific adapter (TSAd), which was expressed in tumor vessels. Mutation of Y951 to F and introduction of phosphorylated Y951 peptide or TSAd siRNA into endothelial cells blocked VEGF-A-induced actin stress fibers and migration, but not mitogenesis. Tumor vascularization and growth was reduced in TSAd-deficient mice, indicating a critical role of Y951-TSAd signaling in pathological angiogenesis.

• Gjerstad, Vibeke Sundvold; Granum, Stine; Mustelin, T; Andersen, Thorny Cesilie Bie; Berge, Tone; Shapiro, MJ; Shapiro, VS; Spurkland, Anne & Lea, Tor Erling (2005). The C terminus of T cell-specific adapter protein (TSAd) is necessary for TSAd-mediated inhibition of Lck activity. European Journal of Immunology.  ISSN 0014-2980.  35(5), s 1612- 1620
• Lie, BA; Flam, ST; Dahlen, H; Dupuy, Berit Myhre; Spurkland, Anne; Hagelberg, Erika & Thorsby, Erik (2005). High-resolution HLA genotyping of individuals from Easter Island reveals admixture both of European and possible American Indian origin. Tissue Antigens.  ISSN 0001-2815.  66(5), s 564- 564
• Lorentzen, Åslaug Rudjord; Celius, Elisabeth Gulowsen; Ekstrøm, Per Olaf; Wiencke, Kristine; Lie, Benedicte Alexandra; Myhr, KM; Ling, V; Thorsby, Erik; Vartdal, Frode; Spurkland, Anne & Harbo, Hanne Flinstad (2005). Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients. Journal of Neuroimmunology.  ISSN 0165-5728.  166
• Etokebe, Godfrey Essien; Abrahamsen, Tore G; Bogen, Bjarne & Spurkland, Anne (2004). Tumour necrosis factor receptor superfamily member 6 gene mutation detection by denaturing high-performance liquid chromatography. Scandinavian Journal of Immunology.  ISSN 0300-9475.  59, s 496- 503 Vis sammendrag

  Denaturing high-performance liquid chromatography (DHPLC) was evaluated as a tool for diagnostic screening of polymorphisms in the tumour necrosis factor receptor superfamily member 6 (TNFRSF6) also known as CD95, Apo-1 or Fas gene. Exons 1-9 of the TNFRSF6 gene were amplified from genomic DNA of 38 individuals, of which three were known to carry mutations in the TNFRSF6 gene. The TNFRSF6 gene amplicons were analysed for heterozygosity by DHPLC. Samples that displayed heterozygous variation by DHPLC were further analysed by sequencing. Comparison of DHPLC analysis with sequencing results showed an overall 100% concordance for samples in which heterozygosity was detected by DHPLC. Importantly, DHPLC was in all cases able to demonstrate the presence or absence of mutations in exon 9 encoding the death domain of the TNFRSF6 gene, which have been implied as the most frequent genetic cause of autoimmune lymphoproliferative syndrome. Comparison of DHPLC analysis with sequencing results showed an overall 100% concordance for samples in which heterozygosity was detected by DHPLC. In conclusion, DHPLC is a suitable method for the detection of genetic variation in the TNFRSF6 gene.

• Flesland, Øystein; Ip, LS; Storlien, AS; Spurkland, Anne; Larsen, J & Solheim, Bjarte G. (2004). Michrochimerism in immune competent patients related to the leucocyte content of the transfused red blood cell concentrates. Transfusion and Apheresis Science.  ISSN 1473-0502.  31, s 173- 180

Se alle arbeider i Cristin

• Spurkland, Anne (2017). Immun. Kroppens evige kamp for å overleve. Spartacus.  ISBN 9788243008304.  416 s.
• Spurkland, Anne (2011). Frie kaker. Kunsten å bake supergode kaker uten melk/mel/egg/sukker. Spartacus.  ISBN 978-82-430-0623-2.  318 s. Vis sammendrag

  Grunnleggende lærebok om kakebaking for allergikere og andre, med fokus på ingrediensenes kjemiske funksjon i bakverket.

