Lise Roman Moltzau

Image of Lise Roman Moltzau
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Phone +47 22840217
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Visiting address Sognsvannsveien 20 Rikshospitalet 0372 OSLO
Postal address Postboks 1057 Blindern 0316 OSLO

Publications

  • Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C.; Moltzau, Lise Roman; Bjørnerem, Marianne; Paterson, David; Kim, Choel; Levy, Finn Olav & Andressen, Kjetil Wessel (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology.  ISSN 2399-3642.  2:394, s 1- 12 . doi: 10.1038/s42003-019-0641-x
  • Cosson, Marie-Victoire; Hiis, Halvard Gautefall; Moltzau, Lise Roman; Levy, Finn Olav & Krobert, Kurt Allen (2019). Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ? <sub>1</sub> -adrenoceptor-mediated inotropic response. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  131, s 132- 145 . doi: 10.1016/j.yjmcc.2019.04.017
  • Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav; Marton, Janos; Froeyen, Mathy; Olberg, Dag Erlend; Diederich, Marc & Bormans, Guy (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery.  ISSN 1570-1808.  14(7), s 787- 797 . doi: 10.2174/1570180813666161101152943 Show summary
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology.  ISSN 0014-2999.  812, s 174- 183 . doi: 10.1016/j.ejphar.2017.07.014
  • Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy, In Viacheslav Nikolaev & Manuela Zaccolo (ed.),  Microdomains in the Cardiovascular System..  Springer.  ISBN 978-3-319-54578-3.  Chapter.  s 245 - 271
  • Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  471(1), s 219- 225 . doi: 10.1016/j.bbrc.2016.01.132
  • Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  477(1), s 14- 19 . doi: 10.1016/j.bbrc.2016.05.138
  • Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters.  ISSN 0960-894X.  24(18), s 4598- 4602 . doi: 10.1016/j.bmcl.2014.06.083
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind; Lothe, Gustav B; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics.  ISSN 0022-3565. . doi: 10.1124/jpet.114.214882
  • Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  387(5), s 407- 417 . doi: 10.1007/s00210-013-0953-1
  • Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  21(22), s 7134- 7145 . doi: 10.1016/j.bmc.2013.09.004
  • Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry.  ISSN 0223-5234.  64, s 629- 637 . doi: 10.1016/j.ejmech.2013.03.060
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina; Ørstavik, Øivind; Sjaastad, Ivar; Christensen, Geir Arve; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology.  ISSN 0007-1188.  170(2), s 366- 379 . doi: 10.1111/bph.12282
  • Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise; Birkeland, Jon Arne; Skomedal, Tor; Osnes, Jan-Bjørn; Sjaastad, Ivar & Levy, Finn Olav (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE.  ISSN 1932-6203.  7(9) . doi: 10.1371/journal.pone.0045489 Full text in Research Archive.
  • Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology.  ISSN 0007-1188.  162(1), s 54- 71 . doi: 10.1111/j.1476-5381.2010.00890.x
  • Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology.  ISSN 0028-1298.  384(6), s 543- 553 . doi: 10.1007/s00210-011-0670-6
  • Berrade, Luis; Aisa, Bárbara; Ramirez, María; Galiano, Silvia; Guccione, Salvatore; Moltzau, Lise Roman; Levy, Finn Olav; Nicoletti, Ferdinando; Battaglia, Giuseppe; Molinaro, Gemma; Aldana, Ignacio; Monge, Antonio & Perez-Silanes, Silvia (2011). Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action. Journal of Medicinal Chemistry.  ISSN 0022-2623.  54(8), s 3086- 3090 . doi: 10.1021/jm2000773
  • Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry.  ISSN 0968-0896.  18(24), s 8600- 8613 . doi: 10.1016/j.bmc.2010.10.011
  • Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR).  ISSN 0008-6363.  85(4), s 763- 772 . doi: 10.1093/cvr/cvp364
  • Kloster, Martine Müller; Hafte, Tolesa Tilahun; Moltzau, Lise Roman; Hallan, Elin; Dahle, Maria Krutå; Skålhegg, Bjørn Steen; Gaudernack, Gustav; Levy, Finn Olav; Naderi, Soheil & Blomhoff, Heidi Kiil (2008). EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cellular Signalling.  ISSN 0898-6568.  20(6), s 1169- 1178 . doi: 10.1016/j.cellsig.2008.02.007

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  • Marshall, Serena; Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B; Lunde, Per Kristian; Monteresi, Stefania; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Zaccolo, Manuela; Carlson, Cathrine Rein & Sjaastad, Ivar (2015). Dual PDE3A coupling to AKAP18 and SERCA2 Controls SERCA2 Activity in adult cardiomyocytes.
  • Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eirik; Levy, Finn Olav & Moltzau, Lise Roman (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology.  ISSN 2050-6511.  16, s A66- A66 . doi: 10.1186/2050-6511-16-S1-A66
  • Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Qvigstad, Eric & Levy, Finn Olav (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
  • Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Lunde, Marianne; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2013). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Aronsen, Jan Magnus; Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Erik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
  • Hougen, Karina; Aronsen, Jan Magnus; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman; Qvigstad, Eirik; Skomedal, Tor; Tasken, Kjetil; Carlson, Cathrine Rein & Sjaastad, Ivar (2012). PDE3A is part of the SERCA2-AKAP18delta macromolecular complex in cardiomyocytes.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR).  ISSN 0008-6363.  93, s S18- S18 . doi: 10.1093/cvr/cvr332
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
  • Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Osnes, Jan-Bjørn & Levy, Finn Olav (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
  • Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav; Skomedal, Tor; Osnes, Jan-Bjørn & Qvigstad, Eirik (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
  • Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz; Skomedal, Tor; Osnes, Jan-Bjørn; Levy, Finn Olav & Qvigstad, Eirik (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology.  ISSN 0767-3981.  22, s 17- 17
  • Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Skomedal, Tor; Levy, Finn Olav; Osnes, Jan-Bjørn & Qvigstad, Eirik (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  42(6), s S152- S152
  • Brattelid, Trond; Bekkevold, Silje Veslemøy; Qvigstad, Eirik; Moltzau, Lise Roman; Sandnes, Dagny Lise; Birkeland, Jon Arne; Sjaastad, Ivar & Levy, Finn Olav (2006). The 5-HT4 receptor - a foetal gene reactivated in heart failure?. Journal of Pharmacological Sciences.  ISSN 1347-8613.  101, s 76- 76
  • Brattelid, Trond; Bekkevold, Silje Veslemøy; Qvigstad, Eirik; Moltzau, Lise Roman; Sandnes, Dagny Lise; Birkeland, Jon Arne; Sjaastad, Ivar & Levy, Finn Olav (2006). The 5-HT4 receptor - a foetal gene reactivated in heart failure?. Journal of Molecular and Cellular Cardiology.  ISSN 0022-2828.  40, s 944- 944

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Published Feb. 25, 2014 9:53 AM