Hesso Farhan

Professor - Cellesignalering
Bilde av Hesso Farhan
English version of this page
Telefon +47 22851217
Rom 1238
Brukernavn
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1112 Blindern 0372 OSLO
Emneord: Cellebiologi, Celle signalering, Kreft, metastase, Membrantransport, Proteostase

Publikasjoner

Viktige Publikasjoner:

 

1) Cui Y, Parashar S, Zahoor M, Needham PG, Mari M, Zhu M, Chen S, Ho HC, Reggiori F, Farhan H*, Brodsky JL*, Ferro-Novick S. A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science. 365, 53-60. (2019)

* Equal contribution

 

2) Centonze FG, Reiterer V, Nalbach K, Saito K, Pawlowski K, Behrends C, Farhan H. LTK is an ER-resident receptor tyrosine kinase that regulates secretion. J Cell Biol.  218, 2470-2480. (2019)

 

3) Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H. The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7function. EMBO Journal 36(3):260-273. (2017)

 

4) Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel B, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C. (2015) TECPR2 cooperates with LC3C to regulate COPII dependent ER export. Mol Cell, 60(1):89-104 (2015).

 

5) Millarte V, Boncompain G, Tillmann K, Perez F, Sztul E, Farhan H. Phospholipase C gamma 1 regulates early secretory trafficking and cell migration via interaction with p115. Mol Biol Cell. 26(12):2263-78. (2015)

 

6) Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Sharan R, Legler DF, Weiss M, Farhan H. Regulation of Sec16 levels and dynamics links proliferation and secretion. J Cell Sci. 128(4):670-682. (2015)

 

7) Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nature Commun. 5:4839. (2014)

 

8) Reiterer V, Fey D, Kolch W, Kholodenko B, Farhan H.Pseudophosphatase STYX modulates cell fate decisions and cell migration by spatio-temporal regulation of ERK1/2. Proc Natl Acad Sci. 110(31):E2934-2943. (2013)

 

9) Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady N, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D and Ivan Dikic I. Phosphorylation of the Autophagy Receptor Optineurin restricts Salmonella Growth. Science 333:228-233. (2011)

 

10) Farhan H, Wendeler MW, Mitrovic S, Fava E, Silberberg Y, Sharan R, Zerial M, Hauri HP. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. J Cell Biol 189:997-1011. (2010)

 

11) Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J  27:2043-2054. (2008)