Se alle arbeider i Cristin

• Sundbye, Bodil; Hauge, Siri Helene; Spurkland, Anne; Blomberg, Bjørn & Ørmen, Torfinn (2018, 05. august). Epidemiene som truer verden.  Verdens Gang.
• Borowicz, Pawel; Gopalakrishnan, Ramakrishna Prabhu; De Souza, Gustavo Antonio; Abrahamsen, Greger; Sundvold-Gjerstad, Vibeke & Spurkland, Anne (2017). The interactome of TSAd phosphopeptides in T cells.
• Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger; Kjelstrup, Hanna & Spurkland, Anne (2017). The regulatory role of Lck Tyr192 in T cell receptor signalling.
• Borowicz, Pawel & Spurkland, Anne (2016). Intracellular signaling in CRISPR mutated Jurkat T cells.
• Borowicz, Pawel; Sundvold-Gjerstad, Vibeke; Abrahamsen, Greger & Spurkland, Anne (2016). Generation of CRISPR/Cas9 mutants in order to study TCR signalling pathway.
• Spurkland, Anne (2016). Gjenkjent. Vis sammendrag

  Blogginnlegg om immunforsvaret med utgangpsunkt i ungdomsserien Skam på NRK P3

• Spurkland, Anne (2016). Immunforsvaret. Kroppens evige kamp for å overleve.
• Spurkland, Anne (2016). Multiple sclerosis genetics.
• Spurkland, Anne (2016). Regulation of Lck specificity in TCR signal initiation.
• Spurkland, Anne (2016). Skam. Vis sammendrag

  Blogginnlegg om immunforsvaret, med utgangspunkt i ungdomsserien Skam på NRK P3

• Spurkland, Anne (2016). Skamløs?. Vis sammendrag

  Blogginnlegg om immunforsvaret, med utgangspunkt i ungdomsserien Skam på NRK P3

• Spurkland, Anne (2016, 25. mars). Slik virker immunforsvarets hukommelse. [Internett].  Forskning.no.
• Spurkland, Anne (2013). Immunforsvaret. Kroppens evige kamp for å overleve.
• Spurkland, Anne (2013). Immunforsvaret. Kroppens evige kamp for å overleve.
• Tilset, Mats; Boye, Erik & Spurkland, Anne (2013). Glemte sykdommer rammer 1 milliard. Aftenposten (morgenutg. : trykt utg.).  ISSN 0804-3116.
• Berge, Tone; Leikfoss, Ingvild Sørum; Spurkland, Anne; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2012). Multiple sclerosis-associated single nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in thymic tissue.
• Leikfoss, Ingvild S; Mero, Inger-Lise; Dahle, Maria Krudtaa; Lie, Benedicte Alexandra; Harbo, Hanne Flinstad; Spurkland, Anne & Berge, Tone (2012). Multiple Sclerosis Associated Single Nucleotide Polymorphisms in CLEC16A Correlate with Reduced SOCS1 and DEXI Expression in Thymic Samples. Scandinavian Journal of Immunology.  ISSN 0300-9475.  76(2), s 196- 196
• Leikfoss, Ingvild Sørum; Berge, Tone; Harbo, Hanne Flinstad & Spurkland, Anne (2012). Multiple sclerosis-associated single nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in thymic tissue.
• Spurkland, Anne (2012). Maten, tarmen og immunforsvaret.
• Spurkland, Anne (2012). Om cøliaki og om frie kaker.
• Spurkland, Anne (2012). Om matallergi og frie kaker.
• Flåm, Karoline H. & Spurkland, Anne (2011, 08. oktober). Menn blir sykere enn kvinner.  VG. Vis sammendrag

  Kvinner har trolig sterkere immunforsvar enn menn – og det hele koker ned til X-faktoren. Bokstavelig talt.

