Michael Frisk

• Frisk, Michael; Le, Christopher; Shen, Xin; Røe, Åsmund Treu; Hou, Yufeng; Manfra, Ornella; Silva, Gustavo Jose Justo; van Hout, Isabelle; Norden, Einar Sjaastad; Aronsen, Jan Magnus; Laasmaa, Martin; Espe, Emil Knut Stenersen; Zouein, Fouad A.; Lambert, Regis P.; Dahl, Christen Peder; Sjaastad, Ivar; Lunde, Ida Gjervold; Coffey, Sean; Cataliotti, Alessandro; Gullestad, Lars; Tønnessen, Theis; Jones, Peter P; Altara, Raffaele & Louch, William Edward (2021). Etiology-dependent impairment of diastolic cardiomyocyte calcium homeostasis in heart failure with preserved ejection fraction. Journal of the American College of Cardiology.  ISSN 0735-1097.  77(4), s 405- 419 . doi: 10.1016/j.jacc.2020.11.044 Full text in Research Archive.
• Altara, Raffaele; Silva, Gustavo Jose Justo; Frisk, Michael; Spelta, Francesco; Zouein, Fouad A.; Louch, William Edward; Booz, George W. & Cataliotti, Alessandro (2020). Cardioprotective Effects of the Novel Compound Vastiras in a Preclinical Model of End-Organ Damage. Hypertension.  ISSN 0194-911X.  75(5), s 1195- 1204 . doi: 10.1161/HYPERTENSIONAHA.120.14704
• Frisk, Michael; Høyland, Maren; Zhang, Lili; Vindas, Marco; Øverli, Øyvind & Johansen, Ida Beitnes (2020). Intensive smolt production is associated with deviating cardiac morphology in atlantic salmon. Aquaculture.  ISSN 0044-8486.  529 . doi: 10.1016/j.aquaculture.2020.735615 Full text in Research Archive. Show summary

  High pre-slaughter mortality rates of Atlantic salmon (Salmo salar L.) are a reoccurring welfare issue and economic burden in aquaculture. Sudden death immediately prior to slaughter is particularly problematic given the considerable resources invested to reach this stage. Although the underlying causes of such mortality are largely unknown, cardiac deformities and diseases have become increasingly prevalent observations in deceased fish. The factors leading to this pathology remains to be revealed. Thus, we presently examined if intensive smolt production and concordant fast growth rates in young fish is associated with altered cardiac morphology at later production stages in Atlantic salmon. The observed alterations were subsequently related to mortality risk following de-lousing in a facility with a cardiomyopathy syndrome (CMS) outbreak. We observed that intensive smolt production is indeed associated with slower growth rates at sea, distinct pathological cardiac morphological alterations, and expression of cardiac pathology markers. Moreover, the observed cardiac alterations co-occurred with CMS-related cardiac rupture at a different production facility. The present study demonstrates a clear link between pace of growth at early rearing stages and cardiac deformities later in life. Furthermore, these cardiac deformities are associated with cardiac rupture and mortality in individuals with CMS during delousing. We therefore believe that a slower pace of smolt production improves cardiac health and reduces the risk of mortality during CMS outbreaks.

• Tazmini, Kiarash; Frisk, Michael; Lewalle, Alexandre; Laasmaa, Martin; Morotti, Stefano; Lipsett, David Bruce; Manfra, Ornella; Skogestad, Jonas; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Edwards, Andrew G.; Grandi, Eleonora; Niederer, Steven A.; Øie, Erik & Louch, William Edward (2020). Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes. Circulation Research.  ISSN 0009-7330.  126(7), s 889- 906 . doi: 10.1161/CIRCRESAHA.119.315641 Full text in Research Archive.
• Colli, Dylan; Blood, S Ryan; Sankarankutty, Aparna C; Sachse, Frank B.; Frisk, Michael; Louch, William Edward & Kekenes-Huskey, Peter M (2019). A Matched-Filter-Based Algorithm for Subcellular Classification of T-System in Cardiac Tissues. Biophysical Journal.  ISSN 0006-3495.  116(8), s 1386- 1393 . doi: 10.1016/j.bpj.2019.03.010
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Buonarati, Olivia R.; Cataliotti, Alessandro; Hell, Johannes W.; Sjaastad, Ivar; Christensen, Geir Arve & Louch, William Edward (2019). Cardiomyocyte substructure reverts to an immature phenotype during heart failure. Journal of Physiology.  ISSN 0022-3751.  597(7), s 1833- 1853 . doi: 10.1113/JP277273 Full text in Research Archive.
