Ingrid Melle

Professor

Norwegian version of this page

Email ingrid.melle@medisin.uio.no

Phone +47 23 02 73 50

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Visiting address Sognsvannsveien 21 Building 4

Postal address P.O. Box 1039 Blindern 0315 Oslo Norway

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Academic interests

My research is based in the NORMENT K.G. Jebsen Centre for Psychosis Research as co-director and head of the Illnes trajectories and outcome prediction research group. My initial research background was from the first generation of early intervention in psychosis studies. This experience raised my interest in the development of psychotic disorders; in particular environmental risk factors, early illness phases and how these shape long-term course and outcome. My current research is focused on:

Mechanisms associated with environmental risk factors, gene x environment interactions: early trauma, migration and cannabis.
Early illness phases in schizophrenia and bipolar disorders, with a particular focus on negative symptoms, emotional dysregulation, cognitive- and social dysfunction.
Risk factors for the development of chronic illness and premature death, in particular suicide risk.

Teaching

Psychiatry; Medical students.

Introductory research course in mental – and substance use disorders; PhD students.

Background

MD from the University of Trondheim 1981, licensed psychiatrist 1992, PhD from the University of Oslo 2000.

1992-2006: Clinical director at Lien Treatment Centre for early psychosis treatment and assistant research director at the Dept for Research and Development, Division of Psychiatry, Ullevål University Hospital (“TIPS project”)

2006-2012: Head of Psychosis Research Section, Ullevål University Hospital/Oslo University Hospital

2010-: Professor II, University of Oslo.

2013-: Co-director, NORMENT K.G.Jebsen Centre for Psychosis Research.

2013-: Head of Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine.

Appointments

Member of Scientific Advisory Board for the South-Eastern Norway Regional Health Authority. Member of steering groups for the Norwegian Network for Severe Mental Illnesses (“NORSMI”).

Collaborations

Leader of Regional Research Network Psychotic Disorders (with Ahus, Vestfold, Vestre Viken and Innlandet).

Main ongoing research collaborations:

With research groups in schizophrenia and bipolar disorders at the University Hospitals in Stavanger, Bergen, Trondheim and Tromsø. (“NASATS”).

With the researchers in bipolar disorders at the Hopital Albert Chenevier/ INSERM - Institut Mondor de Recherche Biomedicale, Creteil, Frankrike.

With researchers in schizophrenia at the UCLA Semel Institute, Los Angeles, CA and Yale University School of Medicine, New Haven, CT, USA.

With other European researchers into negative symptoms in schizophrenia through the research network EuroNES.