  • Eck, Franziska; Phuyal, Santosh; Smith, Matthew D.; Kaulich, Manuel; Wilkinson, Simon; Farhan, Hesso & Behrends, Christian (2020). ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis. Journal of Cell Science.  ISSN 0021-9533.  133(18), s 1- 16 . doi: 10.1242/jcs.243477 Fulltekst i vitenarkiv.
  • Farhan, Hesso (2020). Rendezvous of Retro-2 at the ER. Nature Chemical Biology.  ISSN 1552-4450.  16(3), s 229- 230 . doi: 10.1038/s41589-020-0475-3 Fulltekst i vitenarkiv.
  • Farhan, Hesso (2020). Tyrosine kinase signaling in and on the endoplasmic reticulum. Biochemical Society Transactions.  ISSN 0300-5127.  48(1), s 199- 205 . doi: 10.1042/BST20190543 Fulltekst i vitenarkiv.
  • Gilljam, Karin Margaretha; Holm, Kristine Lillebø; Zahoor, Muhammad; Centonze, Federica Grazia; Farhan, Hesso & Blomhoff, Heidi Kiil (2020). Differential Effects of Reactive Oxygen Species on IgG versus IgM Levels in TLR-Stimulated B Cells. Journal of Immunology.  ISSN 0022-1767.  204(8), s 2133- 2142 . doi: https://doi.org/10.4049/jimmunol.1901131
  • Reiterer, Veronika; Pawlowski, Krzysztof; Desrochers, Guillaume; Pause, Arnim; Sharpe, Hayley J. & Farhan, Hesso (2020). The dead phosphatases society: a review of the emerging roles of pseudophosphatases. The FEBS Journal.  ISSN 1742-464X.  287(19), s 4198- 4220 . doi: 10.1111/febs.15431 Fulltekst i vitenarkiv.
  • Centonze, Federica Grazia & Farhan, Hesso (2019). Crosstalk of endoplasmic reticulum exit sites and cellular signaling. FEBS Letters.  ISSN 0014-5793.  s 1- 9 . doi: 10.1002/1873-3468.13569 Fulltekst i vitenarkiv.
  • Centonze, Federica Grazia; Reiterer, Veronika; Nalbach, Karsten; Saito, Kota; Pawlowski, Krzysztof; Behrends, Christian & Farhan, Hesso (2019). LTK is an ER-resident receptor tyrosine kinase that regulates secretion. Journal of Cell Biology.  ISSN 0021-9525.  218(8), s 2470- 2480 . doi: 10.1083/jcb.201903068 Fulltekst i vitenarkiv.
  • Cui, Yixian; Parashar, Smriti; Zahoor, Muhammad; Needham, Patrick; Mari, Muriel; Zhu, Ming; Chen, Shulian; Ho, Hsuan-Chung; Reggiori, F; Farhan, Hesso; Brodsky, Jeffrey L & Ferro-Novick, Susan (2019). A COPII subunit acts with an autophagy receptor to target endoplasmic reticulum for degradation. Science.  ISSN 0036-8075.  365(6448), s 53- 60 . doi: 10.1126/science.aau9263 Fulltekst i vitenarkiv. Vis sammendrag
  • Phuyal, Santosh & Farhan, Hesso (2019). Multifaceted Rho GTPase Signaling at the Endomembranes. Frontiers in Cell and Developmental Biology.  ISSN 2296-634X.  7(127) . doi: 10.3389/fcell.2019.00127 Fulltekst i vitenarkiv.
  • Plissonnier, Marie-Laure; Cottarel, Jessica; Piver, Eric; Kullolli, Majlinda; Centonze, Federica Grazia; Pitteri, Sharon; Farhan, Hesso; Meunier, Jean-Christophe; Zoulim, Fabien & Parent, Romain (2019). LARP1 binding to hepatitis C virus particles is correlated with intracellular retention of viral infectivity. Virus Research.  ISSN 0168-1702.  271(197679) . doi: 10.1016/j.virusres.2019.197679 Fulltekst i vitenarkiv.
  • Farhan, Hesso; Legler, D; Uetz-von Allmen, Edith & Rippl, Alexandra V (2018). A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking. Journal of Leukocyte Biology.  ISSN 0741-5400. . doi: 10.1002/JLB.2VMA1217-429R
  • Farhan, Hesso & Zahoor, Muhammad (2018). Crosstalk of Autophagy and the Secretory Pathway and Its Role in Diseases. International Review of Cell and Molecular Biology.  ISSN 1937-6448.  337, s 153- 184 . doi: 10.1016/bs.ircmb.2017.12.004 Fulltekst i vitenarkiv.
  • Saponara, Enrica; Visentin, Michele; Baschieri, Francesco; Seleznik, Gitta; Martinelli, Paola; Esposito, Irene; Buschmann, Johanna; Chen, Rong; Parrotta, Rossella; Borgeaud, Nathalie; Bombardo, Marta; Malagola, Ermanno; Caflisch, Amedeo; Farhan, Hesso; Graf, Rolf & Sonda, Sabrina (2018). Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. Journal of Pathology.  ISSN 0022-3417.  246(3), s 352- 365 . doi: 10.1002/path.5147
  • Farhan, Hesso; Kundu, Mondira & Ferro-Novick, Susan (2017). The link between autophagy and secretion: A story of multitasking proteins. Molecular Biology of the Cell.  ISSN 1059-1524.  28(9), s 1161- 1164 . doi: 10.1091/mbc.E16-11-0762 Fulltekst i vitenarkiv.
  • Murphy, James M.; Farhan, Hesso & Eyers, Patrick A. (2017). Bio-Zombie: The rise of pseudoenzymes in biology. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 537- 544 . doi: 10.1042/BST20160400
  • Reiterer, Veronika; Pawłowski, Krzysztof & Farhan, Hesso (2017). STYX: A versatile pseudophosphatase. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 449- 456 . doi: 10.1042/BST20160279
  • Reiterer-Farhan, Veronika; Figueras‐Puig, Cristina; Le Guerroue,, Francois; Confalonieri, Stefano; Vecchi, Manuela; Jalapothu, Dasaradha; Kanse, Sandip; Deshaies, Raymond J; Di Fiore, Pier Paolo; Behrends, Christian & Farhan, Hesso (2017). The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function. EMBO Journal.  ISSN 0261-4189.  36(3), s 260- 273 . doi: 10.15252/embj.201694795
  • Farhan, Hesso (2016). Regulation of EGFR surface levels by COP II-dependent trafficking. Journal of Cell Biology.  ISSN 0021-9525.  215(4), s 441- 443 . doi: 10.1083/jcb.201611014

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Publisert 23. aug. 2016 15:00 - Sist endret 19. feb. 2020 19:41