Manoj Amrutkar

Image of Manoj Amrutkar
Norwegian version of this page
Mobile phone +4740994132
Room A2.3064
Visiting address Department of Pharmacology Rikshospitalet Sognsvannsveien 20 0372 Oslo
Postal address OUS, Rikshospitalet Postboks 4950 Nydalen 0424 Oslo
Other affiliations Faculty of Medicine (Student)


  • Amrutkar, Manoj; Larsen, Emma Kristine; Aasrum, Monica; Finstadsveen, Anette Vefferstad; Andresen, Per Arne; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2020). Establishment and Characterization of Paired Primary Cultures of Human Pancreatic Cancer Cells and Stellate Cells Derived from the Same Tumor. Cells.  ISSN 2073-4409.  9:227(1), s 1- 18 . doi: 10.3390/cells9010227 Full text in Research Archive.
  • Amrutkar, Manoj; Aasrum, Monica; Verbeke, Caroline Sophie & Gladhaug, Ivar Prydz (2019). Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells. BMC Cancer.  ISSN 1471-2407.  19(596) . doi: 10.1186/s12885-019-5803-1 Full text in Research Archive.
  • Cansby, Emmelie; Kulkarni, Nagaraj M; Magnusson, Elin; Kurhe, Yeshwant; Amrutkar, Manoj; Nerstedt, Annika; Ståhlman, Marcus; Sihlbom, Carina; Marschall, Hanns-Ulrich; Borén, Jan; Blüher, Matthias & Mahlapuu, Margit (2019). Protein Kinase MST3 Modulates Lipid Homeostasis in Hepatocytes and Correlates With Nonalcoholic Steatohepatitis in Humans. The FASEB Journal.  ISSN 0892-6638.  33(9), s 9974- 9989 . doi: 10.1096/fj.201900356RR
  • Cansby, Emmelie; Nunez-duran, Esther; Magnusson, Elin; Amrutkar, Manoj; Booten, Sheri L.; Kulkarni, Nagaraj M; Svensson, L. Thomas; Borén, Jan; Marschall, Hanns-Ulrich; Aghajan, Mariam & Mahlapuu, Margit (2019). Targeted Delivery of Stk25 Antisense Oligonucleotides to Hepatocytes Protects Mice Against Nonalcoholic Fatty Liver Disease. Cellular and Molecular Gastroenterology and Hepatology (CMGH).  ISSN 2352-345X.  7(3), s 597- 618 . doi: 10.1016/j.jcmgh.2018.12.004 Full text in Research Archive.
  • Lenggenhager, Daniela; Amrutkar, Manoj; Santha, Petra; Aasrum, Monica; Löhr, Johannes-Matthias; Gladhaug, Ivar Prydz & Verbeke, Caroline Sophie (2019). Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions With Pancreatic Cancer Cells. Cells.  ISSN 2073-4409.  8:E23(1), s 1- 18 . doi: 10.3390/cells8010023 Full text in Research Archive.
  • Cansby, Emmelie; Magnusson, Elin; Nunez-duran, Esther; Amrutkar, Manoj; Pedrelli, Matteo; Parini, Paolo; Hoffmann, Jenny; Ståhlman, Marcus; Howell, Brian w.; Marschall, Hanns-Ulrich; Borén, Jan & Mahlapuu, Margit (2018). STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  38(8) . doi: 10.1161/ATVBAHA.118.311241
  • Sutt, Silva; Cansby, Emmelie; Paul, Alexandra; Amrutkar, Manoj; Nunez-duran, Esther; Kulkarni, Nagaraj M; Ståhlman, Marcus; Boren, Jan; Laurencikiene, Jurga; Howell, Brian w.; Enerbäck, Sven & Mahlapuu, Margit (2018). STK25 regulates oxidative capacity and metabolic efficiency in adipose tissue. Journal of Endocrinology.  ISSN 0022-0795.  238(3), s 187- 202 . doi: 10.1530/JOE-18-0182 Full text in Research Archive.
  • Amrutkar, Manoj & Gladhaug, Ivar Prydz (2017). Pancreatic cancer chemoresistance to gemcitabine. Cancers.  ISSN 2072-6694.  9(11:157), s 1- 23 . doi: 10.3390/cancers9110157

