Lise Roman Moltzau

• Andresen, Henriette; Pérez-Ternero, Cristina; Robinson, Jerid; Dickey, Deborah M.; Hobbs, Adrian J. & Potter, Lincoln R. [Show all 9 contributors for this article] (2023). Novel enhancers of guanylyl cyclase-A activity acting via allosteric modulation. British Journal of Pharmacology. ISSN 0007-1188. doi: 10.1111/bph.16203. Full text in Research Archive
• Manfra, Ornella; Calamera, Gaia; Froese, Alexander; Arunthavarajah, Dulasi; Surdo, Nicoletta C. & Meier, Silja [Show all 14 contributors for this article] (2022). CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI: difference from BNP visualized by targeted cGMP biosensors. Cardiovascular Research (CVR). ISSN 0008-6363. 118(6), p. 1506–1519. doi: 10.1093/cvr/cvab167. Full text in Research Archive
• Calamera, Gaia; Moltzau, Lise Roman; Levy, Finn Olav & Andressen, Kjetil Wessel (2022). Phosphodiesterases and Compartmentation of cAMP and cGMP Signaling in Regulation of Cardiac Contractility in Normal and Failing Hearts. International Journal of Molecular Sciences. ISSN 1661-6596. 23:2145(4), p. 1–24. doi: 10.3390/ijms23042145. Full text in Research Archive
• Calamera, Gaia; Li, Dan; Ulsund, Andrea Hembre; Kim, Jeong Joo; Neely, Oliver C. & Moltzau, Lise Roman [Show all 11 contributors for this article] (2019). FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons. Communications Biology. ISSN 2399-3642. 2:394, p. 1–12. doi: 10.1038/s42003-019-0641-x. Full text in Research Archive
• Cosson, Marie-Victoire; Hiis, Halvard Gautefall; Moltzau, Lise Roman; Levy, Finn Olav & Krobert, Kurt Allen (2019). Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the ? <sub>1</sub> -adrenoceptor-mediated inotropic response . Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 131, p. 132–145. doi: 10.1016/j.yjmcc.2019.04.017.
• Moltzau, Lise Roman; Meier, Silja; Andressen, Kjetil Wessel & Levy, Finn Olav (2017). Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy. In Nikolaev, Viacheslav & Zaccolo, Manuela (Ed.), Microdomains in the Cardiovascular System.. Springer. ISSN 978-3-319-54578-3. p. 245–271. doi: 10.1007/978-3-319-54579-0_12.
• Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Hougen, Karina & Skomedal, Tor [Show all 10 contributors for this article] (2017). PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts. European Journal of Pharmacology. ISSN 0014-2999. 812, p. 174–183. doi: 10.1016/j.ejphar.2017.07.014.
• Ahamed, Muneer; Vermeulen, Koen; Schnekenburger, Michael; Moltzau, Lise Roman; Levy, Finn Olav & Marton, Janos [Show all 10 contributors for this article] (2017). Synthesis, Enzyme Assays and Molecular Docking Studies of Fluorinated Bioisosteres of Santacruzamate A as Potential HDAC Tracers. Letters in Drug Design & Discovery. ISSN 1570-1808. 14(7), p. 787–797. doi: 10.2174/1570180813666161101152943. Show summary

  Histone deacetylases (HDACs) emerged as important epigenetic regulators of gene expression. In order to identify potential positron emission tomography (PET) tracers for imaging HDACs, we evaluated in vitro and in cellulo activities of some compounds that were reported as potent HDAC2-selective inhibitors. We observed marked differences between reported activity values and the values obtained in our assays for some of the compounds. To understand the structural basis of the activity of some of these inhibitors, we also performed molecular docking studies to understand their interaction patterns and binding modes with HDAC2. We observed the low affinity compounds 4, 6 and 7 did not showed equal number of key π-π interactions and hydrogen bonding when compared to high affinity compounds, and could be the possible reason for poor inhibition as reflected in in vitro assays. These preliminary experimental and computational results will help to interpret the HDAC affinity values of these key compounds with caution.