• Kolstad, Terje R Selnes; Brink, Jonas van Den; Macquaide, Niall; Lunde, Per Kristian; Frisk, Michael; Aronsen, Jan Magnus; Norden, Einar Sjaastad; Cataliotti, Alessandro; Sjaastad, Ivar; Sejersted, Ole M; Edwards, Andrew; Lines, Glenn Terje & Louch, William Edward (2018). Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes. eLIFE.  ISSN 2050-084X.  7 . doi: 10.7554/eLife.39427 Full text in Research Archive.
• Johansen, Ida Beitnes; Sandblom, Erik; Skov, Peter V.; Gräns, Albin; Ekström, Andreas; Lunde, Ida Gjervold; Vindas, Marco Antonio; Zhang, Lili; Höglund, Erik; Frisk, Michael; Sjaastad, Ivar; Nilsson, Göran Erik & Øverli, Øyvind (2017). Bigger is not better: cortisol-induced cardiac growth and dysfunction in salmonids. Journal of Experimental Biology.  ISSN 0022-0949.  220(14), s 2545- 2553 . doi: 10.1242/jeb.135046 Full text in Research Archive.
• Manfra, Ornella; Frisk, Michael & Louch, William Edward (2017). Regulation of cardiomyocyte T-tubular structure: opportunities for therapy. Current Heart Failure Reports.  ISSN 1546-9530.  14(3), s 167- 178 . doi: 10.1007/s11897-017-0329-9 Full text in Research Archive.
• Parikh, Shan S.; Blackwell, Daniel J.; Gomez-Hurtado, Nieves; Frisk, Michael; Wang, Lili; Kim, Kyungsoo; Dahl, Christen Peder; Fiane, Arnt E; Tønnessen, Theis; Kryshtal, Dmytro O.; Louch, William Edward & Knollman, Bjorn C. (2017). Thyroid and glucocorticoid hormones promote functional t-tubule Development in human-induced pluripotent stem cell-derived cardiomyocytes. Circulation Research.  ISSN 0009-7330.  121(12), s 1323- 1330 . doi: 10.1161/CIRCRESAHA.117.311920
• Frisk, Michael; Ruud, Marianne; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Røe, Åsmund Treu; Zhang, Lili; Norseng, Per Andreas; Sejersted, Ole M; Christensen, Geir Arve; Sjaastad, Ivar & Louch, William Edward (2016). Elevated ventricular wall stress disrupts cardiomyocyte t-tubule structure and calcium homeostasis. Cardiovascular Research (CVR).  ISSN 0008-6363. . doi: 10.1093/cw111
• Gattoni, Sara; Røe, Åsmund Treu; Frisk, Michael; Louch, William Edward; Niederer, Steven A. & Smith, Nicolas P. (2016). The calcium-frequency response in the rat ventricular myocyte: an experimental and modeling study. Journal of Physiology.  ISSN 0022-3751.  594(15), s 4193- 4224 . doi: 10.1113/JP272011
• Louch, William Edward; Frisk, Michael & Eggart, Benjamin (2016). High-speed recording of cardiomyocyte calcium and contraction. Ultra-low calcium signaling measured at high speeds. Optik & Photonik.  ISSN 2191-1975.  4 . doi: 10.1002/opph.201600032
• Røe, Åsmund Treu; Frisk, Michael & Louch, William Edward (2015). Targeting cardiomyocyte Ca2+ homeostasis in heart failure. Current pharmaceutical design.  ISSN 1381-6128.  21(4), s 431- 448 . doi: 10.2174/138161282104141204124129
• Frisk, Michael; Koivumaki, Jussi; Norseng, Per Andreas; Maleckar, Mary; Sejersted, Ole M & Louch, William Edward (2014). Variable t-tubule organization and Ca2+ homeostasis across the atria. American Journal of Physiology. Heart and Circulatory Physiology.  ISSN 0363-6135.  307(4), s H609- H620 . doi: 10.1152/ajpheart.00295.2014

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• Frisk, Michael; Lipsett, David Bruce & Louch, William Edward (2019). Reply to Crocini et al., Journal of Physiology, 2019, JP-LE-2019-278018. Journal of Physiology.  ISSN 0022-3751.  597(11), s 2967- 2968
• Parikh, Shan; Blackwell, DJ; Gomez-Hurtado, N; Frisk, Michael; Wang, L; Kim, K; Dahl, Christen Peder; Tønnessen, Theis; Kryshtal, DO; Knollmann, BC & Louch, William Edward (2017). Thyroid and Glucocorticoid Hormones Promote Functional T-tubule Development in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes. Circulation.  ISSN 0009-7322.  136, s A14975
• Kolstad, Terje R Selnes; Macquaide, Niall; Hake, Johan; Aronsen, Jan Magnus; Frisk, Michael; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2016). Dispersion of ryanodine receptor clusters disrupts calcium sparks in failing cardiomyocyte.
