Birgitte Freiesleben de Blasio

• Di Ruscio, Francesco; Guzzetta, Giorgio; Bjørnholt, Jørgen; Leegaard, Truls Michael; Moen, Aina Elisabeth Fossum; Merler, Stefano & De Blasio, Birgitte Freiesleben (2019). Quantifying the transmission dynamics of MRSA in the community and healthcare settings in a low-prevalence country. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  116(29), s 14599- 14605 . doi: 10.1073/pnas.1900959116 Fulltekst i vitenarkiv.
• Edwards, Christina Hansen; Tomba, Gianpaolo Scalia; Kristiansen, Ivar Sønbø; White, Richard Aubrey & De Blasio, Birgitte Freiesleben (2019). Evaluating costs and health consequences of sick leave strategies against pandemic and seasonal influenza in Norway using a dynamic model. BMJ Open.  ISSN 2044-6055.  9 . doi: 10.1136/bmjopen-2018-027832 Fulltekst i vitenarkiv.
• Engebretsen, Solveig; Engø-Monsen, Kenth; Frigessi Di Rattalma, Arnoldo & De Blasio, Birgitte Freiesleben (2019). A theoretical single-parameter model for urbanisation to study infectious disease spread and interventions. PLoS Computational Biology.  ISSN 1553-734X.  15(3) . doi: 10.1371/journal.pcbi.1006879
• Hauge, Siri Helene; Bakken, Inger Johanne Landsjøåsen; De Blasio, Birgitte Freiesleben & Håberg, Siri Eldevik (2019). Burden of medically attended influenza in Norway 2008‐2017. Influenza and Other Respiratory Viruses.  ISSN 1750-2640.  13(3), s 240- 247 . doi: 10.1111/irv.12627 Fulltekst i vitenarkiv.
• Di Ruscio, Francesco; Bjørnholt, Jørgen; Larssen, Kjersti Wik; Leegaard, Truls Michael; Moen, Aina Elisabeth Fossum & De Blasio, Birgitte Freiesleben (2018). Epidemiology and spa-type diversity of meticillin-resistant Staphylococcus aureus in community and healthcare settings in Norway. Journal of Hospital Infection.  ISSN 0195-6701. . doi: 10.1016/j.jhin.2017.12.019 Fulltekst i vitenarkiv.
• Engebretsen, Solveig; Frigessi, Arnoldo; Engø-Monsen, Kenth; Furberg, Anne-Sofie; Stubhaug, Audun; De Blasio, Birgitte Freiesleben & Nielsen, Christopher Sivert (2018). The peer effect on pain tolerance. Scandinavian Journal of Pain.  ISSN 1877-8860.  18(3), s 467- 477 . doi: 10.1515/sjpain-2018-0060 Fulltekst i vitenarkiv.
• Morris, Sinead E.; De Blasio, Birgitte Freiesleben; Viboud, Cécile; Wesolowski, Amy; Bjørnstad, Ottar Nordal & Grenfell, Bryan T. (2018). Analysis of multi-level spatial data reveals strong synchrony in seasonal influenza epidemics across Norway, Sweden, and Denmark. PLOS ONE.  ISSN 1932-6203.  13(5) . doi: 10.1371/journal.pone.0197519 Fulltekst i vitenarkiv.
• Randjelovic, Ivana; Moghaddam, Amir; De Blasio, Birgitte Freiesleben & Moi, Harald (2018). The role of polymorphonuclear leukocyte counts from urethra, cervix, and vaginal wet mount in diagnosis of nongonococcal lower genital tract infection. Infectious diseases in obstetrics and gynecology.  ISSN 1064-7449.  2018 . doi: 10.1155/2018/8236575
• Andreassen, A Elizabeth S; Jacobsen, Caroline M; De Blasio, Birgitte Freiesleben; White, Richard; Kristiansen, Ivar Sønbø & Elstrøm, Petter (2017). The impact of methicillin-resistant S. aureus on length of stay, readmissions and costs: a register based case-control study of patients hospitalized in Norway. Antimicrobial Resistance and Infection Control.  ISSN 2047-2994.  6 . doi: 10.1186/s13756-017-0232-x Fulltekst i vitenarkiv.
• Di Ruscio, Francesco; Bjørnholt, Jørgen; Leegaard, Truls Michael; Moen, Aina Elisabeth Fossum & De Blasio, Birgitte Freiesleben (2017). MRSA infections in Norway: A study of the temporal evolution, 2006-2015. PLOS ONE.  ISSN 1932-6203.  12(6) . doi: 10.1371/journal.pone.0179771 Fulltekst i vitenarkiv.
• Edwards, Christina; De Blasio, Birgitte Freiesleben; Valcarcel Salamanca, Beatriz & Flem, Elmira (2017). Re–evaluation of the cost–effectiveness and effects of childhood rotavirus vaccination in Norway. PLOS ONE.  ISSN 1932-6203.  12(8) . doi: 10.1371/journal.pone.0183306 Fulltekst i vitenarkiv.
• Marangi, Luigi; Mirinaviciute, Grazina; Flem, Elmira; Tomba, Gianpaolo Scalia; Guzzetta, Giorgio; De Blasio, Birgitte Freiesleben & Manfredi, Piero (2017). The natural history of varicella zoster virus infection in Norway: Further insights on exogenous boosting and progressive immunity to herpes zoster. PLOS ONE.  ISSN 1932-6203.  12(5) . doi: 10.1371/journal.pone.0176845 Fulltekst i vitenarkiv.
• Meijerink, Hinta; White, Richard; Løvlie, Astrid Louise; De Blasio, Birgitte Freiesleben; Dalgard, Olav; Amundsen, Ellen Johanna; Melum, Espen & Kløvstad, Hilde (2017). Modelling the burden of hepatitis C infection among people who inject drugs in Norway, 1973–2030. BMC Infectious Diseases.  ISSN 1471-2334.  17 . doi: 10.1186/s12879-017-2631-2 Fulltekst i vitenarkiv.
• Brisson, Marc; Bénard, Élodie; Drolet, Mélanie; Bogaards, Johannes A; Baussano, Iacopo; Vänskä, Simopekka; Jit, Mark; Boily, M-C; Smith, Megan A; Berkhof, Johannes; Canfell, Karen; Chesson, Harrell W.; Burger, Emily A; Choi, Yoon H; De Blasio, Birgitte Freiesleben; de Vlas, Sake J.; Guzzetta, Giorgio; Hontelez, Jan A C; Johannes, Horn; Jepsen, Martin Rudbeck; Kim, Jane J; Lazzarato, Fulvio; Matthijsse, Suzette M; Mikolajczyk, Rafael; Pavelyev, Andrew; Pillsbury, Matthew; Shafer, Leigh Anne; Tully, Stephen P; Turner, Hugo C; Usher, Cara & Walsh, Cathal D. (2016). Population-level impact, herd immunity, and elimination after human papillomavirus vaccination: a systematic review and meta-analysis of predictions from transmission-dynamic models. The Lancet Public Health.  ISSN 2468-2667.  1(1), s e8- e17 . doi: 10.1016/S2468-2667(16)30001-9
• Del Fava, Emanuele; Rimseliene, Grazina; Flem, Elmira; De Blasio, Birgitte Freiesleben; Tomba, Gianpaolo Scalia & Manfredi, Piero (2016). Estimating age-specific immunity and force of infection of varicella zoster virus in Norway using mixture models. PLOS ONE.  ISSN 1932-6203.  11(9) . doi: 10.1371/journal.pone.0163636 Fulltekst i vitenarkiv. Vis sammendrag