• Huszenicza, Zsuzsa; Hem, Cecilie Anne Dahl; Koll, Lise; Ekornhol, Marianne; Sundvold-Gjerstad, Vibeke; Granum, Stine & Spurkland, Anne (2011). Identification of Novel TSAd Interaction Partners. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 353- 354
• Kjensli, Bjørnar & Spurkland, Anne (2011, 01. oktober). Kakebakingens kjemi. [Internett].  http://www.forskning.no/.
• Spurkland, Anne (2011, 15. oktober). Ekko kroppen spesial. [Radio].  NRK P2. Vis sammendrag

  Direkte sendt Ekkko fra Fredrikkeplassen i forbindelse med Idefestivalen. Tema: Menneskekroppen, karbohydrater, lavkarbodiett, kaker for allergikere.

• Sundvold-Gjerstad, Vibeke; Kristiansen, Tone Fredsvik; Granum, Stine; Berge, Tone; Koster, Gerbrand; Skjeldal, Frode Miltzow; Koll, Lise; Bakke, Oddmund & Spurkland, Anne (2011). T cell Specific Adapter Protein (TSAd) Relocates the Tec Family Protein Tyrosine Kinase Itk from the Plasma Membrane to the Perinuclear Area. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 359- 359
• Sørum, Ingvild; Mero, Inger-Lise; Gustavsen, Marte Wendel; Muggerud, Aslaug; Sæther, Hanne Skarpodde; Lie, Benedicte Alexandra; Spurkland, Anne; Berge, Tone & Harbo, Hanne Flinstad (2011). Molecular Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A. Scandinavian Journal of Immunology.  ISSN 0300-9475.  73(4), s 377- 377
• Booth, DR; Heard, RN; Stewart, GJ; Cox, M; Scott, RJ; Lechner-Scott, J; Goris, A; Dobosi, R; Dubois, B; Saarela, J; Leppa, V; Peltonen, L; Pirttila, T; Cournu-Rebeix, I; Fontaine, B; Bergamaschi, L; D'Alfonso, S; Leone, M; Lorentzen, A.R.; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Spurkland, Anne; Link, J; Kockum, I; Olsson, T; Hillert, J; Ban, M; Baker, A; Kemppinen, A; Sawcer, S; Compston, A; Robertson, NP; De Jager, PL; Hafler, DA; Barcellos, LF; Ivinson, AJ; McCauley, JL; Pericak-Vance, MA; Oksenberg, JR; Hauser, SL; Sexton, D & Haines, J (2010). Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nature Genetics.  ISSN 1061-4036.  42(6), s 469- 470
• Lorentzen, AR; Karlsen, Tom Hemming; Olsson, M; SMESTAD, CATHRINE; Mero, Inger-Lise; Woldseth, B; Sun, JY; Senitzer, David; Celius, Elisabeth Gulowsen; Thorsby, Erik; Spurkland, Anne; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2009). Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis. European Journal of Neurology.  ISSN 1351-5101.  16, s 19- 19
• Mero, Inger-Lise; Lorentzen, AR; Ban, Maria; SMESTAD, CATHRINE; Celius, Elisabeth Gulowsen; Aarseth, JH; Myhr, Kjell Morten; Link, Jenny; Hillert, Jan; Olsson, Tomas; Kockum, Ingrid; Masterman, T.; Oturai, Anette; Søndergaard, Henrik; Sellebjerg, Finn; Saarela, J; Kemppinen, A; Spurkland, Anne; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2009). The TYK2 gene is associated with susceptibility to multiple sclerosis. Multiple Sclerosis.  ISSN 1352-4585.  15(9), s S186- S186
• Lorentzen, Åslaug Rudjord; Karlsen, Tom Hemming; Olsson, Marita; Smestad, Cathrine; Mero, Inger-Lise; Woldseth, Bente; Sun, Ji-Yao; Senitzer, David; Celius, Elisabeth Gulowsen; Thorsby, Erik; Spurkland, Anne; Lie, Benedicte Alexandra & Harbo, Hanne Flinstad (2008). Protection against multiple sclerosis conferred by carriage of the inhibitory killer immunoglobulin-like receptors (KIRs) ligand HLA-Bw4. Vis sammendrag