Tags: Nordic, USA

Hjell, Gabriela; Mørch-Johnsen, Lynn; Holst, René; Tesli, Natalia; Bell, Christina; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Werner, Maren Caroline Frogner; Melle, Ingrid; Andreassen, Ole Andreas; Lagerberg, Trine Vik; Steen, Nils Eiel & Haukvik, Unn Kristin H. (2020). Disentangling the relationship between cholesterol, aggression, and impulsivity in severe mental disorders. Brain and Behavior. ISSN 2162-3279. . doi: 10.1002/brb3.1751
Laskemoen, Jannicke Fjæra; Aas, Monica; Vaskinn, Anja; Berg, Akiah Ottesen; Lunding, Synve Hoffart; Barrett, Elizabeth Ann; Melle, Ingrid & Simonsen, Carmen Elisabeth (2020). Sleep Disturbance Mediates the Link Between Childhood Trauma and Clinical Outcome in Severe Mental Disorders. Psychological Medicine. ISSN 0033-2917. . doi: https://doi.org/10.1017/S0033291720000914
Lunde, Ketil Berge; Mehlum, Lars; Melle, Ingrid & Qin, Ping (2020). Deliberate self-harm and associated risk factors in young adults: the importance of education attainment and sick leave. Social Psychiatry and Psychiatric Epidemiology. ISSN 0933-7954. . doi: 10.1007/s00127-020-01893-x
Lyngstad, Siv Hege; Bettella, Francesco; Aminoff, Sofie Ragnhild; Athanasiu, Lavinia; Andreassen, Ole Andreas; Færden, Ann & Melle, Ingrid (2020). Associations between schizophrenia polygenic risk and apathy in schizophrenia spectrum disorders and healthy controls. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 141(5), s 452- 464 . doi: 10.1111/acps.13167
Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Engen, Magnus Johan; Haatveit, Beathe; Ihler, Henrik Myhre; Wedervang-Resell, Kirsten; Simonsen, Carmen Elisabeth; Melle, Ingrid & Færden, Ann (2020). Trajectory and early predictors of apathy development in first-episode psychosis and healthy controls: a 10-year follow-up study. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-020-01112-3
Romm, Kristin Lie; Nilsen, Liv; Gjermundsen, Kristine; Holter, Marit; Fjell, Anne; Melle, Ingrid; Repål, Arne & Lobban, Fiona (2020). Remote Care for Caregivers of People With Psychosis: Mixed Methods Pilot Study. JMIR Mental health. ISSN 2368-7959. 7(7) . doi: 10.2196/19497
Storvestre, Guttorm Breivik; Jensen, Arvid; Bjerke, Espen; Tesli, Natalia; Røsæg, Cato; Friestad, Christine; Andreassen, Ole Andreas; Melle, Ingrid & Haukvik, Unn Kristin H. (2020). Childhood trauma in persons with schizophrenia and a history of interpersonal violence. Frontiers in Psychiatry. ISSN 1664-0640. 11
Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid & Haug, Elisabeth (2020). Basic self-disturbances are associated with Sense of Coherence in patients with psychotic disorders. PLOS ONE. ISSN 1932-6203. 15(4), s 1- 11 . doi: 10.1371/journal.pone.0230956 Show summary
Background The Sense of Coherence (SOC) theory gives a possible explanation of how people can experience subjective good health despite severe illness. Basic self-disturbances (BSDs) are subtle non-psychotic disturbances that may destabilize the person’s sense of self, identity, corporeality, and the overall ‘grip’ of the world. Aim Our objective was to investigate associations between BSDs and SOC in patients with psychotic disorders. Design This is a cross-sectional study of 56 patients diagnosed with psychotic disorders inside and outside the schizophrenia spectrum (35 schizophrenia, 13 bipolar, and eight other psychoses). SOC was measured using Antonovsky’s 13-item SOC questionnaire, and BSDs were assessed using the Examination of Anomalous Self-Experience (EASE) manual. Diagnosis, symptoms, and social and occupational performance were assessed using standardized clinical instruments. Results We found a statistically significant correlation (r = ) between high levels of BSDs and low levels of SOC (r = -0.64/p<0.001). This association was not influenced by diagnostics, clinical symptoms or level of functioning in follow-up multivariate analyses. Conclusion A statistically significant association between BSDs and SOC indicates that the presence and level of self-disturbances may influence the person's ability to experience life as comprehensive, manageable and meaningful. However, the cross-sectional nature of the study precludes conclusions regarding the direction of this association.
Tesli, Natalia; van der Meer, Dennis; Rokicki, Jaroslav; Storvestre, Guttorm Breivik; Røsæg, Cato; Jensen, Arvid; Hjell, Gabriela; Bell, Christina; Fischer-Vieler, Thomas; Tesli, Martin Steen; Andreassen, Ole Andreas; Melle, Ingrid; Agartz, Ingrid & Haukvik, Unn Kristin H. (2020). Hippocampal subfield and amygdala nuclei volumes in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-020-01098-y Full text in Research Archive.
Vaskinn, Anja; Haatveit, Beathe; Melle, Ingrid; Andreassen, Ole Andreas; Ueland, Torill & Sundet, Kjetil Søren (2020). Cognitive Heterogeneity Across Schizophrenia and Bipolar Disorder: A Cluster Analysis of Intellectual Trajectories. Journal of the International Neuropsychological Society. ISSN 1355-6177. . doi: https://doi.org/10.1017/S1355617720000442
Werner, Maren Caroline Frogner; Wirgenes, Katrine Verena; Haram, Marit; Bettella, Francesco; Lunding, Synve Hoffart; Rødevand, Linn Nilsen; Hjell, Gabriela; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas & Steen, Nils Eiel (2020). Indicated association between polygenic risk score and treatment-resistance in a naturalistic sample of patients with schizophrenia spectrum disorders. Schizophrenia Research. ISSN 0920-9964. 218, s 55- 62 . doi: 10.1016/j.schres.2020.03.006
Lee, Phil H.; Antilla, Verneri; Won, Hyejung; Feng, Yen-Chen A.; Rosenthal, Jacob; Zhu, Zhaozhong; Tucker-Drob, Elliot M.; Nivard, Michel G.; Grotzinger, Andrew D.; Posthuma, Danielle; Yu, Dongmei; Stahl, Eli A.; Walters, Raymond K.; Anney, Richard J.L.; Duncan, Laramie E.; Ge, Tian; Belangero, Sintia I.; Cook, Edwin H.; Hoekstra, Pieter J.; Keski-Rahkonen, Anna; Kirov, George; Luykx, Jurjen J.; Rohde, Luis A.; Agerbo, Esben; Arranz, M.J.; Asherson, Philip; Bækvad-Hansen, Marie; Bellgrove, Mark A.; Belliveau Jr, Richard A.; Buitelaar, Jan; Bybjerg-Grauholm, Jonas; Casas, Miquel; Chambert, Kimberly; Cerrato, Felecia; Churchhouse, Claire; Cormand, Bru; Crosbie, Jennifer; Dalsgaard, Søren; Haavik, Jan; Hakonarson, Hakon; Hansen, Christine S.; Mors, Ole; Zayats, Tetyana; Bettella, Francesco; Hope, Sigrun; Hultman, Christina M.; Nærland, Terje; Bøen, Erlend; Elvsåshagen, Torbjørn; Ødegaard, Ketil Joachim; Malt, Ulrik Fredrik; Melle, Ingrid; Reinbold, Céline Sonja; Smeland, Olav Bjerkehagen; Wang, Yunpeng; Espeseth, Thomas; Knudsen, Gun Peggy Strømstad; Le Hellard, Stephanie; Reichborn-Kjennerud, Ted; Jönsson, Erik Gunnar; Andreassen, Ole Andreas; Agartz, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne & Joa, Inge (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell. ISSN 0092-8674. 179(7), s 1469- 1482 . doi: 10.1016/j.cell.2019.11.020 Full text in Research Archive.
Aas, Monica; Bellivier, Frank; Bettella, Francesco; Henry, Chantal; Gard, Sebastien; Kahn, Jean-Pierre; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Melle, Ingrid; Leboyer, Marion; Jamain, Stéphane; Andreassen, Ole Andreas & Étain, Bruno (2019). Childhood maltreatment and polygenic risk in bipolar disorders. Bipolar Disorders. ISSN 1398-5647. s 1- 8 . doi: 10.1111/bdi.12851
Aas, Monica; Elvsåshagen, Torbjørn; Westlye, Lars Tjelta; Kaufmann, Tobias; Athanasiu, Lavinia; Djurovic, Srdjan; Melle, Ingrid; van der Meer, Dennis; Martin-Ruiz, Carmen; Steen, Nils Eiel; Agartz, Ingrid & Andreassen, Ole Andreas (2019). Telomere length is associated with childhood trauma in patients with severe mental disorders. Translational psychiatry. ISSN 2158-3188. 9 . doi: 10.1038/s41398-019-0432-7 Full text in Research Archive.
Aas, Monica; Pizzagalli, Diego A.; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Ueland, Torill; Melle, Ingrid; Agartz, Ingrid; Steen, Nils Eiel & Andreassen, Ole Andreas (2019). Elevated hair cortisol is associated with childhood maltreatment and cognitive impairment in schizophrenia and in bipolar disorders. Schizophrenia Research. ISSN 0920-9964. . doi: 10.1016/j.schres.2019.01.011 Full text in Research Archive.
Anderssen, Jannicke Fjæra; Büchmann, Camilla Bakkalia; Barrett, Elizabeth Ann; Høegh, Margrethe Collier; Haatveit, Beathe; Vedal, Trude Seselie Jahr; Ueland, Torill; Melle, Ingrid; Aas, Monica & Simonsen, Carmen Elisabeth (2019). Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. s 1- 11 . doi: 10.1007/s00406-019-01075-0
Anderssen, Jannicke Fjæra; Simonsen, Carmen Elisabeth; Büchmann, Camilla Bakkalia; Barrett, Elizabeth Ann; Bjella, Thomas; Lagerberg, Trine Vik; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Melle, Ingrid & Aas, Monica (2019). Sleep disturbances in schizophrenia spectrum and bipolar disorders ? a transdiagnostic perspective. Comprehensive Psychiatry. ISSN 0010-440X. 91, s 6- 12 . doi: 10.1016/j.comppsych.2019.02.006 Full text in Research Archive.
Bauer, Michael; Glenn, Tasha; Alda, Martin; Andreassen, Ole Andreas; Angelopoulos, Elias; Ardau, Raffaella; Ayhan, Yavuz; Baethge, Christopher; Bauer, Rita; Baune, Bernhard T.; Becerra-Palars, Claudia; Bellivier, Frank; Belmaker, Robert H.; Berk, Michael; Bersudsky, Yuly; Bicakci, Şule; Birabwa-Oketcho, Harriet; Bjella, Thomas; Cabrera, Jorge; Wo Cheung, Eric Y.; Del Zompo, Maria; Dodd, Seetal; Donix, Markus; Etain, Bruno; Fagiolini, Andrea; Fountoulakis, Kostas N.; Frye, Mark A.; Gonzalez-Pinto, Ana; Gottlieb, John F.; Grof, Paul; Harima, Hirohiko; Henry, Chantal; Isometsä, Erkki T.; Janno, Sven; Kapczinski, Flávio; Kardell, Mathias; Khaldi, Slim; Kliwicki, Sebastian; Konig, Barbara; Kot, Timur L.; Krogh, Rikke; Kunz, Mauricio; Lafer, Beny; Landén, Mikael; Larsen, Erik R.; Lewitzka, Ute; Licht, Rasmus W.; Lopez-Jaramillo, Carlos; MacQueen, Glenda; Manchia, Mirko; Marsh, Wendy; Martinez-Cengotitabengoa, Monica; Melle, Ingrid; Meza-Urzua, Fatima; Ming, Mok Yee; Monteith, Scott; Morken, Gunnar; Mosca, Enrica; Mozzhegorov, Anton A.; Munoz, Rodrigo; Mythri, Starlin V.; Nacef, Fethi; Nadella, Ravi K.; Nery, Fabiano G.; Nielsen, René E.; O'Donovan, Claire; Omrani, Adel; Osher, Yamima; Sørensen, Helle Østermark; Ouali, Uta; Ruiz, Yolanda Pica; Pilhatsch, Maximilian; Pinna, Marco; da Ponte, Francisco D.R.; Quiroz, Danilo; Ramesar, Raj; Rasgon, Natalie; Reddy, Mrinalini S.; Reif, Andreas; Ritter, Philipp; Rybakowski, Janusz K.; Sagduyu, Kemal; Raghuraman, Bharathram Sathur; Scippa, Ângela M.; Severus, Emanuel; Simhandl, Christian; Stackhouse, Paul W.; Stein, Dan J.; Strejilevich, Sergio; Subramaniam, Mythily; Sulaiman, Ahmad Hatim; Suominen, Kirsi; Tagata, Hiromi; Tatebayashi, Yoshitaka; Tondo, Leonardo; Torrent, Carla; Vaaler, Arne; Vares, Edgar; Veeh, Julia; Vieta, Eduard; Viswanath, Biju; Yoldi-Negrete, Maria; Zetin, Mark; Zgueb, Yosra & Whybrow, Peter C. (2019). Association between solar insolation and a history of suicide attempts in bipolar I disorder. Journal of Psychiatric Research. ISSN 0022-3956. 113, s 1- 9 . doi: 10.1016/j.jpsychires.2019.03.001
Bjørnestad, Jone Ravndal; Hegelstad, Wenche; Berg, Henrik; Davidson, Larry; Joa, Inge; Johannessen, Jan Olav; Melle, Ingrid; Stain, Helen J. & Pallesen, Ståle (2019). Social media and social functioning in psychosis: A systematic review. Journal of Medical Internet Research. ISSN 1438-8871. 21(6), s 1- 22 . doi: 10.2196/13957 Full text in Research Archive.
Di Sero, Alessia; Jørgensen, Kjetil Nordbø; Nerland, Stener; Melle, Ingrid; Andreassen, Ole Andreas; Jovicich, Jorge & Agartz, Ingrid (2019). Antipsychotic treatment and basal ganglia volumes: Exploring the role of receptor occupancy, dosage and remission status. Schizophrenia Research. ISSN 0920-9964. 208, s 114- 123 . doi: 10.1016/j.schres.2019.04.002
Drange, Ole Kristian; Smeland, Olav Bjerkehagen; Shadrin, Alexey A.; Finseth, Per Ivar; Witoelar, Aree; Frei, Oleksandr; Psychiatric Genomic Consortium, Bipolar Disorder Working Group; Wang, Yunpeng; Hassani, Sahar; Djurovic, Srdjan; Dale, Anders; Andreassen, Ole Andreas; Bøen, Erlend; Elvsåshagen, Torbjørn; Agartz, Ingrid; Melle, Ingrid; Morken, Gunnar; Stordal, Eystein; Vaaler, Arne; Ødegaard, Ketil Joachim; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, MacIej; Pers, Tune H; Holmans, Peter A.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E & Pedersen, Carsten Bøcker (2019). Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes. Frontiers in Neuroscience. ISSN 1662-4548. 13 . doi: 10.3389/fnins.2019.00220 Full text in Research Archive. Show summary
Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, it is not established if this relation is of genetic origin. Here, we applied statistical methods based on the conditional false discovery rate (FDR) framework to detect genetic overlap between AD and BIP and utilized this overlap to increase the power to identify common genetic variants associated with either or both traits. Methods: We obtained genome wide association studies data from the International Genomics of Alzheimer’s Project part 1 (17,008 AD cases and 37,154 controls) and the Psychiatric Genetic Consortium Bipolar Disorder Working Group (20,352 BIP cases and 31,358 controls). We used conditional QQ-plots to assess overlap in common genetic variants between AD and BIP. We exploited the genetic overlap to re-rank test-statistics for AD and BIP and improve detection of genetic variants using the conditional FDR framework. Results: Conditional QQ-plots demonstrated a polygenic overlap between AD and BIP. Using conditional FDR, we identified one novel genomic locus associated with AD, and nine novel loci associated with BIP. Further, we identified two novel loci jointly associated with AD and BIP implicating the MARK2 gene (lead SNP rs10792421, conjunctional FDR = 0.030, same direction of effect) and the VAC14 gene (lead SNP rs11649476, conjunctional FDR = 0.022, opposite direction of effect). Conclusion: We found polygenic overlap between AD and BIP and identified novel loci for each trait and two jointly associated loci. Further studies should examine if the shared loci implicating the MARK2 and VAC14 genes could explain parts of the shared and distinct features of AD and BIP.