  This study applies mixture modelling to examine age-specific immunity to varicella zoster virus (VZV) infection in Norway based on the first large-scale serological study in the general population. We estimated the seropositive proportions at different ages and calculated the underlying force of infection by using a sample of 2103 residual sera obtained from patients seeking primary and hospital care. A rapid increase in the VZV-associated immunity is observed in the first years of life with 63% of children being immune by age 5. The increase in the immunity levels slows down thereafter, with a large proportion of adults still susceptible by age 20 (around 14.5%), thus at risk of serious sequelae of varicella infection. The corresponding force of infection peaks during the preschool period, subsequently declines to a minimum between ages 10 and 20 years, and afterwards moderately increases to reach a plateau lasting throughout the childbearing period. In comparison with the traditional cut-off approach, mixture modelling used the whole data without producing any inconclusive cases, led to an unbiased classification of individuals between susceptible and immune, and provided a smoother immune profile by age. These findings represent an important step towards any decision about the introduction of varicella vaccination in Norway, as they are a primary input for mathematical transmission models aimed at evaluating potential vaccination scenarios.

• Edwards, Christina Hansen; Tomba, Gianpaolo Scalia & De Blasio, Birgitte Freiesleben (2016). Influenza in workplaces: Transmission, workers' adherence to sick leave advice and European sick leave recommendations. European Journal of Public Health.  ISSN 1101-1262.  26(3), s 478- 485 . doi: 10.1093/eurpub/ckw031
• Guzmán Herrador, Bernardo Rafael; De Blasio, Birgitte Freiesleben; Carlander, Anneli; Ethelberg, Steen; Hygen, Hans Olav; Kuusi, Markku; Lund, Vidar; Löfdahl, Margareta; MacDonald, Emily; Martinez-Urtaza, Jaime; Nichols, Gordon; Schönning, Caroline; Sudre, Bertrand; Trönnberg, Linda; Vold, Line; Semenza, Jan C. & Nygård, Karin Maria (2016). Association between heavy precipitation events and waterborne outbreaks in four Nordic countries, 1992-2012. Journal of Water and Health.  ISSN 1477-8920.  14(6), s 1019- 1027 . doi: 10.2166/wh.2016.071
• Guzmán Herrador, Bernardo Rafael; De Blasio, Birgitte Freiesleben; Lund, Vidar; MacDonald, Emily; Vold, Line; Wahl, Erik & Nygård, Karin Maria (2016). Vannbårne utbrudd i Norge i perioden 2003–12 :. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(7), s 612- 616 . doi: 10.4045/tidsskr.15.0114
• Molin, Sol-Britt; De Blasio, Birgitte Freiesleben & Olsen, Anne Olaug (2016). Is the risk for sexually transmissible infections (STI) lower among women with exclusively female sexual partners compared with women with male partners? A retrospective study based on attendees at a Norwegian STI clinic from 2004 to 2014. Sexual Health.  ISSN 1448-5028.  13(3), s 257- 264 . doi: 10.1071/SH15193
• De Blasio, Fabio V; Liow, Lee Hsiang; Schweder, Tore & De Blasio, Birgitte Freiesleben (2015). A model for global diversity in response to temperature change over geological time scales, with reference to planktic organisms. Journal of Theoretical Biology.  ISSN 0022-5193.  365, s 445- 456 . doi: 10.1016/j.jtbi.2014.10.031