  Background: Combinations of killer immunoglobulin-like receptors (KIRs) and HLA class I ligands that reduce natural killer (NK) cells inhibition may increase the risk of autoimmune diseases. Multiple sclerosis (MS) is affecting the central nervous system and is presumed to be an autoimmune disease. There are significant genetic associations to genes in the HLA class II region (DRB1*1501-haplotype),but associations to genes in the HLA class I region have also been reported (for instance A2, A3 and Cw*05). We investigated whether there might be associations to given KIRs and/or their HLA class I ligands . Materials and methods: 631 Norwegian MS patients and 555 Norwegian controls were typed for the presence or absence of genes encoding inhibiting KIRs (KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL5, KIR3DL1, KIR3DL2 and KIR3DL3) and activating KIRs (KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5 and KIR2DL4) using sequence specific primers. HLA-A, -B, -C and –DRB1 typing was performed by direct sequencing or sequence specific primers. Results: We found no significant differences in gene carrier frequencies of inhibitory and activating KIRs in MS patients as compared to controls when p-values were adjusted for number of KIR genes investigated. However, the frequency of the HLA-Bw4 specificity was significantly reduced in MS patients as compared to controls (41.5% vs. 55.1%, p=4.9*10-6), even in individuals who did not carry any of the known HLA class II risk alleles (DRB1*1501,DRB1*03 and DRB1*01, p=0.002). No HLA class II independent associations were observed to genes at the HLA-C or HLA -A loci. Conclusion: The presence of the HLA-Bw4 specificity seems to protect against MS in an HLA class II independent manner. Ongoing analyses aim to characterize possible interaction effects between HLA-Bw4 and KIR3DL1 and KIR3DS1, as well as between HLA-C1 and C2 groups and their corresponding receptors.

• Kantarci, OH & Spurkland, Anne (2008). Parent of origin in multiple sclerosis: Understanding inheritance in complex neurologic diseases. Neurology.  ISSN 0028-3878.  71, s 786- 787
• Lorentzen, Åslaug Rudjord; Ban, Maria; Booth, David; Heard, Robert; Stewart, Graeme; Goris, An; Dobosi, Rita; Dubois, Benedicte; Celius, Elisabeth Gulowsen; Harbo, Hanne Flinstad; Spurkland, Anne; Olsson, Tomas; Kockum, Ingrid; Link, Jenny; Hillert, Jan; Mihalova, Tania; Strange, Richard; Hawkins, Clive; Ingram, Gillian; Robertson, Neil; De Jager, Philip L; Hafler, David A; Barcellos, Lisa; Ivinson, Adrian; Pericak-Vance, Margaret; Oksenberg, Jorge; Hauser, Stephen L; McCauley, Jacob; Sexton, David; Haines, Jonathan; Baker, Amie; Sawcer, Stephen & Compston, Alastair (2008). The expanding genetic overlap between multiple sclerosis and type 1 diabetes. Vis sammendrag

  A familial clustering of autoimmune disease is well recognised and suggests that some susceptibility genes may predispose to autoimmunity in general whereas other genes lead to specific disease. On the basis of this hypothesis it may be expected that variants of established relevance in one autoimmune disease might also be relevant in other related conditions. To investigate this we tested seven single nucleotide polymorphisms (SNPs) that are known to be associated with type I diabetes in a large multiple sclerosis dataset consisting of 2,369 trio families, 5,737 cases and 10,296 unrelated controls. Samples were recruited from across six countries: Australia, Belgium, Norway, Sweden, United Kingdom (UK) and the United States of America (USA) within the IMSGC. Two of these seven SNPs emerged as also being associated with multiple sclerosis; rs12708716 from the C-type lectin domain family 16, member A (CLEC16A) gene (p=1.6x10-15) and rs763361 from the CD226 gene (p=5.4x10-8). In each case the allele associated with increased risk for multiple sclerosis was identical to that showing evidence for association with T1D. These findings thereby confirm two additional multiple sclerosis susceptibility genes and lend support to the notion of commonality amongst autoimmune susceptibility genes.