Engen, Magnus Johan; Simonsen, Carmen Elisabeth; Melle, Ingrid; Færden, Ann; Lyngstad, Siv Hege; Haatveit, Beathe; Vaskinn, Anja & Ueland, Torill (2019). Cognitive functioning in patients with first-episode psychosis stratified by level of negative symptoms: A 1-year follow-up study. Psychiatry Research. ISSN 0165-1781. 281, s 1- 7 . doi: 10.1016/j.psychres.2019.112554
Ferrara, Maria; Guloksuz, Sinan; Li, Fangyong; Burke, Shadie; Tek, Cenk; Friis, Svein; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Melle, Ingrid; Simonsen, Erik & Srihari, Vinod H. (2019). Parsing the impact of early detection on duration of untreated psychosis (DUP): Applying quantile regression to data from the Scandinavian TIPS study. Schizophrenia Research. ISSN 0920-9964. 210, s 128- 134 . doi: 10.1016/j.schres.2019.05.035
Gjerde, Priyanthi Borgen; Simonsen, Carmen Elisabeth; Lagerberg, Trine Vik; Steen, Nils Eiel; Ueland, Torill; Andreassen, Ole Andreas; Steen, Vidar Martin & Melle, Ingrid (2019). Improvement in verbal learning over the first year of antipsychotic treatment is associated with serum HDL levels in a cohort of first episode psychosis patients. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. s 1- 10 . doi: 10.1007/s00406-019-01017-w Full text in Research Archive.
Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Reponen, Elina Johanna; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2019). Association between leptin levels and severity of suicidal behaviour in schizophrenia spectrum disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(5), s 464- 471 . doi: 10.1111/acps.13019 Full text in Research Archive.
Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Agartz, Ingrid; Djurovic, Srdjan; Melle, Ingrid; Andreassen, Ole Andreas; Donohoe, Gary; Gill, M; Corvin, A & Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics. ISSN 0148-7299. . doi: 10.1002/ajmg.b.32716
Hess, JL; Tylee, JS; Mattheisen, M; Agartz, Ingrid; Andreassen, Ole Andreas; Djurovic, Srdjan; Jönsson, Erik Gunnar; Melle, Ingrid; Holmans, P.; Faraone, Stephen V. & Glatt, Stephen J. (2019). A polygenic resilience score moderates the genetic risk for schizophrenia. Molecular Psychiatry. ISSN 1359-4184. . doi: 10.1038/s41380-019-0463-8
Icick, Romain; Melle, Ingrid; Étain, Bruno; Ringen, Petter Andreas; Aminoff, Sofie Ragnhild; Leboyer, Marion.; Aas, Monica; Henry, Chantal; Bjella, Thomas; Andreassen, Ole Andreas; Bellivier, Frank & Lagerberg, Trine Vik (2019). Tobacco smoking and other substance use disorders associated with recurrent suicide attempts in bipolar disorder.. Journal of Affective Disorders. ISSN 0165-0327. 256, s 348- 357 . doi: 10.1016/j.jad.2019.05.075
Kaufmann, Tobias; van der Meer, Dennis; Doan, Nhat Trung; Schwarz, Emanuel; Lund, Martina Jonette; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M.; Baur-Streubel, Ramona; Bertolino, Alessandro; Bettella, Francesco; Beyer, Mona K.; Bøen, Erlend; Borgwardt, Stefan; Brandt, Christine Lycke; Buitelaar, Jan; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Còrdova Palomera, Aldo; Dale, Anders; de Quervain, Dominique J.F.; di Carlo, Pasquale; Djurovic, Srdjan; Dørum, Erlend Solberg; Eisenacher, Sarah; Elvsåshagen, Torbjørn; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Haatveit, Beathe; Håberg, Asta; Harbo, Hanne Flinstad; Hartman, Catharina A; Heslenfeld, Dirk J; Hoekstra, Pieter J; Høgestøl, Einar August; Jernigan, Terry L.; Jonassen, Rune; Jönsson, Erik Gunnar; Kirsch, Peter; Kłoszewska, Iwona; Kolskår, Knut-Kristian; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Lovestone, Simon; Lundervold, Arvid; Lundervold, Astri; Maglanoc, Luigi Angelo; Malt, Ulrik Fredrik; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pauli, Paul; Pergola, Giulio; Persson, Karin Ester Torun; Richard, Geneviève; Rokicki, Jaroslav; Sanders, Anne-Marthe; Selbæk, Geir; Shadrin, Alexey A.; Smeland, Olav Bjerkehagen; Soininen, Hilkka; Sowa, Piotr; Steen, Vidar Martin; Tsolaki, Magda; Ulrichsen, Kristine Moe; Vellas, Bruno; Wang, Lei; Westman, Eric; Ziegler, Georg C.; Zink, Mathias; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2019). Common brain disorders are associated with heritable patterns of apparent aging of the brain. Nature Neuroscience. ISSN 1097-6256. 22(10), s 1617- 1623 . doi: 10.1038/s41593-019-0471-7 Full text in Research Archive.
Lam, Max; Hill, W. David; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Davies, Gail; Stahl, Eli; Huckins, Laura; Liewald, David C.; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Hartmann, Annette M.; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Deary, Ian J.; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2019). Pleiotropic meta-analysis of cognition, education, and schizophrenia differentiates roles of early neurodevelopmental and adult synaptic pathways. American Journal of Human Genetics. ISSN 0002-9297. 105(2), s 334- 350 . doi: 10.1016/j.ajhg.2019.06.012 Full text in Research Archive.
Mucci, Armida; Vignapiano, Annarita; Bitter, István; Austin, Stephen F.; Delouche, Camille; Dollfus, Sonia; Erfurth, Andreas; Fleischhacker, W. Wolfgang; Giordano, Giulia M.; Gladyshev, Igor; Glenthøj, Birte; Gütter, Karoline; Hofer, Alex; Hubeňák, Jan; Kaiser, Stefan; Libiger, Jan; Melle, Ingrid; Nielsen, Mette Ø.; Papsuev, Oleg; Rybakowski, Janusz K.; Sachs, Gabriele; Üçok, Alp; Wójciak, Paweł & Galderisi, Silvana (2019). A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale. European Neuropsychopharmacology. ISSN 0924-977X. 29(8), s 947- 959 . doi: 10.1016/j.euroneuro.2019.05.006
Mullins, Niamh; Bigdeli, Tim B.; Børglum, Anders D.; Coleman, Jonathan R.I.; Demontis, Ditte; Mehta, Divya; Power, Robert A.; Ripke, Stephan; Stahl, Eli A.; Starnawska, Anna; Anjorin, Adebayo; Corvin, Aiden; Sanders, Alan R.; Forstner, Andreas J.; Reif, Andreas; Koller, Anna C.; Świątkowska, Beata; Baune, Bernhard T.; Müller-Myhsok, Bertram; Penninx, Brenda W.J.H.; Pato, Carlos; Zai, Clement; Rujescu, Dan; Hougaard, David M.; Quested, Digby; Levinson, Douglas F.; Binder, Elisabeth B.; Byrne, Enda M.; Agerbo, Esben; Streit, Fabian; Mayoral, Fermin; Bellivier, Frank; Degenhardt, Franziska; Breen, Gerome; Morken, Gunnar; Turecki, Gustavo; Rouleau, Guy A.; Grabe, Hans J.; Völzke, Henry; Jones, Ian; Giegling, Ina; Agartz, Ingrid; Melle, Ingrid; Lawrence, Jacob; Walters, James T.R.; Strohmaier, Jana; Shi, Jianxin; Hauser, Joanna; Biernacka, Joanna M.; Vincent, John B.; Kelsoe, John; Strauss, John S.; Lissowska, Jolanta; Pimm, Jonathan; Smoller, Jordan W.; Guzman-Parra, José; Berger, Klaus; Scott, Laura J.; Jones, Lisa A.; Azevedo, M. Helena; Trzaskowski, Maciej; Kogevinas, Manolis; Rietschel, Marcella; Boks, Marco; Ising, Marcus; Grigoroiu-Serbanescu, Maria; Hamshere, Marian L.; Leboyer, Marion; Frye, Mark; Nöthen, Markus M.; Alda, Martin; Preisig, Martin; Nordentoft, Merete; Boehnke, Michael; O'Donovan, Michael C.; Owen, Michael J.; Pato, Michele T.; Renteriá, Miguel E.; Budde, Monika; Weissman, Myrna M.; Wray, Naomi R.; Bass, Nicholas; Craddock, Nicholas; Smeland, Olav Bjerkehagen; Andreassen, Ole Andreas; Mors, Ole; Gejman, Pablo V.; Sklar, Pamela; McGrath, Patrick; Hoffmann, Per; McGuffin, Peter; Lee, Phil H.; Mortensen, Preben Bo; Kahn, René S.; Ophoff, Roel A.; Adolfsson, Rolf; Van der Auwera, Sandra; Djurovic, Srdjan; Kloiber, Stefan; Heilmann-Heimbach, Stefanie; Jamain, Stéphane; Hamilton, Steven P.; McElroy, Susan L.; Lucae, Susanne; Cichon, Sven; Schulze, Thomas G.; Hansen, Thomas; Werge, Thomas; Air, Tracy M.; Nimgaonkar, Vishwajit; Appadurai, Vivek; Cahn, Wiepke; Milaneschi, Yuri; Fanous, Ayman H.; Kendler, Kenneth S.; McQuillin, Andrew & Lewis, Cathryn M. (2019). GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores. American Journal of Psychiatry. ISSN 0002-953X. 176(8), s 651- 660 . doi: 10.1176/appi.ajp.2019.18080957 Full text in Research Archive.
Mørch, Ragni Helene; Dieset, Ingrid; Færden, Ann; Reponen, Elina Johanna; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Gardsjord, Erlend Strand; Aas, Monica; Iversen, Trude; Joa, Inge; Morken, Gunnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Thor & Andreassen, Ole Andreas (2019). Inflammatory markers are altered in severe mental disorders independent of comorbid cardiometabolic disease risk factors. Psychological Medicine. ISSN 0033-2917. 49(10), s 1749- 1757 . doi: 10.1017/S0033291718004142 Show summary
Background. Inflammation and immune activation have been implicated in the pathogenesis of severe mental disorders and cardiovascular disease (CVD). Despite high level of comorbidity, many studies of the immune system in severe mental disorders have not systematically taken cardiometabolic risk factors into account. Methods. We investigated if inflammatory markers were increased in schizophrenia (SCZ) and affective (AFF) disorders independently of comorbid CVD risk factors. Cardiometabolic risk factors (blood lipids, body mass index and glucose) and CVD-related inflammatory markers CXCL16, soluble interleukin-2 receptor (sIL-2R), soluble CD14 (sCD14), macrophage inhibitory factor and activated leukocyte cell adhesion molecule (ALCAM) were measured in n = 992 patients (SCZ, AFF), and n = 647 healthy controls. We analyzed the inflammatory markers before and after controlling for comorbid cardiometabolic risk factors, and tested for Association with psychotropic medication and symptom levels. Results. CXCL16 ( p = 0.03) and sIL-2R (p = 7.8 × 10−5) were higher, while sCD14 ( p = 0.05) were lower in patients compared to controls after controlling for confounders, with significant differences in SCZ for CXCL16 ( p = 0.04) and sIL-2R ( p = 1.1 × 10−5). After adjustment for cardiometabolic risk factors higher levels of sIL-2R ( p = 0.001) and lower sCD14 ( p = 0.002) remained, also in SCZ (sIL-2R, p = 3.0 × 10−4 and sCD14, p = 0.01). The adjustment revealed lower ALCAM levels ( p = 0.03) in patients. We found no significant associations with psychotropic medication or symptom levels. Conclusion. The results indicate that inflammation, in particular enhanced T cell activation and impaired monocyte activation, are associated with severe mental disorders independent of comorbid cardiometabolic risk factors. This suggests a role
Onyeka, Ifeoma Nkeiruka; Høegh, Margrethe Collier; Eien, Eldbjørg Marie Nåheim; Nwaru, Bright I. & Melle, Ingrid (2019). Comorbidity of Physical Disorders Among Patients With Severe Mental Illness With and Without Substance Use Disorders: A Systematic Review and Meta-Analysis. Journal of Dual Diagnosis (JDD). ISSN 1550-4263. 15(3), s 192- 206 . doi: 10.1080/15504263.2019.1619007
Richards, Alexander L.; Pardiñas, Antonio F.; Frizzati, Aura; Tansey, Katherine E.; Lynham, Amy J.; Holmans, Peter; Legge, Sophie E.; Savage, Jeanne E.; Agartz, Ingrid; Andreassen, Ole Andreas; Blokland, Gabriella A. M.; Corvin, Aiden; Cosgrove, Donna; Degenhardt, Franziska; Djurovic, Srdjan; Espeseth, Thomas; Ferraro, Laura; Gayer-Anderson, Charlotte; Giegling, Ina; van Haren, Neeltje E.M.; Hartmann, Annette M.; Hubert, John J.; Jönsson, Erik Gunnar; Konte, Bettina; Lennertz, Leonhard; Olde Loohuis, Loes M.; Melle, Ingrid; Morgan, Craig; Morris, Derek W.; Murray, Robin M.; Nyman, Håkan; Ophoff, Roel A.; van Os, Jim; Petryshen, Tracey L.; Quattrone, Diego; Rietschel, Marcella; Rujescu, Dan; Rutten, Bart P. F.; Streit, Fabian; Strohmaier, Jana; Sullivan, Patrick F.; Sundet, Kjetil Søren; Wagner, Michael; Escott-Price, Valentina; Owen, Michael J.; Donohoe, Gary; O'Donovan, Michael C. & Walters, James T R (2019). The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia. Schizophrenia Bulletin. ISSN 0586-7614. . doi: 10.1093/schbul/sbz061 Show summary
BACKGROUND: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. METHODS: We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results were then meta-analyzed across all samples. A genome-wide association studies (GWAS) of cognition was conducted in schizophrenia cases. RESULTS: PRS for both population IQ (P = 4.39 x 10-28) and EA (P = 1.27 x 10-26) were positively correlated with cognition in those with schizophrenia. In contrast, there was no association between cognition in schizophrenia cases and PRS for schizophrenia (P = .39), BD (P = .51), or MDD (P = .49). No individual variant approached genome-wide significance in the GWAS. CONCLUSIONS: Cognition in schizophrenia cases is more strongly associated with PRS that index cognitive traits in the general population than PRS for neuropsychiatric disorders. This suggests the mechanisms of cognitive variation within schizophrenia are at least partly independent from those that predispose to schizophrenia diagnosis itself. Our findings indicate that this cognitive variation arises at least in part due to genetic factors shared with cognitive performance in populations and is not solely due to illness or treatment-related factors, although our findings are consistent with important contributions from these factors.
Ringen, Petter Andreas; Reponen, Elina Johanna; Vedal, Trude Seselie Jahr; Andreassen, Ole Andreas; Steen, Nils Eiel & Melle, Ingrid (2019). Predictors for antipsychotic dosage change in the first year of treatment in schizophrenia spectrum and bipolar disorders. Frontiers in Psychiatry. ISSN 1664-0640. 10:649, s 1- 8 . doi: 10.3389/fpsyt.2019.00649 Full text in Research Archive.
Romm, Kristin Lie; Gardsjord, Erlend Strand; Gjermundsen, Kristine; Aguirre, Manuela; Berentzen, Lars-Christian & Melle, Ingrid (2019). Designing easy access to care for first-episode psychosis in complex organizations. Early Intervention in Psychiatry. ISSN 1751-7885. s 1276- 1282 . doi: 10.1111/eip.12802 Full text in Research Archive.
Rødevand, Linn; Steen, Nils Eiel; Elvsåshagen, Torbjørn; Quintana, Daniel; Reponen, Elina Johanna; Mørch, Ragni Helene; Lunding, Synve Hoffart; Vedal, Trude Seselie Jahr; Dieset, Ingrid; Melle, Ingrid; Lagerberg, Trine Vik & Andreassen, Ole Andreas (2019). Cardiovascular risk remains high in schizophrenia with modest improvements in bipolar disorder during past decade. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139(4), s 348- 360 . doi: 10.1111/acps.13008 Show summary
