Ingrid Melle
Academic interests
I am co-director of the NORMENT Centre and head of the Centre's "Illness trajectories and outcome prediction" research group. My current research is focused on:
- Mechanisms associated with environmental risk factors, gene x environment interactions: early trauma, migration and cannabis.
- Early illness phases in psychotic- and bipolar disorders, with a particular focus on negative symptoms and treatment response.
- Risk factors for the development of chronic illness and premature death, in particular suicide risk.
Teaching
Psychiatry; Medical students.
Introductory course in psychosocial research methods; PhD students.
Background
MD from the University of Trondheim 1981, licensed psychiatrist 1992, PhD from the University of Oslo 2000.
1992-2006: Clinical director at the treatment centre for early psychosis treatment and assistant research director at the Dept for Research and Development, Division of Psychiatry, Ullevål University Hospital.
2006-2012: Head of Psychosis Research Section, Ullevål University Hospital/Oslo University Hospital.
2010-2020: Professor II, University of Oslo.
2013-2020: Head of Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine.
2013-: Co-director, NORMENT Centre.
2020-: Professor I, University of Oslo
Collaborations
With research groups in psychotic and bipolar disorders at the University Hospitals in Stavanger, Bergen and Trondheim.
With the researchers in bipolar disorders at the University of Paris- Diderot - Paris, France.
With researchers in schizophrenia at the UCLA Semel Institute, Los Angeles, CA.
With other European researchers into negative symptoms in schizophrenia through the research network EuroNES.
Publications
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Dollfus, Sonia; Mucci, Armida; Giordano, Giulia M.; Bitter, István; Austin, Stephen F. & Delouche, Camille [Show all 24 contributors for this article] (2022). European Validation of the Self-Evaluation of Negative Symptoms (SNS): A Large Multinational and Multicenter Study. Frontiers in Psychiatry. ISSN 1664-0640. 13. doi: 10.3389/fpsyt.2022.826465.
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van der Meer, Dennis; Shadrin, Alexey; O'Connell, Kevin; Bettella, Francesco; Djurovic, Srdjan & Wolfers, Thomas [Show all 17 contributors for this article] (2022). Boosting Schizophrenia Genetics by Utilizing Genetic Overlap With Brain Morphology. Biological Psychiatry. ISSN 0006-3223. doi: 10.1016/j.biopsych.2021.12.007.
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Trubetskoy, Vassily; Pardiñas, Antonio F.; Qi, Ting; Panagiotaropoulou, Georgia; Awasthi, Swapnil & Bigdeli, Tim B. [Show all 434 contributors for this article] (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature. ISSN 0028-0836. 604(7906), p. 502–508. doi: 10.1038/s41586-022-04434-5.
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Høegh, Margrethe Collier; Melle, Ingrid; Aminoff, Sofie Ragnhild; Olsen, Stine Holmstul; Lunding, Synve Hoffart & Ueland, Torill [Show all 7 contributors for this article] (2022). Affective lability and social functioning in severe mental disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. doi: 10.1007/s00406-022-01380-1.
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Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis. Translational Psychiatry. ISSN 2158-3188. 12(1). doi: 10.1038/s41398-022-01811-6.
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Pardiñas, Antonio F.; Smart, Sophie E.; Willcocks, Isabella R.; Holmans, Peter A.; Dennison, Charlotte A. & Lynham, Amy J. [Show all 70 contributors for this article] (2022). Interaction Testing and Polygenic Risk Scoring to Estimate the Association of Common Genetic Variants with Treatment Resistance in Schizophrenia. JAMA psychiatry. ISSN 2168-6238. 79(3), p. 260–269. doi: 10.1001/jamapsychiatry.2021.3799.
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Engen, Magnus Johan; Vaskinn, Anja; Melle, Ingrid; Færden, Ann; Lyngstad, Siv Hege & Flaaten, Camilla Bärthel [Show all 12 contributors for this article] (2022). Cognitive and Global Functioning in Patients With First-Episode Psychosis Stratified by Level of Negative Symptoms. A 10-Year Follow-Up Study. Frontiers in Psychiatry. ISSN 1664-0640. 13:841057, p. 1–13. doi: 10.3389/fpsyt.2022.841057.
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Løkhammer, Solveig; Stavrum, Anne-Kristin Støbakk; Polushina, Tatiana; Aas, Monica; Ottesen, Akiah & Andreassen, Ole [Show all 8 contributors for this article] (2022). An epigenetic association analysis of childhood trauma in psychosis reveals possible overlap with methylation changes associated with PTSD. Translational Psychiatry. ISSN 2158-3188. 12. doi: 10.1038/s41398-022-01936-8. Full text in Research Archive
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Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Shadrin, Alexey; Lunding, Synve Hoffart; Rødevand, Linn & Hjell, Gabriela [Show all 15 contributors for this article] (2022). Limited association between infections, autoimmune disease and genetic risk and immune activation in severe mental disorders. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 116. doi: 10.1016/j.pnpbp.2022.110511.
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Johansen, Ingrid Torp; Steen, Nils Eiel; Haram, Marit; Rødevand, Linn ; Werner, Maren Caroline Frogner & Lunding, Synve Hoffart [Show all 12 contributors for this article] (2022). Sex differences in antipsychotic-related triglyceride levels are associated with metabolic hormone differences in patients with severe mental disorders. Schizophrenia Research. ISSN 0920-9964. 243, p. 55–63. doi: 10.1016/j.schres.2022.02.015.