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Hamina, Aleksi; Odsbu, Ingvild; Borchgrevink, Petter Chr.; Chen, Li-Chia; Clausen, Thomas & Espnes, Ketil Arne
[Vis alle 18 forfattere av denne artikkelen]
(2022).
Cohort Description: Preventing an Opioid Epidemic in Norway – Focusing on Treatment of Chronic Pain (POINT) – A National Registry-Based Study.
Clinical Epidemiology.
ISSN 1179-1349.
14,
s. 1477–1486.
doi:
10.2147/CLEP.S382136.
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Odsbu, Ingvild; Handal, Marte; Borchgrevink, Petter Chr.; Clausen, Thomas & Skurtveit, Svetlana Ondrasova
(2022).
Endringer i opioidbruken i Norge må tas på dypeste alvor.
Tidsskrift for Den norske legeforening.
ISSN 0029-2001.
doi:
10.4045/tidsskr.21.0909.
Fulltekst i vitenarkiv
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Odsbu, Ingvild; Handal, Marte; Hjellvik, Vidar & Skurtveit, Svetlana Ondrasova
(2021).
Trends in long-term use of prescribed opioids in Norway 2010-2019.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
30,
s. 53–53.
doi:
10.1002/pds.5305.
Vis sammendrag
Background
Since 2008, patients with chronic, non-malignant pain conditions can get reimbursement for analgesic opioids. There is limited evidence of analgesic effect of opioids when used over a long time period while the risk of adverse effects is increasing. Thus, closely monitoring of opioid consumption at the population level to detect signs of escalation is needed.
Objectives
To investigate whether there has been a change in the number of long-term users of prescribed opioids over time and according to reimbursement scheme (reimbursed opioids for palliative care, reimbursed opioids for chronic, non-malignant pain, or non-reimbursable opioids).
Methods
Data were retrieved from the Norwegian Prescription Database. The study population consisted of all individuals filling at least one prescription of an opioid (ATC N02A) during 2010-2019. Long-term use was defined as being dispensed more than 180 defined daily doses or more than 4500 mg oral morphine equivalents of opioids a given year and filling prescriptions in at least 3 quarters of the year. Individuals were divided into mutually exclusive groups according to reimbursement scheme in a hierarchical manner; reimbursed opioids for palliative care > reimbursed opioids for chronic, non-malignant pain > non-reimbursable opioids. The proportion of long-term opioid users according to reimbursement scheme was calculated.
Results
The number of long-term opioid users increased from 49,993 in 2010 to 59,996 in 2019. The increase over time was almost solely attributed to an increase among chronic, non-malignant pain patients. The number of long-term users receiving non-reimbursable opioids and opioids for palliative care remained stable over time. In 2019, the majority of the 59,996 long-term users received non-reimbursable opioids only (n=38,006), followed by long-term users receiving opioids for chronic, non-malignant pain (n=14,812), and long-term users receiving palliative care (n=7,178).
Conclusions
The number of long-term opioid users have increased by 20% (10,000 individuals) over an 11 years period in Norway due to an increase in number of long-term users receiving reimbursed opioids to treat chronic, non-malignant pain. More studies are needed to understand whether the introduction of the reimbursement scheme for chronic pain patients has been a contributing factor to the observed increase in number of long-term opioid users and why the majority of the long-term opioid users do not receive opioids according to the reimbursement scheme for chronic, non-malignant pain.
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Odsbu, Ingvild; Handal, Marte; Hjellvik, Vidar & Skurtveit, Svetlana Ondrasova
(2021).
Trends in long-term use of prescribed opioids in Norway 2010-2019.
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Odsbu, Ingvild; Handal, Marte; Hjellvik, Vidar & Skurtveit, Svetlana Ondrasova
(2021).
Trends in long-term use of prescribed opioids in Norway 2010-2019. .
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Handal, Marte; Andersen, Jannike Mørch & Nygaard, Egil
(2019).
Barn født av mødre som bruker opioider under svangerskapet.
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Handal, Marte
(2019).
In utero opioid exposure and risk of ADHD in childhood. A Scandinavian registry linkage study
.
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Handal, Marte
(2019).
Effekter av LAR I svangerskapet: Resultater fra registerforskning
.
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Handal, Marte
(2019).
How does maternal substance use affect the fetus?
.
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Handal, Marte
(2019).
In-utero opioid exposure and risk of infections in childhood
.
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Lupattelli, Angela; Mahic, Milada; Handal, Marte; Ystrøm, Eivind; Reichborn-Kjennerud, Ted & Nordeng, Hedvig Marie Egeland
(2019).