• Eikemo, Hilde; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Levy, Finn Olav; Skomedal, Tor & Osnes, Jan-Bjørn (2016). CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 477(1), p. 14–19. doi: 10.1016/j.bbrc.2016.05.138.
• Eikemo, Hilde; Moltzau, Lise Roman; Hussain, Rizwan; Nguyen, Hong Cam Thi; Qvigstad, Eirik & Skomedal, Tor [Show all 8 contributors for this article] (2016). CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes. Biochemical and Biophysical Research Communications - BBRC. ISSN 0006-291X. 471(1), p. 219–225. doi: 10.1016/j.bbrc.2016.01.132.
• Brudeli, Bjarne; Navaratnarajah, Mirusha; Andressen, Kjetil Wessel; Manfra, Ornella; Moltzau, Lise Roman & Nilsen, Nils Olav [Show all 8 contributors for this article] (2014). Discovery and pharmacological profile of new hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. ISSN 0960-894X. 24(18), p. 4598–4602. doi: 10.1016/j.bmcl.2014.06.083.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Skogestad, Jonas; Ørstavik, Øivind & Lothe, Gustav B [Show all 11 contributors for this article] (2014). Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle. Journal of Pharmacology and Experimental Therapeutics. ISSN 0022-3565. doi: 10.1124/jpet.114.214882.
• Moltzau, Lise Roman; Meier, Silja; Aronsen, Jan Magnus; Afzal, Faraz; Sjaastad, Ivar & Skomedal, Tor [Show all 9 contributors for this article] (2014). Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 387(5), p. 407–417. doi: 10.1007/s00210-013-0953-1.
• Brudeli, Bjarne; Moltzau, Lise Roman; Nguyen, Hong Cam Thi; Andressen, Kjetil Wessel; Nilsen, Nils Olav & Levy, Finn Olav [Show all 7 contributors for this article] (2013). Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist. European Journal of Medicinal Chemistry. ISSN 0223-5234. 64, p. 629–637. doi: 10.1016/j.ejmech.2013.03.060.
• Brudeli, Bjarne; Andressen, Kjetil Wessel; Moltzau, Lise Roman; Nilsen, Nils Olav; Levy, Finn Olav & Klaveness, Jo (2013). Acidic biphenyl derivatives: Synthesis and biological activity of a new series of potent 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 21(22), p. 7134–7145. doi: 10.1016/j.bmc.2013.09.004.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Hougen, Karina & Ørstavik, Øivind [Show all 12 contributors for this article] (2013). SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium. British Journal of Pharmacology. ISSN 0007-1188. 170(2), p. 366–379. doi: 10.1111/bph.12282.
• Brattelid, Trond; Qvigstad, Eirik; Moltzau, Lise Roman; Bekkevold, Silje Veslemøy; Sandnes, Dagny Lise & Birkeland, Jon Arne [Show all 10 contributors for this article] (2012). The Cardiac Ventricular 5-HT4 Receptor Is Functional in Late Foetal Development and Is Reactivated in Heart Failure. PLOS ONE. ISSN 1932-6203. 7(9). doi: 10.1371/journal.pone.0045489. Full text in Research Archive
• Berrade, Luis; Aisa, Bárbara; Ramirez, María; Galiano, Silvia; Guccione, Salvatore & Moltzau, Lise Roman [Show all 13 contributors for this article] (2011). Novel Benzo[b]thiophene Derivatives as New Potential Antidepressants with Rapid Onset of Action. Journal of Medicinal Chemistry. ISSN 0022-2623. 54(8), p. 3086–3090. doi: 10.1021/jm2000773.
• Afzal, Faraz; Qvigstad, Eirik; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Show all 8 contributors for this article] (2011). Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle. Naunyn-Schmiedeberg's Archives of Pharmacology. ISSN 0028-1298. 384(6), p. 543–553. doi: 10.1007/s00210-011-0670-6.
• Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Show all 8 contributors for this article] (2011). Differential regulation of beta(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle. British Journal of Pharmacology. ISSN 0007-1188. 162(1), p. 54–71. doi: 10.1111/j.1476-5381.2010.00890.x.
• Brudeli, Bjarne; Moltzau, Lise Roman; Andressen, Kjetil Wessel; Krobert, Kurt Allen; Klaveness, Jo & Levy, Finn Olav (2010). Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists. Bioorganic & Medicinal Chemistry. ISSN 0968-0896. 18(24), p. 8600–8613. doi: 10.1016/j.bmc.2010.10.011.
• Qvigstad, Eirik; Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Hougen, Karina & Sjaastad, Ivar [Show all 9 contributors for this article] (2010). Natriuretic peptides increase beta(1)-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition. Cardiovascular Research (CVR). ISSN 0008-6363. 85(4), p. 763–772. doi: 10.1093/cvr/cvp364.
• Kloster, Martine Müller; Hafte, Tolesa Tilahun; Moltzau, Lise Roman; Hallan, Elin; Dahle, Maria Krutå & Skålhegg, Bjørn Steen [Show all 10 contributors for this article] (2008). EBV infection renders B cells resistant to growth inhibition via adenylyl cyclase. Cellular Signalling. ISSN 0898-6568. 20(6), p. 1169–1178. doi: 10.1016/j.cellsig.2008.02.007.