• Guzmán Herrador, Bernardo Rafael; Carlander, Anneli; Ethelberg, Steen; De Blasio, Birgitte Freiesleben; Kuusi, Markku; Lund, Vidar; Löfdahl, Margareta; MacDonald, Emily; Nichols, Gordon; Schönning, Caroline; Sudre, Bertrand; Trönnberg, Linda; Vold, Line; Semenza, Jan C. & Nygård, Karin Maria (2015). Waterborne outbreaks in the Nordic countries, 1998 to 2012. Eurosurveillance.  ISSN 1025-496X.  20(24) . doi: 10.2807/1560-7917.ES2015.20.24.21160 Fulltekst i vitenarkiv.
• Guzmán Herrador, Bernardo Rafael; De Blasio, Birgitte Freiesleben; MacDonald, Emily; Nichols, Gordon; Sudre, Bertrand; Vold, Line; Semenza, Jan C. & Nygård, Karin Maria (2015). Analytical studies assessing the association between extreme precipitation or temperature and drinking water-related waterborne infections: a review. Environmental health.  ISSN 1476-069X.  14 . doi: 10.1186/s12940-015-0014-y Fulltekst i vitenarkiv.
• Steens, Anneke; VESTRHEIM, DIDRIK FRIMANN & De Blasio, Birgitte Freiesleben (2015). Pneumococcal vaccination in older adults in the era of childhood vaccination: Public health insights from a Norwegian statistical prediction study. Epidemics.  ISSN 1755-4365.  11, s 24- 31 . doi: 10.1016/j.epidem.2015.01.001 Fulltekst i vitenarkiv.
• White, Richard; MacDonald, Emily; De Blasio, Birgitte Freiesleben; Nygård, Karin Maria; Vold, Line & Røttingen, John-Arne (2015). Projected Treatment Capacity Needs in Sierra Leone. PLOS Currents.  ISSN 2157-3999.  7 . doi: 10.1371/currents.outbreaks.3c3477556808e44cf41d2511b21dc29f Fulltekst i vitenarkiv.
• De Blasio, Birgitte Freiesleben; Flem, Elmira; Latipov, Renat; Kuatbaeva, Ajnagul & Kristiansen, Ivar Sønbø (2014). Dynamic Modeling of Cost-effectiveness of Rotavirus Vaccination, Kazakhstan. Emerging Infectious Diseases.  ISSN 1080-6040.  20(1), s 29- 37 . doi: 10.3201/eid2001.130019 Fulltekst i vitenarkiv.
• Mdala, Ibrahimu; Olsen, Ingar; Haffajee, Anne D; Socransky, Sigmund S; Thoresen, Magne & De Blasio, Birgitte Freiesleben (2014). Comparing clinical attachment level and pocket depth for predicting periodontal disease progression in healthy sites of patients with chronic periodontitis using multi-state Markov models. Journal of Clinical Periodontology.  ISSN 0303-6979.  41(9), s 837- 845 . doi: 10.1111/jcpe.12278
• Mdala, Ibrahimu; Olsen, Ingar; Haffajee, Anne D; Socransky, Sigmund S; De Blasio, Birgitte Freiesleben & Thoresen, Magne (2013). Multilevel analysis of bacterial counts from chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. Journal of Oral Microbiology.  ISSN 2000-2297.  5 . doi: 10.3402/jom.v5i0.20939 Fulltekst i vitenarkiv.
• Mdala, Ibrahimu; Olsen, Ingar; Haffajee, Anne D; Socransky, Sigmund S; Thoresen, Magne & De Blasio, Birgitte Freiesleben (2013). Kan vi forutsi områder i periodontiet som vil utvikle periodontitt?. Den norske tannlegeforenings tidende.  ISSN 0029-2303.  123(8), s 556- 557
• Moxnes, John Fredrik; De Blasio, Birgitte Freiesleben; Leegaard, Truls Michael & Moen, Aina Elisabeth Fossum (2013). Methicillin-Resistant Staphylococcus aureus (MRSA) Is Increasing in Norway: A Time Series Analysis of Reported MRSA and Methicillin-Sensitive S. aureus Cases, 1997–2010. PLOS ONE.  ISSN 1932-6203.  8(8) . doi: 10.1371/journal.pone.0070499
• De Blasio, Birgitte Freiesleben; Iversen, Bjørn Gunnar & Scalia Tomba, Gianpaolo (2012). Effect of vaccines and antivirals during the major 2009 a(H1N1) pandemic wave in Norway – and the influence of vaccination timing. PLOS ONE.  ISSN 1932-6203.  7(1) . doi: 10.1371/journal.pone.0030018 Vis sammendrag

