Ingrid Melle

• Aas, Monica; Ueland, Torill; Mørch, Ragni Helene; Laskemoen, Jannicke Fjæra; Lunding, Synve Hoffart; Reponen, Elina Johanna; Cattaneo, Annamaria; Agartz, Ingrid; Melle, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2021). Physical activity and childhood trauma experiences in patients with schizophrenia or bipolar disorders. World Journal of Biological Psychiatry.  ISSN 1562-2975. . doi: 10.1080/15622975.2021.1907707
• Hegelstad, Wenche ten Velden; Ottesen, Akiah; Bjørnestad, Jone Ravndal; Gismervik, Kristina; Johannessen, Jan Olav; Melle, Ingrid; Stain, Helen J. & Joa, Inge (2021). Childhood interpersonal trauma and premorbid social adjustment as predictors of symptom remission in first episode psychosis. Schizophrenia Research.  ISSN 0920-9964.  232, s 87- 94 . doi: 10.1016/j.schres.2021.05.015 Full text in Research Archive.
• Lagerberg, Trine Vik; Icick, Romain; Aminoff, Sofie Ragnhild; Nerhus, Mari; Barrett, Elizabeth Ann; Bjella, Thomas; Olsen, Stine Holmstul; Høegh, Margrethe Collier & Melle, Ingrid (2021). Substance Misuse Trajectories and Risk of Relapse in the Early Course of Bipolar Disorder. Frontiers in Psychiatry.  ISSN 1664-0640.  12 . doi: 10.3389/fpsyt.2021.656912
• Lunding, Synve Hoffart; Simonsen, Carmen Elisabeth; Aas, Monica; Rødevand, Linn; Werner, Maren Caroline Frogner; Laskemoen, Jannicke Fjæra; Hjell, Gabriela; Ringen, Petter Andreas; Lagerberg, Trine Vik; Melle, Ingrid; Andreassen, Ole Andreas; Ueland, Torill & Steen, Nils Eiel (2021). Childhood trauma and cardiometabolic risk in severe mental disorders: The mediating role of cognitive control. European psychiatry.  ISSN 0924-9338.  64(1) . doi: 10.1192/j.eurpsy.2021.14
• Værnes, Tor Gunnar; Røssberg, Jan Ivar; Melle, Ingrid; Nelson, Barnaby; Romm, Kristin Lie & Møller, Paul (2021). Basic self-disturbance in subjects at clinical high risk for psychosis: Relationship with clinical and functional outcomes at one year follow-up. Psychiatry Research.  ISSN 0165-1781.  300 . doi: 10.1016/j.psychres.2021.113942
• Wolfers, Thomas; Rokicki, Jaroslav; Alnæs, Dag; Berthet, Pierre; Agartz, Ingrid; Kia, Seyed Mostafa; Kaufmann, Tobias; Zabihi, Mariam; Moberget, Torgeir; Melle, Ingrid; Beckmann, Christian F.; Andreassen, Ole Andreas; Marquand, Andre F. & Westlye, Lars Tjelta (2021). Replicating extensive brain structural heterogeneity in individuals with schizophrenia and bipolar disorder. Human Brain Mapping.  ISSN 1065-9471.  42(8), s 2546- 2555 . doi: 10.1002/hbm.25386
• Aas, Monica; Ueland, Torill; Inova, Amina; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Childhood Trauma Is Nominally Associated With Elevated Cortisol Metabolism in Severe Mental Disorder. Frontiers in Psychiatry.  ISSN 1664-0640. . doi: 10.3389/fpsyt.2020.00391 Full text in Research Archive.
• Coleman, Jonathan R.I.; Gaspar, Helena A; Bryois, Julien; Byrne, Enda M; Forstner, Andreas J; Holmans, Peter A; de Leeuw, Christiaan A.; Mattheisen, Manuel; McQuillin, Andrew; Whitehead Pavlides, Jennifer M; Pers, Tune H; Ripke, Stephan; Stahl, Eli A.; Steinberg, Stacy; Trubetskoy, Vassily; Trzaskowski, Maciej; Wang, Yunpeng; Abbott, Liam; Abdellaoui, Abdel; Adams, Mark J; Nordin Adolfsson, Annelie; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Andlauer, Till F.M.; Anjorin, Adebayo; Anttila, Verneri; Van Der Auwera, Sandra; Awasthi, Swapnil; Bacanu, Silviu-Alin; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Beekman, Aartjan T.F.; Belliveau, Richard; Bøen, Erlend; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Ødegaard, Ketil Joachim; Stordal, Eystein; Vaaler, Arne; Andreassen, Ole Andreas & Breen, Gerome (2020). The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Biological Psychiatry.  ISSN 0006-3223. . doi: 10.1016/j.biopsych.2019.10.015 Show summary