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• Meier, Silja; Andressen, Kjetil Wessel; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 9 contributors for this article] (2015). Enhancement of cAMP-mediated inotropic responses by CNP is regulated differently by PDE2 in normal and failing hearts. BMC Pharmacology & Toxicology. ISSN 2050-6511. 16, p. A66–A66. doi: 10.1186/2050-6511-16-S1-A66.
• Marshall, Serena; Aronsen, Jan Magnus; Skogestad, Jonas; Albert, Ingrid; Lothe, Gustav B & Lunde, Per Kristian [Show all 13 contributors for this article] (2015). Dual PDE3A coupling to AKAP18 and SERCA2 Controls SERCA2 Activity in adult cardiomyocytes.
• Meier, Silja; Moltzau, Lise Roman; Aronsen, Jan Magnus; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2014). Enhancement of B1 - adrenoceptor signaling by CNP through NPR-B and regulation by phosphodiesterases in normal and failing hearts.
• Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Lunde, Marianne; Enger, Ulla Helene & Moltzau, Lise Roman [Show all 11 contributors for this article] (2013). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
• Aronsen, Jan Magnus; Aronsen, Jan Magnus; Hougen, Karina; Skogestad, Jonas; Enger, Ulla Helene & Moltzau, Lise Roman [Show all 11 contributors for this article] (2012). PDE3A is part of the SERCA2-AKAP18 macromolecular complex in cardiomyocytes.
• Hougen, Karina; Aronsen, Jan Magnus; Skogestad, Jonas; Enger, Ulla Helene; Moltzau, Lise Roman & Qvigstad, Eirik [Show all 10 contributors for this article] (2012). PDE3A is part of the SERCA2-AKAP18delta macromolecular complex in cardiomyocytes.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Sjaastad, Ivar; Skomedal, Tor & Osnes, Jan-Bjørn [Show all 8 contributors for this article] (2012). NPR-A and NPR-B signal in different functional compartments in failing rat left ventricle. Cardiovascular Research (CVR). ISSN 0008-6363. 93, p. S18–S18. doi: 10.1093/cvr/cvr332.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Show all 10 contributors for this article] (2011). The negative inotropic and positive lusitropic responses to CNP are dependent on SERCA2 activity in failing rat ventricle.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Cam; Christensen, Geir Arve & Sjaastad, Ivar [Show all 10 contributors for this article] (2011). The mechanism of CNP-induced negative inotropic and positive lusitropic responses are dependent on SERCA activity in failing rat ventricle.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Meier, Silja; Nguyen, Hong Cam Thi; Afzal, Faraz & Sjaastad, Ivar [Show all 10 contributors for this article] (2010). Compartmentation of the cGMP signal causes differential functional responses after CNP and BNP stimulation in failing myocardium.
• Qvigstad, Eirik; Afzal, Faraz; Aronsen, Jan Magnus; Moltzau, Lise Roman; Sjaastad, Ivar & Skomedal, Tor [Show all 8 contributors for this article] (2010). The NO/cyclic GMP signalling pathway differentially affects 5-HT4 - and B1-AR mediated inotropic responses in failing ventricle.
• Afzal, Faraz; Aronsen, Jon magnus; Moltzau, Lise Roman; Sjaastad, Ivar; Levy, Finn Olav & Skomedal, Tor [Show all 8 contributors for this article] (2009). Differential regulation of b2-adrenoceptor-mediated responses by PDE3 and PDE4 in failing and non-failing rat myocardium.
• Moltzau, Lise Roman; Aronsen, Jan Magnus; Nguyen, Hong Cam Thi; Sjaastad, Ivar; Afzal, Faraz & Skomedal, Tor [Show all 9 contributors for this article] (2008). Phospodiesterases regulating the negative inotropic response of C-type natriuretic peptide in heart failure. Fundamental & Clinical Pharmacology. ISSN 0767-3981. 22, p. 17–17.
• Afzal, Faraz; Andressen, Kjetil Wessel; Mørk, Halvor Kjeang; Aronsen, Jon magnus; Moltzau, Lise Roman & Sjaastad, Ivar [Show all 10 contributors for this article] (2007). 5-HT4-mediated positive inotropic effect is regulated by phosphodiesterase 3 in failing rat heart and human ventricle. Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 42(6), p. S152–S152.
• Brattelid, Trond; Bekkevold, Silje Veslemøy; Qvigstad, Eirik; Moltzau, Lise Roman; Sandnes, Dagny Lise & Birkeland, Jon Arne [Show all 8 contributors for this article] (2006). The 5-HT4 receptor - a foetal gene reactivated in heart failure? Journal of Pharmacological Sciences (JPS). ISSN 1347-8613. 101, p. 76–76.
• Brattelid, Trond; Bekkevold, Silje Veslemøy; Qvigstad, Eirik; Moltzau, Lise Roman; Sandnes, Dagny Lise & Birkeland, Jon Arne [Show all 8 contributors for this article] (2006). The 5-HT4 receptor - a foetal gene reactivated in heart failure? Journal of Molecular and Cellular Cardiology. ISSN 0022-2828. 40, p. 944–944.

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