  To evaluate the impact of mass vaccination with adjuvanted vaccines (eventually 40% population coverage) and antivirals during the 2009 influenza pandemic in Norway, we fitted an age-structured SEIR model using data on vaccinations and sales of antivirals in 2009/10 in Norway to Norwegian ILI surveillance data from 5 October 2009 to 4 January 2010. We estimate a clinical attack rate of approximately 30% (28.7–29.8%), with highest disease rates among children 0–14 years (43–44%). Vaccination started in week 43 and came too late to have a strong influence on the pandemic in Norway. Our results indicate that the countermeasures prevented approximately 11–12% of potential cases relative to an unmitigated pandemic. Vaccination was found responsible for roughly 3 in 4 of the avoided infections. An estimated 50% reduction in the clinical attack rate would have resulted from vaccination alone, had the campaign started 6 weeks earlier. Had vaccination been prioritized for children first, the intervention should have commenced approximately 5 weeks earlier in order to achieve the same 50% reduction. In comparison, we estimate that a non-adjuvanted vaccination program should have started 8 weeks earlier to lower the clinical attack rate by 50%. In conclusion, vaccination timing was a critical factor in relation to the spread of the 2009 A(H1N1) influenza. Our results also corroborate the central role of children for the transmission of A(H1N1) pandemic influenza.

• De Blasio, Birgitte Freiesleben; Neilson, Aileen Rae; Klemp, Marianne & Skjeldestad, Finn Egil (2012). Modeling the impact of screening policy and screening compliance on incidence and mortality of cervical cancer in the post-HPV vaccination era. Journal of Public Health.  ISSN 0943-1853.  34(4), s 539- 547 . doi: 10.1093/pubmed/fds040 Vis sammendrag