  Background: Mood disorders (including major depressive disorder and bipolar disorder) affect 10% to 20% of the population. They range from brief, mild episodes to severe, incapacitating conditions that markedly impact lives. Multiple approaches have shown considerable sharing of risk factors across mood disorders despite their diagnostic distinction. Methods: To clarify the shared molecular genetic basis of major depressive disorder and bipolar disorder and to highlight disorder-specific associations, we meta-analyzed data from the latest Psychiatric Genomics Consortium genome-wide association studies of major depression (including data from 23andMe) and bipolar disorder, and an additional major depressive disorder cohort from UK Biobank (total: 185,285 cases, 439,741 controls; nonoverlapping N = 609,424). Results: Seventy-three loci reached genome-wide significance in the meta-analysis, including 15 that are novel for mood disorders. More loci from the Psychiatric Genomics Consortium analysis of major depression than from that for bipolar disorder reached genome-wide significance. Genetic correlations revealed that type 2 bipolar disorder correlates strongly with recurrent and single-episode major depressive disorder. Systems biology analyses highlight both similarities and differences between the mood disorders, particularly in the mouse brain cell types implicated by the expression patterns of associated genes. The mood disorders also differ in their genetic correlation with educational attainment-the relationship is positive in bipolar disorder but negative in major depressive disorder. Conclusions: The mood disorders share several genetic associations, and genetic studies of major depressive disorder and bipolar disorder can be combined effectively to enable the discovery of variants not identified by studying either disorder alone. However, we demonstrate several differences between these disorders. Analyzing subtypes of major depressive disorder and bipolar disorder provides evidence for a genetic mood disorders spectrum.

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• Andreassen, Ole Andreas; Malt, Ulrik Fredrik; Malt, Eva Albertsen & Melle, Ingrid (2020). Lærebok i psykiatri Basisversjon. Gyldendal Norsk Forlag A/S.  ISBN 978-82-05-52662-4.  519 s.

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• Vaskinn, Anja; Sundet, Kjetil; Melle, Ingrid; Andreassen, Ole A. & Friis, Svein (2021). The factor structure of social cognition in schizophrenia: Weak evidence for separable domains. Schizophrenia Research: Cognition.  ISSN 2215-0013.  26, s 1- 4 . doi: 10.1016/j.scog.2021.100208 Show summary

  This study examined the factor structure of social cognition in a Norwegian sample of individuals diagnosed with schizophrenia (n = 83). Eight variables from three social cognitive tests from three theoretical domains were included: emotion processing, social perception and theory of mind. Factor analysis with maximum likelihood extraction and oblique rotation resulted in two factors using Kaiser's criterion. Although the two-factor model had better fit than a unifactorial model, it did not represent the data well. Two social cognitive variables did not load on either factor. The two extracted factors did not correspond to an expected distinction between low and high level of processing or between affective and cognitive processes. A non-negligible number of nonredundant residuals between observed and computed correlations suggested poor model fit. In conclusion, this study failed to identify separable dimensions of social cognition in spite of including measures from different theoretical domains.

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