Objective: While CVD risk has decreased in the general population during the last decade, the situation in patients with schizophrenia (SCZ) and bipolar disorder (BD) is unknown. Methods: We compared CVD risk factors in patients with SCZ and BD recruited from 2002‐2005 (2005 sample, N = 270) with patients recruited from 2006‐2017 (2017 sample, N = 1011) from the same catchment area in Norway. The 2017 sample was also compared with healthy controls (N = 922) and the general population (N range = 1285‐4587, Statistics Norway) from the same area and period. Results: Patients with SCZ and BD in the 2017 sample had significantly higher level of most CVD risk factors compared to healthy controls and the general population. There was no significant difference in the prevalence of CVD risk factors in SCZ between the 2005 and 2017 samples except a small increase in glucose in the 2017 sample. There were small‐to‐moderate reductions in hypertension, obesity, total cholesterol, low‐density lipoprotein, systolic and diastolic blood pressure in the BD 2017 sample compared to the 2005 sample. Conclusion: Despite major advances in health promotion during the past decade, there has been no reduction in the level of CVD risk factors in patients with SCZ and modest improvement in BD.
Satizabal, Claudia L.; Adams, Hieab H.H.; Hibar, Derrek; White, Charles C.; Knol, Maria J.; Stein, Jason L.; Scholz, Markus; Sargurupremraj, Muralidharan; Jahanshad, Neda; Roshchupkin, Gennady V.; Smith, Albert V.; Bis, Joshua C.; Jian, Xueqiu; Luciano, Michelle; Hofer, Edith; Teumer, Alexander; van der Lee, Sven J.; Yang, Jingyun; Yanek, Lisa R.; Lee, Tom V.; Li, Shuo; Hu, Yanhui; Koh, Jia Yu; Eicher, John D.; Desrivières, Sylvane; Arias-Vasquez, Alejandro; Chauhan, Ganesh; Athanasiu, Lavinia; Rentería, Miguel E.; Kim, Sungeun; Hoehn, David; Armstrong, Nicola J.; Chen, Qiang; Holmes, Avram J.; den Braber, Anouk; Kloszewska, Iwona; Andersson, Micael; Espeseth, Thomas; Grimm, Oliver; Abramovic, Lucija; Alhusaini, Saud; Milaneschi, Yuri; Papmeyer, Martina; Axelsson, Tomas; Ehrlich, Stefan; Roiz-Santiáñez, Roberto; Kraemer, Bernd; Håberg, Asta; Jones, Hannah J; Pike, G. Bruce; Stein, Dan J.; Stevens, Allison; Bralten, Janita; Vernooij, Meike W.; Harris, Tamara B.; Filippi, Irina; Witte, A Veronica; Guadalupe, Tulio; Wittfeld, Katharina; Mosley, Thomas H.; Becker, James T.; Hagenaars, Saskia P.; Saba, Yasaman; Cuellar-Partida, Gabriel; Amin, Najaf; Hilal, Saima; Nho, Kwangsik; Mirza-Schreiber, Nazanin; Arfanakis, Konstantinos; Becker, Diane M.; Ames, David; Goldman, Aaron L.; Lee, Phil H.; Boomsma, Dorret I.; Lovestone, Simon; Giddaluru, Sudheer; Le Hellard, Stephanie; Mattheisen, Manuel; Bohlken, Marc M.; Kasperaviciute, Dalia; Schmaal, Lianne; Lawrie, Stephen M.; Agartz, Ingrid; Walton, Esther; Tordesillas-Gutierrez, Diana; Davies, Gareth E.; Shin, Jean; Ipser, Jonathan C.; Vinke, Louis N.; Hoogman, Martine; Jia, Tianye; Burkhardt, Ralph; Klein, Marieke; Crivello, Fabrice; Janowitz, Deborah; Carmichael, Owen; Haukvik, Unn Kristin H.; Aribisala, Benjamin S.; Schmidt, Helena; Strike, Lachlan T.; Cheng, Ching-Yu; Risacher, Shannon L.; Putz, Benno; Fleischman, Debra A.; Assareh, Amelia A.; Mattay, Venkata S.; Buckner, Randy L.; Mecocci, Patrizia; Dale, Anders; Cichon, Sven; Boks, Marco P.; Matarin, Mar; Penninx, Brenda W.J.H.; Calhoun, Vince D.; Chakravarty, M. Mallar; Marquand, André F.; Macare, Christine; Kharabian Masouleh, Shahrzad; Oosterlaan, Jaap; Amouyel, Philippe; Hegenscheid, Katrin; Rotter, Jerome I.; Schork, Andrew J.; Liewald, David C.M.; de Zubicaray, Greig I.; Wong, Tien Yin; Shen, Li; Sämann, Philipp G.; Brodaty, Henry; Roffman, Joshua L.; de Geus, Eco J.C.; Tsolaki, Magda; Erk, Susanne; van Eijk, Kristel R.; Cavalleri, Gianpiero L.; Van Der Wee, Nic J.A.; McIntosh, Andrew M.; Gollub, Randy L.; Bulayeva, Kazima B.; Bernard, Manon; Richards, Jennifer S.; Himali, Jayandra J.; Loeffler, Markus; Rommelse, Nanda; Hoffmann, Wolfgang; Westlye, Lars Tjelta; Valdés Hernández, Maria C.; Hansell, Narelle K.; van Erp, Theo G.M.; Wolf, Christiane; Kwok, John B.J.; Vellas, Bruno; Heinz, Andreas; Olde Loohuis, Loes M.; Delanty, Norman; Ho, Beng-Choon; Ching, Christopher R.K.; Shumskaya, Elena; Singh, Baljeet; Hofman, Albert; Homuth, Georg; Psaty, Bruce M.; Bastin, Mark E.; Montgomery, Grant W.; Foroud, Tatiana M.; Reppermund, Simone; Hottenga, Jouke-Jan; Simmons, Andrew; Meyer-Lindenberg, Andreas; Cahn, Wiepke; Whelan, Christopher D; van Donkelaar, Marjolein M.J.; Yang, Qiong; Hosten, Norbert; Green, Robert C.; Thalamuthu, Anbupalam; Mohnke, Sebastian; Hulshoff Pol, Hilleke E.; Lin, Honghuang; Jack, Clifford R.; Schofield, Peter R.; Mühleisen, Thomas W.; Maillard, Pauline; Potkin, Steven G.; Wen, Wei; Fletcher, Evan; Toga, Arthur W.; Gruber, Oliver; Huentelman, Matthew; Davey Smith, George; Launer, Lenore J.; Nyberg, Lars; Jönsson, Erik Gunnar; Crespo-Facorro, Benedicto; Koen, Nastassja; Greve, Douglas N.; Uitterlinden, André G.; Weinberger, Daniel R.; Steen, Vidar Martin; Fedko, Iryna O.; Groenewold, Nynke A.; Niessen, Wiro J.; Toro, Roberto; Tzourio, Christophe; Longstreth, William T.; Ikram, M. Kamran; Smoller, Jordan W.; van Tol, Marie-Jose; Sussmann, Jessika E.; Paus, Tomáš; Lemaître, Hervé; Schroeter, Matthias L.; Mazoyer, Bernard; Andreassen, Ole Andreas; Holsboer, Florian; Depondt, Chantal; Veltman, Dick J.; Turner, Jessica A.; Pausova, Zdenka; Schumann, Gunter; van Rooij, Daan; Djurovic, Srdjan; Deary, Ian J.; McMahon, Katie L; Müller-Myhsok, Bertram; Brouwer, Rachel M.; Soininen, Hilkka; Pandolfo, Massimo; Wassink, Thomas H.; Cheung, Joshua W.; Wolfers, Thomas; Martinot, Jean-Luc; Zwiers, Marcel P.; Nauck, Matthias; Melle, Ingrid; Martin, Nicholas G.; Kanai, Ryota; Westman, Eric; Kahn, René S.; Sisodiya, Sanjay M.; White, Tonya; Saremi, Arvin; van Bokhoven, Hans; Brunner, Han G.; Völzke, Henry; Wright, Margaret J.; van `t Ent, Dennis; Nöthen, Markus M.; Ophoff, Roel A.; Buitelaar, Jan K.; Fernandéz, Guillén; Sachdev, Perminder S.; Rietschel, Marcella; van Haren, Neeltje E.M.; Fisher, Simon E.; Beiser, Alexa S.; Francks, Clyde; Saykin, Andrew J.; Mather, Karen A.; Romanczuk-Seiferth, Nina; Hartman, Catharina A.; DeStefano, Anita L; Heslenfeld, Dirk J.; Weiner, Michael W.; Walter, Henrik; Hoekstra, Pieter J.; Nyquist, Paul A.; Franke, Barbara; Bennett, David A.; Grabe, Hans J.; Johnson, Andrew D.; Chen, Christopher; van Duijn, Cornelia M.; Lopez, Oscar L.; Fornage, Myriam; Wardlaw, Joanna M.; Schmidt, Reinhold; DeCarli, Charles; De Jager, Philip L.; Villringer, Arno; Debette, Stéphanie; Gudnason, Vilmundur; Medland, Sarah E.; Shulman, Joshua M.; Thompson, Paul M.; Seshadri, Sudha; Ikram, M. Arfan; Doan, Nhat Trung & van der Meer, Dennis (2019). Genetic architecture of subcortical brain structures in 38,851 individuals. Nature Genetics. ISSN 1061-4036. 51, s 1624- 1636 . doi: 10.1038/s41588-019-0511-y Full text in Research Archive. Show summary
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Simonsen, Carmen Elisabeth; Aminoff, Sofie Ragnhild; Vaskinn, Anja; Barrett, Elizabeth Ann; Færden, Ann; Ueland, Torill; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2019). Perceived and experienced stigma in first-episode psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 95:152134, s 1- 8 . doi: 10.1016/j.comppsych.2019.152134 Full text in Research Archive.
Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R.I.; Gaspar, Héléna A.; de Leeuw, Christiaan A.; Steinberg, Stacy; Pavlides, Jennifer M. Whitehead; Trzaskowski, Maciej; Byrne, Enda M.; Pers, Tune H.; Holmans, Peter A.; Richards, Alexander L.; Abbott, Liam; Agerbo, Esben; Akil, Huda; Albani, Diego; Alliey-Rodriguez, Ney; Als, Thomas D.; Anjorin, Adebayo; Antilla, Verneri; Awasthi, Swapnil; Badner, Judith A.; Bækvad-Hansen, Marie; Barchas, Jack D.; Bass, Nicholas; Bauer, Michael; Belliveau, Richard; Bergen, Sarah E.; Pedersen, Carsten Bøcker; Bøen, Erlend; Boks, Marco P.; Boocock, James; Budde, Monika; Bunney, William; Burmeister, Margit; Bybjerg-Grauholm, Jonas; Byerley, William; Casas, Miquel; Cerrato, Felecia; Cervantes, Pablo; Chambert, Kimberly; Charney, Alxander W.; Chen, Danfeng; Churchhouse, Claire; Clarke, Toni-Kim; Coryell, William; Craig, David W.; Cruceanu, Cristiana; Curtis, David; Czerski, Piotr M.; Dale, Anders; de Jong, Simone; Degenhardt, Franziska; Del-Favero, Jurgen; Depaulo, J. Raymond; Djurovic, Srdjan; Dobbyn, Amanda L.; Dumont, Ashley; Elvsåshagen, Torbjørn; Escott-Price, Valentina; Fan, Chun Chieh; Fischer, Sascha B.; Flickinger, Matthew; Foroud, Tatiana M.; Forty, Liz; Frank, Josef; Fraser, Christine; Freimer, Nelson B.; Frisén, Louise; Gade, Katrin; Gage, Diane; Garnham, Julie; Giambartolomei, Claudia; Pedersen, Marianne Giørtz; Goldstein, Jaqueline; Gordon, Scott D.; Gordon-Smith, Katherine; Green, Elaine K.; Green, Melissa J.; Greenwood, Tifany A.; Grove, Jakob; Guan, Weihua; Guzman-Parra, José; Hamshere, Marian L.; Hautzinger, Martin; Heilbronner, Urs; Herms, Stefan; Hipolito, Maria; Hoffmann, Per; Holland, Dominic; Huckins, Laura; Jamain, Stéphane; Johnson, Jessica S.; Juréus, Anders; Kandaswamy, Radhika; Karlsson, Robert; Kennedy, James L.; Kittel-Schneider, Sarah; Knowles, James A.; Kogevinas, Manolis; Koller, Anna C.; Kupka, Ralph; Lavebratt, Catharina; Lawrence, Jacob; Lawson, William B.; Leber, Markus; Lee, Phil H.; Levy, Shawn E.; Li, Jun Z.; Liu, Chunyu; Lucae, Susanne; Maaser, Anna; MacIntyre, Donald J.; Mahon, Pamela B.; Maier, Wolfgang; Martinsson, Lina; McCarroll, Steve; McGuffin, Peter; McInnis, Melvin G.; McKay, James D.; Medeiros, Helena; Medland, Sarah E.; Meng, Fan; Milani, Lili; Montgomery, Grant W.; Morris, Derek W.; Mühleisen, Thomas W.; Mullins, Niamh; Nguyen, Hoang; Nievergelt, Caroline M.; Adolfsson, Annelie Nordin; Nwulia, Evaristus A.; O'Donovan, Claire; Loohuis, Loes M. Olde; Ori, Anil P.S.; Oruc, Lilijana; Ösby, Urban; Perlis, Roy H.; Perry, Amy; Pfennig, Andrea; Potash, James B.; Purcell, Shaun M.; Regeer, Eline J.; Reif, Andreas; Reinbold, Céline S.; Rice, John P.; Rivas, Fabio; Rivera, Margarita; Roussos, Panos; Ruderfer, Douglas M.; Ryu, Euijung; Sánchez-Mora, Cristina; Schatzberg, Alan F.; Scheftner, William A.; Schork, Nicholas J.; Shannon Weickert, Cynthia; Shehktman, Tatyana; Shilling, Paul D.; Sigurdsson, Engilbert; Slaney, Claire; Smeland, Olav Bjerkehagen; Sobell, Janet L.; Søholm Hansen, Christine; Spijker, Anne T.; St Clair, David; Steffens, Michael; Strauss, John S.; Streit, Fabian; Strohmaier, Jana; Szelinger, Szabolcs; Thompson, Robert C.; Thorgeirsson, Thorgeir E; Treutlein, Jens; Vedder, Helmut; Wang, Weiqing; Watson, Stanley J.; Weickert, Thomas W.; Witt, Stephanie H.; Xi, Simon; Xu, Wei; Young, Allan H.; Zandi, Peter; Zhang, Peng; Zöllner, Sebastian; Adolfsson, Rolf; Agartz, Ingrid; Alda, Martin; Backlund, Lena; Baune, Bernhard T.; Bellivier, Frank; Berrettini, Wade H.; Biernacka, Joanna M.; Blackwood, Douglas H.R.; Boehnke, Michael; Børglum, Anders D.; Corvin, Aiden; Craddock, Nicholas; Daly, Mark J.; Dannlowski, Udo; Esko, Tõnu; Etain, Bruno; Frye, Mark; Fullerton, Janice M.; Gershon, Elliot S.; Gill, Michael; Goes, Fernando; Grigoroiu-Serbanescu, Maria; Hauser, Joanna; Hougaard, David M.; Hultman, Christina M.; Jones, Ian; Jones, Lisa A.; Kahn, René S.; Kirov, George; Landén, Mikael; Leboyer, Marion; Lewis, Cathryn M.; Li, Qingqin S.; Lissowska, Jolanta; Martin, Nicholas G.; Mayoral, Fermin; McElroy, Susan L.; McIntosh, Andrew M.; McMahon, Francis J.; Melle, Ingrid; Metspalu, Andres; Mitchell, Philip B.; Morken, Gunnar; Mors, Ole; Mortensen, Preben Bo; Müller-Myhsok, Bertram; Myers, Richard M.; Neale, Benjamin M.; Nimgaonkar, Vishwajit; Nordentoft, Merete; Nöthen, Markus M.; O'Donovan, Michael C; Ødegaard, Ketil Joachim; Owen, Michael J.; Paciga, Sara A.; Pato, Carlos; Pato, Michele T.; Posthuma, Danielle; Ramos-Quiroga, Josep Antoni; Ribasés, Marta; Rietschel, Marcella; Rouleau, Guy A.; Schalling, Martin; Schofield, Peter R.; Schulze, Thomas G.; Serretti, Alessandro; Smoller, Jordan W.; Stefansson, Hreinn; Stefansson, Kari; Stordal, Eystein; Sullivan, Patrick F.; Turecki, Gustavo; Vaaler, Arne; Vieta, Eduard; Vincent, John B.; Werge, Thomas; Nurnberger, John I.; Wray, Naomi R.; Di Florio, Arianna; Edenberg, Howard J.; Cichon, Sven; Ophoff, Roel A.; Scott, Laura J.; Andreassen, Ole Andreas; Kelsoe, John & Sklar, Pamela (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics. ISSN 1061-4036. 51(5), s 793- 803 . doi: 10.1038/s41588-019-0397-8 Full text in Research Archive.
Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Vedal, Trude Seselie Jahr; Smeland, Olav Bjerkehagen; Matson, Wayne; Kaddurah-Daouk, Rima; Agartz, Ingrid; Melle, Ingrid; Djurovic, Srdjan; Jönsson, Erik Gunnar; Bogdanov, Mikhail & Andreassen, Ole Andreas (2019). Metabolic dysfunctions in the kynurenine pathway, noradrenergic and purine metabolism in schizophrenia and bipolar disorders. Psychological Medicine. ISSN 0033-2917. 17(2) . doi: 10.1017/S0033291719000400 Full text in Research Archive.
Storvestre, Guttorm Breivik; Valnes, Lars Magnus; Jensen, Arvid; Nerland, Stener; Tesli, Natalia; Hymer, Knut-Erik; Røsæg, Cato; Server, Andres Alonso; Ringen, Petter Andreas; Jacobsen, Morten; Andreassen, Ole Andreas; Agartz, Ingrid; Melle, Ingrid & Haukvik, Unn Kristin H. (2019). A preliminary study of cortical morphology in schizophrenia patients with a history of violence. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 288, s 29- 36 . doi: 10.1016/j.pscychresns.2019.04.013 Full text in Research Archive.
Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Haug, Elisabeth & Melle, Ingrid (2019). Basic Self-Disturbances Independently Predict Recovery in Psychotic Disorders: A Seven Year Follow-up Study. Schizophrenia Research. ISSN 0920-9964. 212, s 72- 78 . doi: 10.1016/j.schres.2019.08.009 Full text in Research Archive. Show summary