  Background In Norway, pap smear screening target women aged 25–69 years on a triennial basis. The introduction of human papillomavirus (HPV) mass immunization in 2009 raises questions regarding the cost-saving future changes to current screening strategies. Methods We calibrated a dynamic HPV transmission model to Norwegian data and assessed the impact of changing screening 20 or 30 years after vaccine introduction, assuming 60 or 90% vaccination coverage. Screening compliance among vaccinated women was assumed at 80 or 50%. Strategies considered: (i) 5-yearly screening of women of 25–69 years, (ii) 3-yearly screening of women of 30–69 years and (iii) 3-yearly screening of women of 25–59 years. Results Greatest health gains were accomplished by ensuring a high vaccine uptake. In 2060, cervical cancer incidence was reduced by an estimated 36–57% compared with that of no vaccination. Stopping screening at the age of 60 years, excluding opportunistic screening, increased cervical cancer incidence by 3% (2060) compared with maintaining the current screening strategy, resulting in 1.0–2.4% extra cancers (2010–2060). The 5-yearly screening strategy elevated cervical cancer incidence by 30% resulting in 4.7–11.3% additional cancers. Conclusion High vaccine uptake in the years to come is of primary concern. Screening of young women <30 years remains important, even under the conditions of high vaccine coverage.

• De Blasio, Birgitte Freiesleben; Xue, Yiting; Iversen, Bjørn Gunnar & Gran, Jon Michael (2012). Estimating influenza-related sick leave in Norway: Was work absenteeism higher during the 2009 A(H1N1) pandemic compared to seasonal epidemics?. Eurosurveillance.  ISSN 1025-496X.  17(33), s 15- 25
• Lavine, Jennie; Bjørnstad, Ottar Nordal; De Blasio, Birgitte Freiesleben & Storsæter, Jann (2012). Short-lived immunity against pertussis, age-specific routes of transmission, and the utility of a teenage booster vaccine. Vaccine.  ISSN 0264-410X.  30(3), s 544- 551 . doi: 10.1016/j.vaccine.2011.11.065
• Mdala, Ibrahimu; Haffajee, Anne D; Socransky, Sigmund S; De Blasio, Birgitte Freiesleben; Thoresen, Magne; Olsen, Ingar & Goodson, Max J (2012). Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery, and systemic and local antibiotics: 2-year results. Journal of Oral Microbiology.  ISSN 2000-2297.  4 . doi: 10.3402/jom.v4i0.17535
• Pitzer, Virginia E.; Atkins, Katherine E.; De Blasio, Birgitte Freiesleben; Van Effelterre, Thierry; Atchison, Christina J.; Harris, John P.; Shim, Eunha; Galvani, Alison P.; Edmunds, W. John; Viboud, Cécile; Patel, Manish M.; Grenfell, Bryan T.; Parashar, Umesh D. & Lopman, Ben A. (2012). Direct and indirect effects of rotavirus vaccination: comparing predictions from transmission dynamic models. PLOS ONE.  ISSN 1932-6203.  7(8) . doi: 10.1371/journal.pone.0042320
• Villani, Antonella; Frigessi, Arnoldo; Liljeros, Fredrik; Nordvik, Monika K. & De Blasio, Birgitte Freiesleben (2012). A Characterization of Internet Dating Network Structures among Nordic Men Who Have Sex with Men. PLOS ONE.  ISSN 1932-6203.  7(7) . doi: 10.1371/journal.pone.0039717
• Xue, Yiting; Kristiansen, Ivar Sønbø & De Blasio, Birgitte Freiesleben (2012). Dynamic modelling of costs and health consequences of school closure during an influenza pandemic. BMC Public Health.  ISSN 1471-2458.  12 . doi: 10.1186/1471-2458-12-962