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  • Chursa, Urszula; Nunez-duran, Esther; Cansby, Emmelie; Amrutkar, Manoj; Sutt, Silva; Ståhlman, Marcus; Olsson, Britt-marie; Borén, Jan; Johansson, Maria e.; Bäckhed, Fredrik; Johansson, Bengt r.; Sihlbom, Carina & Mahlapuu, Margit (2017). Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle. Diabetologia.  ISSN 0012-186X.  60(3), s 553- 567 . doi: 10.1007/s00125-016-4171-5
  • Nunez-duran, Esther; Aghajan, Mariam; Amrutkar, Manoj; Sutt, Silva; Cansby, Emmelie; Booten, Sheri l.; Watt, Andrew; Ståhlman, Marcus; Stefan, Norbert; Haring, Hans-ulrich; Staiger, Harald; Borén, Jan; Marschall, Hanns-Ulrich & Mahlapuu, Margit (2017). Serine/Threonine Protein Kinase 25 Antisense Oligonucleotide Treatment Reverses Glucose Intolerance, Insulin Resistance, and Nonalcoholic Fatty Liver Disease in Mice. Hepatology communications..  ISSN 2471-254X.  2(1), s 69- 83 . doi: 10.1002/hep4.1128
  • Amrutkar, Manoj; Chursa, Urszula; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Sutt, Silva; Borén, Jan; Johansson, Bengt r.; Marschall, Hanns-Ulrich; Blüher, Matthias & Mahlapuu, Margit (2016). STK25 is a critical determinant in nonalcoholic steatohepatitis. The FASEB Journal.  ISSN 0892-6638.  30(10), s 3628- 3643 . doi: 10.1096/fj.201600562R
  • Amrutkar, Manoj; Kern, Matthias; Nunez-duran, Esther; Ståhlman, Marcus; Cansby, Emmelie; Chursa, Urszula; Stenfeldt, Elin; Borén, Jan; Blüher, Matthias & Mahlapuu, Margit (2016). Protein kinase STK25 controls lipid partitioning in hepatocytes and correlates with liver fat content in humans. Diabetologia.  ISSN 0012-186X.  59, s 341- 353 . doi: 10.1007/s00125-015-3801-7
  • Amrutkar, Manoj; Cansby, Emmelie; Chursa, Urszula; Nunez-duran, Esther; Chanclón, Belén; Ståhlman, Marcus; Friden, Vincent; Mannerås-holm, Louise; Wickman, Anna; Smith, Ulf; Bäckhed, Fredrik; Borén, Jan; Howell, Brian w. & Mahlapuu, Margit (2015). Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes.  ISSN 0012-1797.  64, s 2791- 2804 . doi: 10.2337/db15-0060
  • Amrutkar, Manoj; Cansby, Emmelie; Nunez-duran, Esther; Pirazzi, Carlo; Ståhlman, Marcus; Stenfeldt, Elin; Smith, Ulf; Borén, Jan & Mahlapuu, Margit (2015). Protein kinase STK25 regulates hepatic lipid partitioning and progression of liver steatosis and NASH. The FASEB Journal.  ISSN 0892-6638.  29(4), s 1564- 1576 . doi: 10.1096/fj.14-264937
  • Cansby, Emmelie; Nerstedt, Annika; Amrutkar, Manoj; Nunez-duran, Esther; Smith, Ulf & Mahlapuu, Margit (2014). Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  393, s 143- 151 . doi: 10.1016/j.mce.2014.06.014
  • Cansby, Emmelie; Amrutkar, Manoj; Mannerås-holm, Louise; Nerstedt, Annika; Reyahi, Azadeh; Stenfeldt, Elin; Booten, Sheri l.; Carlsson, Peter; Smith, Ulf; Zierath, Juleen r. & Mahlapuu, Margit (2013). Increased expression of STK25 leads to impaired glucose utilization and insulin sensitivity in mice challenged with a high-fat diet. The FASEB Journal.  ISSN 0892-6638.  27(9), s 3660- 3671 . doi: 10.1096/fj.13-228494
  • Nerstedt, Annika; Cansby, Emmelie; Amrutkar, Manoj; Smith, Ulf & Mahlapuu, Margit (2013). Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  375, s 68- 78 . doi: 10.1016/j.mce.2013.05.013

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Published Jan. 19, 2017 10:12 AM - Last modified Apr. 2, 2019 10:46 PM