Hesso Farhan

Professor - Cellesignalering
Bilde av Hesso Farhan
English version of this page
Telefon +47-22851217
Rom 1238
Besøksadresse Sognsvannsveien 9 Domus Medica 0372 OSLO
Postadresse Postboks 1112 Blindern 0372 OSLO
Emneord: Cellebiologi, Cell signalling, Kreft, metastase, Membrantransport


  1. Farhan H, Hsu VW. Cdc42 and Cellular Polarity: Emerging Roles at the Golgi. Trends Cell Biol. 2016 Apr;26(4):241-8.
  2. Alvarez-Miranda EA, Sinnl M, Farhan H. Alteration of Golgi Structure by Stress: A Link to Neurodegeneration? Front Neurosci. 2015 Nov 12;9:435. doi: 10.3389/fnins.2015.00435. eCollection 2015.
  3. Cottarel J, Plissonnier ML, Kullolli M, Pitteri S, Clément S, Millarte V, Si-Ahmed SN, Farhan H, Zoulim F, Parent R. FIG4 is a hepatitis C virus particle-bound protein implicated in virion morphogenesis and infectivity with cholesteryl ester modulation potential. J Gen Virol. 2016 Jan;97(1):69-81.
  4. Stadel D, Millarte V, Tillmann KD, Huber J, Tamin-Yecheskel BC, Akutsu M, Demishtein A, Ben-Zeev B, Anikster Y, Perez F, Dötsch V, Elazar Z, Rogov V, Farhan H, Behrends C. TECPR2 Cooperates with LC3C to Regulate COPII-Dependent ER Export. Mol Cell. 2015 Oct 1;60(1):89-104.
  5. Baschieri F, Farhan H. Endomembrane control of cell polarity: Relevance to cancer. Small GTPases. 2015;6(2):104-7.
  6. Millarte V, Boncompain G, Tillmann K, Perez F, Sztul E, Farhan H. Phospholipase C γ1 regulates early secretory trafficking and cell migration via interaction with p115. Mol Biol Cell. 2015 Jun 15;26(12):2263-78.
  7. Baschieri F, Uetz-von Allmen E, Legler DF, Farhan H. Loss of GM130 in breast cancer cells and its effects on cell migration, invasion and polarity. Cell Cycle. 2015;14(8):1139-47.
  8. Farhan H. Systems biology of the secretory pathway: what have we learned so far? Biol Cell. 2015 Jul;107(7):205-17.
  9. Genau HM, Huber J, Baschieri F, Akutsu M, Dötsch V, Farhan H, Rogov V, Behrends C. CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling. Mol Cell. 2015 Mar 19;57(6):995-1010.
  10. Tillmann KD, Reiterer V, Baschieri F, Hoffmann J, Millarte V, Hauser MA, Mazza A, Atias N, Legler DF, Sharan R, Weiss M, Farhan H. Regulation of Sec16 levels and dynamics links proliferation and secretion. J Cell Sci. 2015 Feb 15;128(4):670-82.
  11. McEwan DG, Richter B, Claudi B, Wigge C, Wild P, Farhan H, McGourty K, Coxon FP, Franz-Wachtel M, Perdu B, Akutsu M, Habermann A, Kirchof A, Helfrich MH, Odgren PR, Van Hul W, Frangakis AS, Rajalingam K, Macek B, Holden DW, Bumann D, Dikic I. PLEKHM1 regulates Salmonella-containing vacuole biogenesis and infection. Cell Host Microbe. 2015 Jan 14;17(1):58-71.
  12. Spinnenhirn V, Farhan H, Basler M, Aichem A, Canaan A, Groettrup M. The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice. J Cell Sci. 2014 Nov 15;127(Pt 22):4883-93.
  13. Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H. Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun. 2014 Sep 11;5:4839.
  14. Reiterer V, Eyers PA, Farhan H. Day of the dead: pseudokinases and pseudophosphatases in physiology and disease. Trends Cell Biol. 2014 Sep;24(9):489-505.
  15. Krug AK, Gutbier S, Zhao L, Pöltl D, Kullmann C, Ivanova V, Förster S, Jagtap S, Meiser J, Leparc G, Schildknecht S, Adam M, Hiller K, Farhan H, Brunner T, Hartung T, Sachinidis A, Leist M. Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP(+). Cell Death Dis. 2014 May 8;5:e1222.
  16. Mazza A, Gat-Viks I, Farhan H, Sharan R. A minimum-labeling approach for reconstructing protein networks across multiple conditions. Algorithms Mol Biol. 2014 Feb 9;9(1):1. doi: 10.1186/1748-7188-9-1. PubMed PMID: 24507724; PubMed Central PMCID: PMC3933684.