• De Blasio, Birgitte Freiesleben; Seierstad, Taral Guldahl & Aalen, Odd O. (2011). Frailty effects in networks: comparison and identification of individual heterogeneity versus preferential attachment in evolving networks. Journal of the Royal Statistical Society, Series C: Applied Statistics.  ISSN 0035-9254.  60, s 239- 259 . doi: 10.1111/j.1467-9876.2010.00746.x
• De Blasio, Birgitte Freiesleben; Kasymbekova, Kaliya & Flem, Elmira (2010). Dynamic model of rotavirus transmission and the impact of rotavirus vaccination in Kyrgyzstan. Vaccine.  ISSN 0264-410X.  28(50), s 7923- 7932 . doi: 10.1016/j.vaccine.2010.09.070
• Xue, Yiting; Kristiansen, Ivar Sønbø & De Blasio, Birgitte Freiesleben (2010). Modeling the cost of influenza: the impact of missing costs of unreported complications and sick leave. BMC Public Health.  ISSN 1471-2458.  10(724) . doi: 10.1186/1471-2458-10-724
• De Blasio, Fabio V & De Blasio, Birgitte Freiesleben (2009). Extinctions in a spatial model of fossil communities subject to correlated environmental disturbance. Ecological Complexity : An International Journal on Biocomplexity in the Environment and Theoretical Ecology.  ISSN 1476-945X.  6(1), s 70- 75 . doi: 10.1016/j.ecocom.2008.10.013
• Zechmeister, Ingrid; de Blasio, Birgitte Freiesleben; Garnett, Geoff P.; Neilson, Aileen Rae; Aileen, Rae Neilson & Siebert, Uwe (2009). Cost-effectiveness analysis of human papillomavirus-vaccination programs to prevent cervical cancer in Austria. Vaccine.  ISSN 0264-410X.  27(37), s 5133- 5141 . doi: 10.1016/j.vaccine.2009.06.039
• Zechmeister, Ingrid; De Blasio, Birgitte Freiesleben & Garnett, Geoff P. (2009). HPV-vaccination for the prevention of cervical cancer in Austria: a model based long-term prognosis of cancer epidemiology. Journal of Public Health.  ISSN 0943-1853. . doi: 10.1007/s10389-009-0276-3
• De Blasio, Fabio V & De Blasio, Birgitte Freiesleben (2008). Extinctions in a spatial model of fossil communities subject to correlated environmental disturbance. Ecological Complexity : An International Journal on Biocomplexity in the Environment and Theoretical Ecology.  ISSN 1476-945X.
• De Blasio, Birgitte Freiesleben; Liljeros, Fredrik & Svensson, Åke (2007). Preferential attachment in sexual networks. Proceedings of the National Academy of Sciences of the United States of America.  ISSN 0027-8424.  104(26), s 10762- 10767
• De Blasio, Birgitte Freiesleben & Wegener, Joachim (2006). Impedance Spectroscopy, In John G. Webster (ed.),  Encyclopedia of Medical Devices and Instrumentation.  John G. Webster.  ISBN 978-0-471-26358-6.  Impedance Spectroscopy.
• De Blasio, Birgitte Freiesleben & De Blasio, Fabio Vittorio (2005). Dynamics of competing species in a model of adaptive radiations and macroevolution. Physical Review E. Statistical, Nonlinear, and Soft Matter Physics.  ISSN 1539-3755.  72(3)
• De Blasio, Birgitte Freiesleben; Iversen, Jens Gustav Heber & Røttingen, John-Arne (2004). Intercellular calcium signalling in cultured renal epithelia: a theoretical study of synchronization mode and pacemaker activity. European Biophysics Journal.  ISSN 0175-7571.  33, s 657- 670
• De Blasio, Birgitte Freiesleben; Laane, Carl Morten M; Walmann, Thomas & Giæver, Ivar (2004). Combining optical and electrical impedance techniques for quantitative measurement of confluence in MDCK-I cell cultures. BioTechniques.  ISSN 0736-6205.  36, s 650- + Vis sammendrag

