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Research interests:

  • Colorectal cancer
  • Pseudomyxoma peritonei
  • Translational research 
  • Nanoparticles

Academic background

  • 2020-           Post-doctoral fellowship Faculty of Medicine, University of Oslo, Norway. 
  • 2017-2020   Post-doctoral fellowship, Department of Tumor Biology, Oslo University Hospital, Norway
  • 2013-2017   PhD candidate, Department of Tumor Biology, Oslo University Hospital, Norway. Faculty of Medicine, University of Oslo, Norway.  
Tags: Cancer, colorectal cancer, pseudomyxoma peritonei, in vivo, imaging


  • Nyakas, Marta Sølvi; Fleten, Karianne Giller; Haugen, Mads Haugland; Engedal, Nikolai; Sveen, Christina & Farstad, Inger Nina [Show all 10 contributors for this article] (2022). AXL inhibition improves BRAF-targeted treatment in melanoma. Scientific Reports. ISSN 2045-2322. 12(1). doi: 10.1038/s41598-022-09078-z. Full text in Research Archive
  • Fleten, Karianne Giller; Eksteen, Jacobus Johannes; Mauseth, Brynjar; Camilio, Ketil André; Vasskog, Terje & Sveinbjørnsson, Baldur [Show all 9 contributors for this article] (2021). Oncolytic peptides DTT-205 and DTT-304 induce complete regression and protective immune response in experimental murine colorectal cancer. Scientific Reports. ISSN 2045-2322. 11. doi: 10.1038/s41598-021-86239-6. Full text in Research Archive
  • Lund-Andersen, Christin; Kristensen, Annette Torgunrud; Fleten, Karianne Giller & Flatmark, Kjersti (2021). Omics analyses in peritoneal metastasis-utility in the management of peritoneal metastases from colorectal cancer and pseudomyxoma peritonei: a narrative review. Journal of Gastrointestinal Oncology (JGO). ISSN 2078-6891. 12(Supplement 1). doi: 10.21037/JGO-20-136. Full text in Research Archive
  • Andersson, Yvonne; Fleten, Karianne Giller; Abrahamsen, Torveig Weum; Reed, Wenche; Davidson, Ben & Flatmark, Kjersti (2021). Anti-Angiogenic Treatment in Pseudomyxoma Peritonei - Still a Strong Preclinical Rationale. Cancers. ISSN 2072-6694. 13:2819(11), p. 1–11. doi: 10.3390/cancers13112819. Full text in Research Archive
  • Flatmark, Kjersti; Torgunrud, Annette ; Fleten, Karianne G; Davidson, Ben; Juul, Hedvig Vidarsdotter & Mensali, Nadia [Show all 8 contributors for this article] (2021). Peptide vaccine targeting mutated GNAS: A potential novel treatment for pseudomyxoma peritonei. Journal for ImmunoTherapy of Cancer (JITC). 9:e003109(10), p. 1–10. doi: 10.1136/jitc-2021-003109. Full text in Research Archive
  • Fleten, Karianne Giller; Lund-Andersen, Christin; Waagene, Stein; Abrahamsen, Torveig Weum; Mørch, Ýrr Asbjørg & Pedersen, Kjetil Boye [Show all 8 contributors for this article] (2020). Experimental Treatment of Mucinous Peritoneal Metastases Using Patient-Derived Xenograft Models. Translational Oncology. ISSN 1944-7124. 13(8). doi: 10.1016/j.tranon.2020.100793. Full text in Research Archive
  • Flørenes, Vivi Ann; Flem-Karlsen, Karine; McFadden, Erin; Bergheim, Inger Riise; Nygaard, Vigdis & Nygård, Vegard Mokleiv [Show all 17 contributors for this article] (2019). A Three-dimensional Ex Vivo Viability Assay Reveals a Strong Correlation Between Response to Targeted Inhibitors and Mutation Status in Melanoma Lymph Node Metastases. Translational Oncology. ISSN 1944-7124. 12(7), p. 951–958. doi: 10.1016/j.tranon.2019.04.001. Full text in Research Archive
  • Fusser, Markus; Øverbye, Anders; Pandya, Abhilash D.; Mørch, Ýrr Asbjørg; Borgos, Sven Even F. & Kildal, Wanja [Show all 16 contributors for this article] (2018). Cabazitaxel-loaded Poly(2-ethylbutyl cyanoacrylate) nanoparticles improve treatment efficacy in a patient derived breast cancer xenograft. Journal of Controlled Release. ISSN 0168-3659. 293, p. 183–192. doi: 10.1016/j.jconrel.2018.11.029. Full text in Research Archive
  • Andersson, Yvonne; Ihler, Synne; Davidson, Ben; Dørum, Anne; Fleten, Karianne Giller & Fodstad, Øystein [Show all 7 contributors for this article] (2017). MOC31PE immunotoxin - targeting peritoneal metastasis from epithelial ovarian cancer. OncoTarget. ISSN 1949-2553. 8(37), p. 61800–61809. doi: 10.18632/oncotarget.18694.