  17. Reitere V, Baschieri F, Millarte V, Farhan H. Methods to study signaling at the Golgi apparatus. Methods Cell Biol. 2013;118:345-58.
  18. Reiterer V, Fey D, Kolch W, Kholodenko BN, Farhan H. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2934-43.
  19. Tillmann KD, Millarte V, Farhan H. Regulation of traffic and organelle architecture of the ER-Golgi interface by signal transduction. Histochem Cell Biol. 2013 Sep;140(3):297-306.
  20. Steeb B, Claudi B, Burton NA, Tienz P, Schmidt A, Farhan H, Mazé A, Bumann D. Parallel exploitation of diverse host nutrients enhances Salmonella virulence. PLoS Pathog. 2013;9(4):e1003301. doi: 10.1371/journal.ppat.1003301. Epub 2013 Apr 25. PubMed PMID: 23633950; PubMed Central PMCID: PMC3636032.
  21. Baschieri F, Farhan H. Crosstalk of small GTPases at the Golgi apparatus. Small GTPases. 2012 Apr-Jun;3(2):80-90. doi: 10.4161/sgtp.19842. Review. PubMed PMID: 22790194; PubMed Central PMCID: PMC3408981.
  22. Millarte V, Farhan H. The Golgi in cell migration: regulation by signal transduction and its implications for cancer cell metastasis. ScientificWorldJournal. 2012;2012:498278.
  23. Zacharogianni M, Kondylis V, Tang Y, Farhan H, Xanthakis D, Fuchs F, Boutros M, Rabouille C. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J. 2011 Aug 16;30(18):3684-700.
  24. Wild P, Farhan H, McEwan DG, Wagner S, Rogov VV, Brady NR, Richter B, Korac J, Waidmann O, Choudhary C, Dötsch V, Bumann D, Dikic I. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science. 2011 Jul 8;333(6039):228-33.
  25. Farhan H, Rabouille C. Signalling to and from the secretory pathway. J Cell Sci. 2011 Jan 15;124(Pt 2):171-80.
  26. Farhan H, Wendeler MW, Mitrovic S, Fava E, Silberberg Y, Sharan R, Zerial M, Hauri HP. MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening. J Cell Biol. 2010 Jun 14;189(6):997-1011.
  27. Farhan H, Hauri HP. Membrane biogenesis: networking at the ER with atlas tin. Curr Biol. 2009 Oct 13;19(19):R906-8.
  28. Reiterer V, Maier S, Sitte HH, Kriz A, Rüegg MA, Hauri HP, Freissmuth M, Farhan H. Sec24- and ARFGAP1-dependent trafficking of GABA transporter-1 is a prerequisite for correct axonal targeting. J Neurosci. 2008 Nov 19;28(47):12453-64.
  29. Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. EMBO J. 2008 Aug 6;27(15):2043-54.
  30. Korkhov VM, Milan-Lobo L, Zuber B, Farhan H, Schmid JA, Freissmuth M, Sitte HH. Peptide-based interactions with calnexin target misassembled membrane proteins into endoplasmic reticulum-derived multilamellar bodies. J Mol Biol. 2008 Apr 25;378(2):337-52.
  31. Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H. GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. J Cell Mol Med. 2009 Jan;13(1):114-24.
  32. Farhan H, Reiterer V, Kriz A, Hauri HP, Pavelka M, Sitte HH, Freissmuth M. Signal-dependent export of GABA transporter 1 from the ER-Golgi intermediate compartment is specified by a C-terminal motif. J Cell Sci. 2008 Mar 15;121(Pt 6):753-61.
  33. Ruggiero AM, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, Robinson MB, Sitte HH, Rothstein JD. The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. J Biol Chem. 2008 Mar 7;283(10):6175-83.
  34. Farhan H, Reiterer V, Korkhov VM, Schmid JA, Freissmuth M, Sitte HH. Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D. J Biol Chem. 2007 Mar 9;282(10):7679-89.
  35. Farhan H, Freissmuth M, Sitte HH. Oligomerization of neurotransmitter transporters: a ticket from the endoplasmic reticulum to the plasma membrane. Handb Exp Pharmacol. 2006;(175):233-49. Review.
  36. Seidel S, Singer EA, Just H, Farhan H, Scholze P, Kudlacek O, Holy M, Koppatz K, Krivanek P, Freissmuth M, Sitte HH. Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action. Mol Pharmacol. 2005 Jan;67(1):140-51.
  37. Korkhov VM, Farhan H, Freissmuth M, Sitte HH. Oligomerization of the {gamma}-aminobutyric acid transporter-1 is driven by an interplay of polar and hydrophobic interactions in transmembrane helix II. J Biol Chem. 2004 Dec 31;279(53):55728-36.
  38. Farhan H, Korkhov VM, Paulitschke V, Dorostkar MM, Scholze P, Kudlacek O, Freissmuth M, Sitte HH. Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1). J Biol Chem. 2004 Jul 2;279(27):28553-63.