  A new method combining optical and electrical impedance measurements is described that enables submicroscopical cell movements to be monitored. The cells are grown on small gold electrodes that are transparent to light. This modified electrical cell-substrate impedance sensor (ECIS) allows simultaneous microscopic recording of both growth and motility; thus enabling cell confluence on the electrodes to be systematically correlated to the impedance in regular time intervals of se4conds and for extended periods of time. Furthermore the technique provides en independent measure of monolayer cell densities that we compare to calculated values from a theoretical model. We have followed the attachment and spreading behaviour of epithelial Madin-Darby canine kidney strain I (MDCK-I) cell sultures on microelectrodes for up to 40h. The studies reveal a high degree of correlation between the measured resistance at 4 kHZ and the corresponding cell confluence in 4- to 6-h intervals with typical linear cross-correlation factors of r equaling approximately 0.9. In summary the impedance measured with the ECIS technique provides a good quantitative measure of cell confluence.

• De, Blasio Birgitte Freiesleben; Røttingen, John-Arne; Sand, Kristin Larsen; Giaever, I & Iversen, Jens Gustav Heber (2004). Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells. Acta Physiologica Scandinavica.  ISSN 0001-6772.  180, s 335- 346

Se alle arbeider i Cristin

• De Blasio, Birgitte Freiesleben (2018). Rotavirusvaksinasjon i Norge er kostnadseffektiv. BestPractice Infeksjon og vaksinasjon.
• De Blasio, Birgitte Freiesleben (2014). Et Innblikk i infeksjonsmodellering--med eksempler.
• Hansen Edwards, Christina; Scalia Tomba, Gianpaolo & De Blasio, Birgitte Freiesleben (2014). Dynamic modeling of the cost-effectiveness of sick leave practices during influenza illness.
• Hansen Edwards, Christina; Scalia Tomba, Gianpaolo & De Blasio, Birgitte Freiesleben (2014). Recommendations and policies for sick leave during seasonal and pandemic influenza in Europe.
• Zechmeister, Ingrid; De Blasio, Birgitte Freiesleben; Garnett, Geoffrey; Neilson, Aileen Rae & Siebert, Uwe (2014). Corrigendum to: Cost-effectiveness analysis of human papillomavirus-vaccination programs to prevent cervical cancer in Austria [Vaccine 27 (2009) 5133-5141]. Vaccine.  ISSN 0264-410X.  32(21), s 2520 . doi: 10.1016/j.vaccine.2014.03.006
• De Blasio, Birgitte Freiesleben (2013). Epidemiologisk matematik--et innblikk i infeksjonsmodellering.
• De Blasio, Birgitte Freiesleben (2013). Helseøkonomisk analyse av skolestenging under en influensa pandemi.
• De Blasio, Birgitte Freiesleben (2013). How to prepare for pandemics? Infectious disease modeling and its use in Norwegian preparedness planning.
• De Blasio, Birgitte Freiesleben (2013). Infectious disease modeling with some examples.
• De Blasio, Birgitte Freiesleben (2013). Influenza surveillance in Norway and Modeling of Influenza Transmission.
• De Blasio, Birgitte Freiesleben (2012). Hvorledes skal vi bekjempe infeksjonssykdommer--ett innblikk i infeksjonsmodellering.
• De Blasio, Birgitte Freiesleben; Neilson, Aileen Rae; Klemp, Marianne & Skjeldestad, Finn Egil (2012). Modeling CC in the post HPV vaccination era in Norway. Acta Obstetricia et Gynecologica Scandinavica.  ISSN 0001-6349.  91, s 81- 82
• Mdala, Ibrahimu; Haffajee, Anne D; Socransky, Sigmund S; De Blasio, Birgitte Freiesleben; Thoresen, Magne; Goodson, Max J & Olsen, Ingar (2012). Hvilken type periobehandling gir best kliniske resultater over tid?.
• Mdala, Ibrahimu; Haffajee, Anne D; Socransky, Sigmund S; De Blasio, Birgitte Freiesleben; Thoresen, Magne & Olsen, Ingar (2012). Hvilken behandling gir de gunstigste endringer i periodontal mikroflora over tid?.
• Mdala, Ibrahimu; Haffajee, Anne D; Socransky, Sigmund S; Thoresen, Magne; De Blasio, Birgitte Freiesleben & Olsen, Ingar (2012). Multistate Markov models for predicting changes in sulcus/pocket depth and attachment level of healthy and diseased sites in chronic periodontitis.
• De Blasio, Birgitte Freiesleben; Neilson, RA & Skjeldestad, Finn Egil (2011). Modeling the impact of screening policy and screeing compliance in the post HPV vaccination era in Norway.
• Mdala, Ibrahimu; Haffajee, AD; Socransky, SS; De Blasio, Birgitte Freiesleben; Thoresen, Magne & Olsen, Ingar (2010). Multilevel analysis of clinical parameters in chronic periodontitis after root planing/scaling, surgery and systemic and local antibiotics: 2-years results.
• De Blasio, Birgitte Freiesleben (2009). Mathematical models of infectious disease transmission--an overview illustrated with examples.
• De Blasio, Birgitte Freiesleben (2009). Rotavirus modelling in Kyrgyzstan.
• De Blasio, Birgitte Freiesleben (2009). Social network study design in the Västra Götaland study.
• De Blasio, Birgitte Freiesleben; Kasymbekova, Kaliya & Flem, Elmira (2009). A dynamic model for assessing the impact of rotavirus vaccination in Kyrgyzstan.
• Xue, Yiting & De Blasio, Birgitte Freiesleben (2009). The Socio‐Economic Impact of Influenza in Norway: Measuring Disease Burden and Economic Costs.
• De Blasio, Birgitte Freiesleben (2008). Graduate School in Biostatistics, UiO.
• De Blasio, Birgitte Freiesleben (2008). Mechanistic infectious disease modelling.
• De Blasio, Birgitte Freiesleben & Gjertsen, Marianne Klemp (2008). Estimating uncertainties of HPB16/18 vaccination--a dynamic modelling approach.
• de Blasio, Birgitte Freiesleben; Neilson, Aileen Rae & Gjertsen, Marianne Klemp (2008). Estimating uncertainties of HPV16/18 vaccination – a dynamic modelling approach. Rapport fra Kunnskapssenteret. 17/2008. Fulltekst i vitenarkiv. Vis sammendrag

