Jan E. Brinchmann

• Brinchmann, Bendik Christian; Skuland, Tonje Schwach; Rambøl, Mia Marie-Elisabeth; Szöke, Krisztina; Brinchmann, Jan E.; Gutleb, Arno C.; Moschini, Elisa; Kubátová, Alena; Kukowski, Klara; Le Ferrec, Eric; Lagadic-Gossmann, Dominique; Schwarze, Per Everhard; Låg, Marit; Refsnes, Magne Arnold; Øvrevik, Johan & Holme, Jørn Andreas (2018). Lipophilic components of diesel exhaust particles induce pro-inflammatory responses in human endothelial cells through AhR dependent pathway(s). Particle and Fibre Toxicology.  ISSN 1743-8977.  15 . doi: 10.1186/s12989-018-0257-1 Fulltekst i vitenarkiv.
• Rambøl, Mia H.; Hisdal, Jonny; Sundhagen, Jon Otto; Brinchmann, Jan E. & Rosales, Antonio (2018). Recellularization of decellularized venous grafts using peripheral blood: a critical evaluation. EBioMedicine.  ISSN 2352-3964.  32, s 215- 222 . doi: 10.1016/j.ebiom.2018.05.012
• Behnan, Jinan; Stangeland, Biljana; Hosainey, Sayied Abdol Mohieb; Joel, Mrinal; Olsen, Thale Kristin; Micci, Francesca; Glover, Joel; Isakson, Pauline & Brinchmann, Jan E. (2017). Differential propagation of stroma and cancer stem cells dictates tumorigenesis and multipotency. Oncogene.  ISSN 0950-9232.  36(4), s 570- 584 . doi: 10.1038/onc.2016.230 Vis sammendrag

  Glioblastoma Multiforme (GBM) is characterized by high cancer cell heterogeneity and the presence of a complex tumor microenvironment. Those factors are a key obstacle for the treatment of this tumor type. To model the disease in mice, the current strategy is to grow GBM cells in serum-free non-adherent condition, which maintains their tumor-initiating potential. However, the so-generated tumors are histologically different from the one of origin. In this work, we performed high-throughput marker expression analysis and investigated the tumorigenicity of GBM cells enriched under different culture conditions. We identified a marker panel that distinguished tumorigenic sphere cultures from non-tumorigenic serum cultures (high CD56, SOX2, SOX9, and low CD105, CD248, αSMA). Contrary to previous work, we found that 'mixed cell cultures' grown in serum conditions are tumorigenic and express cancer stem cell (CSC) markers. As well, 1% serum plus bFGF and TGF-α preserved the tumorigenicity of sphere cultures and induced epithelial-to-mesenchymal transition gene expression. Furthermore, we identified 12 genes that could replace the 840 genes of The Cancer Genome Atlas (TCGA) used for GBM-subtyping. Our data suggest that the tumorigenicity of GBM cultures depend on cell culture strategies that retain CSCs in culture rather than the presence of serum in the cell culture medium.

• Kosik-Kozioł, Alicja; Costantini, Marco; Bolek, Tomasz; Szöke, Krisztina; Barbetta, Andrea; Brinchmann, Jan E. & Święszkowski, Wojciech (2017). PLA short sub-micron fiber reinforcement of 3D bioprinted alginate constructs for cartilage regeneration. Biofabrication.  ISSN 1758-5082.  9:044105(4), s 1- 14 . doi: 10.1088/1758-5090/aa90d7
• Szöke, Krisztina; Daňková, Jana; Buzgo, Matej; Amler, Evžen; Brinchmann, Jan E. & Østrup, Esben (2017). The effect of medium composition on deposition of collagen type 1 and expression of osteogenic genes in mesenchymal stem cells derived from human adipose tissue and bone marrow. Process Biochemistry.  ISSN 1359-5113.  59, s 321- 328 . doi: 10.1016/j.procbio.2016.10.011
• Wollert, Kai C.; Meyer, Gerd P.; Müller-Ehmsen, Jochen; Tschöpe, Carsten; Bonarjee, Vernon V S; Larsen, Alf Inge; May, Andreas E.; Empen, Klaus; Chorianopoulos, Emmanuel; Tebbe, Ulrich; Waltenberger, Johannes; Mahrholdt, Heiko; Ritter, Benedikta; Pirr, Jens; Fischer, Dieter; Korf-Klingebiel, Mortimer; Arseniev, Lubomir; Heuft, Hans-Gert; Brinchmann, Jan E.; Messinger, Diethelm; Hertenstein, Bernd; Ganser, Arnold; Katus, Hugo A.; Felix, Stephan B.; Gawaz, Meinrad P.; Dickstein, Kenneth; Schultheiss, Heinz-Peter; Ladage, Dennis; Greulich, Simon & Bauersachs, Johann (2017). Intracoronary autologous bone marrow cell transfer after myocardial infarction: The BOOST-2 randomised placebo-controlled clinical trial. European Heart Journal.  ISSN 0195-668X.  38(39), s 2936- 2943 . doi: 10.1093/eurheartj/ehx188
• Karlsen, Tommy Aleksander; De Souza, Gustavo Antonio; Ødegård, Bjørn; Engebretsen, Lars & Brinchmann, Jan E. (2016). microRNA-140 Inhibits Inflammation and Stimulates Chondrogenesis in a Model of Interleukin 1beta-induced Osteoarthritis.. Molecular Therapy - Nucleic Acids.  ISSN 2162-2531.  5, s e373 . doi: 10.1038/mtna.2016.64
• Aae, Tommy Frøseth; Randsborg, Per-Henrik; Breen, Anne Berg; Visnes, Håvard; Vindfeld, Søren; Sivertsen, Einar; Løken, Sverre Bertrand; Brinchmann, Jan E.; Hanvold, Heidi Andreassen & Årøen, Asbjørn (2016). Norwegian Cartilage Project - a study protocol for a double-blinded randomized controlled trail comparing arthroscopic microfracture with debridement in focal cartilage defects in the knee. BMC Musculoskeletal Disorders.  ISSN 1471-2474.  17:292 . doi: 10.1186/s12891-016-1156-y
• Behnan, Jinan; Stangeland, Biljana; Langella, Tiziana; Finocchiaro, Gaetano; Murrell, Wayne & Brinchmann, Jan E. (2016). Ultrasonic Surgical Aspirate is a Reliable Source for Culturing Glioblastoma Stem Cells. Scientific Reports.  ISSN 2045-2322.  6 . doi: 10.1038/srep32788 Fulltekst i vitenarkiv.

Se alle arbeider i Cristin

• Karlsen, Tommy Aleksander; Jakobsen, Rune Bruhn & Brinchmann, Jan E. (2017). Early molecular events during in vitro chondrogenesisi, In Kerry Atkinson (ed.),  The biology and therapeutic Application of mesenchymal cells.  Wiley-Blackwell.  ISBN 978-1-118-90751-1.  Chapter 14.  s 167 - 190

Se alle arbeider i Cristin