Background Recovery is the ultimate goal of psychosis treatment . Basic self-disturbances (BSDs) are non-psychotic phenomena associated with clinical outcome, present in prodromal, psychotic and residual phases of psychotic disorders. Aim To investigate the relationship between BSDs and recovery seven years after first treatment in patients with psychotic disorders. Method Prospective longitudinal study of 56 patients recruited during first adequate treatment for schizophrenia (n = 35) and other psychotic disorders (n = 21) (psychotic bipolar disorder, delusional disorder, psychotic disorder NOS). At baseline and follow-up BSDs were assessed using the Examination of Anomalous Self-Experience (EASE) manual, while standard clinical instruments were used to ascertained diagnosis, clinical symptom severity, and functioning. Recovery was defined as absence of psychotic symptoms and regaining of functioning that persisted the last two years before follow-up. Results At follow up, 34% achieved recovery (5 (14%) with schizophrenia and 14 (67%) with other psychoses at baseline). Recovery was predicted by an absence of a schizophrenia diagnosis, low baseline level of BSDs and further reductions in BSDs from baseline to follow-up. Change in BSDs was the strongest predictor, also after adjusting for premorbid adjustment and duration of untreated psychosis, and was not confounded by diagnosis. Conclusion Low baseline levels of basic self-disturbances and further reductions over time independently predict recovery seven years later in first treated psychosis patients.
Sønmez, Nasrettin; Romm, Kristin Lie; Østefjells, Tiril; Grande, Marit; Jensen, Lene Hunnicke; Hummelen, Benjamin; Tesli, Martin Steen; Melle, Ingrid & Røssberg, Jan Ivar (2019). Cognitive behavior therapy in early psychosis with a focus on depression and low self-esteem: A randomized controlled trial. Comprehensive Psychiatry. ISSN 0010-440X. 97 . doi: 10.1016/j.comppsych.2019.152157 Full text in Research Archive.
Tesli, Natalia; Westlye, Lars Tjelta; Storvestre, Guttorm Breivik; Gurholt, Tiril Pedersen; Agartz, Ingrid; Melle, Ingrid; Andreassen, Ole Andreas & Haukvik, Unn Kristin H. (2019). White matter microstructure in schizophrenia patients with a history of violence. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. . doi: 10.1007/s00406-019-00988-0
Vaskinn, Anja; Løvgren, André; Egeland, Maj Kristoffersen; Feyer, Frida Karine; Østefjells, Tiril; Andreassen, Ole Andreas; Melle, Ingrid & Sundet, Kjetil Søren (2019). A randomized controlled trial of training of affect recognition (TAR) in schizophrenia shows lasting effects for theory of mind. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(5), s 611- 620 . doi: 10.1007/s00406-019-00997-z Full text in Research Archive.
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2019). Adipokine levels are associated with insulin resistance in antipsychotics users independently of BMI. Psychoneuroendocrinology. ISSN 0306-4530. 103, s 87- 95 . doi: 10.1016/j.psyneuen.2019.01.001 Full text in Research Archive.
Weibell, Melissa Anne E; Johannessen, Jan Olav; Auestad, Bjørn Henrik; Bramness, Jørgen Gustav; Brønnick, Kolbjørn Kallesten; Haahr, Ulrik; Joa, Inge; Larsen, Tor Ketil; Melle, Ingrid; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Røssberg, Jan Ivar; Simonsen, Erik; Vaglum, Per Jørgen Wiggen; Stain, Helen J.; Friis, Svein & Hegelstad, Wenche (2019). Early substance use cessation improves cognition-10 years outcome in first-episode psychosis patients. Frontiers in Psychiatry. ISSN 1664-0640. 10 . doi: 10.3389/fpsyt.2019.00495 Full text in Research Archive. Show summary
Background: Cognitive impairment may be a risk factor for, as well as a consequence of, psychosis. Non-remitting symptoms, premorbid functioning, level of education, and socioeconomic background are known correlates. A possible confounder of these associations is substance use, which is common among patients with psychosis and linked to worse clinical outcomes. Studies however show mixed results for the effect of substance use on cognitive outcomes. In this study, the long-term associations of substance use with cognition in a representative sample of first-episode psychosis patients were examined. Methods: The sample consisted of 195 patients. They were assessed for symptom levels, function, and neurocognition at 1, 2, 5, and 10 years after first treatment. Test scores were grouped into factor analysis-based indices: motor speed, verbal learning, visuomotor processing, verbal fluency, and executive functioning. A standardized composite score of all tests was also used. Patients were divided into four groups based on substance-use patterns during the first 2 years of treatment: persistent users, episodic users, stop-users, and nonusers. Data were analyzed using linear mixed effects modeling. Results: Gender, premorbid academic functioning, and previous education were the strongest predictors of cognitive trajectories. However, on motor speed and verbal learning indices, patients who stopped using substances within the first 2 years of follow-up improved over time, whereas the other groups did not. For verbal fluency, the longitudinal course was parallel for all four groups, while patients who stopped using substances demonstrated superior performances compared with nonusers. Persistent users demonstrated impaired visuomotor processing speed compared with nonusers. Within the stop- and episodic use groups, patients with narrow schizophrenia diagnoses performed worse compared with patients with other diagnoses on verbal learning and on the overall composite neurocognitive index. Discussion: This study is one of very few long-term studies on cognitive impairments in first-episode psychosis focusing explicitly on substance use. Early cessation of substance use was associated with less cognitive impairment and some improvement over time on some cognitive measures, indicating a milder illness course and superior cognitive reserves to draw from in recovering from psychosis.
Aas, Monica; Dieset, Ingrid; Mørch, Ragni Helene; Steen, Nils Eiel; Hope, Sigrun; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Melle, Ingrid; Agartz, Ingrid & Andreassen, Ole Andreas (2018). Reduced brain-derived neurotrophic factor is associated with childhood trauma experiences and number of depressive episodes in severe mental disorders. Schizophrenia Research. ISSN 0920-9964. . doi: 10.1016/j.schres.2018.08.007 Full text in Research Archive.
Aas, Monica; Djurovic, Srdjan; Ueland, Torill; Mørch, Ragni Helene; Anderssen, Jannicke Fjæra; Reponen, Elina Johanna; Cattaneo, Annamaria; Steen, Nils Eiel; Agartz, Ingrid; Melle, Ingrid & Andreassen, Ole Andreas (2018). The relationship between physical activity, clinical and cognitive characteristics and BDNF mRNA levels in patients with severe mental disorders. World Journal of Biological Psychiatry. ISSN 1562-2975. . doi: 10.1080/15622975.2018.1557345
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; Falcone, Guido; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Nikolaos A.; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; Lee, Phil H.; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine; Letenneur, Luc; Hannequin, Didler; Amouyel, Philippe; Boland, Anne; Deleuze, Jean-François; Duron, Emmanuelle; Vardarajan, Badri N.; Reitz, Christiane; Goate, Alison M.; Huentelman, Matthew; Kamboh, M. Ilyas; Larson, Eric B.; Rogaeva, Ekaterina; St George-Hyslop, Peter; Hakonarson, Hakon; Kukull, Walter A.; Farrer, Lindsay A.; Barnes, Lisa L.; Beach, Thomas G.; Demirci, F. Yesam; Head, Elizabeth; Hulette, Christine M.; Jicha, Gregory A.; Kauwe, John S.K.; Kaye, Jeffery A.; Leverenz, James B.; Levey, AIlan I.; Lieberman, Andrew P.; Pankratz, Vernon S.; Poon, Wayne W.; Quinn, Joseph F.; Saykin, Andrew J.; Schneider, Lon S.; Smith, Amanda G.; Sonnen, Joshua A.; Stern, Robert A.; Van Deerlin, Vivianna M.; Van Eldik, Linda J.; Harold, Denise; Russo, Giancarlo; Rubinsztein, David C.; Bayer, Anthony; Tsolaki, Magda; Proitsi, Petra; Fox, Nick C.; Hampel, Harald; Owen, Michael J.; Mead, Simon; Passmore, Peter; Morgan, Kevin; Nöthen, Markus M.; Rossor, Martin; Lupton, Michelle K.; Hoffmann, Per; Kornhuber, Johannes; Lawlor, Brian; McQuillin, Andrew; Al-Chalabi, Ammar; Bis, Joshua C; Ruiz, Agustin; Boada, Mercè; Seshadri, Sudha; Beiser, Alexa; Rice, Kenneth; van der Lee, Sven J.; De Jager, Philip L.; Geschwind, Daniel H.; Riemenschneider, Matthias; Riedel-Heller, Steffi; Rotter, Jerome I.; Ransmayr, Gerhard; Hyman, Bradley T.; Cruchaga, Carlos; Alegret, Montserrat; Winsvold, Bendik K S; Palta, Priit; Farh, Kai-How; Cuenca-Leon, Ester; Furlotte, Nicholas; Kurth, Tobias; Ligthart, Lannie; Terwindt, Gisela M.; Freilinger, Tobias; Ran, Caroline; Gordon, Scott D.; Borck, Guntram; Adams, Hieab H.H.; Lehtimäki, Terho; Wedenoja, Juho; Buring, Julie E.; Schürks, Markus; Hrafnsdóttir, Maria; Hottenga, Jouke-Jan; Penninx, Brenda; Artto, Ville; Kaunisto, Mari; Vepsäläinen, Salli; Martin, Nicholas G.; Montgomery, Grant W.; Kurki, Mitja I.; Hämäläinen, Eija; Huang, Hailiang; Huang, Jie; Sandor, Cynthia; Webber, Caleb; Muller-Myhsok, Bertram; Schreiber, Stefan; Salomaa, Veikko; Loehrer, Elizabeth; Göbel, Hartmut; Macaya, Alfons; Pozo-Rosich, Patricia; Hansen, Thomas; Werge, Thomas; Kaprio, Jaakko; Metspalu, Andres; Kubisch, Christian; Ferrari, Michel D.; Belin, Andrea C.; van den Maagdenberg, Arn M.J.M.; Zwart, John-Anker; Boomsma, Dorret; Eriksson, Nicholas; Olesen, Jes; Chasman, Daniel I.; Nyholt, Dale R.; Avbersek, Andreja; Baum, Larry; Berkovic, Samuel; Bradfield, Jonathan; Buono, Russell; Catarino, Claudia B.; Cossette, Patrick; De Jonghe, Peter; Depondt, Chantal; Dlugos, Dennis; Ferraro, Thomas N.; French, Jacqueline; Hjalgrim, Helle; Jamnadas-Khoda, Jennifer; Kälviäinen, Reetta; Kunz, Wolfram S.; Lerche, Holger; Leu, Costin; Lindhout, Dick; Lo, Warren; Lowenstein, Daniel; McCormack, Mark; Møller, Rikke S.; Molloy, Anne; Ng, Ping-Wing; Oliver, Karen; Privitera, Michael; Radtke, Rodney; Ruppert, Ann-Kathrin; Sander, Thomas; Schachter, Steven; Schankin, Christoph; Scheffer, Ingrid; Schoch, Susanne; Sisodiya, Sanjay M.; Smith, Philip; Sperling, Michael; Striano, Pasquale; Surges, Rainer; Thomas, G. Neil; Visscher, Frank; Whelan, Christopher D.; Zara, Federico; Heinzen, Erin L.; Marson, Anthony; Becker, Felicitas; Stroink, Hans; Zimprich, Fritz; Gasser, Thomas; Gibbs, Raphael; Heutink, Peter; Martinez, Maria; Morris, Huw R.; Sharma, Manu; Ryten, Mina; Mok, Kin Y.; Pulit, Sara; Bevan, Steve; Holliday, Elizabeth; Attia, John; Battey, Thomas; Boncoraglio, Giorgio; Thijs, Vincent; Chen, Wei-Min; Mitchell, Braxton; Rothwell, Peter; Sharma, Pankaj; Sudlow, Cathie; Vicente, Astrid; Markus, Hugh; Kourkoulis, Christina; Pera, Joana; Raffeld, Miriam; Silliman, Scott; Perica, Vesna Boraska; Thornton, Laura M.; Huckins, Laura M.; Rayner, N. William; Lewis, Cathryn M.; Gratacos, Monica; Rybakowski, Filip; Keski-Rahkonen, Anna; Raevuori, Anu; Hudson, James I.; Reichborn-Kjennerud, Ted; Monteleone, Palmiero; Karwautz, Andreas; Mannik, Katrin; Baker, Jessica H.; O'Toole, Julie K.; Trace, Sara E.; Davis, Oliver S.P.; Helder, Sietske G.; Ehrlich, Stefan; Herpertz-Dahlmann, Beate; Danner, Unna N.; van Elburg, Annemarie A.; Clementi, Maurizio; Forzan, Monica; Docampo, Elisa; Lissowska, Jolanta; Hauser, Joanna; Tortorella, Alfonso; Maj, Mario; Gonidakis, Fragiskos; Tziouvas, Konstantinos; Papezova, Hana; Yilmaz, Zeynep; Wagner, Gudrun; Cohen-Woods, Sarah; Herms, Stefan; Julia, Antonio; Rabionet, Raquel; Dick, Danielle M.; Ripatti, Samuli; Andreassen, Ole Andreas; Espeseth, Thomas; Lundervold, Astri; Steen, Vidar Martin; Pinto, Dalila; Scherer, Stephen W.; Aschauer, Harald; Schosser, Alexandra; Alfredsson, Lars; Padyukov, Leonid; Halmi, Katherine A.; Mitchell, James; Strober, Michael; Bergen, Andrew W.; Kaye, Walter; Szatkiewicz, Jin Peng; Cormand, Bru; Ramos-Quiroga, Josep Antoni; Sánchez-Mora, Cristina; Ribasés, Marta; Casas, Miguel; Hervas, Amaia; Arranz, Maria Jesús; Haavik, Jan; Zayats, Tetyana; Johansson, Stefan; Williams, Nigel; Dempfle, Astrid; Rothenberger, Aribert; Kuntsi, Jonna; Oades, Robert D.; Banaschewski, Tobias; Franke, Barbara; Buitelaar, Jan K.; Vasquez, Alejandro Arias; Doyle, Alysa E.; Reif, Andreas; Lesch, Klaus-Peter; Freitag, Christine; Rivero, Olga; Palmason, Haukur; Romanos, Marcel; Langley, Kate; Rietschel, Marcella; Witt, Stephanie H.; Dalsgaard, Søren; Børglum, Anders D.; Waldman, Irwin; Wilmot, Beth; Molly, Nikolas; Bau, Claiton Henrique Dotto; Crosbie, Jennifer; Schachar, Russell; Loo, Sandra K.; McGough, James J.; Grevet, Eugenio H.; Medland, Sarah E.; Robinson, Elise; Weiss, Lauren A.; Bacchelli, Elena; Bailey, Anthony; Bal, Vanessa; Battaglia, Agatino; Betancur, Catalina; Bolton, Patrick; Cantor, Rita; Celestino-Soper, Patrícia; Dawson, Geraldine; De Rubeis, Silvia; Duque, Frederico; Green, Andrew; Klauck, Sabine M.; Leboyer, Marion; Levitt, Pat; Maestrini, Elena; Mane, Shrikant; Moreno-De-Luca, Daniel; Parr, Jeremy; Regan, Regina; Reichenberg, Abraham; Sandin, Sven; Vorstman, Jacob; Wassink, Thomas; Wijsman, Ellen; Cook, Edwin; Santangelo, Susan; Delorme, Richard; Rogé, Bernadette; Magalhaes, Tiago; Arking, Dan; Schulze, Thomas G.; Thompson, Robert C.; Strohmaier, Jana; Matthews, Keith; Melle, Ingrid; Morris, Derek; Blackwood, Douglas; McIntosh, Andrew; Bergen, Sarah E.; Schalling, Martin; Jamain, Stéphane; Maaser, Anna; Fischer, Sascha B.; Reinbold, Céline S.; Fullerton, Janice M.; Guzman-Parra, José; Mayoral, Fermin; Schofield, Peter R.; Cichon, Sven; Mühleisen, Thomas W.; Degenhardt, Franziska; Schumacher, Johannes; Bauer, Michael; Mitchell, Philip B.; Gershon, Elliot S.; Rice, John; Potash, James B.; Zandi, Peter P.; Craddock, Nick; Ferrier, I. Nicol; Alda, Martin; Rouleau, Guy A.; Turecki, Gustavo; Ophoff, Roel; Pato, Carlos; Anjorin, Adebayo; Stahl, Eli; Leber, Markus; Czerski, Piotr M.; Cruceanu, Cristiana; Jones, Ian R.; Posthuma, Danielle; Andlauer, Till F.M.; Forstner, Andreas J.; Streit, Fabian; Baune, Bernhard T.; Air, Tracy; Sinnamon, Grant; Wray, Naomi R.; MacIntyre, Donald J.; Porteous, David; Homuth, Georg; Rivera, Margarita; Grove, Jakob; Middeldorp, Christel M.; Hickie, Ian; Pergadia, Michele; Mehta, Divya; Smit, Johannes