  Whether HPV16/18 vaccination should be introduced into the Norwegian childhood vaccination programme is currently being discussed. The National Council on Quality and Prioritisation in Health Care discussed the matter in December 2007, and asked the Norwegian Knowledge Centre for the Health Services using a dynamic health economic model to quantify how several unresolved issues regarding long-term efficacy may affect the future burden of cervical cancer and health economics of HPV 16/18 vaccination.

• Ingrid, Zechmeister; De Blasio, Birgitte Freiesleben; Garnett, Geoff; Neilsen, Aileen Rae & Radlberger, Philipp (2008). Should the HPV vaccination be reimbursed in Austria?A cost-effectiveness analysis of vaccination programs compared to current screening.
• Aalen, Odd O. & De Blasio, Birgitte Freiesleben (2007). Mathematical Modelling of infectious disease.
• De Blasio, Birgitte Freiesleben (2007). Modeling the impact of HPV (Human Papilloma Virus) type 16/18 vaccination on the incidence of cervical cancer in Norway.
• De Blasio, Birgitte Freiesleben (2007). Modeling the impact of HPV (Human Papilloma Virus) type 16/18 vaccination on the incidence of cervical cancer in Norway.
• De Blasio, Birgitte Freiesleben (2007). Preferential attachment in sexual networks.
• De Blasio, Birgitte Freiesleben (2007). The Yule process and frailty.
• Gjertsen, Marianne Klemp; Nielson, Aileen Rae Nielson & De Blasio, Birgitte Freiesleben (2007). HPV-vaksiner - effekt, sikkerhet og kostnadseffektivitet. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  127(12), s 1674
• Neilson, Aileen Rae & De Blasio, Birgitte Freiesleben (2007). Økonomisk evaluering av humant papillomavirus (HPV)-vaksinasjon i Norge.
• Neilson, Aileen Rae & de Blasio, Birgitte Freiesleben (2007). Økonomisk evaluering av humant papillomavirus (HPV)-vaksinasjon i Norge. Rapport fra Kunnskapssenteret. 12/2007. Fulltekst i vitenarkiv. Vis sammendrag

  Nasjonalt kunnskapssenter for helsetjenesten ble bedt av Nasjonalt folkehelseinstitutt om å lage en medisinsk metodevurdering av vaksiner mot humant papillomavirus (HPV) -infeksjon. En systematisk oversikt over effekt og bivirkninger har allerede blitt publisert (Rapport fra Kunnskapssenteret nr 5−2007). Formålet med denne andre rapporten er å estimere den potensielle kostnadseffektiviteten av en vaksine som inneholder HPVtypene 16 og 18 (de to mest vanlige årsakene til livmorhalskreft).

• Nielson, Aileen Rae Nielson & De Blasio, Birgitte Freiesleben (2007). Cost-effectiveness of HPV 16/18 vaccination for the prevention of cervical cancer in Norway.
• Zechmeister, Ingrid; De Blasio, Birgitte Freiesleben; Radlberger, Philipp; Wild, Claudia & Kvas, Erich (2007). Ökonomische Evaluation der Impfung gegen humane Papillomaviren (HPV-Impfung) in Österreich.
• De Blasio, Birgitte Freiesleben (2006). Social networks and spread of infectious diseases.
• De Blasio, Birgitte Freiesleben (2005). Preferential attachment in sexual networks.
• de Blasio, Birgitte Freiesleben (2004). Prevalence and determinants of Chlamydia trachomatis infection among heterosexual men and women attending an STI clinic in Oslo, NOrway.
• de Blasio, Birgitte Freiesleben (2004). The distribution of sexual partnerships in Norway and determinants of high number of sexual contacts.
• Blasio, Birgitte Freiesleben De (2002). Electrical impedance measurements of cultured epithelial cells.
• Blasio, Birgitte Freiesleben De & Røttingen, John-Arne (2001). Intracellular calcium and impedance oscillations in MDCK-cells: A lattice stochastic model based on gap junctional flux.

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