Risk of attention deficit hyperactivity disorder in childhood after exposure to serotonergic antidepressants in pregnancy.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
-
Handal, Marte; Skurtveit, Svetlana; Odsbu, Ingvild; Kieler, Helle; Nørgaard, Mette & Öztürk, Buket
[Vis alle 12 forfattere av denne artikkelen]
(2019).
In utero opioid exposure and risk of ADHD in childhood: A Scandinavian registry study.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
28(S2).
doi:
10.1002/pds.4864.
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Skurtveit, Svetlana; Kiselev, Yury; Handal, Marte; Stoltenberg, Camilla; Reichborn-Kjennerud, Ted & Suren, Pål
[Vis alle 8 forfattere av denne artikkelen]
(2019).
Co-Occurring Neuropsychiatric Diagnoses and Use of Psychotropic Drugs in Children with Autism Spectrum Disorder.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
doi:
10.10002/pds.4864.
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Wood, Mollie; Mahic, Milada; Handal, Marte; Skurtveit, Svetlana; Lund, Ingunn Olea & Hernandez-Diaz, Sonia
(2019).
Risk of Neonatal Abstinence Syndrome Following Prenatal Exposure to Methadone vs Buprenorphine.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
doi:
10.1002/pds.4864.
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Lund, Ingunn Olea; Skurtveit, Svetlana; Handal, Marte; Bukten, Anne; Torvik, Fartein Ask & Ystrøm, Eivind
[Vis alle 7 forfattere av denne artikkelen]
(2019).
Association of Constellations of Parental Risk With Children's Subsequent Anxiety and Depression: Findings From a HUNT Survey and Health Registry Study.
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Burdzovic, Jasmina; Torvik, Fartein Ask; Ystrøm, Eivind; Skurtveit, Svetlana; Handal, Marte & Lund, Ingunn Olea
(2019).
Alcohol use disorder (AUD) in offspring following exposure to parental risk constellations during adolescence: A combined HUNT survey and health registries study.
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Steingrímsdóttir, Ólöf Anna; Nielsen, Christopher Sivert; Odsbu, Ingvild; Skurtveit, Svetlana Ondrasova & Handal, Marte
(2018).
Langvarig smerte i Norge.
I Grøholt, Else Karin; Bøhler, Linn & Hånes, Hanna (Red.),
Folkehelserapporten - Helsetilstanden i Norge.
Folkehelseinstituttet.
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Handal, Marte; Nechanska, Blanka; Skurtveit, Svetlana; Mahic, Milada; Mravcik, Viktor & Gabrhelik, Roman
(2018).
Hospitalization of children after prenatal exposure to methadone and buprenorphine: National registry studies from Czech Republic.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Lupattelli, Angela; Chambers, Christina; Bandoli, Gretchen; Handal, Marte; Skurtveit, Svetlana & Nordeng, Hedvig Marie Egeland
(2018).
Maternal use of benzodiazepines and z‐hypnotics during pregnancy and developmental outcomes in offspring at 5 years of age.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
27(S2),
s. 173–173.
doi:
10.1002/pds.4629.
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Skurtveit, Svetlana; Bramness, Jørgen Gustav; Hjellvik, Vidar; Hartz, Ingeborg; Nesvåg, Ragnar & Hauge, Lars Johan
[Vis alle 7 forfattere av denne artikkelen]
(2018).
Increase in diagnosis of depressive disorders contributes to the increase in antidepressant use in adolescents.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Mahic, Milada; Hernandez-Diaz, Sonia; Wood, Mollie; Odsbu, Ingvild; Nørgaard, Mette & Kieler, Helle
[Vis alle 8 forfattere av denne artikkelen]
(2018).
Infections in children after prenatal exposure to methadone and buprenorphine: Nordic registry study.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Handal, Marte; Skurtveit, Svetlana; Nechanská, Blanka; Mahic, Milada; Mravčík, Viktor & Gabrhelík, Roman
(2018).
Hospitalization of children after prenatal exposure to methadone and buprenorphine: National registry study from the Czech Republic.
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Nechanská, Blanka; Mahic, Milada; Mravčík, Viktor; Gabrhelík, Roman; Skurtveit, Svetlana & Handal, Marte
(2018).
Sykelighet hos barn som har vært eksponert for LAR legemidler i fosterlivet. En registerstudie fra Tsjekkia.
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Handal, Marte; Nechanská, Blanka; Skurtveit, Svetlana; Mahic, Milada; Mravčík, Viktor & Gabrhelík, Roman
(2018).
