Aihua Lin

• Rødevand, Linn; Bahrami, Shahram; Frei, Oleksandr; Lin, Aihua; Gani, Osman; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; O'Connell, Kevin; Elvsåshagen, Torbjørn; Winterton, Adriano; Quintana, Daniel; Hindley, Guy Frederick Lanyon; Werner, Maren Caroline Frogner; Djurovic, Srdjan; Dale, Anders Martin; Lagerberg, Trine Vik; Steen, Nils Eiel & Andreassen, Ole Andreas (2021). Polygenic overlap and shared genetic loci between loneliness, severe mental disorders, and cardiovascular disease risk factors suggest shared molecular mechanisms. Translational Psychiatry.  ISSN 2158-3188.  11(1) . doi: 10.1038/s41398-020-01142-4 Full text in Research Archive. Show summary

  Clinical and epidemiological evidence suggest that loneliness is associated with severe mental disorders (SMDs) and increases the risk of cardiovascular disease (CVD). However, the mechanisms underlying the relationship between loneliness, SMDs, and CVD risk factors remain unknown. Here we explored overlapping genetic architecture and genetic loci shared between SMDs, loneliness, and CVD risk factors. We analyzed large independent genome-wide association study data on schizophrenia (SCZ), bipolar disorder (BD), major depression (MD), loneliness and CVD risk factors using bivariate causal mixture mode (MiXeR), which estimates the total amount of shared variants, and conditional false discovery rate to evaluate overlap in specific loci. We observed substantial genetic overlap between SMDs, loneliness and CVD risk factors, beyond genetic correlation. We identified 149 loci jointly associated with loneliness and SMDs (MD n = 67, SCZ n = 54, and BD n = 28), and 55 distinct loci jointly associated with loneliness and CVD risk factors. A total of 153 novel loneliness loci were found. Most of the shared loci possessed concordant effect directions, suggesting that genetic risk for loneliness may increase the risk of both SMDs and CVD. Functional analyses of the shared loci implicated biological processes related to the brain, metabolic processes, chromatin and immune system. Altogether, the study revealed polygenic overlap between loneliness, SMDs and CVD risk factors, providing new insights into their shared genetic architecture and common genetic mechanisms.

• Lin, Aihua; Kuzmina, Anastasiia & Jakobsen, Per Kristen (2020). A boundary integral approach to linear and nonlinear transient scattering.. Applied Numerical Mathematics.  ISSN 0168-9274.  147, s 277- 300 . doi: 10.1016/j.apnum.2019.08.026
• Lin, Aihua & Jakobsen, Per Kristen (2019). A 3D nonlinear Maxwell's equations solver based on a hybrid numerical method. Physica Scripta.  ISSN 0031-8949.  94(8), s 1- 13 . doi: 10.1088/1402-4896/ab166d
• Lin, Aihua & Jakobsen, Per Kristen (2019). On the Ewald Oseen scattering formulation for light scattering: Stability, singularity and parallelization. Physica Scripta.  ISSN 0031-8949.  95:015201(1) . doi: 10.1088/1402-4896/ab3d0d Full text in Research Archive.

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• Elstad, Maja; Skytioti, Maria; Holme, Nathalie Linn Anikken; Zilakos, Ilias & Lin, Aihua (2019). Cardiorespiratory interactions promote the human cardiovascular control.
• Lin, Aihua (2019). Coupling functions to investigate cardiovascular oscillators.
• Ugland, Nora; Lin, Aihua; Bergersen, Tone Kristin; Andersen, Marian Berge; Holme, Nathalie Linn Anikken; Zilakos, Ilias & Elstad, Maja (2019). The hemodynamic effects of skin blood flow in human thermoneutral zone.

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