• Kolstad, Terje R Selnes; Macquaide, Niall; Hake, Johan; Aronsen, Jan Magnus; Frisk, Michael; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2016). Super-resolution imaging reveals dispersion of ryanodine receptor clusters during heart failure.
• Li, Jia; Frisk, Michael; Norseng, Per Andreas; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2016). Regional activation of the Frank-Starling mechanism within the cardiomyocyte.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Christensen, Geir Arve & Louch, William Edward (2016). Sarcolemmal structure and function revert to an immature phenotype in failing cardiomyocytes.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Singh, Neha; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, J. Andrew; Christensen, Geir Arve & Louch, William Edward (2016). BIN1 triggers t-tubule development in cardiomyocytes.
• Ruud, Marianne; Frisk, Michael; Aronsen, Jan Magnus; Dahl, Christen Peder; Jølle, Guro Five; Aakhus, Svend; Lunde, Ida Gjervold; Almaas, Vibeke; Gullestad, Lars; Sjaastad, Ivar; Tønnessen, Theis; Sejersted, Ole M; Norseng, Per Andreas; Christensen, Geir Arve & Louch, William Edward (2016). Mechanical load regulates cardiomyocyte t-tubular structure and Ca2+ homeostasis.
• Ruud, Marianne; Frisk, Michael; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Zhang, Lili; Norseng, Per Andreas; Sjaastad, Ivar; Sejersted, Ole M; Christensen, Geir Arve & Louch, William Edward (2016). Elevated ventricular wall stress disrupts cardiomyocyte t-tubular structure and Ca2+ homeostasis.
• Tazmini, Kiarash; Frisk, Michael; Lipsett, David Bruce; Aronsen, Jan Magnus; Sjaastad, Ivar; Øie, Erik & Louch, William Edward (2016). Pro-arrhythmic consequences of hypokalemia in atrial cardiomyocytes.
• Frisk, Michael (2015). Structure and function of cardiac t-tubules in health and disease.
• Frisk, Michael; Aronsen, Jan Magnus; Dahl, Christen Peder; Lunde, Ida Gjervold; Jølle, Guro Five; Almaas, Victor; Gullestad, Lars; Christensen, Geir Arve; Aakhus, Svend; Sejersted, Ole M; Tønnessen, Theis; Sjaastad, Ivar & Louch, William Edward (2015). Maintained cardiomyocyte t-tubule structure and function in patients with non-dilated hypertrophy.
• Frisk, Michael; Ruud, Marianne; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Røe, Åsmund Treu; Zhang, Lili; Norseng, Per Andreas; Christensen, Geir Arve; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2015). Ventricular wall stress predicts disruption of cardiomyocyte t-tubule structure and Ca2+ homeostasis across the infarcted heart. Biophysical Journal.  ISSN 0006-3495.  108, s 106a
• Kolstad, Terje R Selnes; MacQuaide, Niall; Hake, Johan; Aronsen, Jan Magnus; Frisk, Michael; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2015). Super-resolution imaging of ryanodine receptor cluster organization in normal and failing rat cardiac myocytes.