H.; Jansen, Rick; De Geus, Eco; Dunn, Erin; Li, Qingqin S.; Nauck, Matthias; Schoevers, Robert A.; Beekman, Aartjan T.F.; Knowles, James A.; Viktorin, Alexander; Arnold, Paul; Barr, Cathy L.; Bedoya-Berrio, Gabriel; Bienvenu, O. Joseph; Brentani, Helena; Burton, Christie; Camarena, Beatriz; Cappi, Carolina; Cath, Danielle; Cavallini, Maria; Cusi, Daniele; Darrow, Sabrina; Denys, Damiaan; Derks, Eske M.; Dietrich, Andrea; Fernandez, Thomas; Figee, Martijn; Freimer, Nelson; Gerber, Gloria; Grados, Marco; Greenberg, Erica; Hanna, Gregory L.; Hartmann, Andreas; Hirschtritt, Matthew E.; Hoekstra, Pieter J.; Huang, Alden; Huyser, Chaim; Illmann, Cornelia; Jenike, Michael; Kuperman, Samuel; Leventhal, Bennett; Lochner, Christine; Lyon, Gholson J.; Macciardi, Fabio; Madruga-Garrido, Marcos; Malaty, Irene A.; Maras, Athanasios; McGrath, Lauren; Miguel, Eurípedes C.; Mir, Pablo; Nestadt, Gerald; Nicolini, Humberto; Okun, Michael S.; Pakstis, Andrew; Paschou, Peristera; Piacentini, John; Pittenger, Christopher; Plessen, Kerstin; Ramensky, Vasily; Ramos, Eliana M.; Reus, Victor; Richter, Margaret A.; Riddle, Mark A.; Robertson, Mary M.; Roessner, Veit; Rosário, Maria; Samuels, Jack F.; Sandor, Paul; Stein, Dan J.; Tsetsos, Fotis; Van Nieuwerburgh, Filip; Weatherall, Sarah; Wendland, Jens R.; Wolanczyk, Tomasz; Worbe, Yulia; Zai, Gwyneth; Goes, Fernando S.; McLaughlin, Nicole; Nestadt, Paul S.; Grabe, Hans-Jörgen; Depienne, Christel; Konkashbaev, Anuar; Lanzagorta, Núria; Valencia-Duarte, Ana; Bramon, Elvira; Buccola, Nancy; Cahn, Wiepke; Cairns, Murray; Chong, Siow A.; Cohen, David; Crespo-Facorro, Benedicto; Crowley, James; Davidson, Michael; DeLisi, Lynn; Dinan, Timothy; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Haan, Lieuwe; Hougaard, David; Karachanak-Yankova, Sena; Khrunin, Andrey; Klovins, Janis; Kučinskas, Vaidutis; Keong, Jimmy Lee Chee; Limborska, Svetlana; Loughland, Carmel; Lonnqvist, Jouko; Maher, Brion; Mattheisen, Manuel; McDonald, Colm; Murphy, Kieran C.; Nenadic, Igor; Van Os, Jim; Pantelis, Christos; Pato, Michele; Petryshen, Tracey; Quested, Digby; Roussos, Panos; Sanders, Alan R.; Schall, Ulrich; Schwab, Sibylle G.; Sim, Kang; So, Hon-Cheong; Stogmann, Elisabeth; Subramaniam, Mythily; Toncheva, Draga; Waddington, John; Walters, James; Weiser, Mark; Cheng, Wei; Cloninger, Robert; Curtis, David; Gejman, Pablo V.; Henskens, Frans; Mattingsdal, Morten; Oh, Sang-Yun; Scott, Rodney; Webb, Bradley; Breen, Gerome; Churchhouse, Claire; Bulik, Cynthia M.; Daly, Mark; Dichgans, Martin; Faraone, Stephen V.; Guerreiro, Rita; Holmans, Peter; Kendler, Kenneth S.; Koeleman, Bobby; Mathews, Carol A.; Price, Alkes; Scharf, Jeremiah; Sklar, Pamela; Williams, Julie; Wood, Nicholas W.; Cotsapas, Chris; Palotie, Aarno; Smoller, Jordan W.; Sullivan, Patrick; Rosand, Jonathan; Corvin, Aiden & Neale, Benjamin M. (2018). Analysis of shared heritability in common disorders of the brain. Science. ISSN 0036-8075. 360(6395) . doi: 10.1126/science.aap8757
Berg, Akiah Ottesen; Jørgensen, Kjetil Nordbø; Nerhus, Mari; Athanasiu, Lavinia; Popejoy, Alice; Bettella, Francesco; Norbom, Linn Christin Bonaventure; Gurholt, Tiril Pedersen; Dahl, Sandra Rinne; Andreassen, Ole Andreas; Djurovic, Srdjan; Agartz, Ingrid & Melle, Ingrid (2018). Vitamin D levels, brain volume, and genetic architecture in patients with psychosis. PLOS ONE. ISSN 1932-6203. 13(8) . doi: 10.1371/journal.pone.0200250 Full text in Research Archive.
Bjørnestad, Jone Ravndal; Veseth, Marius; Davidson, Larry; Joa, Inge; Johannessen, Jan Olav; Larsen, Tor Ketil; Melle, Ingrid & Hegelstad, Wenche (2018). Psychotherapy in psychosis: Experiences of fully recovered service users. Frontiers in Psychology. ISSN 1664-1078. 9, s 1- 7 . doi: 10.3389/fpsyg.2018.01675 Full text in Research Archive.
Büchmann, Camilla Bakkalia; Pedersen, Geir Feigum; Aminoff, Sofie Ragnhild; Anderssen, Jannicke Fjæra; Barrett, Elizabeth Ann; Melle, Ingrid & Lagerberg, Trine Vik (2018). Validity of the Birchwood Insight Scale in patients with schizophrenia spectrum- and bipolar disorders. Psychiatry Research. ISSN 0165-1781. 272, s 715- 722 . doi: 10.1016/j.psychres.2018.12.072 Full text in Research Archive. Show summary
The aim of this study is to investigate the validity of the Norwegian version of the Insight Scale (IS) in large and representative samples of patients with schizophrenia spectrum disorders, bipolar I disorder and bipolar II disorder. A total of 997 participants were included (schizophrenia spectrum disorders: 557; bipolar I disorder: 282; bipolar II disorder: 138). Confirmatory factor analysis was conducted to investigate the construct validity and bivariate correlational analysis was applied to investigate convergent validity. Confirmatory factor analyses indicated a reasonable model fit to the original three-factor subscale structure of the IS in all three diagnostic groups. The IS total score and its subscales correlated significantly with both the insight items in the Young Mania Rating Scale and the Positive and Negative Syndrome Scale in both schizophrenia spectrum disorders and bipolar I disorder. In the bipolar II disorder group, however, the IS subscales correlated poorly with both the observer-rated measures. Our study supports the construct validity of the IS in both schizophrenia spectrum disorder- and bipolar disorder populations. The study also demonstrates that patients’ self-reports of insight correspond to observer-based single item ratings of insight in bipolar I disorder and schizophrenia spectrum disorders.
Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Christoforou, Andrea; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd & Deary, Ian J. (2018). Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function. Nature Communications. ISSN 2041-1723. 9(2098), s 1- 16 . doi: 10.1038/s41467-018-04362-x Full text in Research Archive.
de Jong, Simone; Diniz, Mateus Jose Abdalla; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Thompson, Wesley Kurt; Wang, Yunpeng; Djurovic, Srdjan; Melle, Ingrid; Morken, Gunnar; Andreassen, Ole Andreas; Mattingsdal, Morten; Curtis, Charles; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O`Reilly, Paul F.; Belangero, Sintia I.; Bressan, Rodrigo A. & Breen, Gerome (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology. ISSN 2399-3642. 1(163) . doi: 10.1038/s42003-018-0155-y Full text in Research Archive.
Demmo, Christine; Lagerberg, Trine Vik; Kvitland, Levi Røstad; Aminoff, Sofie Ragnhild; Hellvin, Tone; Simonsen, Carmen Elisabeth; Haatveit, Beathe Almenning; Andreassen, Ole Andreas; Melle, Ingrid & Ueland, Torill (2018). Neurocognitive functioning, clinical course and functional outcome in first-treatment bipolar I disorder patients with and without clinical relapse: A 1-year follow-up study. Bipolar Disorders. ISSN 1398-5647. 20(3), s 228- 237 . doi: 10.1111/bdi.12569 Show summary
OBJECTIVES: Due to limited research on the association between recurrence of mood episodes and the longitudinal course of neurocognitive functioning in early phase bipolar I disorder (BD I), the impact of recurrence on neurocognition remains unclear. Further, a strong correlation between neurocognitive impairment and functional impairment has been demonstrated. The longitudinal relationship between neurocognitive impairment and functional outcome in relation to recurrence is, however, not established. METHODS: The current study investigated the longitudinal relationship between neurocognition, recurrence of mood episodes and functional outcome in a sample of first-treatment (FT) BD I patients (N = 42), with and without relapse, during a 1-year follow-up period. The longitudinal course of neurocognitive functioning in the patients was also compared to that of a group of healthy controls (N = 143). RESULTS: Compared to both patients with relapse and healthy controls, no-relapse patients showed neurocognitive improvements. The polarity of the relapse episodes was mostly depressive, and for the no-relapse patients, reduction of symptoms was associated with neurocognitive improvement. No-relapse patients showed better global and occupational functioning. CONCLUSIONS: The current study found different neurocognitive and functional trajectories in FT BD I patients with and without relapse, with differences at follow-up to some degree being mediated by current symptoms. The current findings highlight the importance of treatment focusing on neurocognition and symptom states with the aim of improving functional recovery.
Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Reponen, Elina Johanna; Gran, Jon Michael; Aas, Monica; Michelsen, Annika; Reichborn-Kjennerud, Ted; Nesvåg, Ragnar; Agartz, Ingrid; Melle, Ingrid; Aukrust, Pål; Djurovic, Srdjan; Ueland, Torill & Andreassen, Ole Andreas (2018). An association between YKL-40 and type 2 diabetes in psychotic disorders. Acta Psychiatrica Scandinavica. ISSN 0001-690X. 139, s 37- 45 . doi: 10.1111/acps.12971
Færden, Ann; Lyngstad, Siv Hege; Simonsen, Carmen Elisabeth; Ringen, Petter Andreas; Papsuev, Oleg; Dieset, Ingrid; Andreassen, Ole Andreas; Agartz, Ingrid; Marder, Stephen R. & Melle, Ingrid (2018). Reliability and validity of the self-report version of the apathy evaluation scale in first-episode Psychosis: Concordance with the clinical version at baseline and 12 months follow-up. Psychiatry Research. ISSN 0165-1781. 267, s 140- 147 . doi: 10.1016/j.psychres.2018.05.065 Full text in Research Archive.
Gardsjord, Erlend Strand; Romm, Kristin Lie; Røssberg, Jan Ivar; Friis, Svein; Barder, Helene; Evensen, Julie Horgen; Haahr, Ulrik; Hegelstad, Wenche; Joa, Inge; Johannessen, Jan Olav; Langeveld, Johannes H.; Larsen, Tor Ketil; Ilner, Stein E. Opjordsmoen; Rund, Bjørn Rishovd; Simonsen, Erik; Vaglum, Per Jørgen Wiggen & Melle, Ingrid (2018). Depression and functioning are important to subjective quality of life after a first episode psychosis. Comprehensive Psychiatry. ISSN 0010-440X. 86, s 107- 114 . doi: 10.1016/j.comppsych.2018.07.014
Gjerde, Priyanthi Borgen; Dieset, Ingrid; Simonsen, Carmen Elisabeth; Hoseth, Eva Zsuzsanna; Iversen, Trude Seselie Jahr; Lagerberg, Trine Vik; Lyngstad, Siv Hege; Mørch, Ragni Helene; Skrede, Silje; Andreassen, Ole Andreas; Melle, Ingrid & Steen, Vidar Martin (2018). Increase in serum HDL level is associated with less negative symptoms after one year of antipsychotic treatment in first-episode psychosis. Schizophrenia Research. ISSN 0920-9964. 197, s 253- 260 . doi: 10.1016/j.schres.2017.10.042 Full text in Research Archive. Show summary
Background A potential link between increase in total cholesterol and triglycerides and clinical improvement has been observed during antipsychotic drug treatment in chronic schizophrenia patients, possibly due to drug related effects on lipid biosynthesis. We examined whether changes in serum lipids are associated with alleviation of psychosis symptoms after one year of antipsychotic drug treatment in a cohort of first-episode psychosis (FEP) patients. Methods A total of 132 non-affective antipsychotic-treated FEP patients were included through the Norwegian Thematically Organized Psychosis (TOP) project. Data on antipsychotic usage, serum lipids (total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol and triglycerides (TG)), body mass index (BMI) and clinical state were obtained at baseline and after 12 months. The Positive and Negative Syndrome Scale (PANSS) was used to assess psychotic symptoms. Mixed-effects models were employed to examine the relationship between serum lipids and psychotic symptoms while controlling for potential confounders including BMI. Results An increase in HDL during one year of antipsychotic treatment was associated with reduction in PANSS negative subscores (B = − 0.48, p = 0.03). This relationship was not affected by concurrent change in BMI (adjusted HDL: B = − 0.54, p = 0.02). No significant associations were found between serum lipids, BMI and PANSS positive subscores. Conclusion We found that an increase in HDL level during antipsychotic treatment is associated with improvement in negative symptoms in FEP. These findings warrant further investigation to clarify the interaction between lipid pathways and psychosis.
Gjerde, Priyanthi Borgen; Jørgensen, Kjetil Nordbø; Steen, Nils Eiel; Melle, Ingrid; Andreassen, Ole Andreas; Steen, Vidar Martin & Agartz, Ingrid (2018). Association between olanzapine treatment and brain cortical thickness and gray/white matter contrast is moderated by cholesterol in psychotic disorders. Psychiatry Research : Neuroimaging. ISSN 0925-4927. 282, s 55- 63 . doi: 10.1016/j.pscychresns.2018.10.001
Gohar, Sherif Mostafa Mohamed Ahmed; Dieset, Ingrid; Steen, Nils Eiel; Mørch, Ragni Helene; Vedal, Trude Seselie Jahr; Steen, Vidar Martin; Andreassen, Ole Andreas & Melle, Ingrid (2018). Association between serum lipid levels, osteoprotegerin and depressive symptomatology in psychotic disorders. European Archives of Psychiatry and Clinical Neuroscience. ISSN 0940-1334. 269(7), s 795- 802 . doi: 10.1007/s00406-018-0897-z Full text in Research Archive.
Gurholt, Tiril Pedersen; Osnes, Kåre; Nerhus, Mari; Jørgensen, Kjetil Nordbø; Lonning, Vera Louise Hiorth; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-29141-y Full text in Research Archive.
Hartberg, Cecilie Bhandari; Lange, Elisabeth Heffermehl; Lagerberg, Trine Vik; Haukvik, Unn Kristin H.; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Cortical thickness, cortical surface area and subcortical volumes in schizophrenia and bipolar disorder patients with cannabis use. European Neuropsychopharmacology. ISSN 0924-977X. 28(1), s 37- 47 . doi: 10.1016/j.euroneuro.2017.11.019
Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Attenuated Notch signaling in schizophrenia and bipolar disorder. Scientific Reports. ISSN 2045-2322. 8:5349, s 1- 8 . doi: 10.1038/s41598-018-23703-w Full text in Research Archive.