• Sawcer, Stephen; Booth, David; Heard, Robert; Stewart, Graeme; An, Goris; Dobosi, Rita; Dubois, Benedicte; Oturai, Annette; Soendergaard, Helle B; Sellebjerg, Finn; Saarela, Janna; Leppa, Virpi; Palotie, Aarno; Peltonen, Leena; Fontaine, Bertrand; Cournu-Rebeix, Isabelle; Clerget-Darpoux, Francoise; Weber, Frank; Holsboer, Florian; Muller-Myhsok, Bertram; Rieckmann, Peter; Kroner, Antje; Graham, Colin; Vandenbroeck, Koen; Hawkins, Stanley; D'Alfonso, Sandra; Bergamaschi, Laura; Naldi, Paola; Guerini, Franca R; Salvetti, Marco; Galimberti, Daniela; Hintzen, Rogier; Lorentzen, Åslaug Rudjord; Harbo, Hanne Flinstad; Celius, Elisabeth Gulowsen; Spurkland, Anne; Cucca, Francesco; Marrosu, Maria Giovanna; Comabella, Manuel; Montalban, Xavier; Villoslada, Pablo; Olsson, Tomas; Kockum, Ingrid; Hillert, Jan; Ban, Maria; Walton, Amie; Compston, Alastair; Hawkins, Clive; Mihalova, Tania; Robertson, Neil; Ingram, Gillian; De Jager, Philip L; Hafler, David A; Rioux, John; Daly, Mark; Barcellos, Lisa; Ivinson, Adrian; Periack-Vance, Margaret; Oksenberg, Jorge; Hauser, Stephen L; McCauley, Jacob; Sexton, David & Haines, Jonathan (2008). Refining genetic associations in multiple sclerosis. Lancet Neurology.  ISSN 1474-4422.  7(7), s 567- 569 . doi: 10.1016/S1474-4422(08)70122-4
• SMESTAD, CATHRINE; Brynedal, B; Jonasdottir, G; Lorentzen, AR; Masterman, T.; Akesson, E; Spurkland, Anne; Lie, Benedicte Alexandra; Palmgren, J; Celius, Elisabeth Gulowsen; Hillert, J & Harbo, Hanne Flinstad (2007). The impact of HLA-A and HLA-DRB1 alleles on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. European Journal of Neurology.  ISSN 1351-5101.  14, s 22- 22
• Lie, BA; T Flam, S; Dupuy, Berit Myhre; Spurkland, Anne; Fernandez-Vina, MA; Hagelberg, Erika & Thorsby, E (2006). Evidence of Amerindian ancestry and early European admixture in Easter Island revealed by high-resolution HLA genotyping. Tissue Antigens.  ISSN 0001-2815.  67, s 458- 458
• Lorentzen, AR; SMESTAD, CATHRINE; Ekstrøm, Per Olaf; Oturai, Annette Bang; Åkesson, Eva; Saarela, Janna; Myhr, Kjell-Morten; Lie, Benedicte Alexandra; Celius, Elisabeth Gulowsen; Sorensen, PS; Hillert, Jan; Spurkland, Anne & Harbo, Hanne Flinstad (2006). The role of SH2D2A gene polymorphisms in multiple sclerosis. Multiple Sclerosis.  ISSN 1352-4585.  12(Suppl 1), s S72- S72
• Lorentzen, Åslaug Rudjord; Celius, EG; Ekstrom, P; Wiencke, Kristine; Lie, Benedicte Alexandra; Myhr, KM; Ling, V; Thorsby, Erik; Vartdal, Frode; Spurkland, Anne & Harbo, Hanne Flinstad (2005). The CD28/CTLA4/ICOS gene region does not show assosiation in Norwegian multiple sclerosis patients. Genes and Immunity.  ISSN 1466-4879.  6
• Wiencke, Kristine; Karlsen, TH; Boberg, Kirsten Muri; Harbo, Hanne Flinstad; Lie, Benedicte Alexandra; Thorsby, Erik; Schrumpf, Erik & Spurkland, Anne (2005). Association to the HLA-DR6 haplotype in PSC: Additional effects in the HLA class I/extended class I region. Journal of Hepatology.  ISSN 0168-8278.  42

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