• Kolstad, Terje R Selnes; Macquaide, Niall; Hake, Johan; Aronsen, Jan Magnus; Frisk, Michael; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2015). Super-resolution imaging of ryanodine receptor cluster organization in normal and failing rat cardiac myocytes.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Singh, Neha; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, John Andrew; Christensen, Geir Arve & Louch, William Edward (2015). BIN1 regulates t-tubule growth during cardiac development and disease.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Singh, Neha; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, John Andrew; Christensen, Geir Arve & Louch, William Edward (2015). BIN1 regulates t-tubule growth during cardiac development and disease.
• Lipsett, David Bruce; Frisk, Michael; Aronsen, Jan Magnus; Singh, Neha; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, John Andrew; Christensen, Geir Arve & Louch, William Edward (2015). BIN1 regulates t-tubule growth during cardiac development and diseases.
• Lipsett, David Bruce; Frisk, Michael; Singh, Neha; Aronsen, Jan Magnus; Marszalec, William; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, J. Andrew; Christensen, Geir Arve & Louch, William Edward (2015). Bridging integrator 1 (BIN1) initiates t-tubule Growth during Cardiac Development and disease. Biophysical Journal.  ISSN 0006-3495.  108, s 130a- 130a
• Lipsett, David Bruce; Frisk, Michael; Singh, Neha; Aronsen, Jan Magnus; Marszalec, William; Sjaastad, Ivar; Wasserstrom, Andrew; Christensen, Geir Arve & Louch, William Edward (2015). Bridging integrator 1 (B1N1) initiates t-tubule growth cardiac development and disease.
• Ruud, Marianne; Frisk, Michael; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Norseng, Per Andreas; Sjaastad, Ivar; Sejersted, Ole M; Christensen, Geir Arve & Louch, William Edward (2015). Elevated ventricular wall stress disrupts cardiomyocyte t-tubular structure and Ca2+ homeostasis.
• Ruud, Marianne; Frisk, Michael; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Norseng, Per Andreas; Sjaastad, Ivar; Sejersted, Ole M; Christensen, Geir Arve & Louch, William Edward (2015). Elevated ventricular wall stress disrupts cardiomyocyte t-tubular structure and Ca2+ homeostasis.
• Ruud, Marianne; Frisk, Michael; Norseng, Per Andreas; Røe, Åsmund Treu; Espe, Emil Knut Stenersen; Aronsen, Jan Magnus; Sjaastad, Ivar; Sejersted, Ole M; Christensen, Geir Arve & Louch, William Edward (2015). Regulation of cardiomyocyte t-tubule organization and density by ventricular wall stress. Biophysical Journal.  ISSN 0006-3495.  108, s 443a- 443a
• Tazmini, Kiarash; Frisk, Michael; Aronsen, Jan Magnus; Sjaastad, Ivar; Øie, Eric & Louch, William Edward (2015). Pro-arrhythmic consequences of hypokalemia in atrial cardiomyocytes.
• Frisk, Michael; Espe, Emil Knut Stenersen; Røe, Åsmund Treu; Aronsen, Jan Magnus; Enger, Ulla Helene; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2014). In vivo strain measurements predict regional disruption of cardiomyocyte structure and Ca2+ homeostasis during heart failure..
• Frisk, Michael; Espe, Emil Knut Stenersen; Røe, Åsmund Treu; Aronsen, Jan Magnus; Enger, Ulla Helene; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2014). Regional left ventricular strain and wall stress predict cardiomyocyte T-tubular structure and Ca2+ homeostasis following myocardial infarction.
• Lipsett, David Bruce; Frisk, Michael; Hodne, Kjetil; Singh, Neha; Nygård, Ståle; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, Andrew J.; Christensen, Geir Arve & Louch, William Edward (2014). B1N1 controls longitudinal T-tubule growth in cardiomyocytes during development and disease.