Hoseth, Eva Zsuzsanna; Krull, Florian; Dieset, Ingrid; Mørch, Ragni Helene; Hope, Sigrun; Gardsjord, Erlend Strand; Steen, Nils Eiel; Melle, Ingrid; Brattbakk, Hans-Richard; Steen, Vidar Martin; Aukrust, Pål; Djurovic, Srdjan; Andreassen, Ole Andreas & Ueland, Thor (2018). Exploring the Wnt signaling pathway in schizophrenia and bipolar disorder. Translational psychiatry. ISSN 2158-3188. 8:55, s 1- 10 . doi: 10.1038/s41398-018-0102-1 Full text in Research Archive.
Iversen, Trude Seselie Jahr; Steen, Nils Eiel; Dieset, Ingrid; Hope, Sigrun; Mørch, Ragni Helene; Gardsjord, Erlend Strand; Jørgensen, Kjetil Nordbø; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Side effect burden of antipsychotic drugs in real life - Impact of gender and polypharmacy. Progress in Neuro-psychopharmacology and Biological Psychiatry. ISSN 0278-5846. 82, s 263- 271 . doi: 10.1016/j.pnpbp.2017.11.004
Lyngstad, Siv Hege; Gardsjord, Erlend Strand; Simonsen, Carmen Elisabeth; Engen, Magnus Johan; Romm, Kristin Lie; Melle, Ingrid & Færden, Ann (2018). Consequences of persistent depression and apathy in first-episode psychosis ? A one-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 86, s 60- 66 . doi: 10.1016/j.comppsych.2018.07.015
Maier, Robert M.; Zhu, Zhihong; Lee, Sang Hong; Trzaskowski, Maciej; Ruderfer, Douglas M.; Stahl, Eli A.; Ripke, Stephan; Wray, Naomi R.; Yang, Jian; Visscher, Peter M.; Robinson, Matthew R.; Wang, Yunpeng; Elvsåshagen, Torbjørn; Djurovic, Srdjan; Agartz, Ingrid; Mattingsdal, Morten & Melle, Ingrid (2018). Improving genetic prediction by leveraging genetic correlations among human diseases and traits. Nature Communications. ISSN 2041-1723. 9:989, s 1- 17 . doi: 10.1038/s41467-017-02769-6
Mørch-Johnsen, Lynn; Nerland, Stener; Jørgensen, Kjetil Nordbø; Osnes, Kåre; Hartberg, Cecilie Bhandari; Andreassen, Ole Andreas; Melle, Ingrid; Nesvåg, Ragnar & Agartz, Ingrid (2018). Cortical thickness abnormalities in bipolar disorder patients with a lifetime history of auditory hallucinations. Bipolar Disorders. ISSN 1398-5647. 20(7), s 647- 657 . doi: 10.1111/bdi.12627
Ni, Guiyan; Gratten, Jacob; Wray, Naomi R.; Lee, Sang Hong; Agartz, Ingrid; Djurovic, Srdjan; Joa, Inge; Mattingsdal, Morten; Melle, Ingrid; Andreassen, Ole Andreas & Jönsson, Erik Gunnar (2018). Age at first birth in women is genetically associated with increased risk of schizophrenia. Scientific Reports. ISSN 2045-2322. 8 . doi: 10.1038/s41598-018-28160-z Full text in Research Archive.
Psychiatric Genomics Consorti, Bipolar Sczhizophrenia; Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alxander W.; Ori, Anil P.S.; Domenici, Enrico; Di Florio, A; Papiol, S; Kalman, Janos; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Djurovic, Srdjan; Elvsåshagen, Torbjørn; Joa, Inge; Malt, Ulrik Fredrik; Mattingsdal, Morten; Melle, Ingrid; Morken, Gunnar; Nordentoft, Merete; Nordin, Annelie; Ødegaard, Ketil Joachim; Smeland, Olav Bjerkehagen; Stordal, Eystein; Vaaler, Arne; Wang, Yunpeng; Zheng, Xuebin; Zimprich, Fritz; Zöllner, Sebastian; Corvin, Aiden; Fanous, Ayman H.; Rietschel, Marcella; Gershon, Elliot S.; Schulze, Thomas G.; Cuellar-Barboza, Alfredo B.; Forstner, Andreas J.; Holmans, Peter A.; Nurnberger, John I.; Andreassen, Ole Andreas; Hong Lee, S; O'Donovan, Michael C.; Sullivan, Patrick F.; Ophoff, Roel A.; Wray, Naomi R.; Sklar, Pamela & Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes.. Cell. ISSN 0092-8674. 173(7), s 1705- 1715 . doi: 10.1016/j.cell.2018.05.046
Savage, Jeanne E.; Jansen, Philip R.; Stringer, Sven; Watanabe, Kyoko; Bryois, Julien; de Leeuw, Christiaan A.; Nagel, Mats; Awasthi, Swapnil; Barr, Peter B.; Coleman, Jonathan R.I.; Grasby, Katrina L.; Hammerschlag, Anke R.; Kaminski, Jakob A.; Karlsson, Robert; Krapohl, Eva; Lam, Max; Nygaard, Marianne; Reynolds, Chandra A.; Trampush, Joey W.; Young, Hannah; Zabaneh, Delilah; Hägg, Sara; Hansell, Narelle K.; Karlsson, Ida K.; Linnarsson, Sten; Montgomery, Grant W.; Muñoz-Manchado, Ana B.; Quinlan, Erin B.; Schumann, Gunter; Skene, Nathan G.; Webb, Bradley T.; White, Tonya; Arking, Dan E.; Avramopoulos, Dimitrios; Bilder, Robert M.; Bitsios, Panos; Burdick, Katherine E.; Cannon, Tyrone D.; Chiba-Falek, Ornit; Christoforou, Andrea; Cirulli, Elizabeth T.; Congdon, Eliza; Corvin, Aiden; Davies, Gail; Deary, Ian J.; DeRosse, Pamela; Dickinson, Dwight; Djurovic, Srdjan; Donohoe, Gary; Conley, Emily Drabant; Eriksson, Johan G.; Espeseth, Thomas; Freimer, Nelson A.; Giakoumaki, Stella; Giegling, Ina; Gill, Michael; Glahn, David C.; Hariri, Ahmad; Hatzimanolis, Alex; Keller, Matthew C.; Knowles, Emma; Koltai, Deborah; Konte, Bettina; Lahti, Jari; Le Hellard, Stephanie; Lencz, Todd; Liewald, David C.; London, Edythe; Lundervold, Astri; Malhotra, Anil K.; Melle, Ingrid; Morris, Derek; Need, Anna C.; Ollier, William; Palotie, Aarno; Payton, Antony; Pendleton, Neil; Poldrack, Russell A.; Räikkönen, Katri; Reinvang, Ivar; Roussos, Panos; Rujescu, Dan; Sabb, Fred W.; Scult, Matthew A; Smeland, Olav Bjerkehagen; Smyrnis, Nikolaos; Starr, John M; Steen, Vidar Martin; Stefanis, Nikos C.; Straub, Richard E.; Sundet, Kjetil Søren; Tiemeier, Henning; Voineskos, Aristotle N.; Weinberger, Daniel R.; Widén, Elisabeth; Yu, Jin; Abecasis, Goncalo; Andreassen, Ole Andreas; Breen, Gerome; Christiansen, Lene; Debrabant, Birgit; Dick, Danielle M.; Heinz, Andreas; Hjerling-Leffler, Jens; Ikram, M. Arfan; Kendler, Kenneth S.; Martin, Nicholas G.; Medland, Sarah E.; Pedersen, Nancy L.; Plomin, Robert; Polderman, Tinca J.C.; Ripke, Stephan; van der Sluis, Sophie; Sullivan, Patrick F.; Vrieze, Scott I; Wright, Margaret J. & Posthuma, Daniëlle (2018). Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nature Genetics. ISSN 1061-4036. 50, s 912- 919 . doi: 10.1038/s41588-018-0152-6
Simonsen, Carmen Elisabeth; Færden, Ann; Ueland, Torill; Vaskinn, Anja; Bjella, Thomas; Andreassen, Ole Andreas; Romm, Kristin Lie & Melle, Ingrid (2018). Self-rated disability in first treated episode of psychosis: A 1-year follow-up study. Comprehensive Psychiatry. ISSN 0010-440X. 85, s 48- 54 . doi: 10.1016/j.comppsych.2018.06.004 Full text in Research Archive.
Srinivasan, Saurabh; Bettella, Francesco; Frei, Oleksandr; Hill, W. David; Wang, Yunpeng; Witoelar, Aree; Schork, Andrew J.; Thompson, Wesley Kurt; Davies, Gail; Desikan, Rahul S.; Deary, Ian J.; Melle, Ingrid; Ueland, Torill; Dale, Anders; Djurovic, Srdjan; Smeland, Olav Bjerkehagen & Andreassen, Ole Andreas (2018). Enrichment of genetic markers of recent human evolution in educational and cognitive traits. Scientific Reports. ISSN 2045-2322. 8:12585, s 1- 9 . doi: 10.1038/s41598-018-30387-9 Full text in Research Archive.
Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid & Haug, Elisabeth (2018). Stability in basic self-disturbances and diagnosis in a first treated psychosis: A seven year follow-up study. Schizophrenia Research. ISSN 0920-9964. 202, s 274- 280 . doi: 10.1016/j.schres.2018.07.011 Full text in Research Archive.
van der Meer, Dennis; Rokicki, Jaroslav; Kaufmann, Tobias; Còrdova Palomera, Aldo; Moberget, Torgeir; Alnæs, Dag; Bettella, Francesco; Frei, Oleksandr; Doan, Nhat Trung; Sønderby, Ida Elken; Smeland, Olav Bjerkehagen; Agartz, Ingrid; Bertolino, Alessandro; Bralten, Janita; Brandt, Christine Lycke; Buitelaar, Jan K.; Djurovic, Srdjan; van Donkelaar, Marjolein; Dørum, Erlend Solberg; Espeseth, Thomas; Faraone, Stephen V.; Fernandéz, Guillén; Fisher, Simon E.; Franke, Barbara; Haatveit, Beathe Christin; Hartman, Catharina A.; Hoekstra, Pieter J.; Håberg, Asta; Jönsson, Erik Gunnar; Kolskår, Knut-Kristian; Le Hellard, Stephanie; Lund, Martina Jonette; Lundervold, Astri; Lundervold, Arvid; Melle, Ingrid; Monereo Sanchez, Jennifer; Norbom, Linn Christin Bonaventure; Nordvik, Jan Egil; Nyberg, Lars; Oosterlaan, Jaap; Papalino, Marco; Papassotiropoulos, Andreas; Pergola, Giulio; de Quervain, Dominique J.F.; Richard, Geneviéve´; Sanders, Anne-Marthe; Selvaggi, Pierluigi; Shumskaya, Elena; Steen, Vidar Martin; Tønnesen, Siren; Ulrichsen, Kristine Moe; Zwiers, Marcel P.; Andreassen, Ole Andreas & Westlye, Lars Tjelta (2018). Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes. Molecular Psychiatry. ISSN 1359-4184. s 1- 13 . doi: 10.1038/s41380-018-0262-7 Full text in Research Archive.
Van Erp, Theo G.M.; Walton, Esther; Hibar, Derrek; Schmaal, Lianne; Jiang, Wenhao; Glahn, David C.; Pearlson, Godfrey D.; Yao, Nailin; Fukunaga, Masaki; Hashimoto, Ryota; Okada, Naohiro; Yamamori, Hidenaga; Bustillo, Juan R.; Clark, Vincent P.; Agartz, Ingrid; Mueller, Bryon A.; Cahn, Wiepke; de Zwarte, Sonja M.C.; Hulshoff Pol, Hilleke E.; Kahn, René S.; Ophoff, Roel A.; van Haren, Neeltje E.M.; Andreassen, Ole Andreas; Dale, Anders; Doan, Nhat Trung; Gurholt, Tiril Pedersen; Hartberg, Cecilie Bhandari; Haukvik, Unn Kristin H.; Jørgensen, Kjetil Nordbø; Lagerberg, Trine Vik; Melle, Ingrid; Westlye, Lars Tjelta; Gruber, Oliver; Kraemer, Bernd; Richter, Anja; Zilles, David; Calhoun, Vince D.; Crespo-Facorro, Benedicto; Roiz-Santiañez, Roberto; Tordesillas-Gutiérrez, Diana; Loughland, Carmel; Carr, Vaughan J.; Catts, Stanley; Cropley, Vanessa L.; Fullerton, Janice M.; Green, Melissa J.; Henskens, Frans A.; Jablensky, Assen; Lenroot, Rhoshel K.; Mowry, Bryan J.; Michie, Patricia T.; Pantelis, Christos; Quide, Yann; Schall, Ulrich; Scott, Rodney J.; Cairns, Murray J.; Seal, Marc; Tooney, Paul A.; Rasser, Paul E.; Cooper, Gavin; Shannon Weickert, Cynthia; Weickert, Thomas W.; Morris, Derek W.; Hong, Elliot; Kochunov, Peter; Beard, Lauren M.; Gur, Raquel E.; Gur, Ruben C.; Satterthwaite, Theodore D; Wolf, Daniel H.; Belger, Aysenil; Brown, Gregory G.; Ford, Judith M.; Macciardi, Fabio; Mathalon, Daniel H.; O'Leary, Daniel S.; Potkin, Steven G.; Preda, Adrian; Voyvodic, James; Lim, Kelvin O.; McEwen, Sarah; Yang, Fude; Tan, Yunlong; Tan, Shuping; Wang, Zhiren; Fan, Fengmei; Chen, Jingxu; Xiang, Hong; Tang, Shiyou; Guo, Hua; Wan, Ping; Wei, Dong; Bockholt, Henry J.; Ehrlich, Stefan; Wolthusen, Rick P.F.; King, Margaret D.; Shoemaker, Jody M.; Sponheim, Scott R.; De Haan, Lieuwe; Koenders, Laura; Machielsen, Marise W.; van Amelsvoort, Therese; Veltman, Dick J.; Assogna, Francesca; Banaj, Nerisa; de Rossi, Pietro; Iorio, Mariangela; Piras, Fabrizio; Spalletta, Gianfranco; McKenna, Peter J.; Pomarol-Clotet, Edith; Salvador, Raymond; Corvin, Aiden; Donohoe, Gary; Kelly, Sinead; Whelan, Christopher D.; Dickie, Erin W.; Rotenberg, David; Voineskos, Aristotle N.; Ciufolini, Simone; Radua, Joaquim; Dazzan, Paola; Murray, Robin; Reis Marques, Tiago; Simmons, Andrew; Borgwardt, Stefan; Egloff, Laura; Harrisberger, Fabienne; Riecher-Rössler, Anita; Smieskova, Renata; Alpert, Kathryn I.; Wang, Lei; Jönsson, Erik Gunnar; Koops, Sanne; Sommer, Iris Else Clara; Bertolino, Alessandro; Bonvino, Aurora; Di Giorgio, Annabella; Neilson, Emma; Mayer, Andrew R.; Stephen, Julia M.; Kwon, Jun Soo; Yun, Je-Yeon; Cannon, Dara M.; McDonald, Colm; Lebedeva, Irina; Tomyshev, Alexander S.; Akhadov, Tolibjohn; Kaleda, Vasily; Fatouros-Bergman, Helena & Flyckt, Lena (2018). Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium. Biological Psychiatry. ISSN 0006-3223. . doi: 10.1016/j.biopsych.2018.04.023 Full text in Research Archive.
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Anderssen, Jannicke Fjæra; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Free thyroxine and thyroid-stimulating hormone in severe mental disorders: A naturalistic study with focus on antipsychotic medication. Journal of Psychiatric Research. ISSN 0022-3956. 106, s 74- 81 . doi: 10.1016/j.jpsychires.2018.09.014
Walton, E; Hibar, Derrek; Van Erp, Theo G M; Potkin, Steven G; Roiz-Santiañez, Roberto; Crespo-Facorro, B; Suarez-Pinilla, Paula; van Haren, Neeltje E.M.; de Zwarte, Sonja M.C.; Kahn, René S; Cahn, Wiepke; Doan, Nhat Trung; Jørgensen, Kjetil Nordbø; Gurholt, Tiril Pedersen; Agartz, Ingrid; Andreassen, Ole Andreas; Westlye, Lars Tjelta; Melle, Ingrid; Berg, Akiah Ottesen; Mørch-Johnsen, Lynn Egeland; Færden, Ann; Flyckt, Lena; Fatouros-Bergman, Helena; Jönsson, Erik Gunnar; Hashimoto, Ryota; Yamamori, Hidenaga; Fukunaga, Masaki; Jahanshad, Neda; De Rossi, Pietro; Piras, Fabrizio; Banaj, Nerisa; Spalletta, Gianfranco; Gur, Raquel E; Gur, Ruben C; Wolf, Daniel H.; Satterthwaite, TD; Beard, Lauren M.; Sommer, Iris E; Koops, Sanne; Gruber, Oliver; Richter, A; Krämer, Bernhard; Kelly, S; Donohoe, G; McDonald, C; Cannon, Dara M; Corvin, Aiden; Gill, M; Di Giorgio, Annabella; Bertolino, A; Lawrie, Stephen M; Nickson, Thomas; Whalley, Heather Clare; Neilson, Emma; Calhoun, Vince D.; Thompson, Paul Murray; Turner, J A & Ehrlich, S (2018). Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium. Psychological Medicine. ISSN 0033-2917. 48(1), s 82- 94 . doi: 10.1017/S0033291717001283 Full text in Research Archive.
Wolfers, Thomas; Doan, Nhat Trung; Kaufmann, Tobias; Alnæs, Dag; Moberget, Torgeir; Agartz, Ingrid; Buitelaar, Jan K.; Ueland, Torill; Melle, Ingrid; Franke, Barbara; Andreassen, Ole Andreas; Beckmann, Christian F.; Westlye, Lars Tjelta & Marquand, André F. (2018). Mapping the heterogeneous phenotype of schizophrenia and bipolar disorder using normative models. JAMA psychiatry. ISSN 2168-6238. 75(11), s 1146- 1155 . doi: 10.1001/jamapsychiatry.2018.2467
Aas, Monica; Dieset, Ingrid; Hope, Sigrun; Hoseth, Eva Zsuzsanna; Mørch, Ragni Helene; Reponen, Elina Johanna; Steen, Nils Eiel; Anderssen, Jannicke Fjæra; Ueland, Thor; Aukrust, Pål; Agartz, Ingrid; Andreassen, Ole Andreas & Melle, Ingrid (2017). Childhood maltreatment severity is associated with elevated C-reactive protein and body mass index in adults with schizophrenia and bipolar diagnoses. Brain, behavior, and immunity. ISSN 0889-1591. 65, s 342- 349 . doi: 10.1016/j.bbi.2017.06.005 Full text in Research Archive.
Aas, Monica; Henry, C.; Bellivier, F; Lajnef, M; Gard, S; Kahn, J-P; Lagerberg, Trine Vik; Aminoff, Sofie Ragnhild; Bjella, Thomas; Leboyer, M; Andreassen, Ole Andreas; Melle, Ingrid & Etain, B (2017). Affective lability mediates the association between childhood trauma and suicide attempts, mixed episodes and co-morbid anxiety disorders in bipolar disorders. Psychological Medicine. ISSN 0033-2917. 47(5), s 902- 912 . doi: 10.1017/S0033291716003081