  39. Sitte HH, Farhan H, Javitch JA. Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking. Mol Interv. 2004 Feb;4(1):38-47. Review. PubMed PMID: 14993475.
  40. Cross HS, Kállay E, Farhan H, Weiland T, Manhardt T. Regulation of extrarenal vitamin D metabolism as a tool for colon and prostate cancer prevention. Recent Results Cancer Res. 2003;164:413-25.
  41. Farhan H, Wähälä K, Cross HS. Genistein inhibits vitamin D hydroxylases CYP24 and CYP27B1 expression in prostate cells. J Steroid Biochem Mol Biol. 2003 Mar;84(4):423-9.
  42. Farhan H, Cross HS. Transcriptional inhibition of CYP24 by genistein. Ann N Y Acad Sci. 2002 Nov;973:459-62.
  43. Kállay E, Adlercreutz H, Farhan H, Lechner D, Bajna E, Gerdenitsch W, Campbell M, Cross HS. Phytoestrogens regulate vitamin D metabolism in the mouse colon: relevance for colon tumor prevention and therapy. J Nutr. 2002 Nov;132(11 Suppl):3490S-3493S.
  44. Farhan H, Wähälä K, Adlercreutz H, Cross HS. Isoflavonoids inhibit catabolism of vitamin D in prostate cancer cells. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Sep 25;777(1-2):261-8.
  • Centonze, Federica Grazia & Farhan, Hesso (2019). Crosstalk of endoplasmic reticulum exit sites and cellular signaling. FEBS Letters.  ISSN 0014-5793.  s 1- 9 . doi: 10.1002/1873-3468.13569
  • Farhan, Hesso; Legler, D; Uetz-von Allmen, Edith & Rippl, Alexandra V (2018). A unique signal sequence of the chemokine receptor CCR7 promotes package into COPII vesicles for efficient receptor trafficking. Journal of Leukocyte Biology.  ISSN 0741-5400. . doi: 10.1002/JLB.2VMA1217-429R
  • Farhan, Hesso & Zahoor, Muhammad (2018). Crosstalk of Autophagy and the Secretory Pathway and Its Role in Diseases. International Review of Cell and Molecular Biology.  ISSN 1937-6448.  337, s 153- 184 . doi: 10.1016/bs.ircmb.2017.12.004
  • Saponara, Enrica; Visentin, Michele; Baschieri, Francesco; Seleznik, Gitta; Martinelli, Paola; Esposito, Irene; Buschmann, Johanna; Chen, Rong; Parrotta, Rossella; Borgeaud, Nathalie; Bombardo, Marta; Malagola, Ermanno; Caflisch, Amedeo; Farhan, Hesso; Graf, Rolf & Sonda, Sabrina (2018). Serotonin uptake is required for Rac1 activation in Kras-induced acinar-to-ductal metaplasia in the pancreas. Journal of Pathology.  ISSN 0022-3417.  246(3), s 352- 365 . doi: 10.1002/path.5147
  • Farhan, Hesso; Kundu, Mondira & Ferro-Novick, Susan (2017). The link between autophagy and secretion: A story of multitasking proteins. Molecular Biology of the Cell.  ISSN 1059-1524.  28(9), s 1161- 1164 . doi: 10.1091/mbc.E16-11-0762 Fulltekst i vitenarkiv.
  • Murphy, James M.; Farhan, Hesso & Eyers, Patrick A. (2017). Bio-Zombie: The rise of pseudoenzymes in biology. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 537- 544 . doi: 10.1042/BST20160400
  • Reiterer, Veronika; Pawłowski, Krzysztof & Farhan, Hesso (2017). STYX: A versatile pseudophosphatase. Biochemical Society Transactions.  ISSN 0300-5127.  45(2), s 449- 456 . doi: 10.1042/BST20160279
  • Reiterer-Farhan, Veronika; Figueras‐Puig, Cristina; Le Guerroue,, Francois; Confalonieri, Stefano; Vecchi, Manuela; Jalapothu, Dasaradha; Kanse, Sandip; Deshaies, Raymond J; Di Fiore, Pier Paolo; Behrends, Christian & Farhan, Hesso (2017). The pseudophosphatase STYX targets the F‐box of FBXW7 and inhibits SCFFBXW7 function. EMBO Journal.  ISSN 0261-4189.  36(3), s 260- 273 . doi: 10.15252/embj.201694795
  • Farhan, Hesso (2016). Regulation of EGFR surface levels by COP II-dependent trafficking. Journal of Cell Biology.  ISSN 0021-9525.  215(4), s 441- 443 . doi: 10.1083/jcb.201611014

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Publisert 23. aug. 2016 15:00 - Sist endret 7. juni 2019 10:56