• Lipsett, David Bruce; Singh, Neha; Frisk, Michael; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, J. Andrew; Christensen, Geir Arve & Louch, William Edward (2014). Bridging integrator 1 (BIN1)-induced t-tubule formation in cardiomyocytes. Biophysical Journal.  ISSN 0006-3495.  106(2), s 772a
• Ruud, Marianne; Frisk, Michael; Norseng, Per Andreas; Røe, Åsmund Treu; Sejersted, Ole M; Christensen, Geir Arve & Louch, William Edward (2014). Regulation of cardiomyocyte t-tubule organization by preload and afterload.
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2014). Active and passive stiffness in a hypertrophic rat model of diastolic dysfunction.
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2014). Compensatory alterations in cardiomyocytes Ca2+ homeostasis during aortic stenosis.
• Tazmini, Kiarash; Frisk, Michael; Aronsen, Jan Magnus; Sjaastad, Ivar; Øie, Erik & Louch, William Edward (2014). Pro-arrhythmic consequences of hypokalemia in atrial cardiomyocytes.
• Frisk, Michael; Jølle, Guro Five; Lunde, Ida Gjervold; Skrbic, Biljana; Sejersted, Ole M; Tønnessen, Theis; Sjaastad, Ivar & Louch, William Edward (2013). Aortic Stenosis Triggers T-Tubule Growth in Human and Murine Cardiomyocytes. Biophysical Journal.  ISSN 0006-3495.  104(2), s 603A- 603A
• Frisk, Michael; Jølle, Guro Five; Lunde, Ida Gjervold; Skrbic, Biljana; Sejersted, Ole M; Tønnessen, Theis; Sjaastad, Ivar & Louch, William Edward (2013). Aortic stenosis triggers t-tubule growth in human and murine cardiomyocytes.
• Frisk, Michael; Norseng, Per Andreas; Sejersted, Ole M & Louch, William Edward (2013). Variable t-tubule density and Ca2+ homeostasis across the atria.
• Frisk, Michael; Norseng, Per Andreas; Sejersted, Ole M & Louch, William Edward (2013). Variable t-tubule density and calcium homeostasis across the atria.
• Frisk, Michael; Norseng, Per Andreas; Sejersted, Ole M & Louch, William Edward (2013). Variable t-tubule density and calcium homeostasis across the atria. Circulation.  ISSN 0009-7322.  128
• Lipsett, David Bruce; Singh, Neha; Frisk, Michael; Aronsen, Jan Magnus; Sejersted, Ole M; Sjaastad, Ivar; Wasserstrom, J. Andrew; Christensen, Geir Arve & Louch, William Edward (2013). Bridging integrator1(BIN1)-induced t-tubule formation in cardiomyocytes.
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Lunde, Ida Gjervold; Riise, Jon; Sejersted, Ole M; Christensen, Geir Arve; Tønnessen, Theis; Sjaastad, Ivar & Louch, William Edward (2013). Compensatory alterations in cardiomyocytes Ca2+ homeostasis during aortic stenosis. Circulation.  ISSN 0009-7322.  128
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2013). Active and passive stiffness in a hypertrophic rat model of diastolic dysfunction.
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2013). Compensated Cardiomyocyte Ca2+ Homeostasis in a Rat Model of Diastolic Heart Failure. Biophysical Journal.  ISSN 0006-3495.  104(2), s 603A- 603A
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sejersted, Ole M; Sjaastad, Ivar & Louch, William Edward (2013). Contribution of active and passive stiffness to diastolic dysfunction in rats following aortic bonding.
• Røe, Åsmund Treu; Aronsen, Jan Magnus; Frisk, Michael; Sjaastad, Ivar; Sejersted, Ole M & Louch, William Edward (2013). Contribution of active and passive stiffness to diastolic dysfunction in rats following aortic banding.
• Frisk, Michael; Sejersted, Ole M & Louch, William Edward (2012). Variable t-tubule density and excitation-contraction coupling in rat atrial cardiomyocytes.
• Frisk, Michael; Sejersted, Ole M & Sjaastad, Ivar (2012). Variable t-tubule density and excitation-contraction coupling in rat atrial cardiomyocytes.
• Frisk, Michael; Sejersted, Ole M & Sjaastad, Ivar (2012). Variable t-tubule density and organization in rat atrial cardiomyocytes. Biophysical Journal.  ISSN 0006-3495.  102(3), s 139- 139

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