Hospitalization of Children after Prenatal Exposure to Methadone and Buprenorphine: National Registry Studies from the Czech Republic.
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Handal, Marte
(2018).
Nordic opportunities in registries, cohorts and biobanks. Time for action
.
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Lund, Ingunn Olea; Skurtveit, Svetlana; Handal, Marte; Bukten, Anne; Torvik, Fartein Ask & Ystrøm, Eivind
[Vis alle 7 forfattere av denne artikkelen]
(2018).
Parental drinking and child long-term depression and anxiety: A longitudinal combined survey and registry study.
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Handal, Marte
(2017).
Opioid Maintenance treatment of opioid addicted pregnant women benefits the pregnant women, but what about the fetus?
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Handal, Marte
(2017).
Neonatal Outcomes after Fetal Exposure to Opioid Maintenance Treatment (OMT).
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Handal, Marte; Nechanská, Blanka; Mravčík, Viktor; Skurtveit, Svetlana; Lund, Ingunn Olea & Gabrhelík, Roman
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Neonatal Outcomes after fetal exposure to methadone and buprenorphine: national registry studies from the Czech Republic and Norway.
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Nechanska, Blanka; Mravcik, Viktor; Skurtveit, Svetlana; Lund, Ingunn Olea; Gabrhelik, Roman & Engeland, Anders
[Vis alle 7 forfattere av denne artikkelen]
(2017).
Condition of newborns of women received OMT and opiates during pregnancy: comparison of Czech and Norwegian cohorts.
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Handal, Marte; Nechanska, Blanka; Lund, Ingunn Olea; Gabrhelik, Roman; Mahic, Milada & Engeland, Anders
[Vis alle 8 forfattere av denne artikkelen]
(2017).
OMT or drug abuse during pregnancy - does it affect the offspring? Results from Nationwide registry studies in the Czech Republic and Norway.
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Holdø, Ingvild; Bramness, Jørgen Gustav; Handal, Marte; Hansen, Berit Marina Hjelde; Hjellvik, Vidar & Skurtveit, Svetlana
(2017).
Infants With dispensed hypnotics have a greater risk of developing hyperkinetic disorder in School age.
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Holdø, Ingvild; Bramness, Jørgen Gustav; Skurtveit, Svetlana; Handal, Marte; Hansen, Berit Hjelde & Hjellvik, Vidar
(2017).
Infants with Sleep Problems have a Greater Risk of Developing ADHD in school age.
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Handal, Marte; Mahic, Milada; Hjellvik, Vidar; Lund, Ingunn Olea; Øhman, Inger & Wikner, Birgitta Norstedt
[Vis alle 13 forfattere av denne artikkelen]
(2016).
Background and design: A Scandinavian cohort of pregnant women in opioid maintenance treatment during pregnancy: long term consequences for the child (ScopeOMT).
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Hartz, Ingeborg; Skurtveit, Svetlana; Hjellvik, Vidar; Furu, Kari; Nesvåg, Ragnar & Handal, Marte
(2016).
Antidepressant Drug use Among Adolescents in Norway from 2004 to 2013‐ A Population‐Based Register Study.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Nesvåg, Ragnar; Hartz, Ingeborg; Bramness, Jørgen Gustav; Hjellvik, Vidar; Handal, Marte & Skurtveit, Svetlana
(2016).
Differences Between Genders in Antipsychotic Medication Among Children and Adolescents – Patterns in Use and Underlying Mental Disorders.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Skovlund, Eva; Handal, Marte; Selmer, Randi Marie; Brandlistuen, Ragnhild Eek & Skurtveit, Svetlana
(2016).
Language Development in 3 Year Old Children After Prenatal Exposure to Opioids.
Pharmacoepidemiology and Drug Safety.
ISSN 1053-8569.
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Handal, Marte; Mahic, Milada; Hjellvik, Vidar; Lund, Ingunn Olea; Øhman, Inger & Wikner, Birgitta Nordstedt
[Vis alle 13 forfattere av denne artikkelen]
(2016).
Background and design: A Scandinavian cohort of
pregnant women
in opioid maintenance
treatment
during pregnancy: long term consequences for the child
(ScopeOMT).
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Lund, Ingunn Olea & Handal, Marte
(2016).
Fornuft og følelser i LAR-behandling.
[Avis].
Bergens Tidende.
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Lund, Ingunn Olea & Handal, Marte
(2016).
Den beste behandlingen vi har.
[Avis].
Bergens Tidende.