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Malt, Ulrik Fredrik; Andreassen, Ole Andreas; Malt, Eva Albertsen; Melle, Ingrid & Aarsland, Dag (red.) (2018). Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. 1060 s.

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Feyer, Frida Karine; Andersson, Stein; Büchmann, Camilla Bakkalia; Melle, Ingrid; Andreassen, Ole Andreas & Vaskinn, Anja (2020). Social Perception Predicts Awareness of Illness in Persons With Schizophrenia. Journal of Nervous and Mental Disease. ISSN 0022-3018. Publish Ahead of Print . doi: 10.1097/NMD.0000000000001185
Boe, Anne Seljenes; Mehlum, Lars; Stanley, Barbara; Melle, Ingrid & Qin, Ping (2019). Psychiatric comorbidity in adult deliberate self-harm patients: a literature review and Norwegian observation.
Bøe, Anne Seljenes; Mehlum, Lars; Melle, Ingrid & Qin, Ping (2019). Comorbid psychiatric disorder in adult DSH patients: A Norwegian observation.
Friis, Svein; Melle, Ingrid & McGlashan, Thomas H. (2019). Symptom remission at 12-weeks is a strong predictor for long term outcome. Psychological Medicine. ISSN 0033-2917. . doi: 10.1017/S0033291719006435
Gardsjord, Erlend Strand; Gjermundsen, Kristine; Aguirre, Manuela; Berentzen, Lars-Christian & Melle, Ingrid (2019). Designing easy access to care for first-episode psychosis in complex organizations. Early Intervention in Psychiatry. ISSN 1751-7885. . doi: 10.1111/eip.12802
Østefjells, Tiril; Melle, Ingrid; Romm, Kristin Lie; Sønmez, Nasrettin & Røssberg, Jan Ivar (2019). Metacognitive Beliefs in Psychosis: A 15-Month Follow Up Study.
Aminoff, Sofie Ragnhild; Henry, Chantal; Bettella, Francesco; Etain, Bruno; Berg, Akiah Ottesen; Lagerberg, Trine Vik; Bjella, Thomas; Aas, Monica; Djurovic, Srdjan; Bellivier, Frank; Andreassen, Ole Andreas & Melle, Ingrid (2018). Affective lability and polygenic risk in bipolar disorder.
Andreassen, Ole Andreas; Malt, Eva Albertsen; Malt, Ulrik Fredrik; Aarsland, Dag & Melle, Ingrid (2018). Biopsykososial forståelsesmodell, I: Ulrik Fredrik Malt; Ole Andreas Andreassen; Eva Albertsen Malt; Ingrid Melle & Dag Aarsland (red.), Lærebok i psykiatri. Gyldendal Akademisk. ISBN 978-82-05-49463-3. Kapittel 6. s 135 - 142
Berg, Akiah Ottesen; Melle, Ingrid & Nerhus, Mari (2018). ENVIRONAMNETAL RISK FACTORS AND SYMPTOMS IN IMMIGRANTS WITH PSYCHOTIC DISORDER.
Gurholt, Tiril Pedersen; Nerhus, Mari; Osnes, Kåre; Berg, Akiah Ottesen; Andreassen, Ole Andreas; Melle, Ingrid & Agartz, Ingrid (2018). Hippocampus volume reduction in psychosis spectrum could be ameliorated by vitamin D. Schizophrenia Research. ISSN 0920-9964. 199, s 433- 435 . doi: 10.1016/j.schres.2018.03.011
Lam, Max; Trampush, Joey W.; Yu, Jin; Knowles, Emma; Djurovic, Srdjan; Melle, Ingrid; Sundet, Kjetil Søren; Christoforou, Andrea; Reinvang, Ivar; DeRosse, Pamela; Lundervold, Astri; Steen, Vidar Martin; Espeseth, Thomas; Räikkönen, Katri; Widén, Elisabeth; Palotie, Aarno; Eriksson, Johan G.; Giegling, Ina; Konte, Bettina; Roussos, Panos; Giakoumaki, Stella; Burdick, Katherine E.; Payton, Antony; Ollier, William; Chiba-Falek, Ornit; Attix, Deborah K.; Need, Anna C.; Cirulli, Elizabeth T.; Voineskos, Aristotle N.; Stefanis, Nikos C.; Avramopoulos, Dimitrios; Hatzimanolis, Alex; Arking, Dan E.; Smyrnis, Nikolaos; Bilder, Robert M.; Freimer, Nelson A.; Cannon, Tyrone D.; London, Edythe; Poldrack, Russell A.; Sabb, Fred W.; Congdon, Eliza; Conley, Emily Drabant; Scult, Matthew A.; Dickinson, Dwight; Straub, Richard E.; Donohoe, Gary; Morris, Derek; Corvin, Aiden; Gill, Michael; Hariri, Ahmad R.; Weinberger, Daniel R.; Pendleton, Neil; Bitsios, Panos; Rujescu, Dan; Lahti, Jari; Le Hellard, Stephanie; Keller, Matthew C.; Andreassen, Ole Andreas; Glahn, David C.; Malhotra, Anil K. & Lencz, Todd (2018). Multi-Trait analysis of gwas and biological insights into cognition: A response to Hill (2018). Twin Research and Human Genetics. ISSN 1832-4274. 21(5), s 394- 397 . doi: 10.1017/thg.2018.46
Lunde, Ketil Berge; Mehlum, Lars; Stanley, Barbara; Melle, Ingrid & Qin, Ping (2018). The influence of sick leave and sociodemographic factors on risk for deliberate self-harm: A national study.
Svendsen, Ingrid Hartveit; Øie, Merete Glenne; Møller, Paul; Nelson, Barnaby; Melle, Ingrid & Haug, Elisabeth (2018). Self-disturbances and diagnostic stability in first episode psychosis- a seven year follow-up study.
Vedal, Trude Seselie Jahr; Steen, Nils Eiel; Birkeland, Kåre I.; Dieset, Ingrid; Reponen, Elina Johanna; Laskemoen, Jannicke F.; Rødevand, Linn; Melle, Ingrid; Andreassen, Ole Andreas; Molden, Espen & Jönsson, Erik Gunnar (2018). Response: Are thyroid abnormalities only related to antipsychotic treatment in patients with severe mental disorders?. Journal of Psychiatric Research. ISSN 0022-3956. . doi: 10.1016/j.jpsychires.2018.11.012

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Published Apr. 13, 2011 2:54 PM - Last modified Nov. 13, 2018 12:07 PM

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Early-Onset Schizophrenia and ADHD

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Illness trajectories and outcome prediction

Ingrid Melle

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