  • Fleten, Karianne Giller; Bakke, Kine Mari; Mælandsmo, Gunhild; Abildgaard, Andreas; Redalen, Kathrine Røe & Flatmark, Kjersti (2017). Use of non-invasive imaging to monitor response to aflibercept treatment in murine models of colorectal cancer liver metastases. Clinical and Experimental Metastasis. ISSN 0262-0898. 34(1), p. 51–62. doi: 10.1007/s10585-016-9829-3.
  • Fleten, Karianne Giller; Flørenes, Vivi Ann; Prasmickaite, Lina; Hill, Oliver; Sykora, Jaromir & Mælandsmo, Gunhild [Show all 7 contributors for this article] (2016). hvTRA, a novel TRAIL receptor agonist, induces apoptosis and sustained growth retardation in melanoma. Cell death discovery. ISSN 2058-7716. 2. doi: 10.1038/cddiscovery.2016.81.
  • Flatmark, Kjersti; Sælen, Marie Grøn; Hole, Knut Håkon; Abrahamsen, Torveig Weum; Fleten, Karianne Giller & Hektoen, Helga [Show all 10 contributors for this article] (2016). Individual tumor volume responses to short-course oxaliplatin containing induction chemotherapy in locally advanced rectal cancer – Targeting the tumor for radiation sensitivity? Radiotherapy and Oncology. ISSN 0167-8140. 119(3), p. 505–511. doi: 10.1016/j.radonc.2016.02.020.
  • Vasiliauskaite, Kotryna; Fleten, Karianne Giller; Barkovskaya, Anna; Nygaard, Vigdis; Haugen, Mads Haugland & Engesæter, Birgit Øvstebø [Show all 8 contributors for this article] (2016). Fibroblast-induced switching to the mesenchymal-like phenotype and PI3K/mTOR signaling protects melanoma cells from BRAF inhibitors. OncoTarget. ISSN 1949-2553. 7(15), p. 19997–20015. doi: 10.18632/oncotarget.7671. Full text in Research Archive
  • Repetto-Llamazares, Ada H.V.; Larsen, Roy H.; Patzke, Sebastian; Fleten, Karianne Giller; Didierlaurent, David & Pichard, Alexandre [Show all 8 contributors for this article] (2015). Targeted cancer therapy with a novel anti-CD37 beta-particle emitting radioimmunoconjugate for treatment of non-hodgkin lymphoma. PLOS ONE. ISSN 1932-6203. 10:e0128816(6). doi: 10.1371/journal.pone.0128816.
  • Magnussen, Gry Irene; Emilsen, Elisabeth; Fleten, Karianne Giller; Engesæter, Birgit Øvstebø; Nahse-Kumpf, Viola & Fjær, Roar [Show all 8 contributors for this article] (2015). Combined inhibition of the cell cycle related proteins Wee1 and Chk1/2 induces synergistic anti-cancer effect in melanoma. BMC Cancer. ISSN 1471-2407. 15:462. doi: 10.1186/s12885-015-1474-8.
  • Flatmark, Kjersti; Guldvik, Ingrid Jenny; Svensson, Hege Christin; Fleten, Karianne Giller; Flørenes, Vivi Ann & Reed, Wenche [Show all 9 contributors for this article] (2013). Immunotoxin targeting EpCAM effectively inhibits peritoneal tumor growth in experimental models of mucinous peritoneal surface malignancies. International Journal of Cancer. ISSN 0020-7136. 133(6), p. 1497–1506. doi: 10.1002/ijc.28158.
  • Sælen, Marie Grøn; Ree, Anne Hansen; Kristian, Alexandr; Fleten, Karianne Giller; Furre, Torbjørn & Hektoen, Helga [Show all 7 contributors for this article] (2012). Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma. Radiation Oncology. ISSN 1748-717X. 7. doi: 10.1186/1748-717X-7-165.
  • Størvold, Gro Leite; Fleten, Karianne Giller; Olsen, Cathrine Goberg; Follestad, Turid; Krokan, Hans Einar & Schønberg, Svanhild Margrethe Arentz (2009). Docosahexaenoic acid activates some SREBP-2 targets independent of cholesterol and ER stress in SW620 colon cancer cells. Lipids. ISSN 0024-4201. 44(8), p. 673–683. doi: 10.1007/s11745-009-3324-4.

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  • Åslund, Andreas; Fleten, Karianne Giller; Snipstad, Sofie; Hyldbakk, Astrid; Aursand, Eli Grong & Falck, Annbjørg Eide [Show all 8 contributors for this article] (2021). PACAB: A nanoparticle technology platform for hard-to-treat cancers.
  • Hyldbakk, Astrid; Fleten, Karianne Giller; Snipstad, Sofie; Åslund, Andreas; Folkesson, Evelina & Flatmark, Kjersti [Show all 7 contributors for this article] (2021). ENPERITO: Polymeric nanoparticles for treatment of peritoneal metastases.
  • Fleten, Karianne Giller; Bakke, Kine Mari; Abildgaard, Andreas; Mælandsmo, Gunhild; Redalen, Kathrine Røe & Flatmark, Kjersti (2016). Diffusion-weighted MRI can predict response to aflibercept in in vivo models.
  • Fleten, Karianne Giller & Schønberg, Svanhild Margrethe Arentz (2009). DHA-induced growth inhibtion of SW620 colon cancer cells is in part mediated through phosphorylation of eIF2alpha. NTNU.

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Published May 7, 2019 12:14 PM - Last modified Oct. 28, 2021 5:31 PM